Prevalence Of Fatty Liver Research Articles

Prevalence of and risk factors for fatty liver in the general population of Northern Italy: the Bagnacavallo Study

BackgroundThe estimation of the burden of disease attributable to fatty liver requires studies performed in the general population.MethodsThe Bagnacavallo Study was performed between October 2005 and March 2009. All the citizens of Bagnacavallo (Ravenna, Italy) aged 30 to 60 years as of January 2005 were eligible. Altered liver enzymes were defined as alanine transaminase > 40 U/l and/or aspartate transaminase > 37 U/l.ResultsFour thousand and thirty-three (58%) out of 6920 eligible citizens agreed to participate and 3933 (98%) had complete data. 393 (10%) of the latter had altered liver enzymes and 3540 had not. After exclusion of subjects with HBV or HCV infection, liver ultrasonography was available for 93% of subjects with altered liber enzymes and 52% of those with normal liver enzymes. The prevalence of fatty liver, non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (AFLD) was 0.74 (95%CI 0.70 to 0.79) vs. 0.35 (0.33 to 0.37), 0.46 (0.41 to 0.51) vs. 0.22 (0.21 to 0.24) and 0.28 (0.24 to 0.33) vs. 0.13 (0.11 to 0.14) in citizens with than in those without altered liver enzymes. Ethanol intake was not associated and all the components of the metabolic syndrome (MS) were associated with fatty liver. All potential risk factors were associated with a lower odds of normal liver vs. NAFLD while they were unable to discriminate AFLD from NAFLD.ConclusionsFatty liver as a whole was highly prevalent in Bagnacavallo in 2005/9 and was more common among citizens with altered liver enzymes.

Study of non-alcoholic fatty liver disease in metabolic syndrome

Background: Metabolic syndrome is a clustering of risk factors that increase an individual’s probability of developing atherosclerotic cardiovascular disease, type 2 diabetes mellitus and all cause mortality. Since primary NAFLD has strong association with metabolic syndrome as a whole and various components of metabolic syndrome, it is being debated whether NAFLD is a hepatic component of metabolic syndrome. Hence this study was done to study the prevalence of non-alcoholic fatty liver disease in healthy individuals and in patients with metabolic syndrome and to establish a relationship between NAFLD and Metabolic syndrome.Methods: A total of 122 patients - 61 with metabolic syndrome and 61 without metabolic syndrome fulfilling inclusion and exclusion criteria who presented to the Medicine outpatient Department of Ramaiah Medical College, Bangalore, between October 2014 and September 2016 were included in the study. Baseline variables, laboratory parameters, ultrasound abdomen findings were compared between the groups.Results: Mean age of the subjects in metabolic syndrome group and non-metabolic syndrome group were 52.4±15.4 and 50.7±15.4years respectively. Mean triceps skin fold thickness (in cms) for the subjects in metabolic syndrome group and non-metabolic syndrome group were 19.16±6.1 and 7.59±2.57 respectively (P <0.05). Prevalence of fatty liver on ultrasonography in metabolic syndrome and non-metabolic syndrome were 42.62 % and 21.31% respectively. Overall prevalence of NAFLD was 31.97 %.Conclusions: Overall prevalence of NAFLD from current study was 31.97%. The prevalence of NAFLD was significantly higher in persons with metabolic syndrome than persons without metabolic syndrome.

Diet with greater inflammatory potential is associated with higher prevalence of fatty liver among US adults.

The prevalence of non-alcoholic fatty liver disease (NAFLD) is rising-caused, at least in part, by unhealthy lifestyles including poor dietary choices. We examined the link between the inflammatory potential of diet as measured by the Dietary Inflammatory Index (DII®) and liver function tests [summarised by the fatty liver index (FLI)]. Of 20,643 US NHANES participants, 48.7% were men and the mean age was 47.3 years. Significant associations were apparent between increasing DII score and prevalent fatty liver. Individuals in the fourth DII quartile had nearly a six-fold higher likelihood of fatty liver [odds ratio (OR) = 5.97, 95% confidence interval: 4.44-8.02] compared with those in the first quartile. Moderation analysis indicated a significant impact of adiposity on the link between FLI and DII score (p < 0.001). This study provides further evidence of an association between the inflammatory potential of diet and fatty liver.

