Presence Of Cartilage Research Articles

The importance of femur/acetabulum cartilage in the biomechanics of the intact hip: experimental and numerical assessment

Experimental studies have been made to study and validate the biomechanics of the pair femur/acetabulum considering both structures without the presence of cartilage. The main goal of this study was to validate a numerical model of the intact hip. Numerical and experimental models of the hip joint were developed with respect to the anatomical restrictions. Both iliac and femur bones were replicated based on composite replicas. Additionally, a thin layer of silicon rubber was used for the cartilage. A three-dimensional finite element model was developed and the boundary conditions of the models were applied according to the natural physiological constrains of the joint. The loads used in both models were used just for comparison purposes. The biomechanical behaviour of the models was assessed considering the maximum and minimum principal bone strains and von Mises stress. We analysed specific biomechanical parameters in the interior of the acetabular cavity and on femur's surface head to determine the role of the cartilage of the hip joint within the load transfer mechanism. The results of the study show that the stress observed in acetabular cavity was 8.3 to 9.2 MPa. When the cartilage is considered in the joint model, the absolute values of the maximum and minimum peak strains on the femur's head surface decrease simultaneously, and the strains are more uniformly distributed on both femur and iliac surfaces. With cartilage, the cortex strains increase in the medial side of the femur. We prove that finite element models of the intact hip joint can faithfully reproduce experimental models with a small difference of 7%.

Brushite and Self‐Healing Flexible Polymer‐Modified Brushite Bone Adhesives for Fibular Osteotomy Repair

The study aim was to compare in vitro properties of two experimental bone adhesives (brushite cement and polymer‐modified brushite composite) and then assess their in vivo suitability for fixation of a fibular osteotomy using a lapine model. The composite was produced by replacement of the aqueous phase of the brushite cement (800 × 10−3 M citric acid) by polypropylene glycol‐co‐lactide dimethacrylate. FTIR showed this modification enabled pre‐mixing and better control of set through light activated polymer crosslinking instead of the acid–base brushite reaction. Raman confirmed the brushite component [equimolar monocalcium phosphate (MCPM) and β‐tricalcium phosphate (β‐TCP)] of the composite could react upon water‐sorption to enable long‐term “bulk composite self‐healing.” SEM demonstrated precipitation of brushite crystals in cell culture medium on the composite surface (“surface self‐healing”) and improved cell attachment. The composite was considerably more flexible than the cement (33% strain before yield compared to 4.6% before sharp brittle fracture). This flexibility was used to explain the more complete union of the fibula osteotomy and high callus index observed with composite use. The presence of cartilage at the osteotomy site in one fibula treated with brushite cement, however, indicated the absence of complete bone healing in this case. Raman mapping also confirmed the composite enabled more rapid mineralization of the fracture site compared with the cement. Both materials provided immediate fixation in vivo. More surprisingly both brushite and adhesive composite showed complete degradation by 5 weeks in vivo enabling complete union particularly with the adhesive composite within this time.

FRI0042 Synovial fibroblasts from patients with rheumatoid arthritis differentiate into distinct fibroblast subsets in the presence of cartilage

BackgroundSynovial fibroblasts (SF) are key cellular mediators of joint inflammation and destruction in rheumatoid arthritis (RA). RASF have the potential to migrate to distant cartilage sites where they attach, invade...

Influence of cartilage and menisci on the sagittal slope of the tibial plateaus

We analyzed the magnetic resonance studies of the knee in 80 subjects, 45 men and 35 women with a mean age of 38.9 years, who showed no pathological condition of the joint. Using an imaging visualization software, the sagittal longitudinal axis of the tibia was identified. The angle between this axis and a line tangent to the bone profile of the tibial plateau (bone slope) and to the superior border of the menisci (meniscal slope) were calculated. Thickness of anterior and posterior portion of menisci and underlying cartilage were also measured. The bone slope averaged 8° and 7.7° on the medial and lateral sides, respectively. The mean meniscal slope was 4.1° and 3.3° on the medial and lateral sides, respectively, with a significant difference compared with the bone slope. Menisci and underlying cartilage were significantly thicker in their posterior than their anterior portion (7.6 and 5.2 mm, respectively, in the medial compartment; 8.6 and 5.2 mm, respectively, in the lateral compartment). The presence of cartilage and menisci implies a significant decrease in the posterior tibial slope. In the lateral compartment, the greater the bone slope, the larger the difference between bone and meniscal slope, which means that a marked posterior tilt of the lateral tibial plateau is decreased by the cartilage and meniscus. These findings should be taken into account in planning surgical procedures which affect the slope of the articular tibial surface.

