Prevalence Of Congenital Malformations Research Articles

Association between Maternal Birth Weight and Prevalence of Congenital Malformations in Offspring: The Japanese Environment and Children's Study.

Congenital malformations are functional and structural alterations in embryonic or foetal development resulting from a variety of factors including maternal health status. This study aimed to investigate the association between maternal birth weight (MBW) and the prevalence of congenital malformations in offspring using data from a nationwide birth cohort study in Japan including 103,060 pregnancies. A binary logistic regression model with adjustment for various covariates revealed that an MBW of <2500 g (low MBW) was associated with an increased risk of congenital heart disease (adjusted odds ratio: 1.388, [95% confidence interval: 1.075-1.792]), angioma (1.491 [1.079-2.059]), and inguinal hernia (1.746, [1.189-2.565]), while those with an MBW of ≥4000 g (high MBW) were associated with congenital anomalies of the urinary tract (2.194, [1.261-3.819]) and arrhythmia (1.775, [1.157-2.725]) compared with those with an MBW of 3000-3499 g. Low MBW was associated with cleft lip and/or palate (1.473, [1.052-2.064]), congenital heart disease (1.615, [1.119-2.332]), genital organs (1.648, [1.130-2.405]), hypospadias (1.804, [1.130-2.881]), and inguinal hernia (1.484, [1.189-1.851]) in male infants and CAKUT (1.619, [1.154-2.273]) in female infants, whereas high MBW was associated with congenital heart disease (1.745, [1.058-2.877]) and CAKUT (2.470, [1.350-4.517]) in male infants. The present study is the first to demonstrate a link between MBW and congenital malformations in Japanese children. While these results must be interpreted with caution, MBW should be considered a major predictor of congenital malformation risk.

Prevalence of congenital malformation among neonates born after the use of progesterone for luteal support during IVF and ICSI cycles

Introduction: This study assessed the prevalence of congenital malformation among neonates born after using progesterone for luteal support in patients undergoing IVF and ICSI cycles. Methods: This retrospective cohort study was conducted in the Reproductive Endocrinology and Infertility Department of a tertiary hospital. Two groups were compared: one group received only Cyclogest or Crinone gel, and the other group received a combination of Cyclogest or Crinone gel with Proluton Depot injection Results: A total of 91 patients were included, all of whom took progesterone during their IVF and ICSI cycles. The minimum age of the participants was 21, and the maximum was 41. 16.5% (n=15) patients who received progesterone for luteal support during their IVF and ICSI cycles gave birth to infants with congenital malformation, while 76 (83.5%) did not. The most commonly observed congenital malformation was patent ductus arteriosus, observed in 5 cases (5.49%), followed by delayed speech observed in 2 (2.2%). Brachydactyly, Down syndrome, autism spectrum disorder, and a number of other conditions were observed at a rate of 1.1%. Ultimately, no significant association was found between the two groups and the incidence of congenital malformations (p = 0.121). Conclusion: Our review indicates that the incidence of congenital anomalies was similar across the different treatment groups.

Type of infertility and prevalence of congenital malformations.

Children conceived with assisted reproductive technologies(ART) or after a long waiting time have a higher prevalence of congenital malformations, but few studies have examined the contribution of type of infertility. To quantify the association between causes of infertility and prevalence of malformations. We compared the prevalence at birth of all and severe malformations diagnosed up to age 2 between 6656 children born in 1996-2017 to parents who had previously been assessed for infertility a an academic fertility clinic ("exposed") and 10,382 children born in the same period to parents with no recent medical history of infertility ("reference"). We estimated prevalence ratios (PR) and prevalence differences (PD), by infertility status, type of treatment (non-ART, ART),and infertility diagnosis, in all children and among singletons. Compared with children of parents with no infertility, children of parents with infertility had a higher prevalence of malformations (both definitions), particularly following ART conceptions. After accounting for treatment, ovulatory disorders were associated with a higher prevalence of both all (PR 1.49, 95% confidence interval (CI) 1.15, 1.93; PD 3.8, 95% CI 1.0, 6.6) and severe (PR 1.53, 95% CI 1.02, 2.29; PD 1.8, 95% CI -0.2, 3.7) malformations (the estimates refer to exposed children conceived without treatment). Unexplained and male factor infertility were associated with all and severe malformations, respectively. Estimates among singletons were similar. A diagnosis of ovulatory disorders was associated with all malformations also in analyses restricted to exposed children, regardless of treatment (we did not examine severe malformations, due to limited power). In this study, ovulatory disorders were consistently associated with a higher prevalence of congenital malformations (including severe malformations) among live births, regardless of mode of conception.

