Vocabulary is a very important element in learning the Kadazandusun language. If students does not have sufficient vocabulary, students will face difficulty in understanding the language either in written form or in communication during Kadazandusun language teaching and learning sessions, and difficulty in mastering other language skills too. In that regard, this study was conducted to identify the usage of interactive multimedia-based modules in teaching and learning to enhance student vocabulary, especially in the Kadazandusun language subject. This study is a quasi-experimental study. Quantitative approaches are used in conjunction with pre- and post-test instruments. A total of 40 Year Four students at a school in Tambunan District were the sample of this study, divided into controlled groups (20 people) and treatment groups (20 people). The results showed that there were significant differences in the improvement of vocabulary among the pupils under controlled group and treatment group before and after the teacher uses the interactive multimedia module with a mean pre-test mean score of 3.45 and a mean post-test mean 7.25 whereas for pre-test mean values of the treatment group. is 3.05 and the mean test value is 8.15. Implications of the study show that using interactive multimedia-based modules can be a platform for students to learn vocabulary and can help teachers in adding teaching aids for Kadazandusun language subjects. In conclusion, learning methods using interactive multimedia-based modules are effective in order to improve students’ vocabulary.