Presence Of Lymphoid Follicles Research Articles

Use of appendix in biliary atresia.

Antiperistaltic appendiceal conduit based on its vascular pedicle was used as hepaticoporto-appendico-jejunostomy (HAJ) in 9 infants with advanced stage of biliary atresia. Operative procedure was simple and less time consuming. The postoperative cholangitis was conspicuously absent, possibly due to the role played by the presence of lymphoid follicles in the wall of the appendix. Our early experience with this technique shows that antiperistaltic appendiceal conduit works quite satisfactorily. The procedure has been successfully utilised to reduce the problems contributing post-operative morbidity and mortality in cases with the advanced disease. The HAJ procedure provides a conduit for bilioenteric drainage, that closely resembles to normal anatomy.

Reactive plasmacytic lesions of the bone marrow.

A consecutive series of 1,000 bone marrow aspirates was analyzed for percentage of plasma cells, incidence of plasmacytic satellitosis, associated clinical disease states, lymphoid follicles, lipid granulomas, hemosiderin content, and various combinations thereof. Plasmacytosis was a common finding, and tended to parallel the presence of lymphoid follicles, lipid granulomas and plasmacytic satellitosis. The latter is emphasized as a normal phenomenon, may reflect morphologically a physiologic response of the B cell system to antigenic stimulation, and is conspicuously absent in plasmacytic neoplasia. Various secretory forms of plasma cells are illustrated.

Morphology of lymphoid organs in a cichlid teleost, Tilapia mossambica (Peters).

In Tilapia mossambica organized lymphoid tissues are present in the thymus, head-kidney and spleen, whereas they are lacking in pericardial tissue, liver, mesonephros, intestine and rectum. No lymphoid tissue was observed in the chondrocranium and cartilaginous viscerocranium of young adults. The thymus in Tilapia is encapsulated by thin strands of collagen fibers and consists of outer, middle and inner zones. While middle and inner zones are comparable to the thymic cortex and medulla of higher vertebrates, the homology of the outer zone is not clear. At the anterior end of the thymus, a loose aggregation of lymphocytes without a definite boundary has been observed. The head-kidney is characterized by the presence of lymphoid follicles, a subcapsular sinus, a hilus-like area and lymphatic vessels. The spleen is grossly divisible into white pulp and red pulp; the white pulp contains only a reticular area without definite lymphoid centers and the latter contains predominantly erythrocytes. Morphological changes in the lymphoid organs associated with immune response have been discussed.

Pathogenetic mechanisms of interstitial pulmonary fibrosis in patients with serum antinuclear factor: A histologic and clinical correlation

The clinical features and histologie findings in the lung biopsy specimens of six patients with idiopathic interstitial pulmonary fibrosis and serum antinuclear factor are presented. Patients with diseases commonly associated with interstitial pulmonary fibrosis and/or antinuclear factor, such as systemic lupus erythematosus, rheumatoid arthritis or scleroderma, as well as patients with arthritis or positive lupus erythematosus cell tests, were excluded. The histologic changes were characterized by the coexistence of well-established fibrosis in the alveolar walls and/or the peribronchiolovascular tissues and multiple foci of predominantly lymphocytic infiltrates with some plasma cells and eosinophils. The transition from the lymphocytic infiltrates into fibrosis was evident in most of the biopsy specimens, and the presence of lymphoid follicles with germinal center formation was one of the prominent features. These histologic findings, the presence of antinuclear antibodies, the history of preceding virus-like respiratory tract infections in three of the six patients, facial hyperpigmentation in one, discoid lupus lesions of the scalp in another and renal involvement in a third patient, suggest that the pulmonary lesions in these patients resulted from immune reactions to some agents not unlike those seen in systemic lupus erythematosus.

Long survival in Hodgkin's Disease

Twenty-seven cases of Hodgkin's Disease who survived for 10 years or longer were analysed as to their clinical and histologic aspects. They formed 10% of the total cases seen during an 11-year period. The favourable outcome of the L/H and Nodular Sclerosing varieties is confirmed, these being associated with localised initial manifestations, a slow rate of growth, absence of systemic symptoms, a good response to treatment and a low rate of recurrence. The nodular sclerosing type occurs in a younger age group, has a higher proportion of females and a tendency to involve the cervical and mediastinal regions. Ten cases of the mixed form were seen. These showed a higher rate of recurrence. Other features indicating a good prognosis include a pseudofollicular pattern, incomplete involvement of the lymph node architecture and the presence of lymphoid follicles within the tumour.