Pressure Modulation Research Articles

NIMG-64. SURVIVAL IMPLICATIONS OF POSTOPERATIVE RESTRICTED DIFFUSION IN HIGH-GRADE GLIOMA AND LIMITATIONS OF INTRAOPERATIVE MRI DETECTION

Abstract AIMS In glioma surgery, surgically induced cerebral ischemia may poorly affect overall survival. While intraoperative MRI (iMRI) is an established tool used to maximize extent of resection, its ability to detect cerebral ischemia during surgery has not been studied. Here we evaluate both the association of post-surgical cerebral ischemia on survival independent of new functional deficits and the sensitivity of iMRI in detecting cerebral ischemia. METHODS We retrospectively reviewed 361 cranial surgeries that used a 3 Tesla iMRI. 165 patients met all inclusion criteria and were included in the final analysis. Diffusion weighted imaging (DWI) obtained during iMRI was compared to postoperative DWI obtained within 7 days of the operation in cases where no further resection occurred after the iMRI. RESULTS 42 of 165 patients (25%) showed evidence of restricted diffusion on postoperative (poMRI); 37 of these 42 (88%) lacked evidence of restricted diffusion on iMRI (false-negative rate of 88%, sensitivity of 12%). In high-grade gliomas, poMRI restricted diffusion volume was predictive of overall survival independent of new functional deficit (p = 0.011). CONCLUSION Here we present the largest case series to date analyzing the sensitivity of iMRI in detecting ischemia. In high-grade gliomas, increased volume of ischemia correlated with worsening median overall survival (OS) irrespective of postoperative neurologic deficits. Future work will focus on improving intraoperative detection of ischemia during the hyperacute phase when interventions such as blood pressure modulation or direct application of vasodilator agents may be effective.

Calcitriol prevents SARS-CoV spike-induced inflammation in human trophoblasts through downregulating ACE2 and TMPRSS2 expression

SARS-CoV-2, the causative virus of COVID-19, increases the risk of pregnancy complications including hypertensive disorders and placental inflammation. The spike glycoprotein mediates viral cell entry by interacting with the angiotensin-converting enzyme (ACE)2 in conjunction with the transmembrane serine protease 2 (TMPRSS2). ACE1, ACE2 and renin are components of the renin-angiotensin system (RAS), which regulates blood pressure. As the placenta expresses all these proteins, it is a target for SARS-CoV-2 and a source of blood pressure modulators. Noteworthy, an ACE1/ACE2 ratio imbalance can lead to RAS dysregulation and a bad prognosis in COVID-19 patients. Calcitriol, the most active vitamin D metabolite, negatively regulates RAS, reduces inflammation, and enhances antiviral immunity, thereby protecting against COVID-19 severity. However, contrasting information exists on the regulatory role of calcitriol upon RAS components and SARS-CoV-2 receptors; while the impact of calcitriol on spike-induced inflammation in placental cells has not been explored. Thus, we studied the effects of calcitriol on these parameters using the trophoblast cell line HTR-8/SVneo and primary syncytiotrophoblasts. By RT-qPCR, ELISA, and immunocytochemistry, we found that the spike enhanced proinflammatory cytokines expression and secretion, while calcitriol significantly downregulated this effect. Calcitriol also diminished ACE1, ACE2, TMPRSS2, and renin gene expression, as well as ACE1/ACE2 mRNA ratio. ConclusionsIn the human placenta, calcitriol reduced the gene expression of main RAS components and TMPRSS2, resulting in the inhibition of spike-induced inflammation. This outcome suggest that vitamin D participates in restricting SARS-CoV-2 placental infection by rendering trophoblasts less permissive to infection while helping to regulate maternal blood pressure and decreasing inflammation.

