Preparative Organic Synthesis Research Articles

ChemInform Abstract: NOVEL SYNTHESIS OF SOME TRICYCLIC KETONES VIA LITHIUM DIISOPROPYLAMIDE‐MEDIATED CYCLIZATION OF 2‐(O‐CARBOXYPHENYL)ETHENYLFURANS, ‐THIOPHENES, AND ‐SELENOPHENES

Chemischer InformationsdienstVolume 14, Issue 28 Preparative Organic Chemistry ChemInform Abstract: NOVEL SYNTHESIS OF SOME TRICYCLIC KETONES VIA LITHIUM DIISOPROPYLAMIDE-MEDIATED CYCLIZATION OF 2-(O-CARBOXYPHENYL)ETHENYLFURANS, -THIOPHENES, AND -SELENOPHENES A. HALLBERG, A. HALLBERGSearch for more papers by this authorP. PEDAJA, P. PEDAJASearch for more papers by this author A. HALLBERG, A. HALLBERGSearch for more papers by this authorP. PEDAJA, P. PEDAJASearch for more papers by this author First published: July 12, 1983 https://doi.org/10.1002/chin.198328094Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume14, Issue28July 12, 1983 RelatedInformation

ChemInform Abstract: SIMPLE SYNTHESIS OF 15-HYDROXYPENTADECANOIC ACID FROM 10-UNDECENOIC ACID

Chemischer InformationsdienstVolume 14, Issue 21 Preparative Organic Chemistry ChemInform Abstract: SIMPLE SYNTHESIS OF 15-HYDROXYPENTADECANOIC ACID FROM 10-UNDECENOIC ACID L. I. ZAKHARKIN, L. I. ZAKHARKINSearch for more papers by this authorA. P. PRYANISHNIKOV, A. P. PRYANISHNIKOVSearch for more papers by this author L. I. ZAKHARKIN, L. I. ZAKHARKINSearch for more papers by this authorA. P. PRYANISHNIKOV, A. P. PRYANISHNIKOVSearch for more papers by this author First published: May 24, 1983 https://doi.org/10.1002/chin.198321146Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume14, Issue21May 24, 1983 RelatedInformation

ChemInform Abstract: ASYMMETRIC SYNTHESIS USING OPTICALLY ACTIVE METAL COMPLEXES

Chemischer InformationsdienstVolume 14, Issue 17 Preparative Organic Chemistry ChemInform Abstract: ASYMMETRIC SYNTHESIS USING OPTICALLY ACTIVE METAL COMPLEXES S.-K. MURAHASHI, S.-K. MURAHASHISearch for more papers by this author S.-K. MURAHASHI, S.-K. MURAHASHISearch for more papers by this author First published: April 26, 1983 https://doi.org/10.1002/chin.198317091AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume14, Issue17April 26, 1983 RelatedInformation

ChemInform Abstract: ONE‐STEP SYNTHESIS OF Ω‐HYDROXYCARBOXYLIC ACIDS BY THE REACTION OF Ω‐METALOXYLATED GRIGNARD REAGENTS WITH β‐PROPIOLACTONES

Chemischer InformationsdienstVolume 13, Issue 45 Preparative Organic Chemistry ChemInform Abstract: ONE-STEP SYNTHESIS OF Ω-HYDROXYCARBOXYLIC ACIDS BY THE REACTION OF Ω-METALOXYLATED GRIGNARD REAGENTS WITH β-PROPIOLACTONES T. FUJISAWA, T. FUJISAWASearch for more papers by this authorT. MORI, T. MORISearch for more papers by this authorT. KAWARA, T. KAWARASearch for more papers by this authorT. SATO, T. SATOSearch for more papers by this author T. FUJISAWA, T. FUJISAWASearch for more papers by this authorT. MORI, T. MORISearch for more papers by this authorT. KAWARA, T. KAWARASearch for more papers by this authorT. SATO, T. SATOSearch for more papers by this author First published: November 9, 1982 https://doi.org/10.1002/chin.198245146Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume13, Issue45November 9, 1982 RelatedInformation

