Present Data Research Articles

모바일 화장품 앱 활용현황 및 소비자의 구매행동이 구매만족도에 미치는 영향

While the mobile environment is rapidly absorbing new beauty-related information, the information of mobile cosmetics apps is playing an important role in changing women's personality, beautiful appearance, and life. The purpose of this study is to understand the characteristics of mobile cosmetics apps from this point of view, and through this, the effect of cosmetics apps' utilization status and cosmetics consumers' purchasing behavior on purchase satisfaction. This study was conducted as an empirical analysis through theoretical consideration and questionnaire method. Previous studies, academic journals, reports, and presentation data were collected and analyzed to understand the characteristics and current status of the cosmetics market, and cosmetics purchase behavior through mobile cosmetics apps was analyzed. A questionnaire was conducted and empirical analysis was conducted to analyze the cosmetics purchase behavior, satisfaction, and usage status of cosmetics apps by consumers through the app. The results of the study are as follows. The group that uses mobile cosmetics apps the most is office workers under their 20s, and the preference for cosmetics apps is Olive Young, which is rich in product information, because it is well suited to the lifestyle of the 20s. Housewives in their 50s used offline more than apps. Through this, it can be seen that people in their 20s who are familiar with smartphones use mobile cosmetics apps more than those in their 50s who have difficulty using smartphones. As a result of analyzing the factors affecting the satisfaction of purchasing cosmetics through mobile cosmetics apps, acquisition of makeup information and easy purchase channels were found to have a great influence on purchase satisfaction.

모바일 화장품 앱 활용현황 및 소비자의 구매행동이 구매만족도에 미치는 영향

While the mobile environment is rapidly absorbing new beauty-related information, the information of mobile cosmetics apps is playing an important role in changing women's personality, beautiful appearance, and life. The purpose of this study is to understand the characteristics of mobile cosmetics apps from this point of view, and through this, the effect of cosmetics apps' utilization status and cosmetics consumers' purchasing behavior on purchase satisfaction. This study was conducted as an empirical analysis through theoretical consideration and questionnaire method. Previous studies, academic journals, reports, and presentation data were collected and analyzed to understand the characteristics and current status of the cosmetics market, and cosmetics purchase behavior through mobile cosmetics apps was analyzed. A questionnaire was conducted and empirical analysis was conducted to analyze the cosmetics purchase behavior, satisfaction, and usage status of cosmetics apps by consumers through the app. The results of the study are as follows. The group that uses mobile cosmetics apps the most is office workers under their 20s, and the preference for cosmetics apps is Olive Young, which is rich in product information, because it is well suited to the lifestyle of the 20s. Housewives in their 50s used offline more than apps. Through this, it can be seen that people in their 20s who are familiar with smartphones use mobile cosmetics apps more than those in their 50s who have difficulty using smartphones. As a result of analyzing the factors affecting the satisfaction of purchasing cosmetics through mobile cosmetics apps, acquisition of makeup information and easy purchase channels were found to have a great influence on purchase satisfaction.

The synthetic cathinones MDPHP and MDPV: Comparison of the acute effects in mice, in silico ADMET profiles and clinical reports

