The regulation of the noradrenergic neuron

Abstract

Publisher Summary This chapter discusses the regulation of the noradrenergic neuron. A number of regulatory processes exist that influence the biosynthesis of catecholamines in adrenergic neurons. The large number of events, occurring in a highly synchronized fashion, implies a wide variety of possible regulatory sites. Norepinephrine (NE) that is released into the synaptic cleft can act on presynaptic α-receptors to inhibit the release of additional NE. A further possible mechanism for regulating the release of NE from adrenergic nerves involves prostaglandins of the E type. These compounds are present in most mammalian tissues and an increased formation and release of prostaglandins has been observed in conjunction with increased nerve activity. Nerve growth factor is another substance that appears to be involved in regulating the synthesis of enzymes in adrenergic neurons. When it is administered to newborn rats, for example, it can cause a selective induction of TH and DBH. The increase in the activities of these enzymes is far greater than is that of other enzymes.