Modification of Additional Check Valves and Tube Pressure to Enhance Hydram Pump Capacity and Performance for Agricultural Applications

Pump that operates automatically by relying on natural power from water without using great cost and trouble by pumping hydram. Hydram pumps are one of the types of pumps that are driven by kinetic power, it was discovered by a 1796 Montgolfier in Italy. The purpose is to determine the most optimal water speed of the hydram pump by using different numbers of pressure tubes and several check valves. This research uses a factorial Randomised Group Design (RGD) method. The first treatment is valve variation and the second is variation in the number of tubes. The results showed that the average river water flow velocity was 0.154 meters/second with an average water discharge of 2.61 m3/second under normal flow conditions. The average water flow in the intake pipe is 0.717 meters / second and the volume of water in the pipe is 15.19 liters with an average water discharge entering the intake pipe is 10.804 m3 / second. A combination of three valves and three tube treatments consistently produces greater water discharge than other combinations. The highest efficiency of the hydram pump is found in the combination of three checks.

Modulation of blood pressure by dietary potassium and sodium: Sex differences and modeling analysis.

High Na+ intake has been linked to elevations in blood pressure, whereas K+ has the opposite effect. The underlying mechanisms involve complex interactions among renal function, fluid volume, fluid-regulatory hormones, the vasculature, cardiac function, and the autonomic nervous system. These mechanisms are likely moderated by sex, given the known sex differences in blood pressure regulation and the higher prevalence of hypertension in men. The source of these observed sex differences may be traced to organ and tissue levels, given that kidney function, intrarenal renin-angiotensin system components, renal sympathetic nervous activity, and nitric oxide bioavailability all exhibit sex differences. To assess the functional impact of each of these sex differences, we developed sex-specific computational models to simulate whole-body Na+, K+, and fluid homeostasis, and the effects on blood pressure. The models describe the interactions among the renal system, cardiovascular system, gastrointestinal system, renal sympathetic nervous system, and renin-angiotensin-aldosterone system. Model simulations suggest that women's attenuated blood pressure response to hypertensive stimuli, including high Na+ intake, may be largely attributable to the female renal transporter abundance pattern. Additionally, we investigated the causal link between high K+ intake and blood pressure reduction. The models simulate renal response to high K+ intake, including the immediate gastrointestinal feedforward signals to the kidneys to increase K+ excretion, and the longer-term response to decrease proximal fractional Na+ reabsorption and distal K+ reabsorption. With these assumptions, simulations of high K+ intake yielded kaliuresis, natriuresis, and a substantial reduction in blood pressure, even when combined with high Na+ intake.

Enhanced Study of CO2 Hydrate Formation in Marine Oil–Gas Based on Additive Effect

During marine oil–gas extraction, significant amounts of carbon dioxide (CO2) gas are often produced. Effectively separating these associated CO2 gases during extraction has become a critical technical challenge. Therefore, this paper aims to enhance the efficiency of CO2 hydrate-based capture technology and conduct relevant research. The goal is to increase the driving force for hydrate formation by combining the traditional thermodynamic additive TBAB with pressure modulation and to improve the hydrate formation rate through the use of multiple kinetic promoters. This paper presents the initial investigation into the effect of the thermodynamic accelerator tetrabutylammonium bromide (TBAB) on the characteristics of CO2 hydrate formation. The promotion effects of TBAB solutions with varying mass concentrations (3%, 5%, 7.5%, 10%) and reaction pressures (3 MPa, 4 MPa) were subjected to a systematic analysis, and the optimal conditions were identified as 4 MPa and a 5 wt% TBAB concentration. Subsequently, the impact of combining TBAB with kinetic promoters (SDS, nano Al2O3, L-methionine, L-leucine) on CO2 hydrate generation characteristics was further investigated. In this paper, the effect of a single promoter on the generation characteristics of CO2 hydrate was investigated, and the efficient carbon trapping ability of the complex promoter was verified, which provides theoretical support for the application of CO2 trapping technology using the hydrate method.

Modulation of Blood Pressure through Microbiome Exchange between Milan Normotensive and Hypertensive Rat Strains

Modulation of Blood Pressure through Microbiome Exchange between Milan Normotensive and Hypertensive Rat Strains

Characteristic analysis and diagnosis method optimization of scroll compressor pressure pulsation signal under voltage fluctuation