The 3,4-methylenedioxy-alpha-pyrrolidinohexanophenone (MDPHP) is a synthetic cathinone closely related to 3,4-methylenedioxypyrovalerone (MDPV), one of the most common synthetic cathinones present in the “bath salts”. MDPHP has recently gained attention due to increasing seizures and involvement in human intoxications which occurred in Europe and Italy in the last years, but currently there is a lack of information about its pharmaco-toxicological effects. With the aim at filling this gap, the present study is endeavoured to (i) evaluate the effects of acute administration of MDPHP (0.01–20 mg/kg; i.p.) on behaviour, cardiorespiratory and cardiovascular parameters in CD-1 male mice, comparing them to those observed after administration of MDPV; (ii) predict the ADMET profile of the two analogues using the Plus ADMET Predictor®; (iii) present clinical data related to MDPHP and MDPV-induced intoxications recorded between 2011 and 2023 by the Pavia Poison Control Centre (PCC) − National Toxicology Information Centre (Istituti Clinici Scientifici Maugeri, IRCCS Pavia, Italy). Our results substantiated that MDPHP and MDPV similarly affect sensorimotor and behavioural responses in mice, importantly increased locomotion and induced aggressive behaviour, and, at higher dosage, increased heart rate and blood pressure. These findings are in line with those observed in humans, revealing severe toxidromes typically characterized by Central Nervous System (CNS) alterations (behavioural/neuropsychiatric symptoms), including psychomotor agitation and aggressiveness, cardiovascular and respiratory disorders (e.g. tachycardia, hypertension, dyspnoea), and other peripheral symptoms (e.g. hyperthermia, acidosis, rhabdomyolysis).

탄소중립을 위한 순환자원 활용 시설재료의 성능분석

As the climate crisis and global environmental problems intensify, policies and technologies for reducing greenhouse gas in industry and life are being emphasized, and the development of eco-friendly synthetic materials with low environmental load while reinforcing the performance of natural materials with building or facility materials is becoming a useful strategy for industrialization of greenhouse gas reduction as well as technical aspects. This study was conducted to present basic data for using coffee ground, a circulating resource, as a material for synthetic wood. The possibility of using the leftover coffee grounds as an alternative facility to reduce the environmental load such as carbon emissions was confirmed by producing it as a synthetic deck material through a drying processing process. It was classified into Type I (50% coffee grounds), Type II (20% coffee grounds), and a control, and the quality suitability and performance with KS standards were verified when the content rates of coffee grounds and wood were different. Compared to KS standards (KSF 3230), the performance of synthetic wood deck materials that recycled coffee grounds satisfied the standards under all three types of experimental conditions, and in particular, it was found to be the best in Type I, which mixed coffee grounds ingredients and wood at a 50% ratio. Coffee grounds, which are circulating resources other than household waste, can be alternatives as sustainable materials with excellent performance that meets quality standards while minimizing environmental pollution or carbon emissions.

Analyzing Vital Capacity in Short-Term COVID-19 Survivors between 20 to 40 years and over 40 years Population: Understanding Respiratory Health in New Normal situation

COVID-19 global coronavirus is a pandemic caused by coronavirus 2 (SARS-CoV-2). Coronavirus effect on multiple organ dysfunction but pulmonary function is most affected area of a patients. Pulmonary function or vital capacity have significance in the treatment of COVID affected patients. Vital capacity is defined as the maximal volume of air that can be exhaled from the lungs following maximal inspiration. Present study aim is to compare vital capacity between COVID-19 survivors and non-COVID populations. A total of eight hundred fifty-nine (859) subjects of different ages have been selected for the present study. The present study data were collected by the Multi-Functional Spirometer HI-801 for vital capacity, and the digital weighing scale was used for the measurement of body weight. The collected data was analyzed using descriptive statistics, the mean and the standard deviation (SD). An inferential statistically paired and independent t-test was applied to check the level of significance. The significance level was set at p<0.05. The results of this study, male COVID survivors between the ages of 20 to 40 have better vital capacity recovery than male COVID survivors over the age of 40, while female COVID survivors between the ages of 20 to 40 outperform female COVID survivors over the age of 40. Female COVID-19 survivors generally regain essential capabilities far more quickly than male survivors. We conclude that female COVID survivors recover vital capacity much faster than male COVID survivors.

