Prevalence Of Allergic Rhinitis Research Articles

A Conceptual Review of Allergic Rhinitis According to Ayurveda

The study focuses on the global health concern of allergic rhinitis, a condition that affects approximately 400 million people worldwide. The prevalence of allergic rhinitis characterized by recurrent attacks of sneezing, nasal congestion and rhinorrhoea has increased over the years due to urbanization and environmental pollution. Although modern medicine has developed treatments for allergic rhinitis, it is still incurable. In Ayurveda, there is a concept of Sannipatik disorders, which involves the vitiation of all the three Doshas (Vata, Pitta, and Kapha) in the pathophysiology of the disease. Sannipatik diseases are known to be particularly challenging to treat. The symptoms of allergic rhinitis closely resemble the diseased condition called Sannipatik Pratishayaya in Ayurveda. While modern medicine offers anti-allergic, antihistaminic, corticosteroids, and other treatment options, these are not entirely effective in curing the disease or preventing its recurrence. Additionally, these treatments often come with their own side effects. In contrast, Ayurvedic classical texts provide detailed explanation of the pathophysiology, sign and symptoms and principles of treatment for effective management for Sannipatik Pratishayaya. Thus, the Ayurvedic concept of Sannipatik Pratishyaya and its understanding can be helpful in managing allergic rhinitis. Aim- The aim of the article is to correlate symptomatology of Sannipatik Pratishyaya with allergic rhinitis and discuss the role of various treatment modalities according to Ayurveda. Methods- Literary review of various Ayurvedic texts, electronic databases; online Journals in the field available at various search portals. Result-The final outcome of the study is to find out a permanent treatment measure for this problem that can be further tested by practical application.

Nonelective cesarean section is associated with the prevalence of asthma among Mexican children who attended childcare centers.

The cesarean section (CS) mode of delivery can influence the prevalence of bronchial asthma (BA), allergic rhinitis (AR), or atopic dermatitis (AD) by promoting modifications in the infantile microbiome. To analyze the prevalence of asthma in children who were born through CS and attended childcare centers. The data were obtained through an online survey that was answered anonymously by one of the parents; the survey inquired about the route of delivery of the child and the prevalence of BA, AR, and AD. A total of 525 children were included. The frequency of births by vaginal, elective CS, or nonelective CS was 34.1%, 37.9%, and 28.0%, respectively, and the prevalence of BA, AR, and AD was 4.8%, 19.8%, and 12.4%, respectively. Multivariate analyses identified nonelective CS as a factor associated with the prevalence of BA (odds ratio: 3.51, P = 0.026). Our study shows that being born through nonelective CS can increase the probability of BA in children who attended daycare centers.

The Relationship of Climate Change to Rhinitis

Evidence is mounting that climate change is having a significant impact on exacerbations of rhinitis. Concomitantly, the prevalence of allergic rhinitis is increasing at an accelerated rate. We herein explore the impact of carbon dioxide, barometric pressure and humidity changes, anthropogenic pollutants, on aeroallergens and rhinitis hypersensitivity. Important immune mechanisms underlying the climate-driven effects on rhinitis are discussed. Also, climate change is shifting ecological zones and seasons, increasing weather extremes, and altering regional atmospheric and environmental conditions. The direct impact of these factors on promoting allergic and nonallergic rhinitis are reviewed.

Incidence of grass and weed sensitization in Bangkok, Thailand: a clinical study.

Allergic rhinitis (AR) is a prevalent public health concern globally, significantly impacting quality of life. In Thailand, the prevalence of AR is rising, with grass and weed pollen identified as primary outdoor triggers. This study aimed to (1) assess patterns of pollen sensitization in Thai AR patients and (2) investigate correlations between demographics/clinical data and SPT results. A total of 121 individuals aged ≥18 years with clinically diagnosed AR were recruited. Skin prick testing (SPT) was performed using a panel of commonly encountered tropical grass and weed pollen extracts. SPT wheal sizes and clinical symptom scores were recorded. Correlations between SPT outcomes and symptom scores were analyzed. Among the participants, 104 (85.95%) exhibited positive SPT reactions to at least one pollen type. Nutsedge (76/121), para grass (57/121), and Bermuda grass (48/121) were the most frequently identified allergens. Hurricane grass elicited the strongest reaction, evidenced by the highest average wheal size (6.2 mm). Poly-sensitization was observed in 77 (63.6%) of the SPT-positive individuals, with most cases involving two different pollen extracts (35/77). Notably, AR severity positively correlated with both average wheal size and the number of positive SPT tests. This study highlights nutsedge, para grass, and Bermuda grass as major allergenic pollen sources for Thai AR patients. Including nutsedge, hurricane grass, and careless weed in clinical SPT panels is recommended for improved diagnostic accuracy. Additionally, the positive correlation between AR severity and pollen reaction strength emphasizes the importance of implementing patient education and avoidance strategies.