Under off-design conditions, scroll compressors can lead to reduced efficiency, motor damage, and even cause safety problems such as leaks or explosions. To solve the above problems, this paper analyzes the influence mechanism of different voltages on the spectrum of pressure pulsation signal and modulation signal and provides theoretical support for fault diagnosis and enhances the interpretability of the model. A voltage fault diagnosis method of scroll compressor based on Time-frequency Principal component Convolutional Network (TPCN) model is proposed. By demodulation analysis of the pressure pulsation signal of the low-pressure inlet and high-pressure outlet of the refrigerant in the scroll compressor, the spectrum information of the principal component modulation signal under different voltages is obtained. The pooling strategy is used to accurately identify and extract the fault information in the modulated signal spectrum as the input data of the model. The input data is divided into the training set and the test set according to the ratio of 8:2 to complete the training and testing of the fault diagnosis model. The experimental results show that the accuracy of TPCN model for the diagnosis of 5 types of faults reaches 100 %. The average accuracy of the model is 100 %, which indicates that the model has good stability.

Novel Insights into the Kallikrein-Kinin System in Fulminant Myocarditis: Physiological Basis and Potential Therapeutic Advances.

Fulminant myocarditis (FM) is characterized by rapid cardiac deterioration often instigated by an inflammatory cytokine storm. The kallikrein-kinin system (KKS) is a metabolic cascade known for releasing vasoactive kinins, such as bradykinin-related peptides, possessing diverse pharmacological activities that include inflammation, regulation of vascular permeability, endothelial barrier dysfunction, and blood pressure modulation. The type 1 and type 2 bradykinin receptors (B1R and B2R), integral components of the KKS system, mediate the primary biological effects of kinin peptides.This review aims to offer a comprehensive overview of the primary mechanisms of the KKS in FM, including an examination of the structural components, regulatory activation, and downstream signaling pathways of the KKS. Furthermore, it explores the involvement of the tissue kallikrein/B1R/inducible nitric oxide synthase (TK/B1R/iNOS) pathway in myocyte dysfunction, modulation of the immune response, and preservation of endothelial barrier integrity. The potential therapeutic advances targeting the inhibition of the KKS in managing FM will be discussed, providing valuable insights for the development of clinical treatment strategies.

Microscale Flow Control and Droplet Generation Using Arduino-Based Pneumatically-Controlled Microfluidic Device.

Microfluidics are crucial for managing small-volume analytical solutions for various applications, such as disease diagnostics, drug efficacy testing, chemical analysis, and water quality monitoring. The precise control of flow control devices can generate diverse flow patterns using pneumatic control with solenoid valves and a microcontroller. This system enables the active modulation of the pneumatic pressure through Arduino programming of the solenoid valves connected to the pressure source. Additionally, the incorporation of solenoid valve sets allows for multichannel control, enabling simultaneous creation and manipulation of various microflows at a low cost. The proposed microfluidic flow controller facilitates accurate flow regulation, especially through periodic flow modulation beneficial for droplet generation and continuous production of microdroplets of different sizes. Overall, we expect the proposed microfluidic flow controller to drive innovative advancements in technology and medicine owing to its engineering precision and versatility.

Terms for describing atmospheric deposition of substances on surfaces

Relevance. The need to assess the state of the environment based on the use of terminology for quantitative chemical characteristics of the underlying surface as a result of deposition of pollutants in the composition of wet and dry fallout from the atmosphere. Aim. This study can be a source of information about the terminology used to describe the state of the underlying surface during the deposition of substances from the atmosphere, with links to scientific and technical literature. Methods. Review of some scientific and technical literature and an attempt to select terms used to quantify the ecological state of the underlying surface, mainly snow, after the arrival of substances as part of dry and wet deposition from the atmosphere, depending on the sampling method. Results and conclusions. The author has carried out an analysis of the scientific and technical literature and defined the terms applied to a quantity that has the dimension mass/area*time for assessing the ecological state of the snow cover, such as specific reserve (surface density), deposition density, atmospheric deposition density, precipitation intensity pollutant, daily deposition of chemical elements, technogenic load, dust load, pollution load (element), mass load, gas-aerosol load, technogenic pressure module, input module, atmospheric fallout module, mass of the determined component received at unit area, flux obtained on the basis of sampling during snow chemical survey. An analysis of the scientific and technical literature was also carried out and the terms applied to a value with the same dimension mass/area*time were defined to assess the ecological state of the underlying surface during the deposition of substances from the atmosphere, such as "fallout density", "atmospheric fallout density", “pollutant fallout intensity”, “aggravating substance", "precipitation", "critical load", "flow" obtained based on sample collection using plates, cuvettes, collections.