Hepatic fat and glucose tolerance in women with recent gestational diabetes

ObjectiveWomen with a history of gestational diabetes mellitus (GDM) have an elevated risk of ultimately developing pre-diabetes and diabetes later in life. They also have an increased prevalence of fatty...

Menopause Does Not Affect Fatty Liver Severity In Women: A Population Study in a Mediterranean Area

Estrogens could protect the liver from fatty degeneration, but there is little information about whether menopause is associated with the severity of alcoholic (AFL) and non-alcoholic fatty liver (NAFL). Our aim was to evaluate the distribution of fatty liver detected by ultrasound in pre- and post-menopausal women and the factors associated with these conditions. In this cross-sectional study, the years from menopause were investigated through selfreported information. The degree of fatty liver was assessed through a standardized ultrasound examination (scores 0 to 6, higher values reflecting a greater severity). Liver steatosis was classified as NAFL or AFL based on a daily alcohol intake > 20g/d. The study included 752 women in menopause and 535 in pre-menopause. The years from menopause were not associated with the severity of liver steatosis in NAFL (p for trend=0.74; Spearman correlation=0.04; 95%CI: -0.09 to 0.17), whereas all the indexes of adiposity and the number of metabolic syndrome factors were associated with a higher liver steatosis score. Taking AFL liver steatosis as the outcome, the years since menopause were not significantly associated with liver steatosis in AFL (p for trend=0.50; Spearman correlation=0.09; 95%CI: -0.17 to 0.34), whilst the association between anthropometric parameters and liver steatosis severity resulted stronger in postmenopausal compared to pre- menopausal women. the higher prevalence of fatty liver observed in post-menopausal women is probably not due to menopause per se, but to the adiposity (particularly abdominal) typical of this age and its consequences (such as metabolic syndrome).

IGF1 suppresses cholesterol accumulation in the liver of growth hormone-deficient mice via the activation of ABCA1.

Recently, several clinical studies have suggested that adult growth hormone (GH) deficiency that also has low concentration of IGF1 is associated with an increased prevalence of fatty liver (FL). ATP-binding cassette transporter A1 (ABCA1) is a pivotal regulator of lipid efflux from cells to apolipoproteins and plays an important role on formation of FL. In this study, we determined the effects of IGF1 on ABCA1 expression in GH-deficient mice to clarify its effects on FL. Western blotting, real-time PCR, and a luciferase assay were employed to examine the effect of IGF1. The binding of FoxO1 to the ABCA1 promoter was assessed by chromatin immunoprecipitation (ChIP) assay. Cholesterol accumulation was analyzed by Oil Red O stain and cholesterol content measurement. We confirmed that IGF1 upregulated the ABCA1 expression. The activity of a reporter construct containing the ABCA1 promoter was induced by IGF1, and this effect was blocked by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K). Constitutively active Akt stimulated the ABCA1 promoter activity, and a dominant-negative mutant of Akt or mutagenesis of the FoxO1 response element abolished the effect of IGF1. A ChIP assay indicated that FoxO1 mediated IGF1 transcriptional activity by directly binding to the ABCA1 promoter region. For in vivo experiments, we used an inhibitor for the GH receptor (Pegvisomant) to reduce the IGF1 level. A high-fat diet induced FL in mice (C57BL/6J) given Pegvisomant treatment. IGF1 treatment stimulated ABCA1 expression to improve cholesterol accumulation in these mice. These results show that the PI3K/Akt/FoxO1 pathway contributes to the regulation of ABCA1 expression in response to IGF1 stimulation that suppressed FL in GH-deficient mice.

