Prevalence Of Disease In Patients Research Articles

COPD is associated with increased cardiovascular disease risk independent of phenotype.

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide that frequently presents with concomitant cardiovascular diseases. Despite the pathological distinction between individual COPD phenotypes such as emphysema and chronic bronchitis, there is a lack of knowledge about the impact of COPD phenotype on cardiovascular disease risk. Thus, this study aimed to utilize a nationally representative sample to investigate cardiovascular disease prevalence in patients with COPD with emphysema and chronic bronchitis phenotypes. Data from 31,560 adults including 2504 individuals with COPD, collected as part of the National Health and Nutrition Examination Survey (1999-2018), were examined. A significantly increased cardiovascular disease risk, including coronary heart disease, heart failure, myocardial infarction and stroke, was identified in patients with COPD among all disease phenotypes. Particularly, compared to those without COPD, individuals with chronic bronchitis presented with 1.76 (95% CI: 1.41-2.20) times greater odds, individuals with emphysema with 2.31 (95% CI: 1.80-2.96) times greater odds, while those with a concurrent phenotype (combined chronic bronchitis and emphysema) exhibited 2.98 (95% CI: 2.11-4.21) times greater odds of reporting cardiovascular diseases. Our data confirms that patients with COPD present an elevated risk of developing cardiovascular disease among all phenotypes, with the most marked increase being in those with concurrent chronic bronchitis and emphysema phenotypes. These findings emphasize the need for awareness and appropriate cardiovascular screening in COPD.

Celiac disease prevalence in patients with idiopathic inflammatory myopathies, a cross-sectional study.

Up to 30% of patients with celiac disease (CD) suffer from concurrent autoimmune disease, compared to 3% of the general population. The association between CD and the current clinical phenotypes of inflammatory myopathies (IIM) patients has not been thoroughly addressed. Assess the CD features among patients with IIM and their relationship with the clinical phenotype and the myositis specific (MSA) and associated antibodies (MAA). For this cross-sectional study, we recruited 99 adult patients classified as IIM from a tertiary center in Mexico. We assessed serum MSA, MAA, and CD-associated autoantibodies (IgA anti-tissue transglutaminase (tTG) and both IgA and IgG anti-deaminated gliadin peptide (DGP)). Patients with highly suggestive serology for CD were then tested for IgG anti-endomysium antibodies, and a duodenal biopsy was performed. 70.7% of patients were positive for at least one antibody. Nine duodenal biopsies were taken, revealing findings compatible with celiac disease in two cases. Subjects with anti-MDA5 antibodies were more likely to have positive anti-tTG IgA antibodies (OR 6.76, 95% CI 1.85-24.62, P = 0.013) and suggestive CD serology (OR 6.41, 95% CI 1.62-25.29, P = 0.009). Patients with anti-Mi2 antibodies were more likely to have positive anti-DGP IgG antibodies (OR 3.35, 95% CI 1.12-9.96, P = 0.039), while positivity for these autoantibodies was less frequent in patients with anti-NXP2 antibodies (OR 0.22, 95% CI 0.06-0.80, P = 0.035). There is a higher prevalence of serologic and definite CD in patients with IIM compared to the general population. Identifying this subgroup of patients may have prognostic and therapeutic implications. Key points • The study estimated a serological celiac disease (CD) prevalence of 70.7% in patients with idiopathic inflammatory myopathies (IIM) and a biopsy-confirmed prevalence of 2%, suggesting that IIM patients should be considered a high-risk population for CD. • We identified a significant association between serological CD and the presence of anti-MDA5 and anti-Mi2 antibodies, suggesting a potential justification for celiac disease screening in this specific subgroup of patients. • The impact of gluten-free diets on IIM patients with serological markers of CD remains untested and warrants further investigation through prospective, randomized studies.

Prevalence of carotid artery stenosis and intra-cranial lesions in patients with aortic arch aneurysm and its association with intraoperative regional cerebral oxygen saturation and postoperative neurological outcomes.

