Present Results Research Articles

Dissipative MHD flow of ternary‐hybrid nanofluid over an inclined stretching sheet with heat source and mass flux due to temperature gradient

AbstractAn analysis has been made to illuminate the unsteady MHD slip flow of ternary‐hybrid nanofluid of water conveying spherical Cu, cylindrical Al2O3, and platelet Ag nanoparticles over an inclined stretching sheet. The above complex scenario explores how the presence of a magnetic field affects the behavior of ternary‐hybrid nanofluid over an inclined stretching surface. Understanding this interaction is crucial in advanced thermal systems like cooling mechanisms and energy generation technologies. The study can provide insights into optimizing heat transfer rates, enhancing thermal conductivity and improving efficiency in practical applications by manipulating the flow characteristics and temperature distribution in the system. The heat transfer has been analyzed incorporating Darcy dissipation and heat source in the presence of 1st order velocity slip. The presence of Soret effect makes the study more congenial. Using similarity transformation technique, the governing partial differential equations are converted into a system of ordinary differential equations. The reduced system is dealt with 4th order Runge–Kutta method with shooting technique. The comparison with earlier results gives a reliability of present results. The important findings are: velocity of the flow decelerates for higher values of 1st order slip parameter, velocity of the flow increases with increase in Soret number, increasing values of chemical reaction parameter lead to lower concentration in both the cases, that is, with or without velocity slip.

Activation energy with binary chemical reaction of convective radiative magnetized nanofluid flow with viscous dissipation and pressure gradient

ABSTRACT The present investigation deals with the study of activation energy with the binary chemical reaction on magnetohydrodynamic convective radiative heat and mass transfer of nanofluid flow with internal heat source/sink, viscous dissipation, pressure gradient force, and suction effects. The basic equations of conservation of momentum, energy, and mass diffusion are brought to a set of ordinary differential equations (nonlinear) using suitable similarity transformations, and these are then solved using the Homotopy Perturbation Method (HPM). The validity of the present results is established by comparing them with those obtained by the Runge-Kutta-Fehlberg method (RKFM). The results reveal that the temperature distribution increases with raising the value of the thermal radiation parameter. It is found that the concentration distribution increases by increasing the values of the activation energy parameter. In contrast, the reverse effect is observed by enhancing the chemical reaction parameter, Schmidt number, and pressure gradient parameter. Further, the skin-friction coefficient and Nusselt number decrement by enhancing the value of the Hartmann number, whereas the reverse trend is found by enhancing the pressure gradient and suction parameter values. Also, the Sherwood number retards with an enhancement in the Hartmann number, whereas it rises by increasing the pressure gradient and suction parameters.

Comparison of personality traits of two anti‐oppression groups: Vegans and anarchists

AbstractVeganism and anarchism are burgeoning worldwide, yet very few studies have examined the psychological characteristics of people belonging to these two anti‐oppression groups. The present study investigated whether vegans and anarchists, on the one hand, and activists and non‐activists belonging to these two groups, on the other hand, exhibit distinct personality profiles. To this end, a sample of 180 adults who self‐identify as vegans or anarchists completed an online socio‐demographic questionnaire, the HEXACO Personality Inventory, and the Dark Triad Dirty Dozen. A discriminant function analysis showed that anarchists are more likely than vegans to self‐identify as belonging to a gender other than female or male, or to identify with no gender at all. Further, the proportion of men was larger in the anarchist group than in the vegan group. In terms of personality traits, vegans scored higher on the Conscientiousness, Emotionality, and Honesty–Humility dimensions than anarchists did. Anarchists scored higher than vegans on Openness to Experience and Psychopathy. Activists and non‐activists were not distinguished based on gender or personality traits. While the dynamics of power and oppression toward humans and toward animals share common factors, the present results suggest that veganism and anarchism attract anti‐oppression advocates with distinct personality profiles.

Fully gapped pairing state in spin-triplet superconductor UTe2.