Prevalence of Nonalcoholic Fatty Liver Disease in Normal-weight and Overweight Preadolescent Children in Haryana, India.

To document the prevalence of non-alcoholic fatty liver disease (NAFLD) and metabolic parameters among normal-weight and overweight schoolchildren. Cross-sectional study. Thirteen private schools in urban Faridabad, Haryana. 961 school children aged 5-10 years. Ultrasound testing was done, and 215 with fatty liver on ultrasound underwent further clinical, biochemical and virological testing. Prevalence of fatty liver on ultrasound, and NAFLD and its association with biochemical abnormalities and demographic risk factors. On ultrasound, 215 (22.4%) children had fatty liver; 18.9% in normal-weight and 45.6% in overweight category. Presence and severity of fatty liver disease increased with body mass index (BMI) and age. Among the children with NAFLD, elevated SGOT and SGPT was observed in 21.5% and 10.4% children, respectively. Liver enzyme derangement was significantly higher in overweight children (27% vs 19.4% in normal-weight) and severity of fatty liver (28% vs 20% in mild fatty liver cases). Eleven (8.1%) children with NAFLD had metabolic syndrome. Higher BMI (OR 35.9), severe fatty liver disease (OR 1.7) and female sex (OR 1.9) had strong association with metabolic syndrome. 22.4% of normal-weight and overweight children aged 5-10 years had fatty liver. A high proportion (18.9%) of normal-weight children with fatty liver on ultrasound indicates the silent burden in the population.

Serum uric acid and non-alcoholic fatty liver disease in non-obesity Chinese adults

BackgroundPrevious studies found elevated serum uric acid (SUA) was associated with the development or progression of non-alcoholic fatty liver disease (NAFLD) in general population; in this study we aim to investigate the association of SUA and the severity of NAFLD based on grade of fatty liver on ultrasonography in non-obese subjects.MethodsData were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. The data included completed anthropometry and blood biochemical indicators and the results of abdominal ultrasound. The diagnosis of NAFLD was according to the clinical diagnosis of the Guidelines for the diagnosis and treatment of nonalcoholic fatty liver disease in 2008.ResultsIn total, 95,924 subjects were analyzed in this study. The prevalence rate of lean-NAFLD was 8.16%, among which 7.58% had mild steatosis, and 0.58% had moderate and severe steatosis. The prevalence of fatty liver was increased progressively with SUA. Among which the prevalence of mild fatty liver from Q1 to Q4 were 10.33%, 18.39%, 23.11% and 25.93%; the prevalence of moderate and severe fatty liver from Q1 to Q4 were 1.06%, 2.82%, 5.05% and 7.27%. Lean-subjects with hyperuricemia had an OR of 1.718 (95% CI 1.622–1.820) to have NAFLD, after adjusted for other metabolic disorders. The area under curve (AUC) for detecting mild fatty liver based on SUA was 0.70; and the AUC for detecting moderate and severe fatty liver based on SUA was 0.78.ConclusionsOur data showed positive associations between elevated SUA levels and lean-NAFLD risk in the inland Chinese adults, independent of other metabolic factors. Our study also suggests that SUA could be considered as a simple and non-invasive method to follow up patients with lean-NAFLD.

The Prevalence of Non-Alcoholic Fatty Liver Disease in Patients With Inflammatory Bowel Disease