ChemInform Abstract: CATALYTIC SYNTHESIS OF METHANOL FROM CARBON MONOXIDE/HYDROGEN. IV. THE EFFECTS OF CARBON DIOXIDE

Chemischer InformationsdienstVolume 13, Issue 30 Preparative Organic Chemistry ChemInform Abstract: CATALYTIC SYNTHESIS OF METHANOL FROM CARBON MONOXIDE/HYDROGEN. IV. THE EFFECTS OF CARBON DIOXIDE K. KLIER, K. KLIERSearch for more papers by this authorV. CHATIKAVANIJ, V. CHATIKAVANIJSearch for more papers by this authorR. G. HERMAN, R. G. HERMANSearch for more papers by this authorG. W. SIMMONS, G. W. SIMMONSSearch for more papers by this author K. KLIER, K. KLIERSearch for more papers by this authorV. CHATIKAVANIJ, V. CHATIKAVANIJSearch for more papers by this authorR. G. HERMAN, R. G. HERMANSearch for more papers by this authorG. W. SIMMONS, G. W. SIMMONSSearch for more papers by this author First published: July 27, 1982 https://doi.org/10.1002/chin.198230098AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume13, Issue30July 27, 1982 RelatedInformation

ChemInform Abstract: ENZYME‐CATALYZED ORGANIC SYNTHESIS: ELECTROCHEMICAL REGENERATION OF NAD(P)H FROM NAD(P) USING METHYL VIOLOGEN AND FLAVOENZYMES

Chemischer InformationsdienstVolume 13, Issue 20 Preparative Organic Chemistry ChemInform Abstract: ENZYME-CATALYZED ORGANIC SYNTHESIS: ELECTROCHEMICAL REGENERATION OF NAD(P)H FROM NAD(P) USING METHYL VIOLOGEN AND FLAVOENZYMES R. DICOSIMO, Search for more papers by this authorC.-H. WONG, Search for more papers by this authorL. DANIELS, Search for more papers by this authorG. M. WHITESIDES, Search for more papers by this author R. DICOSIMO, Search for more papers by this authorC.-H. WONG, Search for more papers by this authorL. DANIELS, Search for more papers by this authorG. M. WHITESIDES, Search for more papers by this author First published: May 18, 1982 https://doi.org/10.1002/chin.198220144Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume13, Issue20May 18, 1982 RelatedInformation

ChemInform Abstract: SELECTIVE SYNTHESIS OF (Z)‐ALK‐2‐ENENITRILES FROM ALDEHYDES

Chemischer InformationsdienstVolume 13, Issue 19 Preparative Organic Chemistry ChemInform Abstract: SELECTIVE SYNTHESIS OF (Z)-ALK-2-ENENITRILES FROM ALDEHYDES Y. SATO, Y. SATOSearch for more papers by this authorY. NIINOMI, Y. NIINOMISearch for more papers by this author Y. SATO, Y. SATOSearch for more papers by this authorY. NIINOMI, Y. NIINOMISearch for more papers by this author First published: May 11, 1982 https://doi.org/10.1002/chin.198219162Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume13, Issue19May 11, 1982 RelatedInformation

ChemInform Abstract: ASYMMETRIC SYNTHESIS VIA AXIALLY DISSYMMETRIC MOLECULES. A BINAPHTHOL‐MODIFIED COMPLEX ALUMINUM HYDRIDE REAGENT POSSESSING EXTREMELY HIGH ABILITY OF CHIRA RECOGNITION

Chemischer InformationsdienstVolume 13, Issue 16 Preparative Organic Chemistry ChemInform Abstract: ASYMMETRIC SYNTHESIS VIA AXIALLY DISSYMMETRIC MOLECULES. A BINAPHTHOL-MODIFIED COMPLEX ALUMINUM HYDRIDE REAGENT POSSESSING EXTREMELY HIGH ABILITY OF CHIRA RECOGNITION R. NOYORI, R. NOYORISearch for more papers by this author R. NOYORI, R. NOYORISearch for more papers by this author First published: April 20, 1982 https://doi.org/10.1002/chin.198216105AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume13, Issue16April 20, 1982 RelatedInformation