Analysis of Mathematics Content Knowledge of Mathematics Teachers Based on Bloom's Taxonomy Revision

This study aims to assess mathematics teachers' understanding of Mathematics Content Knowledge based on the Revised Bloom Taxonomy. The method used is quantitative descriptive research with a survey approach. The respondents of this study were mathematics teachers who taught at SMP/MTs in Losari District, Brebes Regency. Data was collected using non-test instruments in the form of questionnaires and question tests. Data analysis involves presenting data, testing differences, and concluding. The results showed that teachers' understanding of Mathematics Content Knowledge in teaching and mastery of the material was categorized as strong. Based on Bloom's revised taxonomy, teachers have good mastery, especially in knowledge dimensions such as factual, conceptual, procedural, and metacognitive knowledge, which are categorized as high. There was no significant difference in the average Mathematics Content Knowledge score of teachers, either with a working period of less than 10 years, 10-15 years, or more than 15 years.

Cutaneous Wound Healing and the Effects of Cannabidiol.

Cutaneous wounds, both acute and chronic, begin with loss of the integrity, and thus barrier function, of the skin. Surgery and trauma produce acute wounds. There are 22 million surgical procedures per year in the United States alone, based on data from the American College of Surgeons, resulting in a prevalence of 6.67%. Acute traumatic wounds requiring repair total 8 million per year, 2.42% or 24.2 per 1000. The cost of wound care is increasing; it approached USD 100 billion for just Medicare in 2018. This burden for wound care will continue to rise with population aging, the increase in metabolic syndrome, and more elective surgeries. To heal a wound, an orchestrated, evolutionarily conserved, and complex series of events involving cellular and molecular agents at the local and systemic levels are necessary. The principal factors of this important function include elements from the neurological, cardiovascular, immune, nutritional, and endocrine systems. The objectives of this review are to provide clinicians engaged in wound care and basic science researchers interested in wound healing with an updated synopsis from recent publications. We also present data from our primary investigations, testing the hypothesis that cannabidiol can alter cutaneous wound healing and documenting their effects in wild type (C57/BL6) and db/db mice (Type 2 Diabetes Mellitus, T2DM). The focus is on the potential roles of the endocannabinoid system, cannabidiol, and the important immune-regulatory wound cytokine IL-33, a member of the IL-1 family, and connective tissue growth factor, CTGF, due to their roles in both normal and abnormal wound healing. We found an initial delay in the rate of wound closure in B6 mice with CBD, but this difference disappeared with time. CBD decreased IL-33 + cells in B6 by 70% while nearly increasing CTGF + cells in db/db mice by two folds from 18.6% to 38.8% (p < 0.05) using a dorsal wound model. We review the current literature on normal and abnormal wound healing, and document effects of CBD in B6 and db/db dorsal cutaneous wounds. CBD may have some beneficial effects in diabetic wounds. We applied 6-mm circular punch to create standard size full-thickness dorsal wounds in B6 and db/db mice. The experimental group received CBD while the control group got only vehicle. The outcome measures were rate of wound closure, wound cells expressing IL-33 and CTGF, and ILC profiles. In B6, the initial rate of wound closure was slower but there was no delay in the time to final closure, and cells expressing IL-33 was significantly reduced. CTGF + cells were higher in db/bd wounds treated with CBD. These data support the potential use of CBD to improve diabetic cutaneous wound healing.

Antioxidant Extracts from Greek and Spanish Olive Leaves: Antimicrobial, Anticancer and Antiangiogenic Effects.