Introduction: It is well-established that central obesity, insulin resistance, and dysplipidemia are common risk factors for the development of non-alcoholic fatty liver disease (NAFLD). Patients with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), often do not have features of the metabolic syndrome. The chronic inflammatory state of IBD may predispose to development of fatty liver, as inflammation is a part of the pathogenesis of fatty liver. The aim of this study is to determine the prevalence of fatty liver in those with diagnosed IBD. Methods: A retrospective chart review was performed on 300 consecutive outpatients with diagnosis codes consistent with IBD (UC, CD, and indeterminate colitis) from 2009-2015 at a single urban academic medical center. IBD diagnosis was biopsy proven or as confirmed by outpatient gastroenterologist documentation. Patients were excluded if they had co-existing liver disease, history of liver transplantation, or paucity of clinical/laboratory data. Demographic information, in addition to liver function tests, BMI, medications, results of imaging studies, and comorbidities, including hypertension and diabetes were recorded. ALT values were deemed abnormal if value > 29. Results: Of the 300 patients with IBD reviewed, 201 patients met criteria and were included in the study. There were 74 patients (36.8%) with an ALT >29. Of those with elevated ALT, 34.1% had UC, and 38.6% had CD. Of those with an ALT >29, 38.0% of patients did not have any follow-up imaging performed. Of those who had imaging, 29.0% (8 patients) had evidence of either steatosis or fatty infiltration. Those who were noted to have hepatic steatosis or fatty liver had mean BMI 32.4, (range 19-46). This compares to an average BMI of 27.1 (range 15-47) for the 199 patients in the IBD cohort that had BMI available. Of the 8 patients who had radiographic evidence of steatosis or fatty infiltration, 50% of them had evidence of HTN and DM. Four of the 8 patients were also actively getting anti-TNF medications. Conclusion: Almost a third of patients with IBD had ALT elevation, and a third of these patients were found to have radiographic evidence of steatosis. Our study confirms the high prevalence of ALT elevation in IBD patients of which a large percentage could be attributable to NAFLD. NAFLD is a potentially serious cause of liver injury and IBD patients, specifically those with metabolic syndrome, may be at increased risk.

Associations between dietary factors and markers of NAFLD in a general Dutch adult population.

The objective of this sudy was to assess the relationship between dietary intake and fatty liver as scored by the validated Fatty Liver Index (FLI) in a large cross-sectional study among a general Dutch adult population. Diet is known to affect liver fat accumulation in humans. 1128 men and women aged 20-70 years were included. Dietary intake was assessed using a validated semiquantitative food frequency questionnaire. FLI was derived from body mass index (BMI), waist circumference, triglycerides and gamma-glutamyltransferase. Associations were adjusted for energy intake, alcohol intake, age, sex, education, smoking and prevalence of hypertension and diabetes. In this population (mean age 53.0±11.4 years; BMI 25.9±4.0 kg/m2; FLI 35.0±27.7), the prevalence of fatty liver as indicated by an FLI>60 was 21.5%. Subjects in the highest FLI category were more likely to be male, older and less physically active. Total protein intake and animal protein intake were positively associated with the highest FLI score versus the lowest (odds ratio (OR) 1.25 per 1 en%, 95% confidence interval (CI) 1.15-1.37 and OR 1.27, 95% CI 1.17-1.38, respectively); for vegetable protein, an inverse association was observed (OR 0.81, 95% CI 0.69-0.94). A similar positive association with FLI was observed when carbohydrates and fat were iso-calorically exchanged for total and animal proteins. Subjects in the high FLI group consumed more protein, especially from animal origin, less carbohydrates and less dietary fibre. The presence of fatty liver was associated with a higher intake of animal protein and total fat, soft drinks and snacks.

Cardiorespiratory Fitness and Risk of Fatty Liver: The Young Finns Study.

