Background: Intradialytic Hypertension is the most common complication in patients undergoing hemodialysis. In some studies, it increases mortality risk among hemodialysis patients. Managing its causative factors can prevent intradialytic hypertension and decrease mortality risk among hemodialysis patients. Objective: To determine the factors related to intradialytic hypertension Method: A cross-sectional study occurred in November 2021 at Roemani Muhammadiyah Hospital Semarang. The inclusion criteria were undergoing hemodialysis ≥3 months, hemodialysis frequency twice a week, aged ≥18 years, communicable, and agreed to join in this study. Meanwhile, patients with incomplete data were excluded. Collected data was then analyzed using SPSS. The dependent variable was gender, duration of hemodialysis, elderly, time dialysis, and diabetes. While the independent variable was intradialytic hypertension that is defined as increasing of systolic blood pressure ≥15 mmHg in the end of hemodialysis session. Result: The prevalence of intradialytic hypertension in this study is 37,8%. Chi-Square analysis showed that patients who had undergone hemodialysis for ≥12 months and time dialysis ≤ 4 hours per dialysis session had a higher risk of intradialytic hypertension (p-value: 0,006; 0,028; PR= 3,844; 2,819). While gender, elderly and diabetes has no significant relationship (p-value: 0,825; 0,587; 0,123). Conclusion: Duration of hemodialysis and time dialysis per session have significant relationship to intradialytic hypertension. While gender, elderly and diabetes