Although aortic aneurysm is associated with vascular aging and atherosclerosis, carotid and intracranial vascular disease prevalence in patients with aortic arch aneurysm remains unclear. Similarly, the effect of carotid and intracranial lesions on postoperative outcomes is unknown. This study aimed to investigate the prevalence of carotid artery stenosis and intracranial lesions in patients with aortic arch aneurysm and its association with intraoperative regional cerebral oxygen saturation (rScO2) and postoperative neurological outcomes, including delirium and cerebral infarction. This retrospective observational study included 133 patients with true aortic arch aneurysm who underwent preoperative magnetic resonance imaging (MRI). We evaluated the prevalence of carotid and intracranial arterial lesions. Symptomatic cerebral infarction and delirium, defined by the confusion assessment method for the intensive care unit, were evaluated for their association with preoperative cerebrovascular lesions. Additionally, changes in regional saturation of the cerebral tissue at different surgical phases were evaluated for patients with and without cerebrovascular lesions. Fifteen (11.3%) patients experienced symptomatic cerebral infarction, and 64 (48.1%) had postoperative delirium. Preoperative MRI showed old infarction, microbleeds, significant carotid artery stenosis, and intracranial lesions in 21.1%, 14.3%, 10.5%, and 7.5% of the patients, respectively. White matter hyperintensities with Fazekas scale 2 were observed in 40.6% of the patients, while Fazekas scale 3 were observed in 18.8% of the patients. Preoperative MRI findings and postoperative neurological outcomes were not significantly different. Seventy-six patients underwent rScO2 monitoring intraoperatively. Changes in rScO2 in patients with and without carotid/cerebrovascular lesions were not significantly different. However, rScO2 was significantly lower in patients who developed cerebral infarction. Significant carotid artery stenosis and intracranial lesions were observed in 10.5% and 7.5% of the patients, respectively. Although preoperative MRI findings and changes in rScO2 or postoperative outcomes showed no significant association, patients with postoperative cerebral infarction showed significantly lower rScO2 intraoperatively.

Characteristics of Primary Morbidity in the Population of the Far Eastern Federal District (Retrospective Analysis)

Background. The peculiarities of the economic and geographical position of the Far Eastern Federal District determine climatic, socio-biological and medical and organizational characteristics that affect the leading criteria for population health. A relevant and priority direction for the development of the macro-region is the study of the main indicators of population health, reflecting the organizational and economic potential of the region, as well as the preservation and promotion of public health based on the formation of a healthy lifestyle and increasing the availability and quality of medical care. Aims — study and analyse the primary morbidity of the adult population in the Far Eastern Federal District. Methods. A retrospective analytical study was carried out. An analysis of the dynamics of primary morbidity by rate of increase (decrease) and a comparative analysis of average annual primary morbidity, including major classes of diseases diagnosed for the first time in life, in the adult population in the macro-region as a whole and in its 11 constituent entities is given. I–IV, VI–XIV, XVII, XIX classes of diseases were taken into account according to the International Classification of Diseases of the 10th revision. Results. The Far Eastern Federal District ranked 5th in descending order by primary morbidity among other Russian macroregions throughout the study period. There was variability in the primary morbidity ranking among the constituent entities of the district. The dynamics of primary morbidity showed a moderate upward trend in 2017, followed by two years of stable trend, and in 2020 there was a moderate downward trend. The prevalence of disease in patients diagnosed for the first time in the population of the other federal districts of the country was characterised by individual variability. At the same time, in most macro-regions a moderate to pronounced decrease in primary morbidity was found in 2020 (rate of increase (decrease) morbidity: from –2.3 to –7.2%), except for the Central Federal District (rate of increase (decrease) morbidity: –0.1%) and the Urals Federal District (rate of increase (decrease) morbidity: –0.2%), where this indicator remained stable. Conclusions. In the Far Eastern Federal District, characteristic variability in the level, dynamics and structure of primary morbidity among the population has been identified. A general pattern with all-Russian indicators was revealed, consisting in a decrease in incidence in most classes of diseases in 2020, except for X Respiratory disease, in which stability remained. The revealed features of the rank distribution of primary morbidity by classes of diseases in the subjects of the district will make it possible to be based on the principle of targeted distribution of funds when planning the volume of medical care to the population.

