Present Invention Research Articles

Synthetic Approaches to Gliclazide: An Antidiabetic Medication

AbstractType 2 diabetes mellitus (T2DM) remains a global health concern, causing a significant threat to world health. Oral anti‐diabetic drugs play a crucial role in effective management of diabetes. Numerous anti‐diabetic medications have been known for a long period, classified according to their chemical groups but because of their low pharmaceutical cost and long‐term efficacy, sulphonylurea (SU) continues to be a well‐positioned medication with a long history of clinical use in treating type 2 diabetes. Among various available SU, Gliclazide stands out due to its significant reduction in cardiovascular mortality and extremely low rate of severe hypoglycaemia. Numerous synthetic methodologies have been developed to create more efficient pathways resulting in less waste and cheaper manufacturing. The present review aims to summarise some recently reported literature for the synthesis of Gliclazide. We have made an effort to highlight their drawbacks and advantages in this comparative analysis. Here we tried to compile different synthetic routes via various methods to synthesise Gliclazide which will serve as a valuable foundation to make potential modifications to the present inventions. This effort ultimately aims to contribute to the enhancement of the society's health and welfare.

Magnetic nanoparticles and quantum dots coupled immuno nano fluorescence assay for visual detection of HPV16-induced cervical cancer cells from cytology/biopsy samples

Biopsy-based histopathology and immunohistochemistry for cervical cancer detection are costly, time-consuming, and require expert personnel for data interpretation. We developed a simple magnetic nanoparticle (MNPs) and quantum dots (QD) coupled immuno nano fluorescence assay (MNPQDCINFA) for visual detection of HPV16-induced cervical cancer cells under UV light from cytology/biopsy samples exploiting host cancer cells expressing viral E7 protein as a biomarker. The E7 domain-specific polyclonal antibodies were generated against the 1–44 amino acid N-terminal (anti-domainN antibody) and 48–98 amino acid C-terminal domain (anti-domainC antibody). These antibodies were bioconjugated with nonfluorescent MNPs (60 % efficiency) and fluorescent QDs (66 % efficiency) to generate capturing (MNPs-anti-domainN antibody) and detecting (QDs-anti-domainC antibody) nano-complex, respectively. Assay conditions, such as concentration of capturing (20 μM) and detecting (50 nM) antibody nano-complexes and incubation duration (30 min), were standardized. The analytical sensitivity using pure HPV16 E7 protein was recorded up to 200 ng with very high specificity to differentiate from other HPV strains E7 proteins. The diagnostic performance characteristics with cytology samples showed 100 % sensitivity and specificity compared to immunofluorescence and biopsy-based histopathology analysis. The present invention can be effectively used for a quick, disposable, rapid cervical cancer cell detection system as an alternate test for immunofluorescence and histopathology.

A study on the efficacy of an attention mechanism-based strategy planning method for stock trading portfolios

In order to take full advantage of the fact that there is a large amount of information and data available in the field of stock trading, this paper develops a new type of stock trading strategy, which reduces investment risk. A stock trading portfolio strategy planning method based on an attention mechanism, as disclosed in the present invention, relates to the field of stock trading technology. The introduction of an attention mechanism allows the strategy to focus on those stocks with higher evaluation coefficients, thereby improving the selectivity and accuracy of the strategy and thus the effectiveness of the portfolio strategy. Furthermore, based on the prediction results of the deep spatio-temporal neural network model, it is possible to determine the stock's short-term trends and identify the optimal trading points. This information can be utilized as a reference for investors, assisting them in making more informed decisions regarding the timing of buying and selling, improving the success rate and yield of trading, enabling them to swiftly and accurately assess the performance of each stock, facilitating timely adjustments to their portfolios, and enabling them to devise the optimal trading strategy and timing for each stock, enhancing the accuracy and efficiency of their trading decisions.

Geogrid-type geotextile made from Typha domingensis fibers with high tensile strength for erosion control

The present invention relates to a geotextile of the geogrid type manufactured with fibers from the Typha domingensis plant, known as cumbungi, recognized for its remarkable tensile strength. This geotextile is developed to mitigate erosive processes and is produced from natural fibers arranged in a mat configuration. This product fit in with the technical fields of civil engineering and textile materials. The central innovation of this geotextile lies in the provision of a natural alternative featuring biodegradable fibers and high tensile strength. Its applications in environmental engineering include erosion prevention, slope stabilization, and reinforcement of road structures, with the fundamental goal of preserving the soil against degradation and erosion. This high-strength geotextile is composed of Typha domingensis fibers skillfully interwoven and connected to form a grid structure, with each unit covering approximately 0.25 m2s. Furthermore, a double layer of waterproofing material is incorporated to provide greater cohesion, environmental durability, and tensile strength. In practical applications, this geotextile demonstrates a remarkable ability to withstand mass movements even before local vegetation develops. This makes it a technological alternative that synergistically combines technological and ecological processes, incorporating the principles of soil bioengineering while offering a sustainable alternative to synthetic geotextiles. The use of this geotextile in the field is preferably combined with living components such as seeds, plant stakes, wood, or rocks for slope or embankment stabilization, with a primary focus on effective erosion control and the promotion of environmental sustainability.