Olea europaea L. is the most valuable species of the Olea type, and its products offer a wide range of therapeutical uses. The olive tree has been extensively studied for its nourishing qualities, and the "Mediterranean diet", which includes virgin olive oil as a key dietary component, is strongly associated with a reduced risk of cardiovascular disease and various malignancies. Olive leaves, a by-product in the olive harvesting process, are valued as a resource for developing novel phytomedicines. For this purpose, two ethanolic extracts obtained from Olivae folium from Spain (OFS) and Greece (OFG) were investigated. Our findings contribute to a wider characterization of olive leaves. Both extracts displayed important amounts of phenolic compounds and pentacyclic triterpenes, OFG having higher concentrations of both polyphenols, such as oleuropein and lutein, as well as triterpenes, such as oleanolic acid and maslinic acid. The antioxidant capacity is similar for the two extracts, albeit slightly higher for OFG, possibly due to metal polyphenol complexes with antioxidant activity. The extracts elicited an antimicrobial effect at higher doses, especially against Gram-positive bacteria, such as Streptococcus pyogenes. The extract with lower inorganic content and higher content of polyphenols and triterpenic acids induced a strong anti-radical capacity, a selective cytotoxic effect, as well as antimigratory potential on A375 melanoma cells and antiangiogenic potential on the CAM. No irritability and a good tolerability were noted after evaluating the extracts on the in vivo Hen's Egg Test-Chorioallantoic Membrane (HET-CAM). Therefore, the present data are suggestive for the possible use of the two types of olive leaf products as high-antioxidant extracts, potentially impacting the healthcare system through their use as antimicrobial agents and as anticancer and anti-invasion treatments for melanoma.

Sex differences in lipidomic and bile acid plasma profiles in patients with and without coronary artery disease

BackgroundLipids, including phospholipids and bile acids, exert various signaling effects and are thought to contribute to the development of coronary artery disease (CAD). Here, we aimed to compare lipidomic and bile acid profiles in the blood of patients with and without CAD stratified by sex.MethodsFrom 2015 to 2022, 3,012 patients who underwent coronary angiography were recruited in the INTERCATH cohort. From the overall cohort, subgroups were defined using patient characteristics such as CAD vs. no CAD, 1st vs. 3rd tertile of LDL-c, and female vs. male sex. Hereafter, a matching algorithm based on age, BMI, hypertension status, diabetes mellitus status, smoking status, the Mediterranean diet score, and the intake of statins, triglycerides, HDL-c and hs-CRP in a 1:1 ratio was implemented. Lipidomic analyses of stored blood samples using the Lipidyzer platform (SCIEX) and bile acid analysis using liquid chromatography with tandem mass spectrometry (LC‒MS/MS) were carried out.ResultsA total of 177 matched individuals were analyzed; the median ages were 73.5 years (25th and 75th percentile: 64.1, 78.2) and 71.9 years (65.7, 77.2) for females and males with CAD, respectively, and 67.6 years (58.3, 75.3) and 69.2 years (59.8, 76.8) for females and males without CAD, respectively. Further baseline characteristics, including cardiovascular risk factors, were balanced between the groups. Women with CAD had decreased levels of phosphatidylcholine and diacylglycerol, while no differences in bile acid profiles were detected in comparison to those of female patients without CAD. In contrast, in male patients with CAD, decreased concentrations of the secondary bile acid species glycolithocholic and lithocholic acid, as well as altered levels of specific lipids, were detected compared to those in males without CAD. Notably, male patients with low LDL-c and CAD had significantly greater concentrations of various phospholipid species, particularly plasmalogens, compared to those in high LDL-c subgroup.ConclusionsWe present hypothesis-generating data on sex-specific lipidomic patterns and bile acid profiles in CAD patients. The data suggest that altered lipid and bile acid composition might contribute to CAD development and/or progression, helping to understand the different disease trajectories of CAD in women and men.Registrationhttps://clinicaltrials.gov/ct2/show/NCT04936438, Unique identifier: NCT04936438.

The Impact of Lexical Bundle Length on L2 Oral Proficiency

Lexical bundles (LBs) are crucial in L2 oral proficiency, yet their complexity in terms of length is under-researched. This study therefore examines the relationship between longer and shorter LBs and oral proficiency among 150 L2 learners of varying proficiency levels at a UK university. Through the analysis of oral presentation data (scores ranging from intermediate to advanced) and employing a combined text-internal and text-external approach (two- to five-word bundles), this study advances an innovative text-internal LB refinement procedure, thus isolating the unique contribution of LB length. Robust regression, dominance analysis, and random forest statistical techniques reveal the predictive power of bigram mutual information (MI) and longer three-to-five-word sequences on higher proficiency scores. Our results show that learners using higher MI score bigrams tend to perform better in their presentations, with a strong positive impact on scores (b = 14.38, 95% CI [8.01, 20.76], t = 4.42; dominance weight = 58.63%). Additionally, the use of longer three-to-five-word phrases also contributes to better performance, though to a lesser extent (dominance weight = 18.80%). These findings highlight the pedagogical potential of a nuanced approach to the strategic deployment of LBs, particularly bigram MI, to foster oral proficiency. Suggestions for future LB proficiency research are discussed in relation to L2 speech production models.