Association between the prevalence of obstructive lung disease and the use of aspirin in a diabetic population

Many diabetic patients take a daily low-dose of aspirin because they are two to three times more likely to suffer from heart attacks and strokes, but its role in obstructive lung diseases is less clear.A total of 1,003 subjects in community practice settings were interviewed at home. Patients self-reported their personal and clinical characteristics, including any history of obstructive lung disease (including COPD or asthma). Current medications were obtained by the direct observation of medication containers. We performed a cross-sectional analysis of the interviewed subjects to assess for a possible association between obstructive lung disease history and the use of aspirin.In a multivariate logistic regression model, a history of obstructive lung disease was significantly associated with the use of aspirin even after correcting for potential confounders, including gender, low income (<USD 30,000/year), number of comorbidities, number of medications, cigarette smoking, and alcohol problems (adjusted odds ratio = 0.67, P = 0.03, 95% confidence interval = 0.47, 0.97). The opposite was found with aspirin and that for diabetic individuals that use insulin. A secondary analysis discovered a significant interaction between aspirin use and insulin: aspirin was associated with lower rates of lung disease except among those taking both drugs where the prevalence is significantly higher.These data suggest a negative correlation between the use of aspirin and obstructive lung disease prevalence in patients with diabetes but not for those that use insulin. Further studies are required to determine if this association is causal.

Chronic Kidney Disease Prevalence in Patients with Colorectal Cancer Undergoing Surgery.

Colorectal cancer (CRC) is a common and mortal disease. Chronic kidney disease (CKD) is the relatively common comorbidity among cancer patients affecting the available therapy and outcomes. However, data on prevalence of CKD in patients with CRC undergoing surgery is limited. The aim of the study was to evaluate the prevalence of CKD in a cohort of 560 consecutive patients with CRC undergoing surgical treatment with curative intent. Neoadjuvant therapy in a form of radiotherapy or radiochemotherapy was administered before the surgery in 67 patients and in 86 patients, respectively. Results: CKD was reported in 10%, diabetes in 25%, and hypertension in 60%, while anemia was reported in 47%. The patients with CKD were more likely to be older and anemic with higher serum CRP, which reflects a general inflammatory state. Relative to patients without this therapy, patients undergoing neoadjuvant radiochemotherapy were older, had significantly lower eGFR and albumin, and higher creatinine, aspartate aminotransferase and INR, before the surgery. All CKD patients, except two, were older than 65 years of age. Conclusions: In order to ensure the best possible outcomes, CKD should be diagnosed and treated appropriately in oncology patients to prevent complications, so they may continue their therapy with the least interruption or discontinuation of treatment.

Evaluation of Celiac Disease Prevalence in Patients with ADHD (Attention Deficite/ Hyperactivity Disorder)

Background: Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common behavioral disorders among children that has a significant impact on family and society. Recently since numerous cases of ADHD alongside celiac disease and improvement of behavioral symptoms of children with ADHD with gluten-free diet have been proposed, this study was conducted to determine the prevalence of celiac disease in children with ADHD based on serological findings in Sistan.&#x0D; Methods: The present study was performed on 76 children with a diagnosis of ADHD referred to the pediatric clinic of Amir Al-Momenin Hospital in Zabol. Demographic, clinical and paraclinical information such as age, sex and celiac laboratory diagnostic tests (anti-TTG and total IgA) were collected and the results were entered in the information form of each child and analyzed.&#x0D; Results: Among the 76 children participating in this study, 58 were male (76.3%) and the age range of patients was 12-2 years (6.9 ± 2.4). The results of the study showed that based on the results of celiac serology tests performed among children with ADHD, no cases of celiac disease were found. In this study, 26 children (34.21%) have anemia. However, the mean of anti-TTG and total IgA in children with anemia and children without anemia were not statistically significant (p value &gt; 0.05).&#x0D; Conclusion: The results of the present study showed that based on serological findings, no cases of celiac disease were observed among children with ADHD.

Fabry disease prevalence in patients with familial Mediterranean fever: A cohort study

Background/Aim: Fabry disease is an X-chromosome inherited disease, which constitutes a rare disease group. Fabry disease has a wide spectrum of symptoms and some of these symptoms that are seen in other diseases. Familial Mediterranean fever (FMF) is a common disease in countries along the Mediterranean coast, including our country. Although typical episodes of recurrent high fever and abdominal pain occur, patients can also present with nonspecific symptoms and signs. This study aimed to investigate the presence of Fabry disease in patients with FMF.&#x0D; Methods: Information about this cohort study was given to all patients who were followed up with a diagnosis of FMF. Those who agreed to sign the informed consent form were included in the study. Fabry disease screening was performed by galactosidase alfa (GLA) gene analysis in female patients and by examining lysosomal alpha galactosidase A (AGALA) enzyme activity in male patients. When enzyme activity was found to be low in male patients, a GLA gene analysis was also performed.&#x0D; Results: Fabry disease was screened in a total of 189 patients with familial Mediterranean fever, and it was not detected in any of our patients. Low AGALA enzyme activity was detected in approximately 20% of the male patients. In the GLA gene analysis performed on these patients, any genetic mutation that could be associated with Fabry disease was not detected.&#x0D; Conclusion: People with Fabry disease or FMF can present with common symptoms, such as arthritis, proteinuria, and abdominal pain. In our study, Fabry disease was not found in any of patients who had a diagnosis of FMF. However, only a few publications on this subject are available. In studies conducted in our country and around the world, it has been shown that GLA gene mutations that may cause Fabry disease can be detected in patients with FMF. However, such a mutation was not detected in our study.