Greenness and its composition and configuration in association with allergic rhinitis in preschool children

BackgroundFew studies focus on the associations of green space composition and configuration with children's allergic rhinitis (AR). MethodsA multi-center population-based cross-sectional study was performed in 7 cities in mainland of China between 2019 and 2020, recruiting 36,867 preschool children. Information on the current AR symptoms and demographics were collected by questionnaire. Exposure to residential greenness was estimated by Normalized Difference Vegetation Index (NDVI, 1000 m buffer) around the residences. Greenness composition was estimated in 3 main categories: forest, grassland, shrubland. Configuration of each category and total greenness (a spatial resolution of 10 m × 10 m) was estimated by 6 landscape pattern metrics to quantify their area, shape complexity, aggregation, connectivity, and patch density. Exposure to daily ambient particulate matter (PM1, PM2.5 and PM10, a spatial resolution of 1 km × 1 km) was estimated. Multilevel logistic regression models were applied to analyze the associations of greenness and its composition and configuration with AR, and mediation effects by PMs were examined by mediation analysis models. ResultsThe prevalence of self-reported current AR in preschool children was 33.1%. Two indicators of forest, Aggregation Index of forest patches (AIforest) (odds ratio (OR):0.92, 95% Confidential Interval (CI): 0.88–0.97), and Patch Cohesion of forest (COHESIONforest) (OR: 0.93, 95% CI:0.89–0.98) showed significantly negative associations with AR symptoms. Mediation analyses found the associations were partially mediated by PMs. Age, exclusive breastfeed duration and season were the potential effect modifiers. The associations varied across seven cities. ConclusionOur findings suggest the inverse associations of the aggregation and connectivity of forest patches surrounding residence addresses with AR symptoms. Since the cross-sectional study only provides associations rather than causation, further studies are needed to confirm our results as well as the underlying mechanisms.

A Comprehensive Analysis of Immunoglobulin E Levels, Allergen-Specific Sensitivities, and Clinical Manifestations in Allergic Dermatological Conditions: A Multicenter Retrospective Study in China.

To assess the correlations between Immunoglobulin E (IgE) levels, pruritus, and lesion severity in patients with eczema, atopic dermatitis, or urticaria. A retrospective study was conducted and data of 814 patients who visited the dermatology or allergy clinics of multiple hospitals, from December 2019 to December 2021, were collected. Patients were divided into children group (<18 years, 325 cases), adult group (18-60 years, 435 cases), and older population group (>60 years, 54 cases) based on the age. Baseline information, pruritus severity, severity of skin lesions, total IgE level, and specific IgE level were recorded to analyze the complex relationship between them. The prevalence of allergic conjunctivitis and allergic rhinitis in the children group was significantly higher than that in the adult and older population group (P < 0.01 or P < 0.05). The positive rate of specific IgE in children group was significantly higher than that in the adult and older population group (P < 0.01). The IgE levels in children with moderate pruritus were significantly lower than those of severe pruritus (63.39vs 114.42 IU/mL, P < 0.05). The IgE levels in children with mild and moderate skin lesions were significantly lower than those in children with severe skin lesions (58.95 vs 72.88 vs 169.15 IU/mL, P < 0.001 or P < 0.01, respectively). Relationships among age, severity of skin pruritus and lesions, and allergen-specific IgE response are complex and subtle, displaying dynamic patterns.