A review of gut microbial metabolites and therapeutic approaches in hypertension

Abstract Background Hypertension is a prevalent and complex disease that is increasingly recognized to be influenced by the gut microbiome and its metabolites. Understanding the relationship between gut microbial metabolites and blood pressure regulation could provide new therapeutic avenues. Main body This review examines the role of key microbial metabolites—short-chain fatty acids, trimethylamine N-oxide, tryptophan derivatives, polyamines, bile acids, and phenylacetylglutamine—in blood pressure regulation. Short-chain fatty acids, produced through dietary fiber fermentation, can lower blood pressure by modulating immune responses and reducing inflammation. Elevated trimethylamine N-oxide levels are associated with increased cardiovascular risk and hypertension, influencing cholesterol metabolism and promoting atherosclerosis. Tryptophan derivatives interact with vascular and renal functions to modulate blood pressure. Polyamines affect blood pressure regulation through their impact on nitric oxide synthesis and vascular tone. Bile acids influence blood pressure via gut microbiota modulation and activation of metabolic receptors. Phenylacetylglutamine has been linked to hypertension through its effects on platelet hyperactivity and thrombosis. Therapeutic approaches targeting these metabolites, including probiotics, prebiotics, fecal microbiota transplantation, dietary interventions, and polyphenols, have shown varying degrees of success. Probiotics and prebiotics promote the growth of beneficial gut bacteria and may lower blood pressure. Dietary interventions, such as the Mediterranean diet, positively affect blood pressure and cardiovascular health by modulating the gut microbiota. Polyphenols, known for their antioxidant properties, are associated with blood pressure reductions and improved vascular function. Fecal microbiota transplantation shows promise in restoring gut microbial balance and improving metabolic health, potentially influencing blood pressure regulation. Conclusion The review highlights the significant role of gut microbial metabolites in regulating blood pressure, offering new avenues for hypertension management. Key metabolites, including short-chain fatty acids, trimethylamine N-oxide, and bile acids, play critical roles in blood pressure modulation. Therapeutic strategies targeting these metabolites, such as probiotics, prebiotics, and dietary interventions, hold promise, though further research is needed to fully understand their mechanisms and optimize their use. Advancing microbiota-based interventions through large-scale studies and exploring personalized therapies will be essential for developing effective treatments in hypertension management.

Survival implications of postoperative restricted diffusion in high-grade glioma and limitations of intraoperative MRI detection.

Here we assess whether the volume of cerebral ischemia induced during glioma surgery may negatively impact survival independently of neurological function. We also evaluate the sensitivity of intraoperative MRI (iMRI) in detecting cerebral ischemia during surgery. We retrospectively reviewed 361 cranial surgeries that used a 3 Tesla iMRI. 165 patients met all inclusion criteria and were included in the final analysis. Diffusion weighted imaging (DWI) obtained during iMRI was compared to postoperative DWI obtained within 7days of the operation in cases where no further resection occurred after the iMRI. 42 of 165 patients (25%) showed at least some evidence of restricted diffusion on postoperative (poMRI). 37 of these 42 (88%) cases lacked evidence of restricted diffusion on iMRI, meaning iMRI had a false-negative rate of 88% and a sensitivity of 12% in assessing the extent of ischemic brain after surgery. In high-grade gliomas, the volume of restricted diffusion on poMRI was predictive of overall survival, independent of new functional deficits acquired during surgery (p = 0.011). This study presents the largest case series to date analyzing the sensitivity of iMRI in detecting surgical ischemia. In high-grade gliomas, increased volume of ischemia correlated with worsening median overall survival (OS) irrespective of postoperative neurologic deficits. Future work will focus on improving intraoperative detection of ischemia during the hyperacute phase when interventions such as blood pressure modulation or direct application of vasodilator agents may be effective.

