Renal Cell Carcinoma Presenting Research Articles

A large bone metastasis as an initial presentation of renal cell carcinoma

A large bone metastasis as an initial presentation of renal cell carcinoma

Paraneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma

BackgroundParaneoplastic cerebellar degeneration is usually associated with gynecological and breast cancer, lung cancer, and Hodgkin’s lymphoma. Renal cell carcinoma has rarely been described as an underlying malignancy in these cases.Case presentationWe report the case of a 75 year-old woman who develop cerebellar ataxia following a respiratory viral infection. During investigation, around 1 year afterward, she noticed constitutional symptoms suggestive of malignancy. Renal carcinoma was found and the hypothesis of paraneoplastic cerebellar degeneration was considered.ConclusionsAs no specific antineuronal antibodies have been described in the setting of renal cell carcinoma, paraneoplastic cerebellar degeneration should be considered when the tumor is detected and other causes are excluded. Immunotherapy should be prescribed as soon as possible.

Case Study

ABSTRACT Cutaneous renal cell carcinoma is a rare finding in the outpatient dermatology clinic. This case portrays an uncommon presentation of cutaneous metastases and provides an overview of the epidemiology and clinical presentation of cutaneous renal cell carcinoma. It also highlights the need to consider cutaneous metastases as a diagnosis in patients, especially those with known underlying malignancies.

Occult Renal Cell Carcinoma Presenting as a Palpable Supraclavicular Virchow's Node

Occult Renal Cell Carcinoma Presenting as a Palpable Supraclavicular Virchow's Node

Sternal resection of a solitary renal cell carcinoma metastasis: a case report and a literature review.

Renal cell carcinoma (RCC) may be metastatic, although solitary sternal metastasis of RCC is a rare medical condition. Here we report an unusual case of a 63-year-old male with a solitary sternal metastasis as an initial presentation of clear-cell renal cell carcinoma. A 63-year-old male presented with a small sternal mass. Chest computer tomography (CT) and a biopsy from the sternal tumour were performed. Histopathological examination revealed the diagnosis of renal clear cell carcinoma metastasis to the sternal bone. On the basis of a subsequently performed abdominal CT the patient was confirmed with a suspicion of a left renal lower pole tumour. Treatment with sunitinib was initiated. Due to the limited response and a growing sternal mass, the patient was admitted to the National Cancer Institute after two cycles of sunitinib therapy. Open left partial nephrectomy was performed followed by the resection of the sternal metastasis two months later. The chest wall was reconstructed with polypropylene mesh combined with transversal rectus abdominis musculocutaneous flap. The postoperative course after the partial nephrectomy was uneventful. The postoperative course of metastasectomy complicated with the right pneumothorax which was successfully treated by insertion of a chest tube. Bleeding from the upper digestive tract also occurred on the seventh postoperative day but was successfully controlled by haemostasis with three 20 ml endoscopic injections of 1:10,000 solution of epinephrine. The patient had been followed up after the surgery for 30 months with biannual chest and abdominal CT scans that showed neither local nor distant recurrence of the disease. Radical surgical treatment of a solitary renal clear cell carcinoma metastasis may offer the best cancer-specific outcomes and improve the quality of life in some patients.

Longitudinally extensive myelitis as first presentation of renal cell carcinoma

Abstract not available.

Indurated Penile Swelling as a Rare Initial Clinical Presentation of Metastatic Renal Cell Carcinoma: a Case Report

Indurated Penile Swelling as a Rare Initial Clinical Presentation of Metastatic Renal Cell Carcinoma: a Case Report

Left Renal Cell Carcinoma Presenting as Right Shoulder Dislocation: First Reported Case

Left Renal Cell Carcinoma Presenting as Right Shoulder Dislocation: First Reported Case

Metastatic renal cell carcinoma to the eyelid: an unusual presentation

Renal cell carcinoma has an unpredictable course with a propensity for metastatic spread. Here we present the case of a female patient with an unusual presentation of metastatic renal cell carcinoma to the eyelid which is extremely rare. Treatment of metastatic renal cell carcinoma is still controversial; however, several authors consider metastasectomy to be a valid option. Unfortunately, little information is available on the utility of systemic treatment after the complete resection of metastatic lesions. Level of evidence: Not applicable for this multicentre audit.

Rare Abdominal Cutaneous Presentation of Clear Cell Renal Cell Carcinoma: A Case Report

Cutaneous metastasis from renal cell carcinoma is rare, typically involves the head and neck, and occurs inlatestage disease, usually in the context of previously diagnosed and treated primary tumour, and after lymphaticspread.This patients’ initial presentation of clear cell renal cell carcinoma was a cutaneous lesion to the ipsilateral abdominal wall. The primary renal tumour was subsequently demonstrated on CT; this also showed no apparent lymph nodeinvolvement despite cutaneous metastatic disease. The patient underwent radical laparoscopic nephrectomy and biological therapy, but disease progression continued, and he passed away within 6 months of diagnosis.

