A field investigation was carried out during the rainy (kharif) season of 1995 and 1996 at Agra, under rainfed conditions, to find out optimum level of nitrogen and effective weed control methods in sesame (Sesamum indicum L.). Four levels of nitrogen (0, 30, 60 and 90 kglha) and 8 weed control treatments, viz. weedy check (W,), 1 hand weeding 21 DAS (W,), pre emergence application of oxyfluorfen Q 0.15 kglha (W,), W, 1 hand weeding, 21 DAS (W,), pre planting incorporation of fluchloralin Q 1.0 kglha (W,), W, 1 hand weeding 21 DAS (W,), pre emergence application of Alachlor Q 1.0 kglha (W,) and W, 1 hand weeding 21 DAS (W,), were replicated 4 times in split plot design. Among the weed control methods tested, dry weight of weeds was reduced and weed control efficiency increased due to the application of pre planting incorporation of fluchloralin Q 1.0 kglha 1 hand weeding. This combination promoted seed yield, protein and oil production on hectare basis in addition to higher seed index and iodine value of oil. Unchecked weed growth lowered seed yield by 31.5%. Increasing N lev els up to 60 kg Nlha increased the seed yield, protein and oil production, however, influence of N on the dry weight of weeds was not noted.