Impact of a prenatal screening program on the Down syndrome phenotype: An interrupted time series analysis.

We hypothesized that children with Down syndrome who were born after the implementation of first-trimester combined screening for trisomy 13, 18, and 21 and a second-trimester ultrasound scan in Denmark would show a milder syndrome phenotype. We investigated the birth biometry, prevalence of congenital malformations, and early childhood morbidity of children with Down syndrome before and after implementation of this screening program. A nationwide register-based study of all live born singletons with Down syndrome in Denmark from 1995 to 2018. In interrupted time series analyses, we studied the temporal developments in birth biometry, prevalence of congenital malformations, and early childhood morbidity related to the implementation of a national prenatal screening program. We included 602 singletons with Down syndrome born before and 308 after implementation of the screening program. Z-scores of birthweight and head circumference increased over time before screening, but this temporal development changed after implementation by -0.05 (95% confidence interval [CI]: -0.11 to 0.01) and -0.05 (95% CI -0.12 to 0.02), respectively. Just after implementation, the prevalence of non-severe congenital heart disease decreased (relative change in odds 0.48 [95% CI: 0.24-0.94]). For severe congenital heart disease, atrioventricular septal defect, and non-heart malformations, this change was 1.16 (95% CI: 0.56-2.41), 0.95 (95% CI: 0.43-2.03), and 0.98 (95% CI: 0.33-2.76), respectively. For all malformations, pre-existing temporal developments did not change following implementation of screening. The implementation was associated with higher odds of admission to a neonatal intensive care unit (relative change 1.98 [95% CI: 0.76-5.26]) and an increased risk of hearing impairment (risk difference 3.4% [95% CI: -0.4% to 7.1%]). In contrast, the implementation was not associated with the incidence of hospital admissions by 2 years of age or with the probability of a thyroid disorder. After implementation of a national prenatal screening program, we did not observe a milder Down syndrome phenotype apart from an apparent reduction in the proportion of children with non-severe congenital heart disease; this result is, however, limited by small numbers.

Period prevalence of antenatally diagnosed congenital abnormalities, Single center study from Saudi Arabia

Objective: To find out the period prevalence of congenital malformation diagnosed in security forces hospital – Riyadh –kingdom of Saudi Arabia, during the study period from Jan 2012 till Dec 2014 and the possible associated risk factors. Method: This is a retrospective chart review of all pregnant ladies who were following at security forces hospital – Riyadh – in the period between Jan 2012 till Dec 2014 in whom congenital abnormalities were diagnosed by ultrasound.Results: Out of 18748 scans done for 9374 patient during the study period, 283 cases of congenital abnormalities were diagnosed, which gives a period prevalence of 3.02%. The majority -around 70% of these anomalies- involved one body system; out of them 31% were renal anomalies. Conclusion: The period prevalence of congenital abnormalities in our study group is similar to that seen in other population worldwide. Strikingly enough, consanguinity in our population appears to play a major associated risk factor.