Epidemiological characterization and risk factors of rhinitis and rhinoconjunctivitis among preschool children in Shanghai, China

BackgroundPrevious studies have reported an increasing prevalence of childhood allergic rhinitis in developing countries. There is still a lack of the recent epidemiology of allergic rhinitis among Chinese preschool children. Therefore, this study explored the prevalence of rhinitis symptoms and identified their associations with potential risk factors among children at the age of 3–6 in Shanghai, China. MethodsValidated International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was adopted to collect information about rhinitis symptoms and potential risk factors. Univariate and multivariate logistic regression analyses were used to assess associations between risk factors and allergic rhinitis and rhinoconjunctivitis. ResultsA total of 6183 questionnaires were included in our study. The prevalence of rhinitis ever, current rhinitis, and physician-diagnosed rhinitis were 32.6%, 29.2%, and 14.3%, respectively, while the prevalence of current rhinoconjunctivitis was 11.3%. The higher prevalence was observed in boys than in girls in terms of rhinitis ever, current rhinitis, current rhinoconjunctivitis and doctor-diagnosed rhinitis. Autumn had the highest prevalence among four seasons. In our multivariate logistic regression analyses, history of allergic diseases and paracetamol use in the last year showed positive associations with the increased risk of both current rhinitis and rhinoconjunctivitis, and antibiotic use was an independent significant risk factor only for current rhinitis. Genetic factors, including maternal and paternal rhinitis, asthma, and eczema, were significantly associated with the prevalence of current rhinitis. Similar associations were seen between these factors and current rhinoconjunctivitis, except for paternal eczema. Among environmental factors, smoking exposure at home, heavy truck traffic in home's street, floor heating system were independent risk factors for both current rhinitis and rhinoconjunctivitis in the adjusted model, while cleaning the house less than once a week was only associated with current rhinitis. ConclusionThe prevalence of current rhinitis was 29.2% among children aged 3–6 in Shanghai, China. Sex differences and seasonal variations were observed in the prevalence of rhinitis symptoms. The identified risk factors would provide a basis for policy makers and medical experts to take intervention measures to prevent allergic rhinitis and rhinoconjunctivitis.

Обоснование необходимости профилактики аллергического ринита на территории Воронежской области

The allergic diseases, the major role in etiology of which is played by allergens present in ambient air, are common. To develop practical guidelines on prevention of allergic rhinitis as the most prevalent disorder in the structure of allergy, it is necessary to estimate all the conditions, both negatively and positively affecting this disorder. The study was aimed to assess factors affecting the incidence, detection, and registration of cases of allergic rhinitis in the Voronezh Region. The report forms № 12 and № 30 provided substantive inputs to the study, along with the laboratory test data provided by private clinics and the social and hygienic monitoring data. Epidemiological analysis was performed by retrospective method; the territories were ranked by various indicators; the correlation analysis method was applied. We determined the incidence rates and the districts at high risk of allergic rhinitis (pollinosis) in all population groups for the period 2012–2021. We determined the structure of aeroallergens identified in private healthcare institutions, assessed the staffing levels of allergists in the public institutions of the Voronezh Region, and identified significant environmental factors. The identified features of the prevalence, diagnosis, and registration of allergic rhinitis in the Voronezh Region can be used to improve preventive measures targeting this allergic disorder.

Three Artemisia pollens trigger the onset of allergic rhinitis via TLR4/MyD88 signaling pathway.