The recently discovered superconductor UTe2 is a promising candidate for spin-triplet superconductors, but the symmetry of the superconducting order parameter remains highly controversial. Here, we determine the superconducting gap structure by the thermal conductivity of ultraclean UTe2 single crystals. We find that the a-axis thermal conductivity divided by temperature κ/T in zero-temperature limit is vanishingly small for both magnetic field H‖a and H‖c axes up to H/Hc2 ∼ 0.2, demonstrating the absence of nodes around the a axis contrary to the previous belief. The present results, combined with the reduction of nuclear magnetic resonance Knight shift, indicate that the superconducting order parameter belongs to the isotropic Au representation with a fully gapped pairing state, analogous to the B phase of superfluid 3He. These findings reveal that UTe2 is likely to be a long-sought three-dimensional strong topological superconductor, hosting helical Majorana surface states on any crystal plane.

Physical activity interventions in workplace health promotion: objectives, related outcomes, and consideration of the setting-a scoping review of reviews.

The workplace is a recognized setting for promoting health among adults, and physical activity (PA) interventions are an integral part of workplace health promotion (WHP). The present review of reviews aims to provide an overview of the main objectives and related outcomes addressed in WHP-related PA interventions, as well as the setting-specific aspects considered in the research field. A scoping review of reviews was conducted. Reviews were included if they were peer-reviewed, written in English, and focused on PA interventions conducted in the context of WHP. A literature search was conducted in PubMed, SPORTDiscus, and Web of Science. Reviews were included if they had been published after the year 2000. Information on the following dimensions was extracted: author, region, number of primary studies included, target group(s), PA interventions included, main objective(s), related outcomes, and setting-specific aspects. A total of 17 reviews were included. Six reviews aimed at solely identifying the effectiveness of promoting daily PA and reducing sedentary behavior. Eleven reviews showed a combined approach considering physical activity behavior and/or health and job-related outcomes. Outcomes in the primary studies were heterogeneous. None of the reviews had an explicit definition of WHP and setting-specific information was very general and sparse. The reported setting-specific information was referred to the general importance of the workplace setting, the specific importance as an access route to target groups, and implementation aspects. Regarding the additional characteristics of the reviews, the selection of primary studies was restricted to a specific region in 2 of the 17 reviews in advance. Three reviews restricted the target group (sedentary workers, women, desk-based workers), while eleven reviews included working adults in general and, three reviews gave no information about the target group. Eleven intervention approaches of the reviews were behaviorally oriented, two focused solely on environmental interventions, and four reviews can be attributed to a combined approach considering behavioral and environmental interventions. For sustainable future developments, the present results indicate a strong need for conceptual consolidation of WHP in the research field of PA interventions. Therefore, both WHP and health-related PA interventions need to take a comprehensive approach comprising behavioral and environmental interventions.

A fresh look at nonsmooth Levenberg–Marquardt methods with applications to bilevel optimization

In this paper, we revisit the classical problem of solving over-determined systems of nonsmooth equations numerically. We suggest a nonsmooth Levenberg–Marquardt method for its solution which, in contrast to the existing literature, does not require local Lipschitzness of the data functions. This is possible when using Newton-differentiability instead of semismoothness as the underlying tool of generalized differentiation. Conditions for local fast convergence of the method are given. Afterwards, in the context of over-determined mixed nonlinear complementarity systems, our findings are applied, and globalized solution methods, based on a residual induced by the maximum and the Fischer–Burmeister function, respectively, are constructed. The assumptions for local fast convergence are worked out and compared. Finally, these methods are applied for the numerical solution of bilevel optimization problems. We recall the derivation of a stationarity condition taking the shape of an over-determined mixed nonlinear complementarity system involving a penalty parameter, formulate assumptions for local fast convergence of our solution methods explicitly, and present results of numerical experiments. Particularly, we investigate whether the treatment of the appearing penalty parameter as an additional variable is beneficial or not.

