Purpose: The purpose of this study is to determine the etiologies of upper GI bleed among inpatients at our institution presenting with hematemesis, melena, and/or hemaotochezia. Our aim is to determine if peptic ulcer disease remains the most common cause of upper GI bleed in our inpatients. Methods: A list of inpatient EGDs performed for indications of hematmesis, melena or hematochezia from January 1, 2010 to March 1, 2012 were collected and findings were reviewed. A total of 1,192 patients had a EGD for evaluation of upper GI bleed. Data regarding NSAIDs, aspirin, clopidogrel, aspirin/clopidogrel, and warfarin use were also collected. Data was anaylzed using an unpaired t-test. Results: A total of 1,192 patients were included in the study. EGD did not reveal a source of bleeding in 407 (34%) patients. The most common cause of upper GI bleed in our study was peptic ulcer disease seen in 53% of patients followed by gastritis, gastropathy, and gastric erosions seen in 43% of patients. When the prevalence of gastritis, gastropathy, and gastric erosions were compared to peptic ulcer disease, the results were statistically significant (P<0.0001). Table 1 show the prevalence of EGD findings among inpatients who presented with upper GI bleed. Out of 1,192, 750 patients did not have NSAIDs, aspirin, clopidogrel, aspirin/clopidogrel, or warfarin use. Table 2 shows the prevalence of positive EGD findings among patients on NSAIDs, antiocagulant or antiplatelet therapy. Prevalence of positive EGD findings among patients on NSAIDs alone versus aspirin and clopidogrel was not statistically significant (P=0.6735). When clopidogrel was compared to NSAIDs the prevalence of positive EGD findings was not statistically significant (P=0.21).Table: Prevalence of EGD findingsTable: [1848] Prevalance of positive EGD findings among patients on NSAIDs, aspirin, clopidogrel, aspirin/clopidogrel, and warfarinConclusion: In our institution, we found peptic ulcer disease to be the most common etiology of upper GI bleed, accounting for 53% of inpatients. This agrees with publications to date that peptic ulcer remains the most common cause of upper GI bleed in hospitalized patients. In our study, there was a high prevalence of positive findings with use of NSAIDs, aspirin, aspirin/clopidogrel, and warfarin, but not with clopidogrel alone. This variance from prior studies may be due to sampling and/or demographic differences. In view of these findings multicenter trials should be conducted to review prevalence of upper GI bleed among hospitalized patients on NSAIDs, anticoagulants, and antiplatelet agents.