Osteochondrolipoma of the Submandibular Region: A Case Report and Review of the Literature

Lipoma is an extremely common and ubiquitous benign soft tissue tumor composed of mature adipose tissue, with frequent differentiation towards other mesenchymal elements such as blood vessels, fibrous tissue, or muscle. They are typically slow-growing, encapsulated, superficial or deep, and have a wide range in size depending on their location. The presence of cartilage or bone is very rare, with most reported cases in the head and neck area. We report the case of an osteochondrolipoma of the submandibular region with associated benign bone marrow elements, with a review of the literature and discussion of the differential diagnosis.

Type IIB procollagen n-propeptide inhibits angigenesis in cartilage

Purpose: A fragment of type II procollagen N-propeptide, PIIBNP, contains the classic integrin binding sequence RGDRGD. This sequence is conserved across species, indicating potential biological function. We have previously shown that recombinant PIIBNP induces death of tumor cells that express integrin αvβ3 and αvβ5. Data from HUVEC cell tube formation assay, mouse aortic ring assay and mouse corneal assay showed that recombinant PIIBNP inhibits angiogenesis both in vitro and in vivo (1). PIIBNP is synthesized by chondrocytes liberated to matrix in cartilage. The goal of this study was to determine the role that PIIBNP plays in cartilage in keeping cartilage avascular and intact. Methods: Detection of PIIBNP from cartilage. Cartilage was isolated from limbs of P1 mice. Cartilage was smashed by crusher and PIIBNP was extracted with SDS loading buffer, resolved by SDS-PEGE, and detected by western blotting. Mouse chondrocyte isolation. Chondrocytes were obtained by enzymatic dissociation of ventral regions of rib cages from newborn mice. Chondrocytes were incubated with or without the presence of MMP inhibitor for 48 hours. The medium from chondrocytes culture were used as the conditioned medium. Cartilage-aorta co-culture: Bovine and mice bones were used as control in the cartilage-aorta co-culture experiments. Mouse cartilage or bone was placed into inserts of a 24-well plate and cocultured with aorta in 3D matrigel for 8 days. The microvessel outgrowth was visualized under a light microscope (NIKON ECLIPS E800) and images were digitally photographed using a Q capture Retiga 2000R camera, and quantified with an Image J software. Results: We have been able to detect PIIBNP in cartilage (Fig. 1A) and chondrocytes conditioned medium (Fig. 1B). In order to reasonably hypothesize an effect of PIIBNP in cartilage, we sought to determine weather cartilage inhibits angiogenesis in mouse aortic ring assays. The results from cartilage-aorta coculture experiments showed that microvessel outgrowth was seen only in control and in the presence of bone, but not in the presence of cartilage (Fig. 2A). Since we and other have detected PIIBNP in cartilage, it is possible that the PIIBNP in cartilage inhibited the microvessel outgrowth. To further confirm this, we performed aorta angiogenesis assay in the presence of chondrocyte conditioned medium and found that the chondrocyte conditioned medium inhibited 80 percent of the microvessel outgrowth as compared with the control (Fig B). MMT inhibitor GM6001 inhibits the production of PIIBNP and the cartilage treated with GM6001 did not inhibit microvessel outgrowth in mouse aortic ring assay. These data suggested that natural PIIBNP in cartilage inhibits angiogenesis. To further investigate the mechanism behind the antiangiogenesis of PIIBNP, we treated HUVEC cells in culture with recombinant proteins. Treatments with PIIBNP, but not GST or mPIIBNP, induced disappearance of VE-cadherin at cell-cell junctions (Fig 3A), suggesting that the engagement of PIIBNP on cell surface elicited a signaling events involved in the inhibition of angiogenesis by PIIBNP. This hypothesis is supported by the fact that the PIIBNP, but not GST or mPIIBNP, induced activation of the Src kinase (Fig 3B), consistent with previous report that integrin αvβ3 signaling induces Src activation and VE-cadherin internalization. Conclusions: We previously showed that recombinant PIIBNP induced tumor cell death via binding to integrin αvβ3 and αvβ5, and suppresses tumor growth in nude mice. The data presented here suggested that the natural occurring PIIBNP in cartilage most likely inhibits angiogenesis. We have detected the existence of PIIBNP from P1 chondrocyte conditioned medium which also inhibits angiogenesis. Since PIIBNP reaches the highest level during cartilage formation and it kills tumor cell, it is an excellent candidate for the molecular mechanism by which cartilage remains avascular and intact.