Thyrotoxic Goiter and Asymptomatic Thyroid Nodule as an Initial Presentation of Clear Cell Renal Cell Carcinoma

Thyroid nodule as a metastasis to renal cell carcinoma (RCC) is rarely found. We present two cases – presented with thyroid nodules and diagnosed as metastatic RCC; one patient had thyrotoxic goiter, whereas the second patient presented with asymptomatic thyroid nodule. Subsequently, hemithyroidectomy and total thyroidectomy were performed, respectively. Then, both patients underwent radical nephrectomy for the primary tumor. At present, patients are under regular oncology follow-up, with no evidence of disease recurrence.

Synchronous renal cell carcinoma and pheochromocytoma presenting as acute decompensated heart failure

We report a 49-year-old woman who presented with a hypertensive crisis and acute heart failure and reduced left ventricular systolic function. An abdominal ultrasonography revealed a huge lobulated heterogeneous mass at the lower pole of the right kidney and a mass over the left suprarenal area, which were further delineated by magnetic resonance imaging. The patient underwent laparoscopic right radical nephrectomy and left adrenalectomy. Histopathological analysis confirmed the diagnoses of clear cell renal cell carcinoma of the right kidney with metastasis to the lung; and atypical pheochromocytoma of the left adrenal gland. Target therapy was initiated, which resulted in stabilization of the patient's tumors and the recovery of her heart function. To avoid a delayed diagnosis and catastrophic outcome, clinicians should consider such rare causes of acute decompensated heart failure.

Papillary renal cell carcinoma presenting as a renal abscess

Renal cell carcinoma (RCC), a highly aggressive and lethal urological malignancy, has a wide variation of signs and symptoms. We report a rare case of papillary RCC (pRCC), presenting as a renal abscess. The knowledge of this association between RCC and a renal abscess is critical to prevent misdiagnosis and/or delayed treatment especially in the elderly and immunocompromised patients.

Clear cell renal cell carcinoma presenting as a single cutaneous metastasis

Renal cell carcinoma (RCC) is the most common kidney tumor in adults, accounting for 2% of all cancers worldwide. It is two times more frequent in men than in women and it can metastasize to the lungs, liver, bones and brain. Skin metastases are unusual. A 79-year-old male with no personal history of malignancy, presents to the Department of Plastic Surgery for excision of a 36/32/14 mm ulcerated tumoral mass located in the right parietal area. Microscopic examination revealed a well-defined multinodular tumor located in the deep dermis, composed of a mostly solid and partially discohesive proliferation of cells featuring clear or granular-eosinophilic cytoplasm and vesicular nuclei with prominent nucleoli, lacking marked atypia. Mitotic rate varied from 2-3 to 12 mitoses per 10HPF. Focal areas of haemorrhage and necrotic debris as well as brisk lymphocytic infiltration were easily identifiable. The expansive and non-infiltrative pattern of growth supported the hypothesis of a metastatic tumor. The scarcity of clinical data and absence of a highly suggestive histopathological aspect, led to multiple differential diagnoses, including: large cell lymphoma, metastatic melanoma and metastatic carcinoma. Immunohistochemical stainings eventually confirmed the diagnosis of cutaneous metastasis of clear cell renal cell carcinoma (CD10+, PAX8+, Vimentin+) and excluded all other differentials (LCA-, Melan A-, AE1/AE3-, CK5/6-). Cutaneous metastases of RCC in the head and neck area are extremely unusual, given the distance from the anatomical site of the primary tumor. This case highlights the importance of careful clinical inspection of the skin in patients with internal organ malignancy.

Unique facial cutaneous metastasis as the primary presentation of an unexpected voluminous renal cell carcinoma

article: Unique facial cutaneous metastasis as the primary presentation of an unexpected voluminous renal cell carcinoma - Giornale Italiano di Dermatologia e Venereologia 2018 Nov 09 - Minerva Medica - Journals

Corrigendum to "Metastatic Renal Cell Carcinoma Presenting as Prolonged Pyrexia and Stauffer's Syndrome: Can a Routine Ultrasound Scan Fail to Detect a Renal Cell Carcinoma?"

[This corrects the article DOI: 10.1155/2018/4215041.].