Fatty liver is an expanding health concern associated with metabolic disturbances and increased risk of cardiovascular disease. Experimental studies in animals have shown associations between fatty liver and cardiorespiratory fitness but limited data exist in humans. The aim of this study was to analyze the links between cardiorespiratory fitness and fatty liver in a population-based sample of adults. Participants were 463 adults (48% men) from the Cardiovascular Risk in Young Finns Study. Cardiorespiratory fitness was measured with a cycle ergometer exercise test as peak oxygen uptake (V˙O2peak [mL·kg·min]) in 2008 to 2009. Hepatic ultrasonographic imaging was performed in 2011 to determine fatty liver. Cardiorespiratory fitness was associated with lower risk of fatty liver (1 mL·kg·min increase in V˙O2peak: risk ratio, 0.90; 95% confidence interval, 0.88-0.93, P < 0.0001; adjusted for age and sex). This association remained significant after further adjustments with physical activity, adiposity, smoking, alcohol consumption, serum lipids, insulin, glucose, and C-reactive protein. Participants who were obese (waist circumference, >80 cm in women and >94 cm in men) but fit (V˙O2peak in the upper age- and sex-specific median) had lower prevalence of fatty liver than participants who were obese and unfit (below median), (11.7% vs 34.8%, P = 0.0003). In a population-based sample of adults, cardiorespiratory fitness is strongly, inversely and independently related with the risk of fatty liver. Importantly, the association is evident also among obese.

The differing influence of several factors on the development of fatty liver with elevation of liver enzymes between genders with metabolic syndrome: A cross-sectional study.

BackgroundNonalcoholic fatty liver disease (NAFLD) is known to be strongly associated with obesity, visceral fat, metabolic syndrome (MS), lifestyle, and lifestyle-related diseases in both males and females. However, the prevalence of NAFLD, MS, and clinical backgrounds is different between males and females.ObjectiveWe conducted a cross-sectional study to examine the differing influence of lifestyle-related factors and visceral fat on fatty liver (FL) with elevation of liver enzymes between males and females with MS.MethodsWe enrolled 42,134 persons who underwent a regular health check-up, and after excluding subjects who fulfilled excluding criteria, the remaining subjects were 2,110 persons with MS. We examined the differing influence of lifestyle-related factors and visceral fat on FL with elevation of alanine aminotransferase (ALT) (ALT elevation was defined as ALT level of ≥31 IU/l in the present study).ResultsThe odds rations for FL with ALT elevation were as follows: WC, 1.83 (95% confidence interval (CI) 1.36–2.46); dyslipidemia, 1.89 (95% CI 1.34–2.68); hemoglobin A1c, 1.36 (95% CI 1.00–1.85); visceral fat type MS (V-type MS), 5.78 (95% CI 4.29–7.80); and light drinker, 0.56 (95% CI 0.41–0.78) in males with MS and BMI, 2.18 (95% CI 1.43–3.33); WC, 1.85 (95% CI 1.27–2.70); diastolic blood pressure, 1.69 (95% CI 1.16–2.45); triglyceride, 2.22 (95% CI 1.56–3.17); impaired glucose tolerance, 1.66 (95% CI 1.11–2.47); and V-type MS, 3.83 (95% CI 2.57–5.70) in females with MS. The prevalence of FL with ALT elevation and ALT was significantly higher in V-type MS than in the subcutaneous fat type MS in both males and females with MS (P < 0.001).ConclusionAlthough V-type MS and WC is a common significant predictor of an increased prevalence of FL with ALT elevation in both males and females with MS, gender, lifestyle-related factors, and MS type in individuals with MS should be considered for the development of FL with ALT elevation.

Low-dose attenuation correction in diagnosis of non-alcoholic fatty liver disease.

Non-enhanced computed tomography (CT) is a valuable modality in the diagnosis of non-alcoholic fatty liver disease (NAFLD). However, it is not clear if low-dose CT attenuation correction (CTAC) scans have the same accuracy to diagnose NAFLD. Our aim is to evaluate the diagnostic accuracy of low-dose CTAC in the diagnosis of NAFLD using non-enhanced CT as a gold standard. A total of 864 patients who underwent a clinically indicated hybrid nuclear imaging scanning between May 2011 and April 2014 were included in the study. Diagnosis of fatty liver was established if an absolute liver attenuation was <40 Hounsfield units and/or a liver-to-spleen ratio was <1.1. The diagnostic accuracy parameters were calculated to detect NAFLD by low-dose CTAC using unenhanced CT as a gold standard. The prevalence of fatty liver by diagnostic CT and low-dose attenuation correction were 9.9 and 12.9% (using liver attenuation <40HU and liver-to-spleen ratio <1.1), respectively, with 32.9 and 34.9% (using absolute liver attenuation or ratio-to-spleen criteria), correspondingly. Low-dose CTAC had sensitivity (81.3%), specificity (94.0%), positive predictive value (60.2%), and negative predictive value (97.8%) using both diagnostic criteria. Using either of the diagnostic criteria resulted in sensitivity (76.8%), specificity (83.5%), PPV (66.3%), and NPV (89.5%). Low-dose CT could be used as a tool to rule out the presence of fatty liver if neither liver attenuation of less than 40 HU nor liver-to-spleen below 1.1 is present.