Effect of Microstructure on the Precipitation of β-Mg2Si during Cooling after Homogenisation of Al-Mg-Si Alloys

For Al-Mg-Si alloys, cooling after homogenisation is a crucial step because the precipitation of the equilibrium β-Mg2Si phase determines the processing capabilities in subsequent steps, as well as the subsequent precipitation age hardening potential, and thus, the final properties. It is therefore important to understand how microstructural variations affect the transformation of β-Mg2Si during cooling after homogenisation. In the present work, alloys with similar effective solute contents of Mg and Si, but with different microstructures and a different amount of primary Al-Fe-Si phases, were produced. Characterisation of the precipitation reaction was performed using interrupted quench experiments with cooling rates of 1–6 K/min, monitored by light optical microscopy (LOM), scanning electron microscopy (SEM) and conductivity measurements. Precipitation kinetics for β-Mg2Si was found to increase in microstructures with shorter secondary dendrite arm spacing (DAS). However, despite measuring both a higher density and volume fraction of the primary phases, no effect on the phase transformation from an increased iron content was found in terms of precipitation kinetics or particle count statistics. Furthermore, comparisons with iron-free high-purity-based alloys revealed that the precipitation reaction for β-Mg2Si was identical in the two different microstructures both in terms of onset temperature and overall kinetics. The present results show that nucleation of β-Mg2Si is not dependent on the larger constituent phases and indicates that overall transformation kinetics is governed by bulk diffusion rates.

Exploration the mediating role of adaptive and maladaptive emotion regulation strategies in the relationship between anxiety sensitivity, neuroticism, dysfunctional attitudes towards sleep, and sleep quality among adolescents

Introduction: While a variety of emotional, personality, cognitive, and behavioral factors are linked to sleep quality during adolescence, a comprehensive understanding of these factors remains elusive. Aim: The present study aimed to explore the mediating role of adaptive and maladaptive emotion regulation strategies in the relationship between anxiety sensitivity, neuroticism, dysfunctional attitudes towards sleep, and sleep quality among second-year high school adolescents. Method: The statistical population of this correlational study, which employed structural equation modeling, consisted of all second-year high school students (boys and girls) in Damghan, Iran, during the 2020-2021 academic year. A sample of 329 adolescents was selected through a multi-stage cluster sampling method. To measure the variables under study, the Dysfunctional Beliefs and Attitudes about Sleep Scale (1993), the Anxiety Sensitivity Index (1986), the Children's Emotion Regulation Questionnaire (2003), and the Sleep Quality Questionnaire (1989) were administered. The collected data was analyzed using Pearson’s correlation coefficient test and structural equation modeling in SPSS-22 and AMOS-24. Results: The present results indicated the good fit of the research model for the data. Both adaptive and maladaptive emotion regulation strategies were found to mediate the relationship between the sleep quality of adolescents and anxiety sensitivity, neuroticism, and dysfunctional attitudes and beliefs about sleep (P<0.001). Conclusion: According to the findings, neuroticism, anxiety sensitivity, and maladaptive emotion regulation strategies are linked to a poor sleep quality. Conversely, adaptive emotion regulation strategies are associated with a higher sleep quality. Emotion regulation strategies were found to mediate the relationship between sleep quality and factors, such as anxiety sensitivity, neuroticism, and dysfunctional attitudes and beliefs about sleep. Mental health professionals are advised to consider the components examined in this study as they can play a crucial role in enhancing the sleep quality of adolscentse.

Effects of Nesting Material Provision and High-Dose Vitamin C Supplementation during the Peripartum Period on Prepartum Nest-Building Behavior, Farrowing Process, Oxidative Stress Status, Cortisol Levels, and Preovulatory Follicle Development in Hyperprolific Sows.