Performance characterization of a wireless sensors network system (WSNS) for measurements of hurricane wind effects on structures

This paper presents a new wireless sensors network system (WSNS) designed for high-resolution absolute pressure measurements, wind speed, and direction. The system is tailored to assess the impact of hurricane winds on residential structures, both in laboratory settings and field environments. Importantly WSNS stands out for its unique ability to provide waterproof, surface-mounted external pressure measurements. The system's performance is evaluated during deployment on a full-scale house model at the Wall of Wind facility. The WSNS sensors were installed on different surfaces of a single-story residential building model. The sensor locations mirrored the locations of surface pressure taps connected to a Scanivalve differential pressure measurement system. Due to the size and shape of the WSNS pressure module, a casing effect was observed, which may result in pressure offsets under certain wind speeds and directions, depending on the sensor's location and the conditions, including dry and light rain (50 mm per hour). The comparison between WSNS and Scanivalve indicates that the sensor's casing geometry does not cause significant differences in the time-averaged measurements for low-turbulence regions. Conversely, this is not true for high-turbulence regions, which should be marked for future deployments using smaller surface-mounted pressure taps.

Steerable ultrasonic propulsion of rigid objects based on circular pressure modulation of a focused sectorial transducer array

As a common disease of human urinary system, the high prevalence and incidence rate of renal calculus have brought heavy burden to society. Traditional ultrasonic lithotripsy struggles with the comprehensive elimination of residual fragments and may inadvertently inflict renal damage. Although focused ultrasound can propel stones by the acoustic radiation force (ARF) with minimal tissue damage and enhanced passage rate, it is still lack of the accurate control for calculi at different locations. A circular pressure modulation approach for steerable ultrasonic propulsion of rigid objects is developed based on a sector-array of focused transducers. The ARF exerted on on-axis rigid spheres (stones) is derived based on acoustic scattering. It is proved that the ARF of focused fields exhibits an axial distribution of increasing followed by decreasing with the peak slightly beyond the focus. As the sphere radius increases, the ARF exerted on spheres at the focus increases accordingly with a decreasing growth rate. Inclined propulsion can be realized by the circular binary pressure modulation with the deflection increased by expanding the angle of power-off sector sources. The maximum deflection angle approaching 60° is determined by the F-number and element number of the sector-array. Experimental propulsions of steel balls are conducted using an 8-element sector-array with motion trajectories captured by a high-speed camera. Distributions of the motion speed and acceleration for steel balls of different radii are calculated through image processing. The ARF of mN level and the deflection angle of 12° are demonstrated by the successful propulsion of steel balls. This research provides an effective and flexible approach of steerable stone propulsion using an ultrasonic power supply without the complex control in amplitude or phase and the high-precision motion of the sector-array, hence promoting the practical application in non-invasive treatment of stones.

Inverse Problem of Permeability Field under Multi-Well Conditions Using TgCNN-Based Surrogate Model

Under the condition of multiple wells, the inverse problem of two-phase flow typically requires hundreds of forward runs of the simulator to achieve meaningful coverage, leading to a substantial computational workload in reservoir numerical simulations. To tackle this challenge, we propose an innovative approach leveraging a surrogate model named TgCNN (Theory-guided Convolutional Neural Network). This method integrates deep learning with computational fluid dynamics simulations to predict the behavior of two-phase flow. The model is not solely data-driven but also incorporates scientific theory. It comprises a coupled permeability module, a pressure module, and a water saturation module. The accuracy of the surrogate model was comprehensively tested from multiple perspectives in this study. Subsequently, efforts were made to address the permeability-field inverse problem under multi-well conditions by combining the surrogate model with the Ensemble Random Maximum Likelihood (EnRML) algorithm. The research findings indicate that modifying the network structure allows for improved integration of the outputs, resulting in prediction accuracy and computational efficiency. The TgCNN surrogate model demonstrated outstanding predictive performance and computational efficiency in two-phase flow. By combining the surrogate model with the EnRML algorithm, the inversion results closely aligned with those from the commercial simulation software, significantly improving the computational efficiency.

