Pressure Pulse Wave Research Articles

Extraction and Comparison of Features by Simultaneous Measurement of Blood Pressure Pulse Wave and Electrocardiogram

Extraction and Comparison of Features by Simultaneous Measurement of Blood Pressure Pulse Wave and Electrocardiogram

995: Maternal central blood pressure is associated with middle cerebral artery dopplers

Our objective was to create maternal cardiac profiles of pregnant women using non-invasive measurements of central BP to identify changes in maternal hemodynamics and the effect on the fetus. This was a prospective cohort study of all pregnancies followed in a single perinatal referral center. Antenatal data was collected for analysis. Central BP was measured non-invasively using the Uscom BP+ device, a supra-systolic oscillometric central BP (cBP) device, which measures BP waveforms peripherally in the arm. The BP+ device calculates central BP and pulse pressure waves using a physics-based model of the arteries between the aorta and the cuff. The Student’s t-test was used to compare categorical means and Spearman rank correlation was used to evaluate correlations between continuous variables. 279 women were recruited for the study. The Uscom BP+ device information was categorized by patient and gestational age (GA) based on ultrasound at the time of the visit. Mean maternal age was 32.4 years (19-54). For first trimester (n=121), the mean central systolic BP was 103.1 mmHg (standard deviation 12.4), the mean central diastolic BP was 67.3 mmHg (10.1), and the mean pulse was 81 bpm (11). For second trimester (n=132), the mean central systolic BP was 100.5 mmHg (12.0), the mean central diastolic BP was 66.7 mmHg (10.8), and the mean pulse was 83 bpm (13). For third trimester (n=39), the mean central systolic BP was 105.8 mmHg (13.1), the mean central diastolic BP was 72.8 mmHg (11.7), and the mean pulse was 91 bpm (9). Both central systolic and diastolic BP were correlated to peripheral systolic and diastolic BP (p<0.01). Central BP was not found to be directly correlated to the estimated fetal weight (EFW) (n=167) (p>0.42). Central BP was negatively correlated to the pulsatility index (PI) for the middle cerebral artery (MCA) (n=19) (p<0.05). Additionally, the MCA PI was found to be positively correlated to the EFW (p<0.05). Non-invasive measurement of maternal central BP likely provides a more accurate indicator of utero- placental perfusion pressure and downstream vascular resistance. We demonstrate that maternal central BP correlates to the MCA PI and, vis-à-vis, EFW.

Cuffless Blood Pressure Estimation Using Pressure Pulse Wave Signals.

Pulse transit time (PTT) has received considerable attention for noninvasive cuffless blood pressure measurement. However, this approach is inconvenient to deploy in wearable devices because two sensors are required for collecting two-channel physiological signals, such as electrocardiogram and pulse wave signals. In this study, we investigated the pressure pulse wave (PPW) signals collected from one piezoelectric-induced sensor located at a single site for cuffless blood pressure estimation. Twenty-one features were extracted from PPW that collected from the radial artery, and then a linear regression method was used to develop blood pressure estimation models by using the extracted PPW features. Sixty-five middle-aged and elderly participants were recruited to evaluate the performance of the constructed blood pressure estimation models, with oscillometric technique-based blood pressure as a reference. The experimental results indicated that the mean ± standard deviation errors for the estimated systolic blood pressure and diastolic blood pressure were 0.70 ± 7.78 mmHg and 0.83 ± 5.45 mmHg, which achieved a decrease of 1.33 ± 0.37 mmHg in systolic blood pressure and 1.14 ± 0.20 mmHg in diastolic blood pressure, compared with the conventional PTT-based method. The proposed model also demonstrated a high level of robustness in a maximum 60-day follow-up study. These results indicated that PPW obtained from the piezoelectric sensor has great feasibility for cuffless blood pressure estimation, and could serve as a promising method in home healthcare settings.

Using Smart Wearables to Monitor Cardiac Ejection †.