Hyperprolific sows often experience increased oxidative stress during late gestation and lactation periods, which can adversely affect the farrowing process and overall lactation performance. This study examines the influence of providing a coconut coir mat (CCM; 1 × 1 m) as nesting material, supplementing high-dose vit-C (HVC; 20% vit-C, 10 g/kg feed) as an antioxidant, or both on maternal behavior, the farrowing process, oxidative status, cortisol levels, and preovulatory follicle developments in sows with large litters. In total, 35 sows (Landrace × Yorkshire; litter size 15.43 ± 0.27) were allocated to the following four treatment groups: control (n = 9, basal diet), vit-C (n = 8, basal diet + HVC), mat (n = 10, basal diet + CCM), and mat + vit-C (n = 8, basal diet + HVC + CCM). A post-hoc analysis showed that compared with sows that were not provided CCM, mat and mat + vit-C groups demonstrated increased durations of nest-building behavior during the period from 24 h to 12 h before parturition (p < 0.05 for both), reduced farrowing durations, and decreased intervals from birth to first udder contact (p < 0.01 for both). The mat group exhibited lower advanced oxidation protein product (AOPP) levels during late gestation and lactation periods than the control group (p < 0.05). Sows with HVC supplementation showed longer farrowing durations than those without HVC supplementation (p < 0.0001). The vit-C group had higher salivary cortisol levels on day 1 after farrowing than the other treatment groups (p < 0.05). Furthermore, the follicle diameters on day 3 after weaning in the vit-C group tended to be smaller than those in the control group (p = 0.077). HVC supplementation prolonged farrowing and increased the physiological stress on postpartum, and no advantageous effects on maternal behavior and developmental progression of preovulatory follicles were observed. Hence, alternative solutions beyond nutritional approaches are required to address increased oxidative stress in hyperprolific sows and secure their welfare and reproductive performance. The present results substantiated the positive impact of providing CCM as nesting material for sows with large litters on nest-building behavior and the farrowing process, which could mitigate the deleterious consequences induced by peripartum physiological and oxidative stress.

Finite-Sample Bias of the Linear Excess Relative Risk in Cohort Studies of Computed Tomography-Related Radiation Exposure and Cancer.

The linear excess relative risk (ERR) is the most commonly reported measure of association in radiation epidemiological studies, when individual dose estimates are available. While the asymptotic properties of the ERR estimator are well understood, there is evidence of small sample bias in case-control studies of treatment-related radiation exposure and second cancer risk. Cohort studies of cancer risk after exposure to low doses of radiation from diagnostic procedures, e.g., computed tomography (CT) examinations, typically have small numbers of cases and risks are small. Therefore, understanding the properties of the estimated ERR is essential for interpretation and analysis of such studies. We present results of a simulation study that evaluates the finite-sample bias of the ERR estimated by time-to-event analyses and its confidence interval using simulated data, resembling a retrospective cohort study of radiation-related leukemia risk after CT examinations in childhood and adolescence. Furthermore, we evaluate how the Firth-corrected estimator reduces the finite-sample bias of the classical estimator. We show that the ERR is overestimated by about 30% for a cohort of about 150,000 individuals, with 42 leukemia cases observed on average. The bias is reduced for higher baseline incidence rates and for higher values of the true ERR. As the number of cases increases, the ERR is approximately unbiased. The Firth correction reduces the bias for all cohort sizes to generally around or under 5%. Epidemiological studies showing an association between radiation exposure from pediatric CT and cancer risk, unless very large, may overestimate the magnitude of the relationship, while there is no evidence of an increased chance for false-positive results. Conducting large studies, perhaps by pooling individual studies to increase the number of cases, should be a priority. If this is not possible, Firth correction should be applied to reduce small-sample bias.

Chemogenetic inhibition of the ventral hippocampus but not its direct projection to the prelimbic cortex attenuates context-specific operant responding.