Can Omega-3 prevent the accidence of stroke: a mendelian randomization study

BackgroundThe lipid-lowering effects of Omega-3 fatty acids have been widely reported, yet their impact on ischemic stroke remains controversial. Reports on the protective effects of unsaturated fatty acids, such as Omega-6 and Omega-7, as well as saturated fatty acids in cardiovascular diseases, including hypertension and ischemic stroke, are less frequent.ObjectivesThis study aims to identify fatty acids associated with blood pressure and ischemic stroke through Mendelian randomization. Besides, it seeks to determine whether specific fatty acids can prevent ischemic stroke by managing blood pressure and revealing the specific mechanisms of this action.MethodsThis research involved downloading relevant data from websites and extracting SNPs that met the standard criteria as instrumental variables. Simultaneously, the ‘MR-PRESSO’ package and ‘Mendelian Randomization’ package were used to eliminate confounding SNPs that could bias the study results. Then, inverse variance weighting and the weighted median were employed as primary analysis methods, accompanied by sensitivity analysis to assess the validity of the causal relationships. Initially, multivariable Mendelian randomization was used to identify fatty acids linked to blood pressure and the incidence of ischemic stroke. The causal link between certain fatty acids and the initiation of ischemic stroke was then investigated using bidirectional and mediator Mendelian randomization techniques. Stepwise Regression and the Product of Coefficients Method in mediator Mendelian randomization were utilized to ascertain whether specific fatty acids reduce ischemic stroke risk by lowering blood pressure.ResultsMultivariable Mendelian randomization analysis indicated a potential inverse correlation between Omega-3 intake and both blood pressure and ischemic stroke. Consequently, Omega-3 was selected as the exposure, with blood pressure and ischemic stroke-related data as outcomes, for further bidirectional and mediation Mendelian Randomization analyses. Bidirectional Mendelian Randomization revealed that Omega-3 significantly influences DBP (P = 1.01e-04) and IS (P = 0.016). It also showed that DBP and SBP significantly affect LAS, SVS, CES, IS, and LS. Mediator Mendelian Randomization identified five established mediating pathways: Omega-3-Diastolic blood pressure-Small vessel stroke, Omega-3-Diastolic blood pressure-Cardioembolic stroke, Omega-3-Diastolic blood pressure-Lacunar stroke, Omega-3-Diastolic blood pressure-Large artery atherosclerosis stroke, and Omega-3-Diastolic blood pressure-Ischemic stroke. Of these, four pathways are complete mediation, and one pathway is partial mediation.ConclusionsThe findings suggest that Omega-3 may indirectly reduce the incidence of ischemic stroke by lowering blood pressure. Thus, blood pressure modulation might be one of the mechanisms through which Omega-3 prevents ischemic stroke. In summary, incorporating an increased intake of Omega-3 in the diet can serve as one of the dietary intervention strategies for patients with hypertension. Additionally, it can act as an adjunctive therapy for the prevention of ischemic strokes and their complications.

Ultrafast Decay of Interlayer Exciton in WS2/MoSe2 Heterostructure Under Pressure

AbstractAtomically thin transition metal dichalcogenides (TMDs) heterostructures provide a rich platform for exploring fascinating physics and engineering strategies. A pressure strategy is developed to effectively manipulate the physical properties in such heterostructures. However, there is still a lack of studies on the corresponding pressure‐modulated evolution of carrier dynamics, which is crucial to the performance of electronic and optoelectronic devices. Here, utilizing the diamond anvil cell, the interlayer exciton dynamics of WS2/MoSe2 heterostructure are subtly manipulated by pressure. Intriguingly, with pressure modulation, the enhanced interlayer coupling accelerates the recombination of spatially separated electron and hole, which significantly shortens the interlayer exciton lifetime from 37.10 ps at 0.0 Gpa to 3.03 ps at 2.2 Gpa. For comparison, the intralayer exciton lifetime of monolayer MoSe2 is increased due to the transition of direct to indirect bandgap under pressure. Furthermore, the pressure‐regulated band structure and interlayer coupling are confirmed by photoluminescence and Raman spectroscopy. The results demonstrate that pressure provides a powerful tuning knob for interlayer exciton relaxation of TMDs heterostructure, which is attractive to various electronic and optoelectronic applications based on such heterostructure.