Prevalence of congenital malformations and deformities of the osteomuscular system in live newborns in Mexico, 2008-2017

Prevalence of congenital malformations and deformities of the osteomuscular system in live newborns in Mexico, 2008-2017

Factors and prevalence of congenital malformations in the Republic of Tajikistan

Aim. To establish the factors and prevalence of congenital malformations in the Republic of Tajikistan.Materials and methods. This study was conducted based on statistical data from the State Institution “Republican Center for Medical Statistics and Information”, the State Institution “National Center for Reproductive Health” and other sectoral reports of the Ministry of Health and Social Protection of the Population of the Republic of Tajikistan. Statistical data processing was performed based on MS Office 2019.Results. An analysis of 600 cards showed that in the structure of risk factors causing congenital malformations, the first place is occupied by acute and chronic non-genital infectious diseases (38%), second anaemia (29.8%). The third place is poor obstetric history: multiple voluntary abortions, intrauterine growth retardation, stillbirth, the birth of a child with defects, preeclampsia), (20.8%) with circulatory failure in the mother-child system (16.3%). The percentage of children born with congenital birth defects from marriages of close relatives is 5% of the analyzed charts.Conclusion. Thus, the main reasons for the growth of CM in newborns are burdened obstetric history and heredity, bad habits and occupational hazards, past viral and bacterial infections, and late prenatal diagnosis.

Successful Reproductive Outcome Following Challenging Surgical Management of Mullerian Anomalies

Background: Mullerian duct anomalies consist of a set of structural malforma-tions of reproductive organ resulting from abnormal development of the paramesonephric or Müllerian ducts. The prevalence of these anomalies ranges from 0.001 to 10% in the general population and from 8-10% in women with an adverse reproductive history. The aim of this study was to diagnose different type of mullerian anomalies and to evaluate the reproductive outcome that occurs as a result of surgical management of malformation of genital tract. Methods: A prospective observational study of mullarian anomalies and its diagnosis &amp; reproductive outcome was observed by using data from women with congenital anomalies attended in OPD either with complains or incidental diagnosis with HSG,during laparoscopy at tertiary care center. Total 100 women with different types of mullarian anomalies were included in study. Results: Most common utero-vaginal anomaly seen in present study was septate uterus with on basis of clinical examination. Out of 100 patient (35)35% were diagnosed mullerian agenesis. Cervico vaginal agenesis (15)15%, Septate uterus 28(28%), Bicornaute uterus 7(7%), Transverse vaginal septum 5 % ,unicornuate 5%, Didelphi’s with longitudinal vaginal septum 2%, Microperforate Hymen 3(3%). Among all patients 26 patients were pregnant. Among primary amenorrhea 35 patient of mullarian agenesis after progressive non-surgical vaginal dilatation 22 patient had no coital difficulty. 5 patients were need vaginoplasty. Among 15 patients of cervicovaginal agenesis 6 become menstruating, 2 were pregnant, 6 patient failed anastomosis, needed total abdominal hysterectomy 3 patients on oral pill. Among 5 transverse vaginal septum, 5 having regular menestration among 2 become pregnant. Among other mullarian anamolies after challenging surgical management 22 patient become pregnant. Conclusion: Present study shows prevalence of congenital malformation of female reproductive tract is 0.83% at our .....

Prevalência de malformações congênitas entre 2015 e 2019 em Rondônia (RO), Amazônia, Brasil

Abstract Objectives: to determine and characterize the prevalence of congenital malformations among live births in Rondônia, from 2015 to 2019. Methods: an ecological study was conducted using publicly available data at Sistema de Informações sobre Nascidos Vivos collected in January 2021. The prevalence of congenital malformation and possible associations were calculated. The strength of the association between variables was measured using the odds ratio. Variables that were statistically significant at the 5% level were selected for adjusted odds ratio calculation using logistic regression models. The R programming language was used for all analyses and interactions with the database. A 95% confidence interval was considered. Results: a total of 1,110 records were analyzed. The overall prevalence of congenital malformation was 8.36, with higher rates observed among mothers over 35 years, those with low educational levels, unmarried status, and preterm birth. Infants with low birth weight and low Apgar scores also had higher prevalence rates of congenital malformations. Conclusion: the prevalence of congenital malformations in the state was similar to the national average, but regional disparities were observed and warrant further investigation.