Prevalence of coronary artery calcification in Japanese patients with psoriasis: A close correlation with bilateral diagonal earlobe creases.

Psoriasis is a multifactorial inflammatory disorder, in which the inflammation affects not only the skin but also the other internal organs, and can induce cardiovascular and cerebrovascular involvements. However, few predictive factors of cardiovascular diseases have been clarified in patients with psoriasis. This study was performed to verify whether diagonal earlobe creases (ELC) can reflect the hidden comorbidities in Japanese psoriatic patients. Prevalence and subtypes of ELC were analyzed in patients with psoriatic and with non-psoriatic skin diseases, and the correlation with coronary artery calcification (CAC) or fatty liver (FL) detected by computed tomography. Prevalence of CAC was approximately twice higher than data of a Japanese resident-based study previously reported. Generally, prevalence of ELC in a psoriatic group and mean age of psoriatic groups accompanied by ELC were higher and younger than those of a non-psoriatic skin disease group, respectively. Statistically significant differences were detected in the mean age of total or male subjects accompanied by bilateral ELC with complete and incomplete length. Bilateralism of ELC was closely correlated with prevalence of CAC and CAC on multiple branches in psoriatic patients (P = 6.6e-6 and odds ratio [OR] = 14.1, P = 0.00884 and OR = 10.7, respectively), but not with that of FL. On the contrary, body mass index of more than 25 was closely correlated with prevalence of FL, but not that of CAC. Comorbidities of psoriatic patients are frequently unnoticed. ELC, an apparatus-related feature, can be a useful predictive factor for hidden coronary artery involvements in psoriatic patients.

Body mass index is associated with type 2 diabetes mellitus in Chinese elderly.

BackgroundThere is limited information on the association between metabolic syndrome components including body mass index (BMI) and type 2 diabetes mellitus in elderly Chinese population. Therefore, we investigated whether components of metabolic syndrome are associated with type 2 diabetes mellitus in elderly.MethodsA total of 479 hospitalized patients (aged 65–95 years) with recently diagnosed type 2 diabetes mellitus were studied retrospectively in a cross-sectional study and compared with 183 subjects with prediabetes and 62 subjects without glucose metabolism abnormalities.ResultsBMI (24.69±3.59 versus 23.92±3.08 and 23.56±3.25 kg/m2), blood pressure, cholesterol, triglyceride, liver enzymes and prevalence of fatty liver were higher in patients with type 2 diabetes mellitus as compared with elderly subjects with prediabetes or normal glucose metabolism separately (all P<0.05). Multivariable regression analysis showed that BMI was associated positively with insulin resistance and inversely with insulin sensitivity in type 2 diabetes mellitus group (all P<0.05).ConclusionHigher BMI was associated with increased insulin resistance and decreased insulin sensitivity in elderly Asian population with type 2 diabetes mellitus.