Keterampilan Membaca Berbasis Strategi Metakognitif pada Mahasiswa Perbankan dan Keuangan Politeknik Negeri Medan

This research aims to determine English reading skills through metacognitive strategies. This research method uses descriptive and qualitative methods. Data in the form of English learning results in tertiary institutions. Research data analysis uses data reduction, data presentation, and drawing data conclusions. The results of this research show that authentic assessment is appropriate to use for English reading skills because it can measure individual reading performance and development. Besides that, the use of metacognitive strategies can be a clear link between students' English reading abilities and the development of their abilities. Second, an authentic assessment pattern that is suitable for students, namely prioritizing learner characteristics, meaning that each individual assessment is different from other individuals because it is based on performance or self-mastery in reading skills.

Clinical Decision Support Systems in Adults with Chronic Respiratory Disease: A Systematic Review

Background: A sub-optimal uptake of clinical guidelines is reported across healthcare settings in many chronic respiratory disease populations. Clinical decision support systems (CDSS) are systems which analyse and present data so that users can make decisions more easily and are suggested as part of the solution to poor adoption of guidelines. Aims: The aim of this review was to describe the literature on CDSS in chronic respiratory disease management, their function and the features that may impact their effectiveness. Methods: The electronic databases PubMed, MEDLINE, EMBASE, Web of Science, the trial registries Cochrane Central Register of Controlled Trials, EU Clinical Trial Register, ClinicalTrials.gov and World Health Organisation (WHO) trial registry were searched with the aid of a medical librarian. All searches began from September 2019 to March 2021. Data from relevant studies were extracted independently by 2 review authors using Covidence software and Microsoft Excel. Study quality was assessed. CDSS description and indication, function and the theory underpinning the CDSS (e.g., guidelines, expert opinion, etc.) were themed and summarised. The presence or absence of the important CDSS features were recorded i.e., (i) computer-based decision support, (ii) automatic provision of decision support as part of clinician workflow, (iiii) provision of decision support at the time and location of decisionmaking and (iv) provision of recommendations rather than just assessments. Results: Of the 2647 articles screened, 27 papers or abstracts (n = 22 full text and n = 5 abstracts) describing 26 studies met all inclusion and exclusion criteria. The 26 studies evaluated asthma care (n = 16), COPD care (n = 9) and both asthma and COPD care (n = )]. The highest level of evidence was generated by RCTs (n = 7). The 26 studies described 24 different CDSS. Most were based solely or in part on clinical and best practice guidelines. Whilst most CDSS had multiple functions, which were wide ranging, medicines management was the most prevalent function. Most systems had 3 out of 4 of the specific system features that have been correlated with improvements in clinical practice. Generally, in both controlled studies and in other study designs, patient and process outcome measures were commonly reported with performance outcomes measures less commonly reported. Fewer positive effects were reported in the higher quality studies (i.e. controlled studies). The success rate of the CDSS was higher in those studies that had 3 out of the 4 important CDSS features. Conclusion: Many CDSS in adults with asthma and COPD improve patient, process and performance outcomes.

Risk of Cardiovascular Events in Metabolically Healthy Overweight or Obese Adults: Role of LDL-Cholesterol in the Stratification of Risk.