An individual’s cardiovascular state is a crucial aspect of a healthy life. However, it is not routinely assessed outside the clinical setting. Smart wearables use photoplethysmography (PPG) to monitor the arterial pulse wave (PW) and estimate heart rate. The PPG PW is strongly influenced by the ejection of blood from the heart, providing an opportunity to monitor cardiac parameters using smart wearables. The aim of this study was to investigate the feasibility of monitoring left ventricular ejection time (LVET) and left ventricular contractility (LVC) from the PPG PW at the wrist. PPG PWs were simulated under a range of cardiovascular conditions using a numerical model of PW propagation. LVET and LVC were estimated from the first and second derivatives of the PPG PWs and compared to reference values extracted from the blood pressure PW at the aortic root. There was strong agreement between the estimated and reference values of LVET, indicating that it may be feasible to assess LVET from PPG signals, including those acquired by smart watches. The correlations between the estimated and reference values of LVC were less strong, indicating that further work is required to assess contractility robustly using smart wearables. This study demonstrated the feasibility of assessing LVET using smart wearables that could allow individuals to monitor their cardiovascular state on a daily basis.

Arterial stiffness, ambulatory blood pressure monitoring and their association with cardiovascular risk in patients with chronic kidney disease and arterial hypertension.

The aim – to investigate arterial stiffness, daily profile of blood pressure (BP) and their association with cardiovascular risk (CVR) in patients with chronic kidney disease (CKD) and arterial hypertension (AH). 20 patients with CKD (stage 1-2) and AH (stage 1-2) were enrolled in the study (7 males and 13 females, mean age – 55±8,4 years. Depending on CVR risk patients were distributed into three groups: low (&lt;1%), moderate (1-10%) and high risk (≥10%). The highest proportion – patients with moderate risk (50%). Statistically significant association between age and CVR was discovered. Arterial stiffness (measured by pulse pressure and pulse wave velocity) raised with increase of CVR risk. The best values of endothelial function were observed in the group of high risk patients. More than half of patients had non-dipping daily blood pressure profile. Patients in group of high risk presented the highest mean sysolic BP and morning elevation BP.

A2063 Effect of the rosuvastatin on pulse pressure and arterial stiffness in aged patients with isolated systolic hypertension without hyperlipidemia

Objectives: To observe the effect of rosuvastatin on pulse pressure (PP) and brachial-ankle pulse wave velocity (baPWV)of aged patients with isolated systolic hypertension (ISH) without hyperlipidemia. Methods: A total of 102 aged ISH patients without hyperlipidemia were randomly divided into therapeutic group (62 cases, treated with rosuvastatin)and the control group (60 cases, treated with Placebo). The SBP, DBP, PP and baPWV were recorded. Results: 2 months after therapy, the effects were no significant differences between the two groups. Until the 4th month, compared with the control group, SBP, PP and baPWV of the therapeutic group decreased significantly (P < 0.05).6 months after therapy, the difference of SBP, PP and baPWV between the two groups was more significant (P < 0.01). Conclusion: Rosuvastatin may reduce the PP and PWV of aged ISH patient. Rosuvastatin is speculated beneficial to decrease arterial stiffness.

A16547 The Association of Central Aortic Stiffness with Left Atrial Phasic Function in Patients with Hypertension

Objectives: We aimed to explore the relationship between central aortic stiffness and LA phasic function in hypertensive (HTN) patients. Methods: 2D-speckle-tracking strain echocardiography was performed on 218 HTN (110 male, 55 ± 14 years) with preserved LV ejection fraction (EF > 50%). Phasic LA function (reservoir, conduit, contractile) was analyzed. Global longitudinal LA strain (LA LS) was measured as an average value from apical 4C and 2C views. Central hemodynamics including central pulse pressure (PP), PP amplification, augmentation index ([email protected]) and pulse wave velocity (PWV) were measured, Results: Central hemodynamic parameters showed significant correlations with global LALS ([email protected]: r = − 0.18, p = 0.03; PWV: r = − 0.25, p < 0.01) and passive LA EF, reflecting LA conduit function (AIx @75: r = − 0.29, p < 0.01: central PP: r = − 0.19, p = 0.02: PP amplification: r = 0.27, p < 0.01), while no significant correlation between peripheral PP and LA functional parameters was noted. Correlations between LA conduit function and central hemodynamic parameters were more prominent in patients without LVH than those with LVH (Figure). Multiple regression analysis showed independent correlations between LA conduit function and [email protected] 75 (p = 0.04). Conclusion: The central hemodynamic showed better correlations with LA functional parameters than peripheral hemodynamic parameters. Central aortic stiffness in patients with hypertension may contribute to impairment of LA conduit function before LV remodeling occurs

