Present paper studies the thermal-diffusion and diffusion-thermo effects on Casson nanofluid flow in the presence of chemical reaction with inclined magnetic field. A similarity analysis was used to transform the system of partial differential equations, together with boundary conditions into a system of dimensionless couple ordinary differential equations. A robust spectral collocation method has been adopted to obtain the solution of the transformed flow equations with corresponding boundary conditions. The impact of various controlling parameters on dimensionless velocity, temperature and nanoparticle concentration are presented graphically and discussed. The effect of the flow pertinent parameters on skin friction, Nusselt number and Sherwood number are presented in tabular form. Finally, an increase in Prandtl number and thermophoresis parameter reduce the temperature field of the flow, while increase in Eckert number enhanced the temperature profile.