P173 Increased prevalence of celiac disease in patients with cystic fibrosis: a systematic review and meta analysis

P173 Increased prevalence of celiac disease in patients with cystic fibrosis: a systematic review and meta analysis

Cardiac features of Noonan syndrome in Japanese patients.

Cardiovascular disease is one of the most important problems in long-term follow-up for Noonan syndrome. We examined cardiovascular issues and clinical manifestations, with a focus on the cardiovascular disease and prognosis of patients with Noonan syndrome. This single-centre study evaluated patients who were clinically and genetically diagnosed with Noonan syndrome. Forty-three patients diagnosed with Noonan syndrome were analysed. The most prevalent responsible mutation was found in PTPN11 (25/43). The second and third most prevalent causative genes were SOS1 (6/43) and RIT1 (5/43), respectively, and 67.4% of genetically diagnosed patients with Noonan syndrome had structural cardiovascular abnormalities. Pulmonary valve stenosis was prevalent in patients with mutations in PTPN11 (8/25), SOS1 (4/6), and RIT1 (4/5). Hypertrophic cardiomyopathy was found in two of three patients with mutations in RAF1. There was no difference in the cardiovascular events or cardiovascular disease prevalence in patients with or without PTPN11 mutations. The proportion of RIT1 mutation-positive patients who underwent intervention due to cardiovascular disease was significantly higher than that of patients with PTPN11 mutations. Patients who underwent any intervention for pulmonary valve stenosis exhibited significantly higher pulmonary flow velocity than patients who did not undergo intervention, when they visited our hospital for the first time. All patients who underwent intervention for pulmonary valve stenosis had a pulmonary flow velocity of more than 3.0 m/s at first visit. These findings suggest that genetic information can provide a clinical prognosis for cardiovascular disease and may be part of genotype-based follow-up in Noonan syndrome.

Coronary Artery Disease Prevalence in Patients Having Essential Hypertension with Or Without Diabetes Mellitus Detected by Cardiac MIBI Scan

BACKGROUND &amp; OBJECTIVE: The aim of this retrospective study was to find the prevalence of coronary artery disease (CAD) in hypertensive patients with or without diabetes mellitus.&#x0D; METHODOLOGY: Data of patients having essential hypertension (n=931) referred to PINUM from April 2017 to December 2018 for stress/rest cardiac MIBI scan was analyzed. This data was divided into two groups. HD group contains data of patients having hypertension with diabetes mellitus (n=456, 48.98% of total population, M:F=245:211). While data of patients having hypertension without diabetes mellitus was placed in H group (n=475, 51.02% of total population, M: F=254:221).&#x0D; RESULTS: Prevalence of CAD is higher in HD group than in H group (47.8% vs. 30.1%; p&lt;0.001). CAD is more prevalent in males than females in both groups (53.9 % vs. 40.8% in HD group, and 39.4% vs. 19.5% in H group). This difference in prevalence of CAD in HD and H groups is more marked in females (40.8% vs. 19.5%; p&lt;0.001) than males (53.9 % vs. 39.4%; p=0.001). Prevalence of CAD in patients with typical presentation is not statistically significant in HD and H groups (72.3% vs. 68.4%; p=0.645), while in subjects with atypical presentation prevalence is significantly higher in HD group than H group (40.8% vs. 26.8%; p&lt;0.001).&#x0D; CONCLUSION: Prevalence of CAD is higher in the group of patients having essential hypertension with diabetes mellitus than the group of patients having essential hypertension without diabetes mellitus.

