17 COMPARISON ASYMMETRIC DIMETHYLARGININE LEVELS BETWEEN PATIENTS WITH INTRADIALYTIC HYPERTENSION AND STABLE BLOOD PRESSURE IN MOHAMMAD HOESIN HOSPITAL PALEMBANG

Abstract

Background: The annual global growth of chronic renal failure cases is around 7% and in Indonesia is 12.5% of its population. The common complication in haemodialyzed ESRD patients is hemodynamic changes like hypertension. The prevalence of intradialytic hypertension is 5–15%. Endothelial dysfunction have a role in hemodynamic change during haemodialysis. Important humoral factors in the form of vasoactive substance are NO as a vasodilator, ADMA as an endogenous inhibitor of NO synthesis and ET-1 as a vasoconstrictor. The purpose of this journal is to know the difference in serum ADMA levels before and after haemodialysis between stable blood pressure and intradialytic hypertension in patients with chronic renal failure. Methods: The study design was observational analytic study with case control design. The study was conducted in Haemodialysis Unit of Mohammad Hoesin Hospital Palembang from November 2015-April 2016. The total subjects were 24 patients, 12 were in intradialytic hypertension group and 12 were in stable blood pressure group (control group). The measurements of ADMA levels were performed before and after haemodialysis. Results: In all two groups, most of the patients were aged between 37–48 years. There were 14 (58.3%) men and 10 (41.7%) women. The mean ADMA levels in intradialytic hypertension group and control group were 0,26 ± 0,15 μmol/L and 0,17 ± 0,09 μmol/L (p = 0,09) Conclusion: In the two groups, there are changes in the ADMA levels between the ones before haemodialysis and those after haemodialysis, but not significant.