The prevalence of allergic rhinitis is high, making it a relatively common chronic condition. Countless patients suffer from seasonal Allergic rhinitis (AR). The objective of this investigation is to examine the potential involvement of common pollen allergens in seasonal allergic rhinitis, and study the proposed mechanism of Toll-like receptor 4 (TLR4)/Myeloid differentiation primary response gene 88 (MyD88) signaling pathway in the induction of AR. A mouse AR model (sensitized group) was constructed with pollen extracts and ovalbumin(OVA) of Artemisia annua (An), Artemisia argyi (Ar) and Artemisia Sieversiana (Si), and thereafter, AR symptom score was performed. After successful modeling, mouse serum and nasal mucosa tissues were extracted for subsequent experiments. The expression levels of immunoglobulin E (IgE), Interleukin (IL)-4, IL-5, IL-13 and Tumor Necrosis Factor-α (TNF-α) in serum were detected using Enzyme-linked immunosorbent assay (ELISA); Hematoxylin-eosin (H&E) staining methods were used to observe the pathological changes of the nasal mucosal tissue; Utilizing immunohistochemistry (IHC) staining, the expression levels of TLR4, MyD88 and Nuclear factor kappa B (NF-κB) p65 in mouse nasal mucosa were quantified; The mRNA and protein expression levels of TLR4, MyD88 and NF-κB p65 in nasal mucosa of sensitized mice were detected with Quantitative reverse transcription PCR (qRT-PCR) and Western Blot. Finally, the in vitro culture of Human nasal mucosal epithelial cells (HNEpC) cells was conducted, and cells were treated with 200µg/ml Artemisia annua pollen extractand OVA for 24h. Western Blot assay was used to detect the expression level of TLR4, MyD88 and NF-κB p65 proteins before and after HNEpC cells were treated with MyD88 inhibitor ST-2825. On the second day after AR stimulation, the mice showed obvious AR symptoms. H&E results showed that compared to the control group, the nasal mucosal tissue in the sensitized group was significantly more inflamed. Furthermore, ELISA assay showed increased expression levels of IgE, IL-4, IL-5, IL-13 and TNF-α in serum of mice induced by OVA and Artemisia annua pollen, Artemisia argyi pollen and Artemisia Sieversiana pollen than those of the control group. However, the expression level of IL-2 was lower than that of the control group (P < 0.05). Using Immunohistochemistry staining visually observed the expression levels of TLR4, MyD88 and NF-κB p65 in mouse nasal mucosa tissues and quantitatively analyzed. The expression levels of TLR4, MyD88 and NF-κB p65 in the sensitized group were higher than those in the control group, and the differences were statistically significant (P < 0.05). The results from qRT-PCR and Western Blot showed that the mRNA and protein expression levels of TLR4, MyD88 and NF-κB p65 in nasal mucosa of the sensitized group were significantly higher than those in the control group (P < 0.05). Finally, HNEpC cells were cultured in vitro and analyzed using Western Blot. The expression levels of TLR4, MyD88 and NF-κB p65 in OVA and An groups were significantly increased (P < 0.05). After ST-2825 treatment, TLR4 protein expression was significantly increased (P < 0.05) and MyD88 and NF-κB p65 protein expression were significantly decreased (P < 0.05). To sum up, the occurrence and development of AR induced by OVA and pollen of Artemisia annua, Artemisia argyi and Artemisia Sieversiana were related to TLR4/MyD88 signal pathway.

A Perception-Based Survey on Practice Patterns Pertaining to the Diagnosis and Management of Allergic Rhinitis in India.

Allergic rhinitis (AR) is increasingly prevalent in India, affecting a significant portion of the population and adversely impacting their quality of life. This nationwide survey aimed to explore the perceptions and clinical preferences of Indian physicians regarding the perceived prevalence, common symptoms, and various available treatments for AR. This cross-sectional, observational, digital questionnaire-based survey was conducted from September 2022 to March 2023, involving physicians sharing insights on prevalence rates, diagnostic approaches, medication preferences, and immunotherapy practices in AR management. A total of 1608 physicians participated in this survey. The majority of physicians (n=684, 42.5%) reported that the prevalence of AR in routine clinical practice is between 21 and 40%. Physicians also noted a substantial burden of AR with asthma (n=626, around 40%). Total IgE count was reported as a mandatory test for the diagnosis of AR by 47.5% of physicians (n=764). For the management of mild cases of seasonal or perennial AR, 980 (60.9%) physicians preferred fexofenadine as an oral antihistamine of choice. Fluticasone furoate was the preferred intranasal corticosteroid (INCS) option (67.1% of physicians (n=1079)), for the management of patients with moderate to severe AR, the most recommended duration of INCS therapy was two to fourmonths (40.9% of physicians). Doctors recommended a montelukast and antihistamine combination in mild AR (n=152, 9.5%), mild AR not responding to antihistamine alone (n=291, 18.1%), moderate to severe AR along with INCS (n=252, 15.7%), and AR with mild asthma (n=74, 4.6%). The majority of physicians (n=1512, 75.6%) preferred using fexofenadine in combination with montelukast for the management of AR. The majority of physicians (n=839, 52.2%) opined that the efficacy rate of oral montelukast-fexofenadine was 60-90% in the management of mild-moderate AR. Around 55.3% of physicians (n=889) had not used immunotherapy in their clinical practice. These observations offer a holistic view of how Indian physicians perceive the management of AR, a condition highly prevalent in India and often associated with asthma. It also highlights the treatment strategies employed in their day-to-day clinical practice.