Prevalence of congenital malformations from 2015 up to 2019, in Rondônia (RO), Amazon, Brazil

Resumo Objetivos: determinar e caracterizar a prevalência de malformações congênitas entre nascidos vivos em Rondônia, no período de 2015 a 2019. Métodos: estudo ecológico, com dados públicos disponíveis no Sistema de Informações sobre Nascidos Vivos coletados em janeiro de 2021. Foi calculada a prevalência das malformações e as possíveis associações. A força de associação entre as variáveis foi medida pela razão de odds. Aquelas variáveis consideradas estatisticamente significante ao nível de 5% foram selecionadas para o cálculo de razão de odds ajustada, usando modelo de regressão logística. A linguagem de programação R foi usada para todas as análises e interação com o banco de dados. O Intervalo de Confiança considerado foi de 95%. Resultados: foram analisados 1.110 registros. A prevalência geral de malformação congênita foi de 8,36, sendo maior entre mães com idade acima de 35 anos, baixa escolaridade, solteiras, com partos prematuros; crianças com baixo peso ao nascer e baixos escores de Apgar. Conclusão: a prevalência de malformação congênita no estado foi próxima da nacional, mas houve discrepâncias entre as regiões de saúde que merecem uma investigação futura.

Epidemiological and clinical profile of congenital malformations in Benghazi Pediatric Hospital

Objectives: The objectives were to assess the nature and the frequency of congenital malformations among infants and children who were admitted to Benghazi pediatric hospital and to study the associated maternal and neonatal risk factors.&#x0D; Patients and methods: A cross-sectional study design was used for this study. It included infants and children aged (0-16 yrs.) who were admitted to Benghazi Children Hospital and who were following the genetic clinic, during the period of March 2016 to March 2017. These cases had dysmorphic features and multiple congenital malformations. A record sheet was used to collect the required data from cases. Results: The total number of patients was 81 children, 51.85% were females, 48.15% were males and infants represented 62%. Cases with a history of consanguineous marriage represented 28.40%. Equal proportions of mothers (1.23%) had a history of diabetes, epilepsy and cardiomyopathy. Nearly a quarter of cases, (24.69%) were low birth weight. Prevalence of congenital malformations (CMs) according to organs were; CVS (50.62%), musculoskeletal (44.44%), eye (24.7%), limb defect (17.3%), GIT (14.8%), ear (14.8%), CNS (11.11%), urogenital (external &amp; internal)(11%), cleft lip &amp; palate (9.9%) and Trisomy 21 syndrome (48.1%). Trisomy 21 syndrome have a high frequency of CHD compared to other syndromes; 67.9% had CHD, P=.01. Most cases (90%) died within the first year of life, p=.002. Twenty-six percent of the studied population died during the study period.&#x0D; Conclusion: Most children with CMs and chromosomal abnormalities died within the first year of life. There is a limitation of screening tools, which could lead to imprecise genetic counseling. CM is a significant cause of morbidity and admission. The highest prevalence of CMs was CVS. Trisomy 21 syndrome was the most prevalent chromosomal abnormalities; these cases were at more risk to have CHD compared to other syndromes. There is a shortage of medical services, which applied as segmental services.