Previous work has demonstrated the importance of the prelimbic cortex (PL) in contextual control of operant behavior. However, the associated neural circuitry responsible for providing contextual information to the PL is not well understood. In Pavlovian fear conditioning the ventral hippocampus (vH) and its projection to the PL have been shown to be important in supporting the effects of context on learning. The present experiments used chemogenetic inhibition of the direct vH-PL projection or the vH to determine involvement in expression of context-specific operant behavior. Rats were injected with an inhibitory DREADD (hM4Di) or mCherry-only into the vH, and subsequently trained to perform a lever press response for a food pellet in a distinct context. The DREADD ligand clozapine-n-oxide (CNO) was then delivered directly into the PL (experiment 1) and then systemically (experiment 2) prior to tests of the response in the training context as well as an equally familiar but untrained context. vH (systemic CNO) but not vH-PL (intra-PL CNO) inhibition was found to attenuate operant responding in its acquisition context. A third experiment, using the same rats, showed that chemogenetic inhibition of vH also reduced Pavlovian contextual fear. The present results suggest that multisynapatic connections between the vH and PL may be responsible for integration of contextual information with operant behavior.

Intellectual property in professional and technological education: transversal and interdisciplinary strategy in integrated secondary education

The project deals with the insertion of Intellectual Property (IP) as a transversal and interdisciplinary strategy in the integrated high school courses of the Federal Institute of Education, Science and Technology of Pará (IFPA) Campus Belém. We understand that socioeconomic development permeates IP, in direct proportion to technological innovation becoming more and more present, with the process of education and dissemination of IP as a generating problem, and as a dispersing core of research for formative convergence on the Campus of IFPA Belém , anchored in the Education and Dissemination constructs. We chose to develop the Action-Research methodology, taking into account the strategic actions proposed with the target audience. We hope to present results on the efficiency of convergence, based on a growing number of technological products developed and disseminated. Make an educational product viable at the end of the process, tending to IP as a didactic strategy. This project aims to make it possible to understand two different aspects and fields of protection of IP, in addition to highlighting the role of integration between IP and Professional and Technological Education (EPT) in the integral development of the being and its relations with the economy. Ultimately, this development, which originates locally, expands and occupies a prominent place on the global stage as technological innovation becomes the focus of competitiveness. It is expected that, by incorporating IP and the development of its competencies in the teaching-learning curriculum, students and teachers can instigate, in addition to an interest in science, inventiveness or planning, a vision of the market or entrepreneurship, resilience, attitudes and values .

Expression of the immune checkpoint molecules CD226 and TIGIT in preeclampsia patients

BackgroundImbalanced immune responses are involved in developing preeclampsia (PE). We wish to explore the expression and potential changes of immune checkpoint molecules TIGIT, CD226 and CD155 in PE patients.MethodsThe expression of the immune checkpoint molecules TIGIT, CD226 and CD155 in different lymphocyte subpopulations was determined by flow cytometry in 24 patients with PE and compared to 24 healthy pregnant women of the same gestational age as the controls.​Serum CD155 was detected by ELISA in the patients with PE compared to controls.ResultsThe percentages of CD4+ and CD8+ T lymphocytes in the peripheral blood of PE patients were not significantly different from those of the controls, whereas the regulatory T cells (Tregs) in PE patients were significantly lower than those in controls (6.43 ± 1.77% vs. 7.48 ± 1.71%, P = 0.0420). The expression of TIGIT and CD226 showed different percentages on CD4+ T cells, CD8+ T cells and Treg cells. However, the difference in the percentages of TIGIT, CD226 on these T cells between the two groups was not statistically significant. The level of CD155 in peripheral serum of PE patients was 6.64 ± 1.79 ng/ml, which was not significantly different from that in the control group 5.61 ± 1.77 ng/ml, P = 0.0505. The present results demonstrate that TIGIT, CD226 and CD155 are not present at altered immune conditions in the peripheral blood of patients with PE, compared with normal pregnant women.ConclusionThe immune checkpoint molecules TIGIT, CD226 and CD155 are not abnormally expressed in PE patients.