Association between environmental mercury exposure and allergic disorders in Korean children: Korean National Environmental Health Survey (KoNEHS) cycles 3–4 (2015–2020)

Although previous studies have suggested potential adverse effects of mercury on a child’s immune system, the associations have been inconsistent. We aimed to determine the association between urinary mercury levels and allergic diseases in Korean children with high mercury exposure. Data from 853 and 710 children aged 6–11 years in the Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015–2017) and cycle 4 (2018–2020) were analyzed. We examined the association between mercury exposure and the prevalence of atopic dermatitis (AD), asthma, allergic rhinitis (AR), and allergic multimorbidity. After adjusting for all covariates, the urinary mercury level was positively associated with AD in the 2015–2017 study (OR = 1.34, 95% CI = 1.01, 1.79) and AR in 2018–2020 study (OR = 1.46, 95% CI = 1.01, 2.10). Pooled effects showed OR of 1.34 (95% CI = 1.01, 1.79) for AD and 1.47 (95% CI = 1.01, 2.12) for allergic multimorbidity. The association with allergic multimorbidity was greater in boys (OR = 1.88, 95% CI = 1.01, 3.49) than in girls (OR = 1.25, 95% CI = 0.73, 2.14). These results suggest that environmental mercury exposure may exacerbate symptoms of atopic dermatitis and allergic multimorbidity in children.

Probiotic Lactobacillus plantarum GUANKE effectively alleviates allergic rhinitis symptoms by modulating functions of various cytokines and chemokines.

Currently, the prevalence of allergic rhinitis (AR) remains high and there is a great need to develop better and safer ways to alleviate AR symptoms. The Lactobacillus plantarum GUANKE probiotic was reported as an immunomodulator through maintaining Th1/Th2 balance. This study aimed to determine the efficacy of GUANKE in AR subjects. Adults aged from 18 to 60 years old and previously suffered from AR were recruited and received GUANKE probiotics treatment for 4 weeks. The questionnaires of Total nasal symptom scores (TNSS), total non-nasal symptom score (TNNSS), and rhinitis control assessment test (RCAT) were used to assess the effectiveness before and after treatment. The serum allergen-specific IgE and cytokines were also determined at baseline and after 4 weeks of probiotics administration. The results showed that TNSS and TNNSS were significantly reduced and the RCAT score was significantly increased compared to baseline. The sub-symptom score of rhinorrhea, itching, sneezing, and tearing in each questionnaire also showed significant changes, and the serum IgE level was markedly decreased. We further measured inflammatory-related proteins in serum and found that a total of 20 proteins (6 upregulated and 14 downregulated) were significantly changed compared to baseline, including IL-4, IL-7, IL-20, IL-33, CXCL1, CXCL5, CXCL6, CXCL11, CCL4, CCL23, TGF-alpha, LAP-TGF-beta-1, MMP-1, MMP-10, AXIN1, NT-3, OSM, SCF, CD6, and NRTN. Enrichment analysis showed that these significantly altered proteins were mainly enriched in cytokine and chemokine-related signaling pathways. Taken together, this study demonstrated the Lactobacillus plantarum GUANKE can serve as an effective immunobiotic for the treatment of AR, which is realized through maintaining the Th1/Th2 balance by modulating the functions of various cytokines and chemokines.

Allergic rhinitis and other comorbidities associated with asthma control in Thailand.

Asthma and allergic rhinitis (AR) can coexist and cause disabilities. This study aimed to assess the association between AR, asthma control, asthma-related quality of life, and other comorbidities. A cross-sectional study was conducted in adults with asthma in six hospitals in Thailand. The outcomes were association of asthma control assessed by the asthma control test (ACT), AR, and asthma comorbidities. Not-well-controlled asthma was defined as ACT scores ≤22. The severity of AR was determined by visual analog scale (VAS). Severe AR was defined as VAS ≥5. Asthma-related quality of life (AQLQ), comorbidities, and total IgE were recorded. A total of 682 asthmatic patients were included. Median (IQR) age was 58.0 (47.0-64.0) years. 69.9% were female. Not-well-controlled asthma was present in 44.7%. The prevalence of AR was 86.1%. Moderate/severe persistent AR was diagnosed in 21.7% and severe AR was diagnosed in 30.2% of the patients. Inhaled corticosteroid-containing regimens were prescribed in 97.7% of patients. Intranasal corticosteroid and antihistamine were prescribed in 65.7 and 31.7%, respectively. Patients with not-well-controlled asthma had higher body mass index, VAS scores, proportions of pollution exposure, aeroallergen sensitization, severe AR, nasal polyp, urticaria, food allergy, gastroesophageal reflux disease, depression and anxiety, peptic ulcer, and asthma exacerbations, but younger age, lower AQLQ scores, and lower FEV1. Correlation was found between AR severity and ACT (r = -0.461, p < 0.001), AQLQ (r = -0.512, p < 0.001), and total IgE (r = 0.246, p < 0.023). Multiple regression analysis revealed that ACT, AQLQ, and percentage of FEV1/FVC were significantly associated with severe AR. Allergic rhinitis is prevalent in Thai asthmatic patients. AR severity is associated with asthma control, quality of life, and pulmonary function. Comprehensive care is essential for patients with uncontrolled asthma, particularly when coexisting with conditions.