The Prevalence of Congenital Malformations and Anomalies of the Chest Organs and Systems among Adult Population of the Kabardino-Balkarian Republic

The objective: to assess the prevalence and structure of congenital malformations and anomalies of the chest organs and systems among adult population of the Kabardino-Balkarian Republic.Subjects. 1,729 patients with suspected respiratory tuberculosis examined from 2016 to 2021 inclusive in Differential Diagnostic Department of TB Dispensary by the Ministry of Health of the Kabardino-Balkarian Republic.Results. In 89 (5.1%) patients, congenital anomalies and malformations of the chest organs and systems were detected, 42/89 (47.2%) had one more concurrent respiratory pathology; oncological diseases (42.9%) and respiratory tuberculosis (23.8%) prevailed. In patients with malformations of the musculoskeletal system of the chest organs, tuberculosis was more often detected, oncological diseases were equally frequent in patients with malformations of the musculoskeletal system and mediastinum.

Epidemiological characteristics of congenital malformations: data from the Moscow Region register

The aim of this work is to analyze the epidemiology of congenital malformations in different populations in comparison with the data of the regional register of congenital malformations of the Moscow Region. The article provides a brief description and results of the work of international organizations that collect and analyze data on the prevalence and structure of congenital anomalies — EUROCAT (European network of population-based registries for the epidemiological surveillance of congenital anomalies) and ICBDSR (The International Clearinghouse for Birth Defects Surveillance and Research). For countries where there are no monitoring systems for congenital malformations recording, the Modell World Database of Congenital Diseases (MGDb) has been developed, which makes it possible to calculate the estimated population prevalence of congenital malformations in these regions. According to international registers, the most common groups of congenital malformations are malformations of the cardiovascular, genitourinary, central nervous systems and malformations of the extremities. To date, the epidemiological picture of the prevalence and structure of congenital malformations around the world looks stable.The article analyzes data from the population-based register of congenital malformations in the Moscow Region from 2011 to 2019, with a coverage of 83% of births in the region. The overall prevalence of congenital malformations was 25.42 per 1000 births. It is determined that the structure of congenital malformations in the Moscow Region is comparable to the data of international studies, but one should pay attention to the lower frequency of most groups of malformations, which is most likely due to insufficient registration of malformations. The Moscow Region register of congenital malformations provides relevant and qualitative data on the frequency and structure of the congenital malformations in the region, which allows, if necessary, to extrapolate obtained prevalence rates to other constituent entities of the Russian Federation as well.

Dynamics of the incidence of congenital malformations in children in Chelyabinsk based on the results of epidemiological monitoring in 2012–2017

Congenital malformations are not only a medical, but also a serious social problem, since this pathology is a leading cause of perinatal, neonatal, and infant morbidity, disability, and mortality.Purpose. To analyze the variation dynamics in the incidence of groups of congenital malformations, the structure of congenital malformations according to the average incidence, and the consistency of changes in the incidence of individual groups of congenital anomalies in children of Chelyabinsk based on the results of epidemiological monitoring in 2012–2017.Material and methods. To assess the frequencies of congenital malformations, we used the monitoring data of the Regional Medicaland Genetic Consultation Office in Chelyabinsk for the period from 2012 to 2017, for Down syndrome (T21) from 2012 to 2018. The total number of newborns over the six-year period was 102,308, of which 2101 children were registered with congenital malformations, including live-born, stillborn children, and fetuses with malformations identified through prenatal diagnostics. Clinical data on newborns was grouped into 11 congenital malformations categories based on the International Classification of Diseases. The statistical analysis of the monitoring results was carried out using methods of descriptive statistics, samples comparisons, correlation, and cluster analysis.Results. The incidence of all registered congenital malformations in newborns in Chelyabinsk was 20.7 per 1000 births (95% CI: 17.4–25.4) during the study period. In newborns of the Chelyabinsk city in 2012–2017, the prevalence of congenital malformations of the circulatory system (42.8%), chromosomal abnormalities (11.9%), and anomalies of the musculoskeletal system (10.3%) was observed. The relative frequency of Down syndrome for the period from 2012 to 2018 ranged from 1.51‰ to 2.42‰, considering both children born with this pathology and the data on prenatal diagnostics.Conclusion. The hierarchy of congenital malformations was reproduced from year to year with a predominance of circulatory anomalies, chromosomal anomalies, and musculoskeletal anomalies of the system. The overall incidence of all congenital malformations in Chelyabinsk in 2012–2017 does not exceed the average values for the Russian Federation, while the incidence of Down syndrome exceeded the average national level.