Concept of combined strain-stress state control of long span structures

Purpose: Argumentation of necessity of special protective system design to protect structures in seismic zones and remote areas from specific loads. Such protective system combines seismic isolation and internal force control systems.Research findings: Restrictions of long-span structures construction are reviewed. Such restrictions are caused by building conditions embodied in National Building Codes and Standards. Combined and separate use of seismic isolation and internal force control systems is a critical specific load protection. Present inventions and experience in the field of seismic isolation and internal force control systems are reviewed.Value: The article determines problems of protective system design based on the control for combined strain-stress state.

Esterified Conditioner and Repairing Agent for Salinity Affected Agricultural Soil of India

Various bio-conversion reactions given by lipases such as hydrolysis, transesterification, esterification, alcohoysis, acidolysis and aminolysis. The potential esterification process in soil plays important role not only as a fertilizer or nutrient but also act as a modulator to alter the conditions of soil and help in uptake of nutrient and minerals. This potential formulation accumulates micro-nutrients and mineral that promotes growth of plants. The trials of vegetable plants and grains shown significant increase in crop yield per hector area. The bulk density and field capacity of the soil are also significantly change and act as soil conditioner also influence the growth of plants. The micronutrients uptake of plant helps optimize the soil pH and improve the soil conditions. The inventors of present invention tested formulation as plant growth promoters that enhance crop characteristics like panicle length, plant height, grain or fruit yield and add to nutrient value of the crop. Our product is fatty acid composite which play crucial role as plant growth promoter along with reducing seed germination time and increasing plant crop yield, it also beneficial to work under water stress conditions and variant geo-climatic conditions.

Vibraharp: perkusinio-klavišinio instrumento klaviatūros dėklas ir jo naudojimo būdas

The present invention (Vibraharp bag, LT6937B) is a keyboard bag for a percussion keyboard instrument (vibraphone, marimba, xylophone, or the like) for the safe operation and transportation of the keyboard, which is the most essential and expensive component of this class instruments. Unlike known bags for a similar purpose, this bag uses special internal key tabs which, when placed on the keyboard, inserts into the gaps between adjacent keys, thus separating them and preventing them from coming into mutual contact, under various operating and transport conditions. This bag helps to protect the keyboard of the instrument from unwanted physical impact and damage, and allows for more convenient and efficient mounting and unmounting of the keyboard during assembly and disassembly of the instrument.

A New Gesture Recognition Technology Used in Intelligent Inspection Drones

The present invention relates to an alarm method for recognizing gestures based on a camera, comprising: setting a gesture data set; establishing a frame by the camera to recognize the trend of human activities; recognizing human gestures by using a convolutional neural network; comparing a captured binary gesture image with a security gesture, and setting a counter parameter with a value of 1; if the gesture image is successfully compared with the security gesture, setting the value of the parameter to plus 1; if comparison between the gesture image and the security gesture fails, setting the value of the parameter to 0; and when the value of the parameter is greater than three, establishing a signal for the camera and the receiving device. The camera of the present invention uses the convolutional neural network to recognize human gesture, processes the human gesture and compares a gesture image with a security gesture. After the conditions are met, the position is sent to a receiving device of the police officer on duty to call the police in time, thereby reducing the frequency of crime. In the whole process, the camera is used for the capturing, and a person injured can effectively prevent more serious persecution without shouting.

Improved Operation and Method of a Reaction Turbine for Enhancing Net Head

In a reaction turbine, the amount of energy harnessed depends on discharge and net head. The two variables are mutually exclusive or in which one variable is dependent on another and in which the increase of head will decrease the flow required by the hydraulic turbine or vice versa. There is a need for improving the existing hydropower system and the method for enhancing the net head of a reaction turbine is essential. The present invention will hold the key in novelty during the design and excavation of tail race channel or for Renovation, Modernization and Uprating (RMU) of the existing old hydro power plants. The proper redesign of tail water channel, selecting suitable width, depth and by adopting flow regulating means will yield improve the net head substantially and thereby saving of discharge to an extent. The present invention enables to improve net head and saves discharge considerably, thereby enhancing the capacity factor of the hydro plant. The novelty and the innovation is granted an Indian patent for the method of enhancing the net head of a reaction turbines.