Jacob s disease secondary to coronoid process osteochondroma. A case report

The formation of a new joint between a pathologically elongated coronoid process and the body of the malar homolateral bone is known as Jacob's disease. Coronoid process hyperplasia was first described in 1853 by Von Langenbeck, and it was not until 1899 when Oscar Jacob described the disease that it was named after him. Jacobs's disease is an uncommon entity with only a few documented cases in the literature. The condition first manifests with progressive limitation of mouth opening and facial asymmetry. Pain is uncommon and it mainly affects young patients. Different factors have been postulated as possible causes, including temporal muscle hyperactivity, previous trauma, chronic disc displacement of the ipsilateral temporomandibular joint, endocrine stimuli, and genetic alterations. Definitive diagnosis is by histopathology and it is necessary to confirm bone hyperplasia, the presence of cartilage and synovial capsule forming the new joint between the malar bone and the coronoid process. We report a 52-year-old woman patient with a history of childhood trauma in the right preauricular region. She came to our department with a 2-year history of progressive limitation of mouth opening. Computed tomography (CT) revealed a right coronoid process elongation, in contact with the homolateral malar bone, causing it to deform. Surgery with general anesthesia was performed using an intraoral vestibular approach. Histopathology confirmed the diagnoses of Jacob's disease.

Cartilage Degeneration is Associated with Augmented Chemically-induced Joint Pain in Rats: A Pilot Study

Osteoarthritis arising from cartilage degeneration is the most common cause of joint pain. However, the relationship between joint pain and cartilage degeneration is not well understood. We asked whether the inflammatory mediators participate in the joint pain in the presence of cartilage degeneration. We observed electromyographic responses of hindlimb flexors to four inflammatory mediators (bradykinin, ATP, acetylcholine, and serotonin) injected in normal rat knees and in those with monosodium iodoacetate (MIA)-induced arthritis. Joint cartilage of all the rats with MIA-induced arthritis histologically showed severe degeneration. We observed greater magnitude and longer duration responses in the MIA-induced arthritis than normal joints with all four mediators. The data suggested nociceptors in osteoarthritic joints are more sensitive to inflammatory mediators than in normal joints. Such nociceptive sensitization to inflammatory mediators may participate in the joint pain in osteoarthritis.

Chondro-osteoblastic Metaplasia in Canine Benign Cutaneous Lipomas

Lipomas are common benign adipose tissue tumours in dogs. Variants of lipomas are characterized by an additional component (e.g. capillaries in angiolipomas or fibrous connective tissue in fibrolipomas). In human medicine, the presence of cartilage or bone within a lipoma is a rare event. Mechanical stress, tropic disturbances, contact with periosteum and other unknown factors may contribute to this transformation. The present report describes the clinical, gross and microscopical findings of four cases of chondrolipoma and two cases of osteolipoma in the canine skin. The possible histogenesis for these tumours in the dog is discussed.

Periosteal osteoblastoma: report of a case with a rare histopathologic presentation and review of the literature

Osteoblastoma is an uncommon benign bone tumor most commonly located in the vertebral column or metaphysis of a long bone. Periosteal location is rare. We report a periosteal-based osteoblastoma, arising from the proximal tibia, in a 20-year-old woman who presented with knee swelling and pain of 2-year duration. Imaging studies showed a metaphyseal surface-based lesion with patchy radiodensities. The cortico-medullary junction was intact. The lesion was totally excised. Histopathologic evaluation disclosed immature bone and osteoid deposition in a vascularized stroma, associated with numerous osteoblasts and osteoclasts rimming the bony trabeculae. Plate-like arrangements of cartilage in the margin of the neoplastic tissue were also identified. At 16 months postoperatively, the patient was well without recurrence. Although extremely unusual, the presence of cartilage does not necessarily exclude the diagnosis of osteoblastoma.

