Prevalence Of Gastrointestinal Cancers Research Articles

Evaluation of prescribing trends in patients with gastrointestinal cancers; A prospective observation study

Background: To Evaluate the prescribing trends in patients with gastrointestinal cancers; A prospective observational study in Bharath Hospital and Institute of Oncology, Mysuru.
 Methodology: Six hundred and seventy eight patients were screened and 111 were enrolledinto the study based on inclusion and exclusion criteria and the same was taken for further analysis.
 Results: Out of 111 patients with gastrointestinal carcinoma, 66 patients (54%) are between age of 41-50 years. In these study 78 patients (70.3%) were males, 91 patients (81.98%) are from rural area, in our study 69 patients were (62.16%) illiterate. In this study, the prevalence of GI cancer was 16.37% was observed. Doublet chemotherapy regimen (18.11%) was frequently prescribed, in which 71.11% of patients who received FOLFOX and ECF had carcinoma of GI while paclitaxel + carboplatin (8.10%). Singlet regimen 5-Flurouracil (1.80%), Capecitabine (0.90%) were highly prescribed among the different cancer types. The most commonly prescribed supportive care medications Palenosetron (90.99%) dexamethasone (90.99%) and ranitidine (23.42%), filgrastim (83.33%) were prescribed among all cycles of chemotherapy.
 Conclusion: Prevalence of gastrointestinal cancer in the study was 16.37% and more male were diagnosed gastrointestinal cancers.

Estimation and prediction for incidence, mortality and prevalence of common gastrointestinal tract cancers in China, in 2008

To estimate the incidence, mortality and prevalence of most common gastrointestinal tract cancers (esophageal, gastric and colorectal cancers) in China in 2008 and to predict the related incidence and mortality in the next 20 years. Data from 36 Chinese cancer registries and the Third National Death Survey in China (2004 - 2005) were used to estimate the incidence, mortality and 5-year prevalence of esophageal, gastric and colorectal cancers in China in 2008. Mathematical models were used to predict the incidence and mortality of these cancers in the next 20 years. In 2008, the incident cases of esophageal, gastric and colorectal cancers were estimated to be 259 235, 464 439 and 221 313, respectively, which totally accounted for one third of all the incident cancer cases. Age-standardized incidence rates of esophageal, gastric and colorectal cancers were estimated as 16.7/100 000, 29.9/100 000 and 14.2/100 000, respectively, while the mortality rates were 13.4/100 000, 22.3/100 000 and 6.9/100 000, respectively. The number of 5-year prevalent cases were estimated as 257 352 for esophageal cancer, 680 824 for gastric cancer and 509 140 for colorectal cancer, which correspondingly ranked the seventh, first and third among all the number of cancers, respectively. Till 2030, incident cases of these cancers would reach 484 923, 860 022 and 400 086, while deaths reach 412 916, 678 670 and 211 714, respectively. Esophageal, gastric and colorectal cancers had been the main digestive tract cancers in China, that causing serious health burden. As dramatic increasing burden was predicted in the next two decades for these three cancers, more attention needs to be paid accordingly.

Role of symptoms in diagnosis and outcome of gastric cancer

Gastric cancer is one of the most common cancers and the second most common cause of cancer deaths worldwide. Apart from Japan, where screening programmes have resulted in early diagnosis in asymptomatic patients, in most countries the diagnosis of gastric cancers is invariably made on account on dyspeptic and alarm symptoms, which may also be of prognostic significance when reported by the patient at diagnosis. However, their use as selection criteria for endoscopy seems to be inconsistent since alarm symptoms are not sufficiently sensitive to detect malignancies. In fact, the overall prevalence of these symptoms in dyspeptic patients is high, while the prevalence of gastro-intestinal cancer is very low. Moreover, symptoms of early stage cancer may be indistinguishable from those of benign dyspepsia, while the presence of alarm symptoms may imply an advanced and often inoperable disease. The features of dyspeptic and alarm symptoms may reflect the pathology of the tumour and be of prognostic value in suggesting site, stage and aggressiveness of cancer. Alarm symptoms in gastric cancer are independently related to survival and an increased number, as well as specific alarm symptoms, are closely correlated to the risk of death. Dysphagia, weight loss and a palpable abdominal mass appear to be major independent prognostic factors in gastric cancer, while gastro-intestinal bleeding, vomiting and also duration of symptoms, do not seem to have a relevant prognostic impact on survival in gastric cancer.

Iron deficiency anaemia in general practice: clinical outcomes over three years and factors influencing diagnostic investigations

Background: Iron deficiency anaemia (IDA) may be a sign of significant gastrointestinal disease, and delayed diagnosis may result in chronic morbidity. Studies in patients referred to hospital for investigation of...