Prevalence of Nonalcoholic Fatty Liver Disease in Patients with Severe Hypertriglyceridemia (SHTG) – Initial Baseline data from an Ongoing Phase 2 Study

Prevalence of Nonalcoholic Fatty Liver Disease in Patients with Severe Hypertriglyceridemia (SHTG) – Initial Baseline data from an Ongoing Phase 2 Study

Prevalence and Pattern of Lung Dysfunction in Patients with Type 2 DM Attending a Tertiary Health Care Centre of Tripura by Spirometry

Introduction:- Diabetes has multiple microvascular and macrovascular complications, pulmonary complication though is less researched. In our present study we have tried to find out effects of diabetes mellitus on respiratory system. Methods:- We did pulmonary function test on all patients admitted to Tripura medical college and Dr BRAM teaching hospital with diabetes mellitus after considering inclusion and exclusion criterias. Result:- We have find higher prevalence of restricted lung disease in patients with diabetes mellitus and the relation between restrictive lung disease and HbA1C was statistically significant. Conclusion:- So, should try to pick up lung disorders in diabetes patients from an early stage and try to treat it.

Prevalence of Gaucher disease in patients with unknown cause of splenomegaly and/ or thrombocytopenia in Saudi Arabia: a multicenter cross-sectional study protocol

Prevalence of Gaucher disease in patients with unknown cause of splenomegaly and/ or thrombocytopenia in Saudi Arabia: a multicenter cross-sectional study protocol

Dermatophytosis: An Epidemiological Study in a Tertiary Care Center in Rural Sind

Aims and Objects: Dermatophytosis is a common infection worldwide, and a major public health issue. Hot, humid climates and overcrowding favor the spread of skin infection in general populations. The purpose of the study is to analyze the prevalence of disease in patients attending the outpatient department of dermatology PUMHS-W Nawabshah. &#x0D; Methodology: The study type is cross-sectional, conducted at departments of Dermatology and Pathology, Peoples University of Medical and Health Sciences, Nawabshah, for 3 months, (June 1st, 2020 to August 31st, 2020) after written permission from ERC. A total of 93 cases were included.&#x0D; Skin scraping, nail clippings, hair fragments, and scalp, samples were acquired from patients approaching the Outpatient department. Wood /s lamp examination was carried out in all patients. By using 20% potassium hydroxide (KOH) on a glass slide with the sample and passing over the flame 2-3 times. After confirmation, the samples were streaked on the sterilized Sabouraud dextrose agar medium containing antibiotic, Petri plates were incubated at 25-28 °C for two weeks, all cases were directed towards the microscopic examination, and results were entered into SPSS 20 analyzed and tabulated.&#x0D; Results: Out of 93 suspects 84 (90.3%) samples were positive for fungal infection, and among them, 68 (73.1%) cases gave positive growth, Male predominance is noticed with 60%.Tinea corporis 45.6%is on the top of the list causing infection and T. unguium is the least common1.5%. The adult age group 20-40yrs were more affected followed by the middle-aged group.&#x0D; Conclusion: Dermatophytosis is common in the younger and adult age group, but it is prevalent in our general population irrespective of age and gender.

PREVALENCE OF PERIODONTAL DISEASES IN PATIENTS WITH GOUT

Gout is a systemic disease characterized by an inflammatory reaction at the sites of deposition of sodium monourate crystals in individuals with hyperuricemia and is caused by external factors and (or) genetic factors. Patients with gout often have comorbidities such as cardiovascular disease (including hypertension), diabetes and chronic kidney disease, and dental disease. In the professional literature there are almost no studies of periodontal tissues in patients with gout. The aim of our study was to investigate the prevalence of periodontal disease in patients with gout. The participants were divided into 2 groups: the main one included 150 patients with gout, and the comparative one included 80 people without rheumatic pathology. The age of the subjects ranged from 30 to 50 years or more. The clinical examination was performed according to a standard scheme, which included history taking and analysis of patient’s complaints. According to the results obtained, the patients with gout showed a significantly higher prevalence of periodontal disease in all age groups, compared with individuals with rheumatic pathology. A high percentage of periodontal pathology was observed in the young participants of the main group. The larges share in the structure of periodontal diseases among the patients with gout was represented by advanced generalized periodontitis class I and II, and parodontosis, while the individuals without rheumatic pathology demonstrated a higher percentage of initial stages of periodontal disease. With age, both groups demonstrated the increase in the prevalence of periodontal disease, but in patients with gout, this process was more intense. It can be concluded that systemic disorders associated with gout, among which chronic autoimmune inflammation, oxidative stress, endothelial dysfunction and a high risk of atherosclerosis are very common, can be regarded as predictors of both rapid progression and aggravation of destructive inflammatory lesions of the periodontium.

