Erectile dysfunction (ED) is a condition with a higher prevalence in the elderly. A multinational survey of elderly men conducted in America, France, Germany, Italy, the Netherlands, Spain, and England showed an association with ED in >12,000 men aged 50-80. There is an increasing prevalence of hypercholesterolemia and hypertriglyceridemia in men with ED. Testosterone deficiency is the most common hormonal cause of ED and has recently been considered a global health problem associated with cardiovascular morbidity and mortality.Prostate-specific antigen (PSA)affects prostate volume associated with high testosterone. This study aims to determine age, lipid profile, testosterone, and PSA levels are predictors of ED incidence in BPH patients. Using analytic observational retrospective cohort design, years) with p=0.003, OR 0.2 (95% CI: 0, 07-0.58)which means that there is an increase of 0.2 times ED at age >60 years, lipid profile obtained p=0.016, OR 3.7 (CI95%: 1.22-11.45)which means an increase in cholesterol lipid profile total > 200 mg/dL/ TG > 150 mg/dL occurred 3.7 times ED, testosterone p=0.049 OR 3.5 (95% CI: 0.95-13.44) means low testosterone levels <193 pg/ml cause ED 3.5 times, and PSA p = 0.020, OR 0.3 (95% CI: 0.45-3.33) which means the level of >4 pg/mg causes ED 0.3 times.