An Evaluation of the Relationship Between Professional Self-Esteem and Job Satisfaction Levels of Audiologists According to Their Workplace Types.

The concept of occupational self-esteem is the value judgment developed towards the chosen profession, while job satisfaction includes positive emotional attitudes towards the job. Professional self-esteem and job satisfaction levels of audiologists are a matter of curiosity. To determine the effect of the workplace types of audiologists in Turkey on their professional self-esteem and job satisfaction levels. The study included 307 audiologists working in various types of workplace. Participation in the study was voluntary. A Personal Information Form, Arıcak's Occupational Self-Esteem Scale, and the Minnesota Job Satisfaction Scale were administered in all individuals via Google forms and the scale scores were compared according to the workplace types. A statistically significant relationship was found between professional self-esteem and job satisfaction, age, satisfaction with workplace, satisfaction with working conditions, effect of workplace on professional development, and income satisfaction (p<0.05). However, no statistically significant relationship was found between professional self-esteem and professional tenure and tenure in the current organization (p>0.05). There was a strong positive statistically significant relationship between job satisfaction and professional self-esteem of audiologists working at state hospitals, hearing aid centers, university hospitals, rehabilitation centers, and cochlear implant centers and academics (p<0.05). According to the present results, although the professional self-esteem of audiologists in Turkey showed a small difference according to the type of workplace, their mean score was high. This shows that audiologists enjoy their profession. Job satisfaction levels were lower especially in rehabilitation centers and private hospitals. We think that improving the working conditions of audiologists in private institutions will be effective in improving the services provided to patients by leading to better job satisfaction.

In silico analyses of the involvement of GPR55, CB1R and TRPV1: response to THC, contribution to temporal lobe epilepsy, structural modeling and updated evolution.

The endocannabinoid (eCB) system is named after the discovery that endogenous cannabinoids bind to the same receptors as the phytochemical compounds found in Cannabis. While endogenous cannabinoids include anandamide (AEA) and 2-arachidonoylglycerol (2-AG), exogenous phytocannabinoids include Δ-9 tetrahydrocannabinol (THC) and cannabidiol (CBD). These compounds finely tune neurotransmission following synapse activation, via retrograde signaling that activates cannabinoid receptor 1 (CB1R) and/or transient receptor potential cation channel subfamily V member 1 (TRPV1). Recently, the eCB system has been linked to several neurological diseases, such as neuro-ocular abnormalities, pain insensitivity, migraine, epilepsy, addiction and neurodevelopmental disorders. In the current study, we aim to: (i) highlight a potential link between the eCB system and neurological disorders, (ii) assess if THC exposure alters the expression of eCB-related genes, and (iii) identify evolutionary-conserved residues in CB1R or TRPV1 in light of their function. To address this, we used several bioinformatic approaches, such as transcriptomic (Gene Expression Omnibus), protein-protein (STRING), phylogenic (BLASTP, MEGA) and structural (Phyre2, AutoDock, Vina, PyMol) analyzes. Using RNA sequencing datasets, we did not observe any dysregulation of eCB-related transcripts in major depressive disorders, bipolar disorder or schizophrenia in the anterior cingulate cortex, nucleus accumbens or dorsolateral striatum. Following in vivo THC exposure in adolescent mice, GPR55 was significantly upregulated in neurons from the ventral tegmental area, while other transcripts involved in the eCB system were not affected by THC exposure. Our results also suggest that THC likely induces neuroinflammation following in vitro application on mice microglia. Significant downregulation of TPRV1 occurred in the hippocampi of mice in which a model of temporal lobe epilepsy was induced, confirming previous observations. In addition, several transcriptomic dysregulations were observed in neurons of both epileptic mice and humans, which included transcripts involved in neuronal death. When scanning known interactions for transcripts involved in the eCB system (n = 12), we observed branching between the eCB system and neurophysiology, including proteins involved in the dopaminergic system. Our protein phylogenic analyzes revealed that CB1R forms a clade with CB2R, which is distinct from related paralogues such as sphingosine-1-phosphate, receptors, lysophosphatidic acid receptors and melanocortin receptors. As expected, several conserved residues were identified, which are crucial for CB1R receptor function. The anandamide-binding pocket seems to have appeared later in evolution. Similar results were observed for TRPV1, with conserved residues involved in receptor activation. The current study found that GPR55 is upregulated in neurons following THC exposure, while TRPV1 is downregulated in temporal lobe epilepsy. Caution is advised when interpreting the present results, as we have employed secondary analyzes. Common ancestors for CB1R and TRPV1 diverged from jawless vertebrates during the late Ordovician, 450 million years ago. Conserved residues are identified, which mediate crucial receptor functions.