External validation of prediction models for obstructive coronary artery disease in patients with suspected stable coronary artery disease

Abstract Background Pre-test probability (PTP) is an important tool in the diagnostic work-up for obstructive coronary artery disease (CAD) but must be calibrated to the declining disease prevalence in patients referred to diagnostic testing. Purpose To externally validate the published basic and clinical PTP models in a contemporary angina cohort with low prevalence of CAD and to compare with the reference European Society of Cardiology 2019 PTP (ESC 2019 PTP). Methods The validation cohort consisted of 42.328 patients (54% women, age ≥30 years, no previous CAD) with symptoms of CAD referred for cardiac computed tomography angiography in the western region of Denmark from 2008–2017 (3.3 million inhabitants). Obstructive CAD was defined from either invasive angiography as stenosis &amp;gt;50%, or when performed, from FFR &amp;lt;0.8 in coronary arteries with diameters &amp;gt;2 mm. The basic prediction model included type of angina, sex, and age, and the clinical model added diabetes, family history of CAD, and dyslipidemia. The ESC 2019 PTP was calculated from age, sex, and angina symptoms. Discrimination, calibration, and negative predictive value (NPV) were measured for all three models. Results Obstructive CAD was present in 3718 (8.8%). In the ESC 2019 PTP model, the basic model, and the clinical model 19.5%, 48.5%, and 55.7% were classified as very low risk and only 1.6%, 3.7%, and 3.5% of these had obstructive CAD, respectively (figure 1). Discrimination was similar for the three models with AUC of 0.76 (95% CI 0.75–0.77), 0.74 [0.73–0.75], and 0.76 [0.75–0.76], for the ESC 2019 PTP, basic, and clinical model, respectively. At the clinically relevant very low predicted probability (≤5%) of CAD, the clinical and basic model were very well calibrated, whereas the ESC 2019 PTP model overestimated the CAD prevalence. NPV at cut-off ≤5% were 98.4% [98.1–98.7] for the ESC 2019 PTP model, 96.3% [96.1–96.6] for the basic model, and 96.5% [96.3–96.7] for the clinical model. At cut-off &amp;lt;15%, NPVs were 96.1% [95.8–96.3] for the ESC 2019 PTP model, 94.5% [94.2–94.7] for the basic model, and 94.2% [94.0–94.5] for the clinical model. Conclusion In a population with a prevalence of 8.8% obstructive CAD, a clinical prediction model including diabetes, family history of CAD, and dyslipidemia in addition to the variables of the ESC 2019 PTP model ruled out 36.2% more patients than the ESC 2019 PTP model (23.592 vs. 8245 patients) while only overlooking 1.9% more cases of obstructive CAD when choosing a cut-off ≤5%. Use of this model is therefore potentially cost saving. Funding Acknowledgement Type of funding sources: None. Figure 1Figure 2

Impact of polyvascular disease on the prognosis of acute coronary syndrome

Abstract The polyvascular disease reflects a diffuse atherosclerotic disease. By a prospective and descriptive study, recruiting three hundred thirty-six inpatient coronary care unit for acute coronary syndrome, the aim is to estimate the prevalence, to identify predictors factors and to assess the impact of the polyvascular disease in term of mortality and cardiovascular events (MACE 4points) at one, six and twelve months after discharge. The polyvascular disease is defined by the presence of cerebrovascular disease or peripheral artery disease. The cerebrovascular disease is defined in patients with documented stroke or carotid stenosis assessed by ultrasound; the peripheral artery disease is defined by an anchle brachial index (ABI) inferior to 0.9. The prevalence of polyvascular disease in patients with acute coronary syndrome (Men = 69,0%; mean age = 63,3y) is 28.9%. In our study population, 20.8% have cerebrovascular disease. A significant carotid stenosis is seen in 57 patients (16,7%), half of which have bilateral stenosis. 16.1% of patients have a peripheral artery disease. an ABI less than 0.45 is found in 7 patients (2,1%). 1.8% of patients have abdominal aortic aneurysm. Many factors statistically associated with the polyvascular disease are identified. High blood pressure, thinness, advanced age, prolonged smoking and diabetes are the most powerful predictors. On admission, the polyvascular patients have more likely a KILLIP than or equal to two, anemia and kidney failure. They have an ejection fraction of the left ventricle lower than patients with only coronary artery disease. Their coronary artery disease appears more severe and extensive in coronary angiography. Polyvascular disease appears as an independent and powerful predictor of mortality and cardiovascular events in the short and medium term in patients with acute coronary syndrome. The hazard ratio of polyvascular disease mortality at day 30, 6 months and 12 months of hospitalization are respectively 6.16, 4.44 and 5.91. The hazard ratio for disease polyvascular for cardiovascular events at 6 months and 12 months of hospitalization are 2.79 and 2.90 respectively. Funding Acknowledgement Type of funding sources: Public hospital(s). Main funding source(s): University hospital of Bab ElOued AlgiersUniversity hospital of Douéra Algiers

