Pharmaceutical wastewater treatment using heterogeneous photocatalysis in presence of TiO2 nanoparticles has become a lucrative method because the convectional wastewater and biological treatments usually fail to remove the detrimental effect of different drugs and hormones on the environment. The nanoparticles recovery and reuse is the most challenging task in practice. The main goal of the present study is to recover and reuse of photocatalyst by immobilizing it on the membrane surface. Consequently, two types of immobilization technique have been used here, one is surface immobilization by dipped coating, and other is impregnation of catalyst during fabrication of the membrane. To conduct photocatalysis, an indigenous photo membrane reactor has also been fabricated during the research work. The presence of TiO2 nanoparticles has not only improved the catalytic property of the membrane, but also the contact angle analysis has confirmed the enhanced hydrophilic as well as antifouling property of the surface modified membrane. The fabricated membranes were characterized by scanning electron microscopy (SEM). To analyses the performance of photo membrane reactor as well as TiO2 coated or impregnated membranes, the photocatalytic degradation of aqueous solution of chlorhexidine digluconate (CHD), an antibacterial drug, was performed using the developed system and the removal percentage of CHD obtained from the system was found to be quite appreciable. The results show that the recovery and reuse of the catalyst by the present system is very much significant. Meanwhile, the developed reactor can be operated in cross flow configuration under batch, semi-batch and continuous mode.