A6509 The Obesity Paradox

Objectives: A clue to the “Obesity Paradox” is that patients at the upper extreme of body mass and blood pressure often have youthful arterial pressure waveforms that show optimally-timed wave reflection in the proximal aorta and left ventricle. Central obesity may compress the aorta and conduit arteries in the abdomen, thus decreasing aortic stiffness and delaying return of wave reflection to the heart. Methods: Central aortic pressure waves and indices of wave reflection on the aortic pressure wave were generated from radial tonometry and calibrated to brachial cuff pressures (SphygmoCor, AtCor Medical, Sydney, Australia). Data recorded from 101 patients attending a cardiovascular outpatient clinic at Ruijin Hospital North, Shanghai (table). Subjects were divided into 3 groups according to their Body Mass Index (BMI < = 24 normal, 24–28 overweight, > = 28 obese; for Chinese population). Results: Brachial and aortic pressure values including Systolic (SP), Diastolic (DP), Pulse Pressure (PP), and carotid-femoral pulse wave velocity did not differ significantly between normal and overweight/obese group. Aortic SP and aortic PP were lower for the overweight/obese group than normal, while aortic DP was higher. Despite no difference in standard pressure measurement, there were significant changes (p < 0.05) in indices of aortic pressure wave reflection between normal and overweight/obese groups. Augmented Pressure, Augmentation Index, and pressure amplification (calculated as aortic SP ÷ brachial SP) decreased progressively as BMI increased. Conclusion: The Obesity Paradox, presently unexplained, is likely due to reduced central pressure wave reflection in overweight and obese persons. This study is continuing; the results may explain the obesity paradox in terms of arterial wave travel and reflection.

A15194 INVOLVEMENT OF ENDOTHELIN AND ANGIOTENSIN II IN CHRONIC KIDNEY DISEASE-RELATED ARTERIAL STIFFNESS

Objectives: Increased risk of cardiovascular disease in patients with chronic kidney disease (CKD) has been related to vascular stiffness and isolated systolic hypertension. Using a rat model of CKD with mineral imbalance, we reported that endothelin (ET)A receptor blockade reduced vascular stiffness and hypertension revealing a role for endothelin. This study was designed to investigate whether the protective effect of ETA receptor blockade on vascular stiffness is independent of blood pressure reduction. Methods: CKD was induced in Wistar rats by renal mass ablation and mineral imbalance by a calcium/phosphate-rich diet and vitamin D supplementation (Ca/P/VitD) which increased vascular stiffness. CKD rats given Ca/P/VitD were treated either with the ETA receptor antagonist atrasentan (10 mg/kg/d), the angiotensin AT1 receptor antagonist losartan (25 mg/kg/d) or the combination of hydrochlorothiazide/hydralazine (Hy/Hy; 100 mg/L and 25 mg/L, respectively) for 5 weeks. Hemodynamic parameters were determined by vessels catheterisation in anesthetised animals. Results: Systolic blood pressure and carotid-femoral pulse wave velocity were higher in CKD+Ca/P/VitD rats as compared to CKD control (p < 0.05). Treatment of CKD+Ca/P/VitD rats with atrasentan, losartan and Hy/Hy reduced mean, diastolic and systolic blood pressure (p < 0.05). However, treatment with atrasentan and losartan, but not Hy/Hy, reduced carotid-femoral pulse wave velocity (p < 0.05). Conclusion: The protective effect of ETA and AT1 receptor blockade on vascular stiffness is independent of the blood pressure lowering effect in CKD rats with mineral imbalance. This study reveals a role for both endothéline and angiotensin II in CKD-related vascular stiffness.

Prescribing high-intensity interval exercise by RPE in individuals with type 2 diabetes: metabolic and hemodynamic responses

We tested the hypothesis that rating of perceived exertion (RPE) is a tool as efficient as the heart rate (HR) response to the cardiopulmonary exercise test (CPX) for prescribing and self-regulating high-intensity interval exercise (HIIE), and that metabolic and hemodynamic response to HIIE is superior than to continuous moderate-intensity exercise (MICE) in individuals with type 2 diabetes mellitus (T2DM). Eleven participants (age = 52.3 ± 3 years) underwent HIIE prescribed and self-regulated by RPE (HIIERPE; 25 min), HIIE prescribed and regulated by an individual's HR response to CPX (HIIEHR; 25 min), MICE prescribed and self-regulated by RPE (30 min) and control (30 min of seated resting) intervention in random order. HR, blood pressure (BP), capillary glucose, endothelial reactivity, and carotid-femoral pulse wave velocity were assessed before, immediately after, and 45 min after each intervention. Exercise HR, speed, and distance were measured during exercise sessions. Twenty-four-hour ambulatory BP was measured after each intervention. Exercise HR, speed, and distance were similar between HIIERPE and HIIEHR. BP response was not different among HIIERPE, HIIEHR, and MICE. Capillary glycaemia reduction was greater (P < 0.05) after HIIERPE (48.6 ± 9.6 mg/dL) and HIIEHR (47.2 ± 9.5 mg/dL) than MICE (29.5 ± 11.5 mg/dL). Reduction (P < 0.05) in 24-h (6.7 ± 2.2 mm Hg) and tendency toward reduction (P = 0.06) in daytime systolic (7.0 ± 2.5 mm Hg) ambulatory BP were found only after HIIERPE. These results suggest that HIIE is superior to MICE for reducing glycaemia and ambulatory BP, and that the 6-20 RPE scale is a useful tool for prescribing and self-regulating HIIE in individuals with T2DM.