Concomitant Gastric Metastases From Renal Cell Carcinoma Presenting as a Solitary Polyp: A Case Report

Background Gastric metastases are atypical and represent a late stage of malignant disease. Renal cell carcinoma metastases to the stomach have been discussed in the literature and usually presents as a large, solitary mass or ulcer resembling primary gastric cancer. We report a rare case of a metastatic renal call carcinoma preseting as a solitary gastric polyp Case Report A 62-year-old Caucasian women with history of COPD, PUD with prior partial gastrectomy presented for EGD and colonoscopy for evaluation of anemia. There was no prior history of gastrointestinal bleeding. The EGD showed, a single non-bleeding 6x8 mm sessil polyp in the fundus of stomach, which was completely removed via snare. A clip was placed at the polypectomy site for post polyepectomy bleeding. The colonoscopy at that time was poor prep without significant findings.2626_A Figure 1. CT Abd/Pelvis with renal mass2626_B Figure 2. Post Polypectomy SiteThe histopathologic examination of the excised gastric polyp showed metastatic clear cell renal carcinoma, with free margins of resection. Subsequently, the patient got a CT scan which showed a 5x4 cm renal mass. She had additional imaging studies which showed no other metastatic disease. She underwent repeat EGD which showed no residual polyp tissue, with repeat biopsies from the polypectomy site showing no evidence of malignancy. Patient is awaiting nephrectomy. Discussion Metastatic tumors to the stomach are rare. The reported incidence of metastatic gastric tumors is 0.2-0.7%. Reported primary tumors that spread to the stomach include breast (27%) lung (23%) renal cell (7%) and malignant melanoma (7%). Gastric metastasis from RCC usually presents as a large solitary mass or ulcer, but it can present as small benign-appearing polyps<./p> Presentation of RCC as a gastric polyp is usually a late occurance, happening on average 6.7 years after initial diagnosis of RCC. However, 25-30% of patients with RCC had distant metastases at the time of diagnosis. Typical manifestations in metastatic tumors in stomach include bleeding, anemia, abdominal pain, vomiting or even asymptomatic. The management modalities for gastric metastasis from RCC include gastrectomy, endoscopic resection, embolization, chemotherapy, and immunotherapy. The present case exemplifies that gastric metastases from RCC can be subtle and present as a solitray gastric polyp. This case also highlights the importance of a careful endoscopic examination as well as a thorough histopathologic examination in patients with a history of unexplained anemia.2626_C Figure 3. Pathology showing RCC with surrounding normal gastric tissue

Villous Duodenal Polyp With Foveolar Gastric Metaplasia in a Patient With Recently Resected Papillary Clear Cell Carcinoma: A Case Report

Duodenal foveolar gastric metaplasia is of well-known clinical occurrence, yet involvement in the form of a villous mass is of rare representation. Foveolar gastric metaplasia (FGM) usually seen as polyps on endoscopy has a benign clinical course and is diagnosed through biopsy. We report a case of FGM of the duodenum in a patient undergoing screening for possible metastatic papillary renal cell carcinoma. An 84-year-old African American male was referred to our gastroenterology clinic for incidental radiological findings concerning for gastric and duodenal malignancy. The patient had surveillance CT abdomen with contrast following robotic assisted nephrectomy for right renal cell carcinoma done 6 months earlier. The CT abdomen revealed a heterogeneously enhancing mass involving the distal stomach and extending into the duodenum. It also revealed subtle enhancing liver lesions. The CT findings were not present on radiological images prior to the nephrectomy. The patient denied any abdominal pain, nausea, vomiting, or early satiety. However, the patient reported losing 20-30 pounds over the past 3 years. Upper endoscopy performed revealed a large circumferential villous mass in the duodenal bulb with no signs of active bleeding. Biopsies of the mass were taken endoscopically. Pathological interpretation revealed gastric foveolar mucosa with benign vascular proliferation and no neoplasm identified. The patient was offered an endoscopic ultrasound for further evaluation of the duodenal mass and the hepatic lesions to rule out malignancy. However, the patient refused the procedure and was accepting of death should the procedure yield findings consistent with malignancy. FGM is known for its benign pathology and involvement of the duodenum. Our case signifies the relative rarity of FGM presenting as a villous mass of the duodenum. Narrow band imaging and endoscopic ultrasonography are techniques used frequently to better evaluate duodenal FGM. Given reported cases of renal cell carcinoma presenting as metastasis with gastric polyps and in other cases with concomitant duodenal papillary carcinoma, we raise the question of the correlation between papillary renal cell carcinoma and FGM of the duodenum in this patient.1900_A Figure 1 No Caption available.1900_B Figure 2 No Caption available.1900_C Figure 3 No Caption available.

Rare Presentations of Metastatic Renal Cell Carcinoma with Hematochezia and Anemia

Rare Presentations of Metastatic Renal Cell Carcinoma with Hematochezia and Anemia

Metastatic Renal Cell Carcinoma Presenting as a Solitary Gastric Polyp

Metastatic Renal Cell Carcinoma Presenting as a Solitary Gastric Polyp