Preparation of titanium dioxide nanoparticles from Solanum Tuberosum peel extract and its applications

The present study describes a method for the preparation of green titanium dioxide (TiO2) nanoparticles from the peel of Solanum tuberosum, commonly known as potato, and the potato peel being a kitchen waste. The green synthesized TiO2 (G- TiO2) nanoparticles were characterized using UV-visible spectroscopy, dynamic light scattering, scanning electron microscopy, TEM, XRD, and FTIR spectroscopy. The photocatalytic activity of the G- TiO2 nanoparticles was also shown using the dye bromophenol blue. To explore the biocompatibility of the G- TiO2, the cell viability in normal as well as cancer cells was assessed. Further, the in vivo toxicity of the G- TiO2 nanoparticles was assessed using zebrafish embryos. The novelty of the present invention is to utilize kitchen waste for a useful purpose for the synthesis of titanium dioxide nanoparticles which is known to have UV light scavenging properties. Moreover, the potato peel is a natural antioxidant and possesses a skin-lightening effect. A combination of the potato peel extract and titanium dioxide prepared using the extract will have a combinatorial effect for protecting UV light exposure to the skin and lightening the skin colour.

Relay demonstration on board for final year student

The present invention relates to a relay demonstration board, characterized by a microcontroller, numbers of relays are connected to the microcontroller by a plurality of switches, wherein the first relay is connected to a light bulb for controlling the lighting of the bulb and the second and third relay are connected to a DC motor for controlling the rotational direction of the motor. Accordingly, these objectives may be achieved by following the teachings of the present invention. This invention relates to a relay demonstration board for teaching and learning purpose. An electrical relay is an electromagnetic switch operated by a relatively small electric current that can control a much bigger current and thus enable both circuits to be electrically isolated from each other. Relays have been used in wide variety of applications such as home appliances, digital computers and automation system due to its simplicity, long life and high reliability. The project present invention relates to a relay demonstration board. It is developed to allow students to understand the function of relay and how to connect relay in circuit. The major components include three relays, one light bulb and one direct current (DC) motor. The relays are used for control purpose while the light bulb and DC motor are used as the output. Furthermore, the light can be connected in alternating current (AC) or DC circuit to show students how to connect AC circuit and DC circuit. Besides, this tool are invention can be connected to an external microcontroller such as an Arduino board to provide input and or signal to the circuit.

Innovative Photovoltaic Cooling System

With the ever-increasing adoption of solar energy and the lack of space for PV installations, targeting maximum photovoltaic operational efficiencies has become essential. One of the key challenges faced by PV installations in warm climates is thermal management, which is caused by increasing temperatures due to PV conversion inefficiencies and limited ventilation possibilities in certain installations. Despite prior art, further improvement is still needed to provide a novel system that can offer more efficient and controllable temperature decrease of photovoltaic modules in both land and offshore installations. The present invention, termed IPCoSy, satisfies the aforementioned needs in the art by providing a novel system for cooling a solar panel assembly, including at least one photovoltaic module having a plurality of solar cells generating electrical power and a PV junction box attached to the back of the photovoltaic module. A part of this invention discloses a new type of PV module that is a modification of standard commercial modules. This new PV module incorporates a water chamber at the back of a solar cell assembly to regulate operational temperatures. Another part of this invention presents an after-market cooling system that can be fitted to existing standard PV modules to add the cooling effect. This part of the invention presents solid and flexible water tanks that can be fitted directly into a gap at the back of standard PV modules. Moreover, this invention presents details on parts that distinguish this cooling system from prior art, such as an internal stream spreader to obtain better fluid dynamics and external fittings that allow the PV module to be installed at any tilt angle without jeopardising the cooling effect. Finally, this invention discloses different application areas of this cooling system, such as residential and industrial water heating, reverse osmosis plants and offshore photovoltaic installations, showcasing the product's versatility, adaptability and large market suitability.

Molten air—A new class of high capacity batteries

The present invention relates to rechargeable electrochemical battery cells (molten air batteries). The cells use air and a molten electrolyte, are quasi-reversible (rechargeable) and have the capacity for multiple electrons stored per molecule, have high intrinsic electric energy storage capacities. The present disclosure also relates to the use of such in a range of electronic, transportation and power generation devices, including as greenhouse gas reduction applications, electric car batteries and increased capacity energy storage systems for the electric grid. US patent 10637115 is for the invention of air and carbon or CO2 Molten Air batteries, while US patent 11094980 is for the invention of air and metal, boron and a variety of salt/Molten Air batteries.