Cranial neural crest-derived cells participate in craniofacial skeletal repair

Abstract Introduction: Similarities between skeletal formation and repair have led to the theory that adult fracture repair may parallel development. We hypothesize that since the mandible is derived from cranial neural crest (CNC) and forms via intramembranous ossification, non-stabilized mandibular fractures will heal in a similar fashion. Methods: Non-stabilized osteotomies were created in the right hemi-mandible of adult male mice. Mandibles were harvested at 7, 14, 21, and 28 days and processed for histology. Ossification was assessed and the presence of cartilage determined using histology and in situ hybridization (ISH). To determine the embryologic origins of the regenerate, transgenic mice were generated where CNC cells express GFP constitutively under the Wnt-1 promoter. Fractures were created as described above and processed for frozen section. CNC cells were localized using immunohistochemistry (IHC) for GFP. Closed, non-stabilized tibial fractures were also performed to determine the presence, if any, of CNC-derived cells in appendicular skeletal fractures. Results: In contrast to non-stabilized fractures of the appendicular skeleton, mandibular fractures healed predominantly via intramembranous ossification, with minimal and delayed cartilage production seen via histology and collagen2 ISH. IHC for GFP revealed that the mandibular fracture callous and regenerate was comprised primarily of GFP+, CNC-derived cells. In contrast, the tibial fracture callous was devoid of any CNC-derived cells. Conclusions: These data suggest that mandibular fractures heal by recapitulating their developmental program. These findings have important implications for designing appropriate cell-based approaches to craniofacial regeneration.

Emprego de matriz óssea orgânica bovina e hidroxiapatita no reparo de defeito induzido em crânio de ratos

OBJETIVO: Avaliar a resposta biológica e poder indutor da combinação matriz óssea orgânica bovina e hidroxiapatita. MÉTODOS: Foram produzidos defeitos ósseos em crânios de 20 ratos, Wistar, machos, com peso inicial médio entre 300 e 350 gramas, divididos eqüitativamente em dois grupos. No grupo I o defeito foi preenchido com uma associação de matriz óssea orgânica bovina e hidroxiapatita, ao passo que no grupo II considerado controle, nada foi empregado. Para o estudo histológico foram submetidos à eutanásia, cinco animais de cada grupo, aos 30 e 60 dias de pós-operatório. RESULTADOS: Com 30 dias de pós-operatório a reabsorção óssea foi maior no grupo II. A presença de cartilagem não diferiu entre os momentos de um mesmo grupo, porém houve diferença estatística entre os grupos I e II aos 30 dias, sendo maior no grupo I. Aos 60 dias de pós-operatório, o grupo I apresentava uma maior quantidade de osteoblastos e presença de osso comparativamente ao grupo II. CONCLUSÃO: A combinação matriz óssea orgânica bovina e hidroxiapatita não causa reações adversas e favorece a reparação óssea.

Cartilage in pulmonary valves of Syrian Hamsters

The presence of cartilage in the pulmonary valve has been reported in birds, but not in mammals. We describe here the occurrence of cartilaginous tissue in the pulmonary valves of 40 (11.4%) of 351 Syrian hamsters examined using histological, histochemical and/or immunohistochemical techniques. The cartilaginous deposits were located along the fibrous attachments of the valve leaflets to the wall of the pulmonary artery trunk. Our findings indicate that the proximal attachments of the leaflets to their respective sinuses, and especially that of the ventral leaflet, are the most prone valvular regions to develop cartilaginous foci. Nonetheless, the possible function of these foci remains an open question. Formation of cartilage in the pulmonary valve starts within the first month of life, that is during the period in which the valve reaches histological maturation. The earliest evidence of chondrogenesis is the presence of small groups of cells embedded in a type II collagen-positive extracellular matrix. These groups of cells, which can appear as early as one day after birth, increase moderately in size and differentiate into hyaline cartilaginous tissue. The precursors of the cartilaginous cells are presumed to be neural crest-derived elements. However, the factor or factors involved in the differentiation of these precursors into chondrocytes are still unknown. In this regard, our observations cast doubt on the hypothesis that the formation of cardiac cartilages is primarily due to locally intense mechanical stimulation.

