Objectives: The study objective was to develop an understanding of the relationship between the stress and presenteeism of workers. Methods: The study subjects were workers who were receiving Group Occupational Health Services in Seoul and Gyeonggi-do. For the survey, a structured self-report questionnaire was administered from February 1 to March 30, 2006. Data were collected from 354 employees and analyzed on SPSS 12.0 and AMOS 5.0 program. Results: For present health problems, gastrointestinal problems were ranked highest at 44.9% followed by muskuloskelectal problems, and mental and nervous problems with over 30%. However, compared to the current health condition, the rate of medical cure for the subjects’ health problems was very low. Job and psychosocial stresses exerted a significant effect on the health problems, which in turn exerted a significant effect on the work impairment. In other words, stress exerted a significant effect on presenteeism. Conclusions: Job and psychosocial stresses are the variables which influence presenteeism. Thus, Job and psycosocial stresses need to be controled to prevent the decline of presenteeism.