The effect of music on pain management in preterm infants during daily painful procedures: a systematic review and meta-analysis.

The present systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the effects of music on pain management in preterm neonates during painful procedures. The PubMed, Embase, Web of Science, EBSCO and Cochrane Library databases were searched to identify relevant articles published from their inception to September 2023. The study search strategy and all other processes were implemented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Four RCTs that satisfied the inclusion criteria were included in this meta-analysis. The music group had significantly lower Premature Infant Pain Profile (PIPP) scores during (RR = -1.21; 95% CI = -2.02--0.40, p = 0.0032) and after painful procedures (RR = -0.65; 95% CI = -1.06--0.23, p = 0.002). The music group showed fewer changes in PIPP scores after invasive operations than did the control group (RR = -2.06; 95% CI -3.16--0.96; p = 0.0002). Moreover, our results showed that music improved oxygen saturation during (RR = 3.04, 95% CI = 1.64-4.44, p < 0.0001) and after painful procedures (RR = 3.50, 95% CI = 2.11-4.90, p < 0.00001). However, the change in peak heart rate during and after painful procedures was not statistically significant (RR = -12.14; 95% CI = -29.70-5.41 p = 0.18; RR = -10.41; 95% CI = -22.72-1.90 p = 0.10). In conclusion, this systematic review demonstrated that music interventions are effective for relieving procedural pain in preterm infants. Our results indicate that music can reduce stress levels and improve blood oxygen saturation. Due to the current limitations, large-scale, prospective RCTs should be performed to validate the present results.

Creatinine levels in French children with Down syndrome up to ten years old.

Assess creatinine levels in French children with Down syndrome (DS) on the basis of the relationship between creatinine levels and age. The study included 279 children with DS aged 0 to 10years who had been regularly monitored between 2004 and 2021 in a single genetics department and who had had at least one creatinine measurement. The creatinine level curves were established by estimating the median and the quantiles of order 2.5 and 97.5% according to age. A Generalized Additive Model for Location, Scale, and Shape was used. The results showed higher creatinine levels in children with DS than in children from the general population. Conclusion: The present results allow to propose an original chart of creatinine levels according to age in French children with DS, which should help optimize their medical management and improve the early detection of renal diseases. What is Known: • Creatinine is a product of muscle breakdown and depends on muscle massand children with Down syndrome have muscle and growth characteristics that differ from those of the general paediatric population. • Serum creatinine values in Japanese children with DS are higher than those of children from the general Japanese population. What is New: • Creatinine values in French children with DS are higher than those of children from the general French population. • The proposed original chart for creatinine values according to age, specifically designed for individuals up to 10years old, should serve for further investigation, prevention, and follow-up of children with DS.

