This study aims to study the fracture resistance of additively manufactured polyamide 12 (PA12), specifically when subjected to notches and cracks, and how it varies with the printing direction using Multi Jet Fusion (MJF). The methodology involved conducting tensile tests on V-notched samples, with a focus on different combinations of opening angle (0°-120°) and tip radius (0.2–2 mm). The findings revealed that the sensitivity to the notch opening angle decreased with an increase in the notch tip radius. Furthermore, the fracture resistance for different mode mixities was examined using semi-circular bend (SCB) specimens, with the crack angle varied between 0° and 53°. The results demonstrated two distinct fracture behaviours, namely brittle and ductile, depending on the crack angle. Theoretical analyses revealed that with appropriate tuning, average strain energy density (ASED) can predict the load capacity of notched and cracked PA12 parts manufactured with MJF, within an error range of ± 20 %.