Antibodies to dopamine β-hydroxylase (anti-DβH) were taken up by noradrenergic nerve terminals in the iris following attachment to DβH, and were transported back to, and accumulated in, the superior cervical ganglion (SCG). Concurrent, or prior destruction of noradrenergic terminals with 6-hydroxydopamine, injected intraocularly, blocked the retrograde transport of anti-DβH. However, recovery was rapid, reaching 50% of control values within 1 day. Such transport was characterized by a shorter time period before accumulation could be detected in the SCG and by a slower rate of accumulation. These results suggest that noradrenergic neurons recover their ability to turn over synaptic vesicles by exocytosis and transport these back to the ganglion early during the period of axonal regeneration when the axonal length is shorter than normal. The uptake and transport of anti-DβH was regulated by α-adrenergic agents administered locally in the vicinity of noradrenergic nerve terminals. Thus intraocular injection of phentolamine resulted in an increased accumulation of anti-DβH in the SCG, while amphetamine and the postsynaptic α-receptor antagonist, phenylephrine, decreased accumulation. Clonidine and desipramine, which have a predominant presynaptic action, failed to influence the transport of anti-DβH. These results suggest that in vivo the uptake of anti-DβH can be increased more by local postsynaptic reflex actions than by a mechanism depending on the inhibition of presynaptic α-receptors.