Body dysmorphic disorder in adult orthodontic treatment candidates according to the index of treatment need

Objectives: Body image perception plays an important role in seeking orthodontic treatment. Body dysmorphic disorder (BDD) is a psychological condition where an individual constantly focuses on flaws in their appearance. This study aimed to assess BDD in adult orthodontic treatment candidates according to the index of treatment need (IOTN) in Qazvin city in 2020. Material and Methods: This descriptive study was conducted on 404 eligible patients over 18 years of age presenting to dental clinics in Qazvin seeking orthodontic treatment. The patients were categorized according to their IOTN (grades 1–5) and filled out the Body Deformation Metacognition Questionnaire (BDMCQ). Data were analyzed by t-test and Analysis of Variance using the Statistical Package for the Social Sciences. Results: Of all the patients, 50.2% were grade 1 (no need for treatment),and 1.5% were grade 5 (very great need for treatment). Furthermore, 54.5% of patients had severe BDD. BDD had no significant correlation with gender or marital status (P &gt; 0.05). BDD was significantly correlated with age, educational level, and IOTN grade (P &lt; 0.05). Conclusion: The present results revealed that over 50% of patients seeking orthodontic treatment did not need treatment, according to the IOTN. Dental clinicians are advised to be more careful in accepting patients with a history of psychological problems and numerous surgical procedures who seek cosmetic treatments.

Systematic mapping of climate and environmental framing experiments and re-analysis with computational methods points to omitted interaction bias

Ambitious climate policy requires acceptance by millions of people whose daily lives would be affected in costly ways. In turn, this requires an understanding of how to get the mass public on board and prevent a political backlash against costly climate policies. Many scholars regard ‘framing’, specially tailored messages emphasizing specific subsets of political arguments to certain population subgroups, as an effective communication strategy for changing climate beliefs, attitudes, and behaviors. In contrast, other scholars argue that people hold relatively stable opinions and doubt that framing can alter public opinion on salient issues like climate change. We contribute to this debate in two ways: First, we conduct a systematic mapping of 121 experimental studies on climate and environmental policy framing, published in 46 peer-reviewed journals and present results of a survey with authors of these studies. Second, we illustrate the use of novel computational methods to check for the robustness of subgroup effects and identify omitted interaction bias. We find that most experiments report significant main and subgroup effects but rarely use advanced methods to account for potential omitted interaction bias. Moreover, only a few studies make their data publicly available to easily replicate them. Our survey of framing researchers suggests that when scholars successfully publish non-significant effects, these were typically bundled together with other, significant effects to increase publication chances. Finally, using a Bayesian computational sparse regression technique, we offer an illustrative re-analysis of 10 studies focusing on subgroup framing differences by partisanship (a key driver of climate change attitudes) and show that these effects are often not robust when accounting for omitted interaction bias.

Daytime sleepiness in depression—underestimated in psychiatric inpatients

Abstract Background Sleep disorders are among the most common symptoms of depression. Both the ICD-10/11 and DSM‑5 list sleep disorders of all types as diagnostic criteria for depression, but these are not defined in detail. Objective This study focused on the prevalence of daytime sleepiness and associated sleep disorders in patients diagnosed with a severe depressive episode. Materials and methods In total, 192 inpatients with a moderate/severe depressive episode from an open acute psychiatric ward were included. Sleep history immediately after admission and sleep-related questionnaires, such as the Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS), and Regensburg Insomnia Scale (RIS), were collected. Polysomnographic assessment was performed in 82 patients with suspected sleep disorders. Patient groups (e.g., with and without sleepiness or apnea) were compared. Results The prevalence of daytime sleepiness (ESS &gt; 10) was 25.3%. Fatigue and insomnia were reported in 66.7 and 75.7% of patients, respectively. Polysomnography revealed a prevalence of sleep apnea of 18.2%, and sleep apnea was newly diagnosed in 80% of these patients. Daytime sleepiness was more common in patients with undiagnosed sleep apnea. Patients with daytime sleepiness had more fatigue but did not have more severe depression. Conclusion The present results highlight the importance of assessing sleep history in psychiatric patients, especially those with depression. The ESS may be a useful tool to specifically assess daytime sleepiness as opposed to depression-related fatigue. A systematic assessment of sleepiness and specific sleep disorders, in particular sleep apnea, might contribute to improved treatment of inpatients with depression.