Introduction: High blood pressure might be a trigger for a variety of diseases, including stroke and heart disease, which can reduce quality of life, primarily for individuals of productive age. This research aims to determine the influence of combination of slow deep breathing and autogenic relaxation to blood pressure in hypertension patients with productive age. Method: The research design used Quasi Experimental with Pretest and Posttest Control Group Design approach. The study population were 114 people and sample obtained 36 respondents with hypertension through purposive sampling technique. The intervention was given once a day for 3 consecutive days with a meeting duration around 25-35 minutes. Data were analyzed by Wilcoxon test and Mann Whitney test. Result and analysis: Based on the Wilcoxon test results, it was known that there was an influence of combination of slow deep breathing and autogenic relaxation to blood pressure in the treatment group perlakuan (Systolic pv = 0.000 < α 0.05 and Diastolic pv= 0.001 < α 0.05) and there was no change on blood pressure in control group (Systolic pv= 0.060 > α 0.05, Diastolic pv = 0.180 > α 0.05). The results of the Mann Whitney test showed that there were difference changes in systolic and diastolic blood pressure between the treatment group and the control group (Systolic pv= 0.000 < α 0.05, Diastolic pv= 0.000 < α 0.05). Discussion: The decrease in systolic and diastolic blood pressure occurs due to process of increasing endorphins secretion and stimulating parasympathetic system, resulting in vascular vasodilation. It is recommended for hypertension patients with productive age to able to apply this combination therapy independently with duration 25-30 minutes every day as an effort to lower blood pressure.