Celiac Disease Prevalence in Patients with Chronic Noninflammatory Diarrhea in 2017

Introduction: Celiac disease is an autoimmune disorder. Eating gluten, which is part of the cereals, can lead to intestinal mucosal injury and diarrhea. Although celiac disease is more common today with non-digestive symptoms, we sometimes encounter cases of chronic non-inflammatory diarrhea, which is one of the clinical manifestations of celiac disease. This study was performed to evaluate the prevalence of celiac disease in patients with chronic non-inflammatory diarrhea. Because diarrhea in celiac disease has distinct and efficient treatment we decided to do this study to evaluate the prevalence of celiac disease in patients with chronic non-inflammatory diarrhea. Methods: This was a descriptive cross sectional study on 200 patients with chronic non-inflammatory diarrhea in Yazd in 2017. Stool exam and tissue transglutaminase Antibody (TTG Ab) was done for the patients; upper endoscopy and duodenum biopsy was done for the patients with high serum TTG Ab. Findings analyzed in SPSS.ver.17 statistical software. Chi-Square, t-test and Fisher Exact tests were used for statistical analysis. P-value less than 0.05 was considered significant. Results: Two hundred patients, including 93 (46.5%) men and 107 women (53.5%) participated in this study. The average age was 34.32 ± 17.84 years. Among these cases, 31 patients (15.5%) had celiac disease. Among cases of celiac (16.1%), 15 (16.1%) were male and 16 (15%) were female. The relative frequency of celiac disease was the same in both sexes and in all age groups. Conclusion: Significant portion of patients (15.5%) with chronic non-inflammatory diarrhea has celiac disease.

Association between prevalence of obstructive lung disease and obesity: results from The Vermont Diabetes Information System

BackgroundThe association of obesity with the development of obstructive lung disease, namely asthma and/or chronic obstructive pulmonary disease, has been found to be significant in general population studies, and weight loss in the obese has proven beneficial in disease control. Obese patients seem to present with a specific obstructive lung disease phenotype including a reduced response to corticosteroids. Obesity is increasingly recognized as an important factor to document in obstructive lung disease patients and a critical comorbidity to report in diabetic patients, as it may influence disease management. This report presents data that contributes to establishing the relationship between obstructive lung disease in a diabetic cohort, a population highly susceptible to obesity.MethodsA total of 1003 subjects in community practice settings were interviewed at home at the time of enrolment into the Vermont Diabetes Information System, a clinical decision support program. Patients self-reported their personal and clinical characteristics, including any history of obstructive lung disease. Laboratory data were obtained directly from the clinical laboratory, and current medications were obtained by direct observation of medication containers. We performed a cross-sectional analysis of the interviewed subjects to assess a possible association between obstructive lung disease history and obesity.ResultsIn a multivariate logistic regression model, a history of obstructive lung disease was significantly associated with obesity (body mass index ≥30) even after correcting for potential confounders including gender, low income (<$30,000/year), number of comorbidities, number of prescription medications, cigarette smoking, and alcohol problems (adjusted odds ratio (OR) = 1.58, P = 0.03, 95% confidence interval (CI) = 1.05, 2.37). This association was particularly strong and significant among female patients (OR = 2.18, P = < 0.01, CI = 1.27, 3.72) but not in male patients (OR = 0.97, P = 0.93, CI = 0.51, 1.83).ConclusionThese data suggest an association between obesity and obstructive lung disease prevalence in patients with diabetes, with women exhibiting a stronger association. Future studies are needed to identify the mechanism by which women disproportionately develop obstructive lung disease in this population.