P093 PLASMA PROTEINS PROFILE AND THERAPEUTIC RESPONSIVENESS IN PATIENTS WITH PREECLAMPSIA

Preeclampsia (PE) is a hypertensive syndrome of pregnancy, characterized by target organ damage, related to a high incidence of cardiovascular sequelae. PE requires antihypertensive drug therapy, however, about 40% of patients do not respond to this treatment, leading to worse clinical outcomes. Through the proteomic strategy, we 1) compared the profile of circulating proteins expressed in 10 responsive (R-PE) and 10 non-responsive to antihypertensive therapy (NR-PE), besides 10 healthy pregnant (HP); 2) investigated which proteins are differentially expressed between the groups and 3) found out which signaling pathways are altered between them. The study followed the Declaration of Helsinki and was approved by the Research Ethics Committee of the Ribeirao Preto Medical School, University of Sao Paulo (FMRP-USP, protocol code CAAE-37738620.0.0000.5440). We performed plasma protein quantification using mass spectrometry, the obtained data underwent bioinformatics analyses based on Uniprot, PatternLab for Proteomics, String and MetaboAnalyst softwares. Considering a fold change of 1.5, three proteins showed as significantly differentially expressed between HP and R-PE, one downregulated (transtyretin) and two upregulated (apolipoprotein C1 and hemoglobin subunit beta). Between HP and NR-PE, there were six, two downregulated (clusterin and plasmin heavy chain A) and four upregulated (apolipoprotein A-IV; heparin cofactor II; complement C4B and haptoglobin related protein). Between R-PE and NR-PE there were four, one downregulated (fibronectin) and three upregulated (pregnancy-specific beta-1-glycoprotein 1 (PSG1); complement C4B (C4B) and complement C4A (C4A). Regarding PE, C4A and C4B intensity peaks were correlated with blood pressure and creatinine levels. Both, together with PSG1, showed significant correlations with the newborn's weight and gestational week (all p< 0.05). These findings help to understand the pathophysiological mechanisms between the two subgroups of the disease, since the under regulated circulating proteins act in the blood pressure modulation and the upregulated may occur as compensatory mechanisms due to an inflammatory scenario. These data give insights to explain the complexity and clinical consequences of this disorder.

Identifying Organic-Inorganic Interaction Sites Toward Emission Enhancement in Non-Hydrogen-Bonded Hybrid Perovskite via Pressure Engineering.

The interaction between organic and inorganic components in metal hybrid perovskites fundamentally determines the intrinsic optoelectronic performance. However, the underlying interaction sites have still remained elusive, especially for those non-hydrogen-bonded hybrid perovskites, thus largely impeding materials precise design with targeted properties. Herein, high pressure is utilized to elucidate the interaction mechanism between organic and inorganic components in the as-synthesized one-dimensional hybrid metal halide (DBU)PbBr3 (DBU = 1,8-diazabicyclo [5.4.0] undec-7-ene). The interaction sites are identified to be the N from DBU and the Br from inorganic framework by the indicative of enhanced Raman mode under high pressure. The change in interaction strength is indeed derived from the pressure modulation on both distance and spatial arrangement of the nearest Br and N, rather than traditional hydrogen-bonding effect. Furthermore, the enhanced interaction increased charge transfer, resulting in a cyan emission with photoluminescence quantum yields (PLQYs) of 86.6%. The enhanced cyan emission is particularly important for underwater communication due to the much less attenuation in water than at other wavelength emissions. This study provides deep insights into the underlying photophysical mechanism of non-hydrogen-bonded hybrid metal halides and is expected to impart innovative construction with superior performance.

SGLT2 Inhibitors and How They Work Beyond the Glucosuric Effect. State of the Art.

Type 2 diabetes mellitus (T2DM) is associated with a heightened risk of cardiovascular and renal complications. While glycemic control remains essential, newer therapeutic options, such as SGLT2 inhibitors, offer additional benefits beyond glucose reduction. This review delves into the mechanisms underlying the cardio-renal protective effects of SGLT2 inhibitors. By inducing relative hypoglycemia, these agents promote ketogenesis, optimize myocardial energy metabolism, and reduce lipotoxicity. Additionally, SGLT2 inhibitors exert renoprotective actions by enhancing renal perfusion, attenuating inflammation, and improving iron metabolism. These pleiotropic effects, including modulation of blood pressure, reduction of uric acid, and improved endothelial function, collectively contribute to the cardiovascular and renal benefits observed with SGLT2 inhibitor therapy. This review will provide clinicians with essential knowledge, understanding, and a clear recollection of this pharmacological group's mechanism of action.