Cartilage in the Bulbus Arteriosus of Teleostean Fishes

In a comparative study of the cardiac outflow tract in teleostean fishes, eight specimens (two Sardina pilchardus, four Trachurus trachurus, one Coris julis and one Arnoglossus thori) displayed one or two cartilaginous foci in the wall of the bulbus arteriosus. The foci were located in the longitudinal bulbar ridges into which the distal portions of the leaflets of the right and left major bulbo-ventricular valves were attached. The cartilage was of hyaline nature; it consisted of sparsely distributed chondrocytes, embedded in a type II collagen-positive extracellular matrix. Each focus was surrounded by a collagenous capsule into which collagen fibres from the lateral attachments of the valve leaflets were inserted. Presence of cartilage in the attachments of the valve leaflets is not a requisite for normal function of the bulbo-ventricular valves. However, when cartilaginous foci occur at these sites, they may function as competent pivots in the context of the mechanical stimulation to which the lateral portions of the valve leaflets are subjected during cardiac cycle. Previous work carried out by other authors has demonstrated that in birds, the cardiac cartilage is of neural crest origin. The presence of cartilage in the bulbus arteriosus of teleosts points to the possibility that neural crest cells might enter this cardiovascular structure during embryonic development, however, the origin of the chondrocytes occurring in the bulbus arteriosus of teleosts remains an open question.

Avaliação histológica da regeneração óssea do rádio e ulna em cães submetidos ao alongamento com o fixador de Ilizarov

The aim of this study was to evaluate, by microscopic analysis, the quality, the type and orientation of the tissue developed in bone regeneration area, during simultaneous lengthening of radius and ulna using the Ilizarov external fixator. A subperiosteal osteotomy of the distal diaphysis was performed and the bone distraction was performed at rate of 0.5 mm twice a day. A two-ring and four telescopic rod configuration was used and bone distraction started at day six after surgery. Fifteen adult crossbreed dogs weighing from 17 to 30 kg were used. These dogs were divided in five subgroups (A, B, C, D, E.) each containing three animals, which were submitted to euthanasia after the following procedure: A- eight days of distraction, B- 15 days of distraction, C- 22 days of distraction, D- 28 days of distraction and eight days of neutral fixation, E- 28 days of distraction, 60 days of neutral fixation, and 45 days with the external fixator removed. No interference in bone regeneration seemed to occur because of the type and location of the osteotomy, as well as the rate of distraction. Bone repair was efficient and it was predominantly formed by intramembranous ossification, although the presence of cartilage was observed in subgroups B and C.

Development of the clavicles in birds and mammals.

Clavicles (collar bones) are variably present in mammals. Furculae (wishbones)--which may or may not be homologous with clavicles--are variably present and/or fused in birds and present in theropod dinosaurs. In this overview the development of clavicles and furculae is discussed with special attention to modes of skeletogenesis (whether intramembranous or endochondral), numbers of centres of ossification (one in chick furculae; two in murine clavicles), presence of cartilage (primary in clavicles, secondary in furculae), evidence from experimental analysis and from mutations for dependence of both clavicular and furcular growth on mechanical stimulation, and syndromes and mutations affecting clavicular development leading to both under and over development. J. Exp. Zool. 289:153-161, 2001.

Evidence for the Presence of Peroxisome Proliferator-activated Receptor (PPAR) α and γ and Retinoid Z Receptor in Cartilage: PPARγ ACTIVATION MODULATES THE EFFECTS OF INTERLEUKIN-1β ON RAT CHONDROCYTES

Peroxisome proliferator-activated receptor (PPAR) alpha, PPARgamma, and retinoid acid receptor-related orphan receptor (ROR) alpha are members of the nuclear receptor superfamily of ligand-activated transcription factors. Although they play a key role in adipocyte differentiation, lipid metabolism, or glucose homeostasis regulation, recent studies suggested that they might be involved in the inflammation control and especially in the modulation of the cytokine production. This strongly suggests that these transcriptional factors could modulate the deleterious effects of interleukin-1 (IL-1) on cartilage. However, to date, their presence in cartilage has never been investigated. By quantitative reverse transcription-polymerase chain reaction, Western blot, and immunocytochemistry analysis, we demonstrated, for the first time, the presence of PPARalpha, PPARgamma, and RORalpha in rat cartilage, at both mRNA and protein levels. Comparatively, the PPARalpha mRNA content in cartilage was much lower than in the liver but not significantly different to that of the adipose tissue. PPARgamma mRNA expression in cartilage was weak, when compared with adipose tissue, but similar to that found in the liver. RORalpha mRNA levels were similar in the three tissues. mRNA expression of the three nuclear receptors was very differently modulated by IL-1 or mono-iodoacetate treatments. This indicates that they should be unequally involved in the effects of IL-1 on chondrocyte, which is in accordance with results obtained in other cell types. Indeed, we showed that 15d-PGJ2 mainly, but also the drug troglitazone, that are ligands of PPARgamma could significantly counteract the decrease in proteoglycan synthesis and NO production induced by IL-1. By contrast, PPARalpha ligands such as Wy-14,643 or clofibrate had no effect on this process. Therefore, the presence of PPARgamma in chondrocytes opens up new perspectives to modulate the effects of cytokines on cartilage by the use of specific ligands. The function of the two other transcription factors, PPARalpha and RORalpha identified in chondrocytes remains to be explored.