Prevalence and Risk Factors of Allergic Rhinitis; A systematic Review

Allergic rhinitis (AR), an immunoglobulin E-induced nasal infection, significantly impacts nasal mucosa function and quality of life. Its incidence has risen globally, showing variations across income categories. This systematic study aimed to determine the prevalence and risk factors of AR. Data were sourced from PubMed/Medline, Scopus, and Embase, following PRISMA guidelines. English-language articles (2010–2023) discussing AR prevalence and risk factors were included. A total of 15 articles were reviewed, with surveys and national database analyses being predominant (n=15). The search initially yielded 95 studies, of which 15 met inclusion criteria. Enhanced knowledge of prevalence and risk factors is crucial for future treatment improvements. The prevalence of AR has surged, necessitating evidence-based assessments of risk factors. For adults, risk factors include smoking, asthma, family history of AR, drug and food allergies, pollen allergy history, antibiotic use, occupational dust exposure, home renovation, and middle school education. In children, passive smoking, asthma, family history of AR, allergies, eczema, pet ownership, seafood consumption, male gender, and breastfeeding were identified as risk factors. The study highlights AR prevalence\&amp;apos;s correlation with allergic diseases, familial allergy history, and environmental factors. Comprehending these associations is pivotal for enhancing adherence to preventive management plans.

The prevalence of allergic rhinitis and its association with sleep problems among high school students in Saudi Arabia: A cross sectional

Abstract Background: Allergic rhinitis (AR) is one of the most chronic pediatric diseases worldwide that negatively affects sleep quality. Objectives: to determine the prevalence of AR among high school students in Saudi Arabia and to evaluate the association of sleep problems in this demographic. Methods: This cross-sectional study was done in four regions of Saudi Arabia on high school students from grades 10 to 12 (15–18 years) of both genders. Data about the participants demographics were collected and the sleep quality was assessed by the global Pittsburgh Sleep Quality Index (PSQI). Results: the mean age of students was 17.6±1.4 years, 199 (51.2%) were females, 358 (92%) were single, 187 fathers (48.1%) worked in the governmental sector, 198 (50.9%) reported a family monthly income exceeding 10,000 SR, 33 (8.5%) were smokers, and 207 (53.2%) had a family history of chest and nose allergies or AR. The GPA was excellent for 305 (78.4%) students. The most reported nasal symptoms were sneezing 277 (71.2%), and 241 (68.9%) reported nasal symptoms more frequent during the winter. House dust aggravates nasal problems among (61%), 109 (28%) had allergic rhinitis and 151 (38.8%) were poor sleepers. Family history was significantly associated with having AR. A significant association was found between AR and poor sleep and students with AR were 22 times more likely to qualify as poor sleepers than those without (OR=22.2; 95% CI: 12.1–40.7). Conclusion: the results suggest developing strategies to enhance children&amp;apos;s sleep quality and treat AR is crucial to improving their health.