A steel joint for driven precast concrete geothermal energy pile foundations

This invention describes a steel joint used for connecting two precast concrete driven energy pile (DEP) segments which is known as DEP joint. Precast concrete DEPs are cast in segments with a maximum length of 12 m at a concrete factory. DEPs are typically driven into the ground until bedrock; hence, in places where the bedrock is deeper than 12 m, two or more segments must be connected using a joint to produce longer energy piles. DEPs have not been frequently used because no suitable joint existed that could maintain structural integrity and provide leak-proof coupling between the pipes at the joint interface. The present invention addresses this problem by designing a steel joint that can meet the structural and hydraulic requirements of a suitable steel joint for DEPs. Each quadratic concrete energy pile segment is prefabricated in a concrete factory, where the heat transfer pipes are embedded inside the steel cage of each segment. The steel DEP joint is installed at one or both ends of each concrete segment, and has two or four sidewall channels, depending upon its size. Heat transfer pipes are coupled between every two segments, inside the sidewall channels, while the energy piles are installed at a construction site. The sidewall channels are protected using steel shielding plates that are riveted to the joint so that the pipes and the coupling inside the sidewall channels are protected against harsh frictions during the installation of the DEPs in the ground. The steel joint facilitates the installation of longer precast concrete energy piles up to the bedrock depth, especially in sites where the bedrock is deeper than a single segment length. The main advantages of precast concrete energy piles compared to cast-in-place piles are that they enable better quality control and quality assurance, as well as being easier, faster, and cheaper to install. The invented DEP joint has passed structural integrity tests as required according to the BS EN 12794 standard, and also passed hydraulic pressure tests according to the ASTM F2164 – 21; hence, it is certified to be used in construction projects. We are now looking for potential licensees to start manufacturing the joints and using them in the energy pile industry.

Preparation method of a whole nutrient special medical food with thickening function for dysphagia

Dysphagia, a serious health issue, is common in healthcare residents and the elderly. The invention provides a method and a formulation for preparing and using a special medical food product for people with dysphagia. The main raw materials used include starch, corn oil, and soy protein. The preparation method of the product is simple, and the concentration can be adjusted to meet the needs of different patients with dysphagia, so that the patients with dysphagia can consume the product safely, and the risk of accidental aspiration can be effectively reduced. The whole nutrition special medical use formula food of the present invention can provide sufficient nutrients, and can meet the basic nutritional requirements needed by the population of patients with dysphagia.

In Vivo Quantitative Assessment of Gestational Choriocarcinoma Development and Progression Using Luminescent Trophoblast Cells.

Gestational trophoblastic diseases (GTD) are a group of pregnancy-related disorders representing rare human tumors. Among GTD is the gestational choriocarcinoma (CC), which is a highly malignant gestational trophoblastic tumor that causes high mortality without timely treatment. The incidence of CC is about 1 in 50,000 pregnancies in developed countries and even higher in developing countries. CC developed from molar pregnancies exhibits even higher incidence rates (3-20 in 1000 pregnancies). In the present invention, we developed the first orthotopic animal model of CC. We demonstrate how to mimic the development of this cancer and observe rapid metastasis, which is seen in CC patients, by injecting the luciferase-positive JEG-3 (JEG-3-Luc) cells directly in the placenta of gravid SCID mice. Gravid mice were injected at 7.5days post coitus (dpc) and followed throughout gestation to assess the parameters of CC development and metastasis. Mice imaged at day 19.5dpc showed placental tumor development and large sites of metastases in the liver, spleen, lung, and peritoneum. This finding emphasizes the importance of placental vascularization in the rapid dissemination of tumor cells. Morphological analyses and histopathological examinations were performed to confirm JEG-3 cell dissemination in different organs of the gravid mice. This is the first time a CC model was developed by injection of tumor cells within the placenta. This technique offers a new tool to study tumor progression with strong perspectives to test anti-tumor agents in vivo.