The objective of this study was to investigate the longitudinal association of metabolically healthy overweight/obese adults with major adverse cardiovascular events (MACE) and the effect of LDL-cholesterol levels on this association. This study was conducted with 15,904 participants from the URRAH study grouped according to BMI and metabolic status. Healthy metabolic status was identified with and without including LDL-cholesterol. The risk of MACE during 11.8 years of follow-up was evaluated with multivariable Cox regressions. Among the participants aged <70 years, high BMI was associated with an increased risk of MACE, whereas among the older subjects it was associated with lower risk. Compared to the group with normal weight/healthy metabolic status, the metabolically healthy participants aged <70 years who were overweight/obese had an increased risk of MACE with an adjusted hazard ratio of 3.81 (95% CI, 1.34-10.85, p = 0.012). However, when LDL-cholesterol < 130 mg/dL was included in the definition of healthy metabolic status, no increase in risk was found in the overweight/obese adults compared to the normal weight individuals (hazard ratio 0.70 (0.07-6.71, p = 0.75). The present data show that the risk of MACE is increased in metabolically healthy overweight/obese individuals identified according to standard criteria. However, when LDL-cholesterol is included in the definition, metabolically healthy individuals who are overweight/obese have no increase in risk.

Investigation of BRAF V600E Mutation in Breast Cancer Patients

The B-Raf is the essential protein in signal pathways inside cells which is affected by cell growth direction. The B-Raf protein encoded by the BRAF gene that is located at chromosome 7, BRAF gene is also pointed out as proto-oncogene. This study aimed to detect the substitution at codon 600 causing a change of valine to glutamic acid (V600E) mutation in Iraqi females to assist its role in initiating breast cancer. Sixty biopsies tissue from breast cancer Iraqi women and 20 women with benign lesions were enrolled in this study. DNA was extracted from breast cancer biopsies samples. PCR and DNA Sequencing techniques were used to screen the BRAF V600E gene mutation as it is an essential event in the initiation of cancer. The results revealed that none Iraqi breast cancer women had BRAF V600E mutation, The annotated BRAF gene has been deposited in DDBJ/GenBank under the accession number LC547435. In conclusion: The present data indicate no BRAF V600E mutation in Iraqi breast cancer females and may not possess a role in breast cancer initiation. The current results may be refer to ineffectiveness of Vemurafenib and Encorafenib therapies that specific for patients with the BRAF V600 mutation. Other studies with large numbers of patients are needed to confirm the result of this study, as the high prevalence of breast cancer among Iraqi women.

Investigation of BRAF V600E Mutation in Breast Cancer Patients

The B-Raf is the essential protein in signal pathways inside cells which is affected by cell growth direction. The B-Raf protein encoded by the BRAF gene that is located at chromosome 7, BRAF gene is also pointed out as proto-oncogene. This study aimed to detect the substitution at codon 600 causing a change of valine to glutamic acid (V600E) mutation in Iraqi females to assist its role in initiating breast cancer. Sixty biopsies tissue from breast cancer Iraqi women and 20 women with benign lesions were enrolled in this study. DNA was extracted from breast cancer biopsies samples. PCR and DNA Sequencing techniques were used to screen the BRAF V600E gene mutation as it is an essential event in the initiation of cancer. The results revealed that none Iraqi breast cancer women had BRAF V600E mutation, The annotated BRAF gene has been deposited in DDBJ/GenBank under the accession number LC547435. In conclusion: The present data indicate no BRAF V600E mutation in Iraqi breast cancer females and may not possess a role in breast cancer initiation. The current results may be refer to ineffectiveness of Vemurafenib and Encorafenib therapies that specific for patients with the BRAF V600 mutation. Other studies with large numbers of patients are needed to confirm the result of this study, as the high prevalence of breast cancer among Iraqi women.

