Present Status Of Diagnosis Research Articles

Current Situation of Diagnosis and Treatment of HER2-Positive Metastatic Breast Cancer Patients in China: A Nationwide Cross-Sectional Survey of Doctors.

The Advanced Breast Cancer Alliance conducted a nationwide investigation to understand the current situation of the diagnosis and treatment of human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer (MBC) patients. In 2019, electronic questionnaires including basic information about respondents, characteristics of patients, and the present status of diagnosis and treatment were sent to 495 doctors from 203 medical centers covering 28 provinces. The factors that influenced treatment plans included the disease process, the performance status, and the economic status of patients. Regimens and response to neoadjuvant/adjuvant chemotherapy were important factors in the decision of the first-line treatment. Overall, 54% of doctors retained trastuzumab and replaced chemotherapy drugs in second-line treatment regimens for patients with progression-free survival (PFS) ≥ 6 months in the first-line setting, while 52% of participants chose pyrotinib plus capecitabine for patients with PFS < 6 months. Economic factors played an important role in doctors' decision-making and the varying treatment options for respondents in first-tier, second-tier, and other cities. This large-scale survey regarding the diagnosis and treatment of HER2-positive MBC patients revealed that clinical decisions made by Chinese doctors followed the guidelines, but their choices were constrained by economic factors.

Lower Extremity Peripheral Artery Disease: Contemporary Epidemiology, Management Gaps, and Future Directions: A Scientific Statement From the American Heart Association.

Lower extremity peripheral artery disease (PAD) affects >230 million adults worldwide and is associated with increased risk of various adverse clinical outcomes (other cardiovascular diseases such as coronary heart disease and stroke and leg outcomes such as amputation). Despite its prevalence and clinical importance, PAD has been historically underappreciated by health care professionals and patients. This underappreciation seems multifactorial (eg, limited availability of the first-line diagnostic test, the ankle-brachial index, in clinics; incorrect perceptions that a leg vascular disease is not fatal and that the diagnosis of PAD would not necessarily change clinical practice). In the past several years, a body of evidence has indicated that these perceptions are incorrect. Several studies have consistently demonstrated that many patients with PAD are not receiving evidence-based therapies. Thus, this scientific statement provides an update for health care professionals regarding contemporary epidemiology (eg, prevalence, temporal trends, risk factors, and complications) of PAD, the present status of diagnosis (physiological tests and imaging modalities), and the major gaps in the management of PAD (eg, medications, exercise therapy, and revascularization). The statement also lists key gaps in research, clinical practice, and implementation related to PAD. Orchestrated efforts among different parties (eg, health care providers, researchers, expert organizations, and health care organizations) will be needed to increase the awareness and understanding of PAD and improve the diagnostic approaches, management, and prognosis of PAD.

A survey on the present status of diagnosis and treatment of Graves′ disease in Jiangsu province

Objective To investigate the management of Graves′ disease in Jiangsu province. Methods According to the 2011 management of GD survey from American Thyroid Association and the 2013 survey from European Thyroid Association, a questionnaire was designed for this survey to acquire the diagnosis, treatment, and follow-up of Graves′ disease among endocrinologists from 35 tertiary hospitals in Jiangsu province. Results A total of 476 valid questionnaires were collected. For patients with symptoms of hyperthyroidism, a large majority of respondents monitored serum FT3, FT4, TSH, thyroid peroxidase antibody, thyroglobulin antibody, TSH receptor antibody, and finding of thyroid ultrasound, accounted for 95.6%, 95.0%, 95.4%, 95.8%, 90.3%, 90.5%, and 93.9% physicians, respectively. 91.2% of physicians preferred anti-thyroid drugs as the first-line treatment, and 92.6% of them gave priority to the use of methimazole. For the duration of anti-thyroid drugs therapy, 41.2% of endocrinologists chose 24 months, while 20% chose 18 months. When patients have moderate and active ophthalmopathy, most respondents with medium or senior professional titles preferred anti-thyroid drugs, while most resident physicians chose radioactive iodine plus corticosteroids. When pregnancy was confirmed in the patients of Graves′ disease, 88% of respondents preferred propylthiouracil during the first trimester of pregnancy, and 58.4% of them would continue propylthiouracil into the second trimester. Conclusion The mastering of basic perception of Graves′ disease knowledge is satisfactory among the endocrinologists. But by comparing to the American and European survey results and related guidelines, there are still some differences in diagnosis and treatment. Therefore, physicians should notice those differences and make improvement on standardized treatment for patients to raise the response ratio while reducing the recurrent events. Key words: Graves′ disease; Present status; Questionnaire

Present status of diagnosis and treatment of hepatolenticular degeneration

Hepatolenticular degeneration (HLD) is an autosomal recessive inherited disorder of copper metabolism. The mutations in the ATP7B gene on chromosome 13 leads to the functional defect of ATP7B, which produces pathological deposits of copper in liver, brain, cornea and kidney, with diverse clinical manifestations in various forms of liver disease, nervous system disease and corneal disease (Kayser-Fleischer rings). Early diagnosis and proper treatment can improve the prognosis of hepatolenticular degeneration. Conversely, it may progress to end-stage liver disease or severe motor dysfunction, which seriously affects patient quality of life.

The development of Special Education Support Center based on the present status of diagnosis and evaluation status

The development of Special Education Support Center based on the present status of diagnosis and evaluation status

肺がん診断の現況

肺がん診断の現況

Strokes; the present status of diagnosis and treatment.

Although research of the past five years has contributed greatly to the knowledge of the diagnosis and treatment of strokes, there is much still to be learned. Atherosclerosis and embolization have been determined the most common causes of strokes; therefore, solution of this problem depends on prevention, reversal and control of these conditions. Anticoagulant therapy has proved effective in preventing recurrent strokes, but its value in acute attacks is less clear. Surgery and constructive rehabilitation are challenging approaches receiving critical study.

Present status of diagnosis and treatment of pheochromocytoma.

For detection and diagnosis of pheochromocytoma the method of urine analysis is considered the most convenient, safe, and accurate. Analysis of blood samples obtained by catheterization at different levels in the vena cava aids in localization. Some features of the clinical symptomatology and the pharmacologic and operative treatment of patients with chromaffin-cell tumors are given.

Gastric acidity before and after development of gastric cancer: its etiologic, diagnostic and prognostic significance.

Excerpt Everyone knows that in gastric cancer the mean gastric secretory activity is subnormal, but to what extent is it subnormal? What factors influence gastric acidity in gastric cancer? Does ca...

Carcinoma of the stomach. Present status of diagnosis and prognosis : Eustermann, George B., and Beuermann, Winfred H., Rochester, Minn. J. Am. M. Ass., Jan. 29, 1927, lxxxviii, 295

Carcinoma of the stomach. Present status of diagnosis and prognosis : Eustermann, George B., and Beuermann, Winfred H., Rochester, Minn. J. Am. M. Ass., Jan. 29, 1927, lxxxviii, 295