Patient-specific pulse wave propagation model identifies cardiovascular risk characteristics in hemodialysis patients.

Risk of cardiovascular associated death in dialysis patients is the highest among all other co-morbidities. Improving the identification of patients with the highest cardiovascular risk to design an adequate treatment is, therefore, of utmost importance. There are several non-invasive cardiovascular state biomarkers based on the pulse (pressure) wave propagation properties, but their major determinants are not fully understood. In the current study we aimed to provide a framework to precisely dissect the information available in non-invasively recorded pulse wave in hemodialysis patients. Radial pressure wave profiles were recorded before, during and after two independent hemodialysis sessions in 35 anuric prevalent hemodialysis patients and once in a group of 32 healthy volunteers. Each recording was used to estimate six subject-specific parameters of pulse wave propagation model. Pressure profiles were also analyzed using SphygmoCor software (AtCor Medical, Australia) to derive values of already established biomarkers, i.e. augmentation index and sub-endocardial viability ratio (SEVR). Data preprocessing using propensity score matching allowed to compare hemodialysis and healthy groups. Augmentation index remained on average stable at 142 ± 28% during dialysis and had similar values in both considered groups. SEVR, whose pre-dialytic value was on average lower by 12% compared to healthy participants, was improved by hemodialysis, with post-dialytic values indistinguishable from those in healthy population (p-value > 0.2). The model, however, identified that the patients on hemodialysis had significantly increased stiffness of both large and small arteries compared to healthy counterparts (> 60% before dialysis with p-value < 0.05 or borderline) and that it was only transiently decreased during hemodialysis session. Additionally, correlation-based clustering revealed that augmentation index reflects the shape of heart ejection profile and SEVR is associated with stiffness of larger arteries. Patient-specific pulse wave propagation modeling coupled with radial pressure profile recording correctly identified increased arterial stiffness in hemodialysis patients, while regular pulse wave analysis based biomarkers failed to show significant differences. Further model testing in larger populations and investigating other biomarkers are needed to confirm these findings.

The use of time-domain analysis on the choice of measurement location for pulse diagnosis research: A pilot study

BackgroundPulse diagnosis researches acquiring pulse waves from the wrist radial artery has not yet addressed the issue of whether this information is affected by differences in the hemodynamic characteristics of pressure waves derived from different locations. This study aimed to clarify whether the blood dynamic states are identical with regard to the “three positions and nine indicators” (三部九候) listed in traditional Chinese medicine (TCM). MethodsA total of 37 participants of CAD group and 20 participants of healthy group were recruited, and pressure pulse waves were measured at 18 locations on both hands. A multivariate analysis (MANOVA) was performed with a “randomized block design” using SPSS 22.0 and R 3.4.1 to examine the time-domain parameters that represented certain hemodynamic characteristics. ResultsIn CAD group, the results showed significant differences (p < 0.05) among the h1, h2, h3, h1/t, and h3/h1 measurements of the pulse waves using different indicators at the same position; the h1, h2, h3, and h1/t measurements of the pulse waves at different positions using the indicator “Superficial”; and the h1, h2, h3, h1/t, and h3/h1 measurements of the pulse waves at different positions using the indicator “Medium”. In healthy group, the results showed significant differences (p < 0.05) among the h1, h2, h3, and h1/t measurements of the pulse waves using different indicators at the same position; the h1, h2, and h1/t measurements of the pulse waves at different positions using the same indicator. ConclusionBecause of the differences in the hemodynamic characteristics among the different positions and indicators, the article might provide a new opinion for future pulse diagnosis investigations to carefully consider the measurement location to ensure the completeness of the information.