A histopathological study of esophageal atresia and tracheoesophageal fistula

Background/Purpose: Histopathologic examination of the esophagus has not been reported often in esophageal atresia (EA) and tracheoesophageal fistula (TEF). Abnormal esophageal motility has been reported after successful repair of EA and TEF, although the exact etiology of this motility disorder remains unclear. Histological evaluation of the fistulous portion of the esophagus has been performed to document any abnormality that may be responsible for the abnormal motility.Methods: Histopathological study of fistulous segment of esophageal atresia and distal TEF was conducted on 65 patients, which included autopsy material from 3 patients in whom the entire esophagus was examined by serial section. Special stains were administered to each specimen to look for tracheobronchial remnants and the arrangement of muscle fibers. Clinical evaluation was performed in 27 patients who were available for review 6 months to 9 years after successful surgical treatment. These patients were categorized into 3 groups according to their clinical status.Results: These findings showed that the majority of these patients have tracheobronchial remnants in the esophagus in the form of abnormal mucous glands and ducts, abnormal mucin secretion, presence of cartilage, and a disorganized muscle coat.Conclusions: The presence of abnormal mucous glands and abnormal mucin secretion has not been highlighted before. Although tracheobronchial remnants and a disorganized muscle coat are common findings in the fistulous portion of the esophagus, these may not reflect the structure of the remaining esophagus.

Use of computed tomography image processing for mapping of human cervical facet surface geometry

Vertebral facets transmit a significant percent of spinal loading, provide translational, rotational, and axial stability for the spine, and are responsible for the coupling between lateral bending and rotational motions. The shape and the orientation of vertebral facets vary with level and are influenced by degenerative processes. These variations may play an important role in many cases of neck pain, back pain, and instability. To determine whether the shape and orientation of cervical facets can be accurately measured from computed tomography (CT) data, the surfaces of 39 human cervical facets were non-invasively digitized from reconstructed three-dimensional CT data and then invasively digitized using a hand-held three-dimensional probe before and after bleaching away the cartilage. Digitized data describing the facet surfaces were fit to both plane and spherical surfaces. For the adult cervical vertebrae that we measured, the presence of cartilage had no significant effect on the measured shape or orientation of the facets. The orientation of the facet surfaces measured from CT data was within 11 deg of that measured using the hand-held probe. Quantitative measurements of facet shape (flat or spherical) and surface irregularity were similar between CT and hand digitized surfaces. These results suggest that individual facet geometries can be accurately quantified using non-invasive CT examinations. Non-invasively determined variations in facet geometries may assist in the diagnosis of back pain, neck pain and instability.

A CASE OF BRONCHOGENIC CYST OF THE ESOPHAGUS

A bronchogenic cyst is a congenital cyst arising as a result of developmental aberration of the primitive foregut. It rarely arises in the esophageal wall. This paper describes a case of bronchogenic cyst arising in the abdominal esophagus. A 60-year-old man was seen at the hospital because of disturbance in swallowing. A slight smooth stenosis at the cardia was visualized by rcentgenographic study. Ultrasonography, computed tomography, and a magnetic resonance imaging revealed that an abnormal mass in the anterior wall of the abdominal esophagus was cystic. Laparotomy was performed, and a tumor protruding from the right side of the abdominal esophagus was removed. The excised tumor was 5.5×5.0×4.0cm in size and 63g in weight with a smooth and grayish white surface. On section cystic wall was thin but elastic hard, and brown and slightly thick liquid was contained. Histological findings revealed that the cyst wall was lined with ciliated columnar epithelium and contained cartilage showing bronchogenic. The cyst was diagnosed as bronchogenic cyst of the esophagus. Only 15 cases of paraesophageal bronchogenic cyst including this case in which the presence of cartilage was confirmed have been reported in Japan.