Prevalence of congenital malformations in newborns in the Araucanía region

Annually, 7.9 million neonates in the world have developmental anomalies. Together with prema turity, they constitute the main causes of mortality during the first year of life in developed and de veloping countries. In Chile, the estimated prevalence is 3.9% of all live births. There are no reports on the prevalence of malformations in the Araucanía Region. to estimate the prevalence of congenital malformations at birth in neonates hospitalized in a Neonatology Service. cross-sectional study. Reference population: 54,241 live births at the Regional Hospi tal of Temuco over a 10-year period. Cases came from the neonatology hospital discharge database according to the ICD 10 classification, from January 1, 2009, to December 31, 2018. Descriptive and analytical statistics were performed with the STATA 15 software. 949 neonates with one or more congenital malformations were identified. The overall prevalence of neonates with malforma tions was 1.7%, the most prevalent being ventricular septal defect 40.9 x 10,000 live newborns (LNB), atrial septal defect 21.5 x 10,000 LNB, cleft lip and palate 14.0 x 10,000 LNB, congenital hypertrophic cardiomyopathies 8.1 x 10,000 LNB, and congenital rectal atresia and stenosis or absence of the anus 7.9 x 10,000 LNB. the overall prevalence of malformations is similar to that reported for the country. When analyzing by type, we found significantly higher incidences than those repor ted in previous studies.

Congenital anomalies and early neonatal mortality: A tertiary hospital study.

Background: The prevalence of congenital anomalies at birth is underestimated in developing countries due to the unavailability of perinatal diagnostic tests or accurate medical records. The prevalence of congenital defects may help to establish a baseline, track changes over time, and uncover etiological clues.&#x0D; Objectives: This study aims to evaluate the prevalence and types of major congenital anomalies in one of the main referral tertiary centers in Baghdad, highlighting the parent and neonatal characteristics and assessing the mortality rate in this group of patients.&#x0D; Patients and Methods: A prospective cohort study was conducted in Baghdad Teaching Hospital during the period between May 2017 and May 2018. Total deliveries were 6553, all live neonates with congenital anomalies were included regardless of their gestational age or birth weight. The patient's hospital notes were reviewed for the patient's characteristics, parentage, maternal chronic disease, and drug history, and other study parameters. The early neonatal outcome was assessed within 7 days of the delivery.&#x0D; Results: The prevalence of congenital malformations was 21.5 per 1000 birth with the highest frequent anomaly affecting the nervous system (41.1%) followed by multiple syndromic malformations (12.8%) and digestive system (11.3%). The mean maternal age was 27.8 (±7.8) ranging from 14-47. The rate of diseased mothers was 18.4%, only half of them were on regular medications. Out of a total of 399 early neonatal death during the study period, death due to congenital malformations constituted 19.8%. Congenitally deformed patients died at a rate of 56%, which was significantly associated with gestational age and neonatal birth weight.&#x0D; Conclusion: The prevalence of congenital abnormalities has increased in the same hospital over the last decade. Mortality rate of these patients is high and associated with gestational age and birth weight. It is critical to test for congenital malformations early in pregnancy, particularly for high-risk parents with advanced age, consanguinity, and history of congenital anomalies.