Abstract P106: Association Of Pulse Wave Velocity With Hypertension And Anthropometric Measurements In 6-8 Years Old Children In Mthatha, South Africa

Hypertension is becoming a major health problem in children worldwide. There is evidence suggesting a complex association between hypertension, endothelial function and other cardiovascular disease risk factors in the adult population. Very few studies have investigated the relationship between hypertension and endothelial function in sub-Saharan children. The aim of this study was to explore the relationship between blood pressure parameters and pulse wave velocity (PWV) in 6-8 years old children in the Eastern Cape of South Africa. A cross-sectional study of 202 children (103 girls and 99 boys) aged 6-8 years old was conducted between March and November 2017. General anthropometric measurements were measured and blood pressure measurements were recorded. Blood pressure measurements were converted to blood pressure percentiles for height, age and sex. Flow mediated slowing was used to measure endothelial function. The prevalence of hypertension and prehypertension was higher in girls compared to boys (7.9% and 28.7% vs 7.1% and 20.2% respectively). Systolic and diastolic pressure (SBP, DBP) and pulse pressures were similar in boys and girls. No sex related difference in PWV was noted thought the strength of correlation was different. PWV correlated modestly with age, SBP, DBP and mean arterial BP in females (r= 0.24, 0.30, 0.40, 0.49 p&lt;0.05) and in males (r= 0.38, 0.36, 0.34, 0.39; p&lt;0.05). Blood pressure and PWV correlated modestly with anthropometric measurements in females but not in males. This study in a sub-Saharan African population of 6-8 year old children showed that even though there was no sex difference in blood pressure, the prevalence of hypertension and pre-hypertension were different. PWV correlated differently with blood pressure parameters and anthropometric measurements in males and females.

A study of bubble collapse pressure pulse waves from small scale underwater explosions near the water surface

Explosive detonators have been used to study the effect of proximity of the water surface on the pressure wave generated by the collapse of an underwater explosive bubble. Transducers at four different depths recorded the pressure pulse, and a low resolution high speed video camera was used to observe the overall dynamics of the bubble. The detonators were fired at selected depths (z) within the range of 6.0–161.3 cm, corresponding to dimensionless depth (γ) values of approximately 0.3–9.0 where γ = z/Rmax, and Rmax is the maximum radius of the bubble during its first pulsation. Analysis of the recorded pressure waves was complicated by the superposition of the emitted wave with its reflection from the water surface. Despite this difficulty there was clear evidence of a dependency of the peak pressure (Pmax) and impulse (I) of the emitted wave on γ. The pressure pulse generated by the deeper events (γ > 3.4) did not appear to be strongly influenced by the water surface, exhibiting only a weak dependence on γ. However, Pmax and I decreased markedly for shallower detonations in the range γ ≈ 1.6–2.8. Imaging results showed that this decrease was associated with migration of the bubble away from the surface during its collapse. A markedly different behaviour was observed when γ was decreased further to 1.1. It was found that although the bubble was still repelled from the surface and I continued to decrease, Pmax increased dramatically. Details of the pulse and imaging results suggested a more complex bubble collapse behaviour at this depth. For shallower values of γ (<0.6) the bubble did not collapse and appeared to breach the water surface and ingest additional gas from the atmosphere.

Study on mechanism of layered water injection by pressure pulse control

In this paper, the simulation analysis of layered waterflood is performed by software and the basic theory is used to verify the analysis. The simulation result data is analyzed and a reasonable control scheme is developed. According to the law of signal transmission and pressure pulse wave generation and change, it is coded so that the pulse signal is decoded by the pressure sensor as an instruction command that can be executed, and the water nozzle is changed by controlling each adjustable nozzle to execute the corresponding instruction. Opening size, and then achieve stratified water distribution.

Pressure Wave Velocity in Fluid-Filled Pipes with and without Deposits in the Low-Frequency Range

Solid pipeline deposits can be mapped by analyzing reflections of hydraulic pressure pulse waves in the low-frequency range. To determine the amount and position of the deposits, an inverse problem is solved: the pressure pulse is measured in one or several positions, and the pipeline that generated this pulse must be determined. To solve this problem, estimates of the pressure pulse velocity are essential. This study implements a finite-element axisymmetric model for fluid-filled pipelines and applies it to numerically study low-frequency estimates of the pressure wave velocity in pipes with deposits that appear frequently in pipelines of the petroleum industry. Finite-element simulations include deposit thicknesses in the range up to and covering 90% of the internal diameter of the pipe. The results show how deposits with different stiffness affect the pressure wave velocity. Inputs to the model are the geometry and parameters (thickness, Young’s modulus, and Poisson’s ratio) of the pipe and the deposits.