Comparative knock analysis of HCNG fueled spark ignition engine using different heat transfer models and prediction of knock intensity by artificial neural network fitting tool

Hydrogen and its careers have a lot of potential in transportation industry due to lesser emissions and better performance. Performance of hydrogen enriched compressed natural gas (HCNG) fueled engine is limited by Knock. The purpose of this study is to investigate knock intensity (KI) by different convective heat transfer models. This study can be used to train electronic control unit (ECU) of engine operating on different loads from low to high speed. In present study, experimentation have been performed on HCNG fueled spark ignition engine at different operating conditions by varying hydrogen amount in HCNG, by varying load of engine, by varying exhaust gas recirculation (EGR) rate in air and by varying speed of engine to calculate in-cylinder pressure, knock intensity (KI) and heat transfer rate (HTR). Six convective heat transfer models (Assanis, Eichelberg, Han, Hohenberg, Nusselt and Woschni) have been incorporated in quasi dimensional combustion model (QDCM) to calculate the parameters of HCNG engine. Comparative and predictive analysis using artificial neural network fitting tool (ANNFT) of aforementioned simulated models have been performed with experimental findings to attain the efficient model for knock intensity of HCNG engine. Woschni model, predicts the minimum error of 0.37 % & 0.86 % b/w experimental and simulated in-cylinder pressure and indicated mean effective pressure respectively. Han model predicts the minimum error of 3.8 % b/w experimental and simulated knock intensity operating at 11.2 % EGR. Maximum error of 20.3 % at 2.4 % EGR is attained by using Woschni model in knock intensity calculation. The best suited algorithm for present data set is Bayesian regularization utilized in ANNFT to predict knock intensity effectively. The findings of this study can be utilized in the development of HCNG engine.

(036) BASELINE CHARACTERISTICS OF PATIENTS UNDERGOING GENDER AFFIRMING HYSTERECTOMIES

Abstract Introduction Gender affirming hysterectomies (GAH) are one of the many interventions offered to people with uteruses who are seeking gender affirming care. Gender affirming care, especially hormones, has been shown to improve sexual satisfaction outcomes, but no research currently exists on sexual function or orgasm experience after gender affirming hysterectomy in particular. Post-hysterectomy sexual function has only been examined in cisgender populations, and has found mixed results on sexual health, wellness, and function. Research on sexual function and orgasm experience after GAH is needed to inform evidence-based recommendations and advance our understanding of sexual pleasure in a population that has historically been under-researched. Objective To achieve a better understanding of how gender affirming hysterectomies impact the experience of sex through a standardized analysis of orgasms and sexual function. Methods This project is a prospective study of patients receiving gender affirming hysterectomies at a single tertiary care center (November 2023-ongoing). Baseline characteristics (pre-hysterectomy) have been collected and analyzed via surveys asking about demographics, sexual practices, medical history, orgasm satisfaction (Orgasm Rating Scale) and sexual function (Transmasculine Sexual Functioning Index). Results We currently have 5 patients enrolled and anticipate a sample size of 30 participants by mid-February 2024. We plan to present pre-hysterectomy data describing participants’ overall sexual function and satisfaction. We anticipate a diversity of sexual practices and wellbeing. Conclusions There is a dearth in the current literature describing sexual function of individuals pursuing GAH. Further characterizing this population's pre-operative sexual practices and satisfaction will improve our ability to counsel patients considering GAH. Comparing this baseline data to sexual function post-GAH will provide insight into how GAH impacts ability to perform sexually and its influence on overall sexual satisfaction. This data will allow us to provide evidence-based recommendations regarding the impact of hysterectomy on orgasm and sexual function in patients seeking GAH. Disclosure No.

