This work aims to is to study the flame propagation characteristics of the hydrogen/liquefied petroleum gas (LPG) premixed gas in a closed tube. With the aid of a self-developed square glass explosion tube and a high-speed camera, the characteristic parameters (i.e., flame structure, flame tip speed, maximum explosion overpressure, maximum rate of explosion pressure rise, deflagration index) were obtained and analyzed the explosion characteristics of the premixed gas. The results show that the time for the flame to reach the end of the pipe decreased, and the maximum explosion overpressure increases as the hydrogen addition ratio increases. However, the explosion overpressure and flame propagation velocity increased slowly when the hydrogen addition ratio was less than 40%, While the explosion overpressure and flame propagation velocity increased drastically in the range of hydrogen addition ratio 40–80%. Therefore, the key turning point for LPG hydrogenation is when the hydrogen volume fraction is 40%. The peak explosion flame propagation velocity and the peak explosion pressure showed the change law of increasing first and then decreasing with the equivalent ratio increasing. The Pmax and Vmax are 6.4 bar and 71.2 m/s respectively. The explosive flame structure of the premixed gas formed a "multiple tulip" structure after the typical tulip flame structure due to the influence of hydrodynamic. In addition, the propagation law of H2-LPG-Air premixed flame in the pipeline was influenced by the interaction of pressure wave and flame front velocity, and Pmax trajectory and Vmax curve showed similar oscillation law. Hence, the study provides crucial data for the prevention and control of H2-LPG-Air gas mixture combustion and explosion accidents.