Prevalencia de malformaciones congénitas en la Unidad de Perinatología del Hospital Universitario de Caracas

Objective: To determine the frequency of congenital malformations diagnosed by prenatal ultrasound in the “Dr. Freddy Guevara Zuloaga” Perinatology Unit of the University Hospital of Caracas, Venezuela, in the period between January 1, 2015 and December 31, 2020. Methods: Retrospective, descriptive, cross-sectional study. The statistical records of the Unit were reviewed, with a population of 56,712 and 1844 patients were included in accordance with the inclusion criteria. Results: A general prevalence of 3.3% was obtained. The largest number of studies was conducted in 2016 (12,781). The highest prevalence of congenital malformations was 4.6%, in 2018. In order of frequency, the affected systems were: central nervous system, cardiovascular, genitourinary, gastrointestinal and abdominal wall. Less frequently, abnormalities of the face and neck, chest and lung, musculoskeletal system, and tumors were diagnosed. The most frequent malformations were: pyelic dilation (152 / 8.2%), ventriculomegaly (143 / 7.6%), gastroschisis (114 / 6.1%), Arnold Chiari type II (71 / 3.8%), acraniaexencephaly sequence (66 / 3.5%) and ventricular septal defect (64 / 3.4%). Conclusion: The frequency of congenital malformations diagnosed by ultrasound was 3.3%. The most frequently affected areas were the central nervous, cardiovascular and genitourinary systems.

Prevalence of congenital malformations in the Republic of Sakha (Yakutia)

Purpose. The study aims at assessing and analyzing the prevalence of congenital malformations in the Republic of Sakha (Yakutia) based on the data from birth defects surveillance from 2012 to 2019.Material and methods. The data of congenital malformations monitoring in the Republic of Sakha (Yakutia) for 2012–2019 are analyzed. There were revealed 1104 cases of congenital malformations of obligate registration. The total number of births was 122,413. The prevalence of birth defects was calculated per 10000 births.Results. The prevalence of congenital malformations in the Republic of Sakha was obtained. The analysis of the dynamics of the congenital malformations prevalence has been carried out. No changes in the birth defects prevalence for the analyzed period have been shown.Conclusion. Regional monitoring makes it possible to obtain and analyze congenital malformations prevalence.

Pattern and Prevalence of Congenital Malformation and Genetic Disorders among Offspring of Consanguineous Parents in Quetta

This cross-sectional study was carried out to examine the pattern and prevalence of congenital malformation/ genetic disorders among the offspring of consanguineous marriages in Quetta, Pakistan. A survey was conducted among 105 married couples from different areas of Quetta city. 89 out of 105 consanguineous couples were related as first cousins, followed by second cousin (n=16) and third cousin (n=6) couples. Consanguineous marriages were common among women who were illiterate (43.8%) and unemployed (87.6%). Highest number of child mortality (61.9%) and abnormalities (32.1%) were observed among the children of first cousin marriages. The most common congenital malformation /genetic disorders were mental retardation (24.13%), followed by diabetes (10.3%), deafness (6.8%) and thalassemia (6.8%). Among all the inter-related marriages, first cousin marriages are at highest risk to have babies with congenital anomalies.&#x0D;

Effect of consanguinity on birth weight and birth defects in the Agadir region of Morocco

The material of this study consists of 3701 newborns in the neonatology section, Maternity Hassan II Hospital, Agadir, Morocco from April 2016 to April 2018. For each newborn, several variables were recorded (birth weight, sex, consanguinity, gestational age, economic and social situation of parents, etc.). They types of birth defects have been classified according to the International Classification of Diseases (ICD-10). Of the 3701 newborns, 171 are carriers of congenital anomalies. This represents a prevalence of 4.6% (95% CI: 3.9% - 5.3%). The prevalence of LBW was 8.7% (95% CI: 7.7% - 9.6%). Of all newborns, 715 (19,64 %) were from consanguineous marriages and the mean inbreeding coefficient for the present study was 0.012. The prevalence of congenital malformations were more frequently observed in consanguineous (7.69%) compared to non-consanguineous (3.76%). A significant association with consanguinity was observed for the congenital anomaly (p-value = 0.00052) and for LBW (p-value = 0.0008). Consanguinity was identified as significant risk factors associated with LBW and CA in this study.