STRATEGIC DECISION SUPPORT: DEVELOPING A DASHBOARD FOR MANAGERIAL INSIGHTS IN HIGH-LEVEL TVET STUDENTS' ENROLMENT AT UNIVERSITI MALAYSIA PAHANG AL-SULTAN ABDULLAH

The purpose of this study was to create a dashboard with information visualisation to assist Universiti Malaysia Pahang Al-Sultan Abdullah (UMPSA) in managerial decision-making and to critically and hierarchically present data regarding the enrolment of Malaysian Diploma Vocational (MDV) students into high-level Technical Vocational Education and Training (TVET) programs at UMPSA. The Cross Industry Standard Process for Data Mining (CRISP-DM) model was applied in this research followed by dashboard development using Microsoft Power BI. The CRISP-DM model consists of six continuous and connected phases, namely business understanding, data understanding, data preparation, data modelling, data visualisation, and data synchronise and update. The data was obtained from the Undergraduate Records Management Unit, Centre for Academic Management, UMPSA. The database was used in the development of the dashboard to store information in the form of reports and for data visualisation purposes. The findings hope to assist the management of UMPSA in making better decisions and planning the enrolment process of prospective students. The dashboard outlines several initiatives and best practices that should be implemented by the Malaysian Government, the Ministry of Higher Education, and UMPSA through the UMPSA 2021–2025 Strategic Plan to empower the high-level TVET agenda.

MACCABI-RED, community emergency care at the press of a button: a descriptive study.

Maccabi-RED is a new service developed in Israel that allows primary care staff to direct urgent cases to specialists in the community for evaluation in their local clinics on the same day as an alternative to an emergency department (ED) visit. A primary care physician or a nurse can activate the service, and all nearby specialists receive "a call" and can decide if they are willing to accept it, thus allowing the patient to avoid an unnecessary visit to the ED. To quantify and characterize the medical care provided by this service in a large national healthcare system. Multicenter, community-based, retrospective cohort study. All Maccabi-RED visits recorded between September 2021 and August 2022 were included. Patient characteristics were compared to national demographics. Descriptive statistics were used to present data regarding recorded diagnoses, treating physicians, treatments or referrals provided, and subsequent emergency department admissions or hospitalizations. 31831 visits were recorded. Most frequent diagnoses were musculoskeletal pain (12.1%), otitis or otalgia (7.8%), contusions (7.6%), fractures (7.1%), foreign body (6.7%), pregnancy-related symptoms (6.3%), and upper-respiratory or unspecified viral infection (6.3%). The most common treatments reported were foreign body removal (5%) and cast application (3.5%). Only 7.8% of visits resulted in emergency department admission within seven days (any cause). The average time from patient request to physician treatment was 91 min. Maccabi-RED is being widely used by patients nationwide. Additional studies are needed to investigate whether Maccabi-RED reduces emergency department visits and costs.

Combining the Pharmaceutical and Toxicological Properties of Selected Essential Oils with their Chemical Components by GC-MS Analysis.

In the current investigation, a comprehensive analysis was carried out on essential oils (EOs) extracted from six aromatic plant species, namely Rosmarinus officinalis, Pelargonium graveolens, Thymus vulgaris, Origanum vulgare, Laurus nobilis, and Aloysia citrodora. An exploration was conducted into the chemical composition using Gas Chromatography-Mass Spectrometry (GC/MS), antioxidant properties assessed through DPPH, ABTS, CUPRAC, FRAP, MCA, and PBD assays, ecotoxicological impacts evaluated via allelopathy and the Daphnia magna heartbeat test, as well as bio-pharmacological effects including anticancer activity and gene expression analysis. Results revealed strong antioxidant activity in all essential oils, with T. vulgaris EO (2748.00 mg TE/g) and O. vulgare EO (2609.29 mg TE/g) leading in CUPRAC assay. R. officinalis EO showed the highest α-amylase inhibition at 1.58 mmol ACAE/g, while O. vulgare EO excelled in α-glucosidase inhibition at 1.57 mmol ACAE/g. Additionally, cytotoxic effects were evaluated on human colorectal cancer (HCT116) cells. A. citrodora, O. vulgare, and R. officinalis EOs were found the most potent anticancer, as also witnessed by their higher modulatory effects on the gene expression of BAX and Bcl-2. Collectively, the present data highlight the importance to implement the knowledge and to valorize the supply chain of aromatic plants.