Association between diet and measures of arterial stiffness in type 1 diabetes – Focus on dietary patterns and macronutrient substitutions

Background and aimsIncreased arterial stiffness contributes to diabetic vascular complications. We identified dietary factors related to arterial stiffness in individuals with type 1 diabetes, a population with high risk of cardiovascular disease. Methods and resultsAltogether, 612 participants (40% men, mean ± standard deviation age 45 ± 13 years) completed a validated diet questionnaire and underwent measurements of arterial stiffness. Of these, 470 additionally completed a food record. Exploratory factor analysis was applied to identify dietary patterns from the diet questionnaires, and nutrient intakes were calculated from food record entries. Arterial stiffness was measured by applanation tonometry. Of the seven dietary factors formed, the factor scores of “Full-fat cheese and eggs” and “Sweet” patterns were negatively associated with measures of arterial stiffness. In the multivariable macronutrient substitution models, favouring carbohydrates over fats was associated with higher aortic mean arterial pressure and aortic pulse wave velocity. When carbohydrates were consumed in place of proteins, higher aortic pulse pressure, aortic mean arterial pressure, and augmentation index were recorded. Replacing energy from alcohol with proteins, was associated with lower aortic pulse pressure, aortic mean arterial pressure, and augmentation index. Relative distributions of dietary fatty acids were neutral with respect to the measures of arterial stiffness. ConclusionThe macronutrient distribution of the diet is likely to affect the resilience of the arteries. Our observations suggest that reducing energy intake from carbohydrates and alcohol may be beneficial. These observations, especially those dealing with dietary patterns, need to be confirmed in a longitudinal study.

Unconstrained Monitoring of Biological Signals Using an Aortic Pulse Wave Sensor.

This paper proposes a system to extract biological signals from aortic pulse waves which are measured by a microphone type pulse wave sensor. Theproposed system enables extraction of three biological signals corresponding to respiratory rate, pulse pressure wave, and RR interval simply by sitting on the seat on which the sensor is laid. Experiment results demonstrated that the mean absolute errors between the signals measured by the proposed system and the conventional sensors are as low as 0.38 times per minute for the respiratory rate, 11.2 mmHg for the pulse pressure wave, and 16.6 ms for the RR interval. The proposed system thus may be applied to monitor the physiological state of a human subject to prevent accident caused by health condition.

The Calibration Method for Blood Pressure Pulse Wave Measurement Based on Arterial Tonometry Method.

In this study, we report a method to accurately calibrate the forces measured by a wearable device for measuring blood pressure pulse waves by the arterial tonometry method to obtain blood pressure measurements. A device based on the arterial tonometry method and a commercially available manometer was used for this research. The force and the blood pressure were simultaneously measured at three measurement heights using the arterial tonometry device and the manometer. The proposed calibration was found to reduce the influence of the inclination of the lower arm. As a result, the average coefficient of determination of the regression equations between the force and the blood pressure was 0.96. Thus, it was concluded that the proposed method can be used to accurately calibrate the measured forces to obtain blood pressure measurements with a high coefficient of determination.

Reliability analysis of an integrated device of ECG, PPG and pressure pulse wave for cardiovascular disease

Cardiovascular diseases (CVD) are the leading cause of death globally and the mortality has been increasing in recent two decades. Most of cardiovascular diseases are preventable by early and long-term monitoring. The common option of physical examinations for CVD includes ECG, photoplethysmography (PPG), pressure pulse wave (PPW). An integrated device was designed and developed by gathering three physiological signals of ECG, PPG, and PPW synchronusly in this research. The tri-modal device was tested for reliability and stability on the synchronism of R-R intervals, distribution of peaks, and noise suppression. The experiment results displayed that the white noise and dark noise was well controlled. In the test of synchronism, PPG and PPW of the P-P intervals show a good linearity in correspondence with the ECG of R-R intervals in cardiac cycle. There is no significant difference in peak distribution of three modal signals from 4 volunteers. Thus, the equipment has excellent properties of anti-electromagnetic interference, removing movement artifacts and light tightness and may be developed to a promising tool for multi-modal diagnosis in CVD.