Prevalence of non-alcoholic fatty liver disease among obese children in North Kerala, India

Background: Obesity and related co-morbidities are increasing at an alarming pace all over the world. Non-alcoholic fatty liver disease (NAFLD) is the asymptomatic involvement of the liver mainly seen in obese individuals. NAFLD can progress to chronic liver disease and has to be identified early. The aims of our study were to determine the prevalence of nonalcoholic fatty liver disease among obese children in our local population. To determine the prevalence of abnormal liver enzymes in obese children.Methods: Cross sectional descriptive study in a tertiary care center among children aged 5-18 years for a 1 year period. NAFLD was diagnosed based on ultrasonography. Alanine amino transferase more than 40IU/l was taken as abnormal.Results: A total of 65 patients were enrolled in the study. The prevalence of NAFLD in the study group was 60%. 20% had elevated alanine amino transferase levels.Conclusions: The prevalence of fatty liver in Kerala is comparable to that in the West. Since this is a public health issue more population based studies are needed on a larger group to find out the exact magnitude of the problem.

145: THE PREVALENCE OF FATTY LIVER IN OVERWEIGHT AND OBESE CHILDREN COMPARED TO NORMAL CHILDREN

Background and aims:Nonalcoholic fatty liver disease is the most common cause of liver disease worldwide and is defined as a disorder of excess fat accumulation in the liver. This study...

P323 Fatty liver assessment in inflammatory bowel disease patients using controlled attenuation parameter

Background: It is well recognized that inflammatory bowel disease (IBD) patients are at risk of developing nonalcoholic fatty liver disease (NAFLD). Our aim was to assess the prevalence of fatty liver in IBD patients as quantified by controlled attenuation parameter (CAP), compared to conventional methods of detecting hepatic steatosis. Methods: For this observational study, we prospectively evaluated all IBD patients presenting for a disease flare or follow-up visit in our clinic, during a 12 month period (Nov 1st 2015 – Oct 31st, 2016). Clinical characteristics and laboratory data were recorded. Hepatic steatosis was evaluated by abdominal ultrasound, hepatic steatosis index (HSI) and transient elastography with CAP (Fibroscan, Echosens, Paris). Significant steatosis (S≥1) was defined for a CAP value over 236 [1], and the cut-off of HSI for detecting NAFLD was set at ≥36 [2]. Results: Altogether 36 IBD patients (17 ulcerative colitis, UC and 19 Crohn's disease, CD), mean age 43±13 years, 52.8% female, were included in the analysis. All patients denied alcohol use of more than 20 g/day. No significant difference in the two groups (UC, CD) was seen regarding disease activity (remission/flare – 52.9/47.1% in the UC group, 47.4/51.6% in the CD group), BMI (23.7 and 23.4 respectively), mean hemoglobin values (13.38 and 13.48 g/dl, respectively) or inflammatory markers (ESR 18 and 19.9 mm/h, fibrinogen 523 and 520 mg/dl, respectively). UC patients had higher mean cholesterol values (197.4 vs. 175 mg/dl) and 2 of them were diabetic (compared to none in the CD group). Mean CAP was similar among the two groups – 222 for UC and 223 dB/m for CD, as well as mean HSI, with values of 35±6 and 34±5, respectively. Ultrasound and HIS both identified 8/36 (22.2%) patients with fatty liver, whereas CAP assessment detected 3 more patients (11/36, 30.5%) with significant steatosis (S≥1). NAFLD-IBD patients were more likely to have CD, history of resection, steroid use and longer disease duration – Table 1. Table 1. Comparison of IBD patients with/without NAFLD using CAP assessment Conclusions: CAP outperformed conventional ultrasound and HSI in detecting fatty liver in IBD patients. This result needs to be explored in larger cohorts.

SAT-467 - Prevalence of fatty liver and fibrosis in patients with type 2 diabetes mellitus and previously undetected liver disease as assessed by transient elastography and ultrasound

SAT-467 - Prevalence of fatty liver and fibrosis in patients with type 2 diabetes mellitus and previously undetected liver disease as assessed by transient elastography and ultrasound

Association between soil heavy metals and fatty liver disease in men in Taiwan: a cross sectional study

ObjectivesMetabolic factors are major risk factors for non-alcoholic fatty liver disease although other factors may also contribute to development of fatty liver disease. We explored the association between exposure to...