Laboratory-scale extraction of Hildegardia barteri (Mast.) Kosterm. seed oil with different solvents, purified with membrane filtration

Abstract The shortcomings encountered from the use of conventional methods of refining draw considerable attention when it comes to the processing of edible oils. The present invention to this effect is the usage of membrane technology, which stands out as a suitable alternative, as it offers significant advantages such as minimal chemical additions, low energy consumption, and the retention of nutrients and other desired components. This paper seeks to ascertain the quality of edible oil extracted by different solvents, refined via membrane filtration. Amounts of 25 mL of crude oil sample were extracted with three different solvents (n-hexane, ethanol, and n-hexane-ethanol blend) from seeds of Hildegardia barteri (Mast.) Kosterm. and were refined using a micro-filter of pore size of 0.45 µm and an ultrafiltration membrane with 50 kDa cut off before bleaching and deodorizing to obtain table oil. Proximate composition and elemental analyses were carried out on the table oil samples produced and compared with food-grade standards. Results obtained showed 0.133–0.53% moisture content, 0.04% ash, 98.90–99.67% ether extract, 0.23% carbohydrate, and elemental compositions of 51.60–55.00% C, 6.12–6.30% H, 6.21–6.28% O, 0.01–0.02% N, and 13.0–15.0% P for edible oil samples. The findings of this study indicate that edible oil produced from the seeds of H. barteri via membrane technology yields good-quality oil for commercial production, except for the need to enhance further reduction of phosphorus content.

Steroid sulfatase inhibitors and sulfated C19 steroids for proteotoxicity-related diseases: a patent spotlight.

Aging and proteotoxicity go hand in hand. Inhibiting proteotoxicity has been proposed to extend lifespan. This invention describes a new strategy to limit proteotoxicity and to extend the lifespan. Loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase, elevates the pool of sulfated steroid hormones, increases longevityand ameliorates protein aggregation diseases. The present invention provides a group of molecules for use in the prevention of aging-associated proteotoxicity caused by proteinaggregation diseases and/or to increase the lifespan of a eukaryotic organism. These molecules are either steroid sulfatase inhibitors or sulfated C19 steroids, both of which reproduce the phenotype of sul-2 mutants. One particular representative example is STX-64. Potential applications of the claims have been demonstrated in animal models of Parkinson's disease, Huntington's diseaseand Alzheimer's disease.

Role of EhretialaevisRoxb.. (Ajan Vruksha/Khandu Chakka) Medicated Thread in Fistula- In- Ano: - Randomised Clinical Trial

Ehretialaevisroxb. is a traditional herbal plant used for various purposes, mainly wound healing and pain relief. This plant isalso known as AjanVruksha and commercially known as Khandu Chakk. Wound healing & pain relief activities of Ehretialaevisroxb.(AjanVruksha/Khandu Chakka) are used for making a novel herbal medicated thread in fistula- in- ano to avoid the untoward effects oftraditional Ksharsutra, commonly used in Ayurved practice for Fistula-in ano management. Fistula in ano is the abnormal tract having oneopening inside the anal canal and one opening at the perianal skin. Many modalities are available for the treatment of fistula in ano, likeKsharsutra, fistulotomy, fibrin glue injection, and fistula plug. Sometimes there are many tracts. Novel herbal thread comprisesehretialaevisroxb., Achyranthesaspera Linn., Ficusracemosa. A novel herbal thread was applied in group A of 75 patients and in group B of 75patients, a conventional thread was applied. The study is based on a superior clinical trial. To determine the efficacy of the compositionof the present invention, the clinical parameters of pain, bleeding, discharge, itching, tenderness, hyper granulation, and unit cutting timewere evaluated after every week. The novel thread was found more efficient in pain relief, discharge, etching, cutting rate, bleeding, andhyper granulation, than a conventional thread in this study. We aim to provide a medicated thread for fistula-in- ano, which canovercome deficiencies associated with the known arts and provide effective and safe treatment for affected patients. And to achieve thisaim, our objectives are to assess the efficacy of Novel Medicated thread and Conventional Ksharsutra in promoting healing in fistula- inano,along with comparing the efficacy of both threads.

Impact of Ultrasound Treatment Duration on Dihydrate Precursor Implying the Sesquihydrate Route

AbstractThe present invention relates to a technique for synthesizing vanadium phosphorus oxide (VPO) catalyst employing an ultrasonic treatment approach while assessing phase composition and hydrocarbon oxidation activity to a conventionally synthesized catalyst. The ultrasonic treatment approach has been shown to produce a catalyst with improved surface constitution and accelerated hydrocarbon conversion in 3 h, as opposed to the typically heating process, which takes 24 h. Product selectivity is influenced by the nature of the catalyst, with an integration consisting of (VO)2P2O7 (V4+) and VOPO4 (V5+) being optimal for high rate of conversion. A 39 % conversion rate and 89 % maleic anhydride selectivity were achieved under optimum reaction conditions.