Prevalence of food allergy and other atopy among children with eosinophilic esophagitis in single center retrospective study, Riyadh, Saudi Arabia

Background: Eosinophilic esophagitis (EoE) is increasingly recognized as a significant public health issue in pediatric populations. The multifaceted mechanisms involving genetic, environmental, and immunological factors, particularly the role of allergens, are central to understanding EoE&amp;apos;s pathogenesis. This study aims to analyze the prevalence of food allergies and atopic diseases among children diagnosed with EoE, offering insights into their interrelations and informing improved management strategies. Methods: This retrospective study analyzed 47 pediatric patients diagnosed with EoE at the Allergy and Gastroenterology Clinic, Children&amp;apos;s Hospital, King Saud Medical City, Riyadh, from February 2012 to December 2018. Patients were selected based on documented food allergies, anaphylactic reactions, comorbid atopic conditions, positive radioallergosorbent test (RAST) results, and elevated eosinophilia. Data collection involved medical records and detailed family questionnaires. Immunological assays and endoscopic biopsies were used for diagnosis, with EoE defined as more than 15 eosinophils/high power field. Results: The study population predominantly comprised Saudi males, with a mean age of 8.36 years. A significant portion had consanguineous parents. Notable findings include a high prevalence of asthma (46.8%), allergic rhinitis (23.4%), and eczema (25.5%). The most common food allergens identified were peanuts, nuts, and seafood. Asthma severity varied, with ventolin and fluticasone being the most prescribed medications. Laboratory investigations showed elevated white blood cell, absolute neutrophil count, lymph, eosinophil sedimentation rat (ESO), eosinophil percentage, and immunoglobulin E (IgE) levels. RAST indicated specific allergen sensitivities in 34.0% of patients. Conclusion: This study provides essential insights into the demographic, clinical, and therapeutic aspects of pediatric EoE, emphasizing the importance of a comprehensive, personalized approach to management.

Allergen Sensitization and Its Association With Allergic Diseases in the Korean Population: Results From the 2019 Korea National Health and Nutrition Examination Survey.

Allergen exposure is the most potent factor in allergen sensitization, which affects the exacerbation and severity of allergic diseases. Due to industrialization and climate change, the pattern of allergen sensitization has changed over time, and the incidence of allergic diseases has also increased. This study investigated the status of allergen sensitization in the Korean population and its effects on allergic diseases. A total of 2,386 participants aged ≥ 10 years, who underwent 7 specific immunoglobulin E tests for aeroallergens (Dermatophagoides farinae [Der f], dog dander, cat epithelium, birch, oak, Japanese hop, and ragweed), were selected among the participants of the 2019 Korean National Health and Nutrition Examination Survey. We compared the demographic characteristics, combined allergic diseases, and sinusitis symptoms between the atopic and non-atopic groups. The prevalence of allergen sensitization in the general Korean population was 45%, and Der f was the most frequent cause of sensitization (39.9%). The prevalence of sensitization to indoor allergens was highest among teenagers and those belonging to the 20- to 29-year age group (P < 0.001). In contrast, there was a high prevalence of sensitization to outdoor allergens among individuals belonging to the age group of 60-69 years. The prevalence of atopic dermatitis (odds ratio [OR], 2.559; 95% confidence interval [CI], 1.689-3.878), allergic rhinitis (OR, 3.075; 95% CI, 2.426-3.897), and otitis media (OR, 1.481; 95% CI, 1.092-2.007) significantly increased by allergen sensitization. Patients with allergen sensitization were more likely to experience the symptoms of rhinitis and sinusitis. The study findings confirmed that allergen sensitization occurs in approximately half of the general Korean population and affects the prevalence and symptoms of allergic diseases. This suggests that active allergy tests and diagnosis of allergic diseases are necessary in Koreans.

Associations between traffic-related air pollution and allergic rhinitis outpatient visits in three cities of Gansu Province.

