During the last week of March 2020, millions of workers around the world transitioned to working from home due to the COVID-19 pandemic. While much research has explored the behavioural and psychological aspects of work-from-home (WFH), few studies have provided data-driven evaluations of indoor environmental quality (IEQ). This paper presents findings from a summer 2022 field study of IEQ conditions in WFH settings, involving 95 participants in the North American Pacific Northwest. Sensors installed on participants' work desks continuously measured total volatile organic compounds (tVOC), particulate matter (PM2.5), carbon dioxide (CO2) air temperature, humidity, and sound pressure levels (SPLs). Participants also completed surveys on home and workspace characteristics, as well as their subjective assessments of IEQ, well-being, and productivity. The study found that mean indoor concentrations of tVOC, PM2.5, and CO2 were 262 ppb, 5 µg/m3, and 712 ppm, respectively. Indoor air temperature ranged between 14.7–32.3°C, with a mean of 22.8°C, while relative humidity and SPL averaged at 52.5% and 53.7 dBA. Statistically-significant associations were observed between IEQ variables and factors such as residence type, cooking habits, workspace type, and window availability. A future paper will assess the surveyed behavioural and psychological characteristics in greater detail.