Emerging evidence indicates an increasing prevalence of allergic rhinitis (AR), potentially linked to air quality. The aim of the present study was to assess the relationship between traffic-related air pollutants (TRAPs) and outpatient visits for AR. Daily outpatient data for AR, air pollutant concentrations, and meteorological data were collected from January 2018 to December 2020 in Dingxi, Longnan, and Tianshui. Utilizing a Quasi-Poisson distribution, a generalized additive model (GAM) was employed in conjunction with distributed lag non-linear models (DLNM) to explore the association and lag effects of TRAPs on AR outpatient visits across the three cities. Stratified analyses based on gender, age, and season were conducted. A total of 11 106 outpatient visits for AR were recorded in the three cities. For an increase of 10 μg m-3 in PM2.5, the effect estimates in Dingxi, Longnan, and Tianshui reached their maximum at lag04, lag06, and lag07, respectively, with relative risk (RR) values of 4.696 (95% CI: 1.890, 11.614), 2.842 (95% CI: 2.102, 4.922), and 1.102 (95% CI: 1.066, 1.140). For NO2, the highest associations were exhibited in Dingxi (RR = 1.262, 95% CI: 1.081, 1.473) at lag07, in Longnan (RR = 2.554, 95% CI: 2.100, 4.805) at lag06, and in Tianshui (RR = 1.158, 95% CI: 1.106, 1.213) at lag07. Meanwhile, the strongest effects observed for a 1 mg m-3 increase in CO were 2.786 (95% CI: 1.467, 5.291) for Dingxi at lag07, 1.502 (95% CI: 1.096, 2.059) for Longnan at lag05, and 1.385 (95% CI: 1.137, 1.686) for Tianshui at lag04. Adults aged 15-64 years appeared to be more susceptible to TRAPs, and the associations were stronger in the cold season. The results of the present study indicate that exposure to TRAPs was positively correlated with outpatient visits for AR.

Prevalence of asthma and allergic rhinitis in children exposed to pets: a meta-analysis.

Pet exposure has always been controversial with childhood asthma and allergic rhinitis. We aimed to understand the prevalence of asthma and allergic rhinitis in children exposed to pets by meta-analysis. We searched articles published from Jan 1, 2012 to Dec 31, 2022 in the Embase, PubMed, Cochrane Library, and Web of Science databases. We included a cross-sectional study that reported the prevalence of asthma and allergic rhinitis in children exposed to pets. Furthermore, we performed subgroup analyses according to pet type and age. In 14 selected studies, the meta-analysis results showed that the pooled prevalence of asthma in children exposed to pets was 19.0% (95% CI 13.3-24.7%), and the pooled prevalence of allergic rhinitis in children exposed to pets was 25.5% (95% CI 12.4-38.5%). The prevalence of asthma in children exposed to cats and dogs was 16.4% (95% CI 9.9-22.8%) and 12.5% (95% CI 8.7-16.2%), respectively. The prevalence of allergic rhinitis was 24.9% (95% CI 2.9-47.0%) and 24.1% (95% CI 2.6-45.6%), respectively. The prevalence of asthma in pet-exposed children was 17.1% (95% CI 12.3-22.0%) in the adolescence group (> 10years) and 26.3% (95% CI 12.2-40.3%) in the childhood group (0-10years). The prevalence of allergic rhinitis was 8.6% (95% CI 7.2-10.0%) in the adolescence group and 46.3% (95% CI 44.0-48.6%) in the childhood age group. The prevalence of asthma and allergic rhinitis in children exposed to pets is different. Exposure to pet cats is more prone to illness, and younger children are more susceptible to disease than older children.

Prevalence and Socioeconomic Impact of Allergic Rhinitis Among Ear, Nose, and Throat Patients of a Tertiary Hospital.

The objectives of this study were to establish the demographic factors of allergic rhinitis patients taking part in the study, to gain insight into the common symptoms experienced by patients with allergic rhinitis, to know the common allergens or triggers that lead to the symptoms of allergic rhinitis and to determine the prevalence of other comorbidities associated with allergic rhinitis. The study was a cross-sectional hospital-based study encompassing both quantitative and qualitative features of the participants involved. The quantitative study involved collecting data on allergic rhinitis clients visiting our tertiary hospital, over the period of March 1, 2021, to June 25, 2021. The quantitative data included the gender and age groups commonly affected, the most common symptom, and the trigger identified. Whilst, the qualitative aspect of the study involved the socioeconomic impact of allergic rhinitis on the clients. The prevalence of allergic rhinitis is 10% at the ENT clinic of our hospital. It was most common in the age group (19-35). Urban residents suffered more from allergic rhinitis than the rural residents. The main presenting complaint was sneezing and the commonest comorbid condition and trigger associated with allergic rhinitis were sinusitis and dust mites respectively. Twenty-nine percent of respondents had experienced reduced productivity at their workplace and in school. Twenty-one percent had experienced depression while 26% perceived the cost of treatment to be greatly expensive. The use of face masks was found not to be beneficial in reducing the symptoms of allergic rhinitis in most clients. The conclusions reached at the end of this study were that the public must be educated on allergic rhinitis and to look out for the triggers, signs, and symptoms of it and then report early to the hospital for appropriate management.