ChemInform Abstract: ASYMMETRIC SYNTHESIS USING ORGANOMETALLIC REAGENTS AND OPTICALLY PURE VINYLIC SULFOXIDES

Chemischer InformationsdienstVolume 13, Issue 16 Preparative Organic Chemistry ChemInform Abstract: ASYMMETRIC SYNTHESIS USING ORGANOMETALLIC REAGENTS AND OPTICALLY PURE VINYLIC SULFOXIDES G. H. POSNER, G. H. POSNERSearch for more papers by this authorJ. P. MALLAMO, J. P. MALLAMOSearch for more papers by this authorK. MIURA, K. MIURASearch for more papers by this authorM. HULCE, M. HULCESearch for more papers by this author G. H. POSNER, G. H. POSNERSearch for more papers by this authorJ. P. MALLAMO, J. P. MALLAMOSearch for more papers by this authorK. MIURA, K. MIURASearch for more papers by this authorM. HULCE, M. HULCESearch for more papers by this author First published: April 20, 1982 https://doi.org/10.1002/chin.198216103AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume13, Issue16April 20, 1982 RelatedInformation

ChemInform Abstract: ENANTIOSELECTIVE SYNTHESIS OF C3‐C10 FRAGMENT (NORTHEASTERN ZONE) OF MAYTANSINOIDS WITH 4 CHIRAL CENTERS (4S,5S,6R,7S)

Chemischer InformationsdienstVolume 13, Issue 8 Preparative Organic Chemistry ChemInform Abstract: ENANTIOSELECTIVE SYNTHESIS OF C3-C10 FRAGMENT (NORTHEASTERN ZONE) OF MAYTANSINOIDS WITH 4 CHIRAL CENTERS (4S,5S,6R,7S) A. I. MEYERS, A. I. MEYERSSearch for more papers by this authorJ. P. HUDSPETH, J. P. HUDSPETHSearch for more papers by this author A. I. MEYERS, A. I. MEYERSSearch for more papers by this authorJ. P. HUDSPETH, J. P. HUDSPETHSearch for more papers by this author First published: February 23, 1982 https://doi.org/10.1002/chin.198208098Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume13, Issue8February 23, 1982 RelatedInformation

ChemInform Abstract: STEREOSPECIFIC SYNTHESIS OF OPTICALLY ACTIVE SUCCINIC‐D2 ACID

Chemischer InformationsdienstVolume 13, Issue 2 Preparative Organic Chemistry ChemInform Abstract: STEREOSPECIFIC SYNTHESIS OF OPTICALLY ACTIVE SUCCINIC-D2 ACID J. S. CHICKOS, Search for more papers by this authorM. BAUSCH, Search for more papers by this authorR. ALUL, Search for more papers by this author J. S. CHICKOS, Search for more papers by this authorM. BAUSCH, Search for more papers by this authorR. ALUL, Search for more papers by this author First published: January 12, 1982 https://doi.org/10.1002/chin.198202144Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume13, Issue2January 12, 1982 RelatedInformation

ChemInform Abstract: WILLIAMSON SYNTHESIS USING POLYETHYLENE GLYCOLS OR POLYETHYLENE GLYCOL ETHERS AS ORGANIC‐AQUEOUS (CONCENTRATED AQUEOUS ALKALI) PHASE TRANSFER CATALYSTS

Chemischer InformationsdienstVolume 12, Issue 45 Preparative Organic Chemistry ChemInform Abstract: WILLIAMSON SYNTHESIS USING POLYETHYLENE GLYCOLS OR POLYETHYLENE GLYCOL ETHERS AS ORGANIC-AQUEOUS (CONCENTRATED AQUEOUS ALKALI) PHASE TRANSFER CATALYSTS K. SUKATA, K. SUKATASearch for more papers by this author K. SUKATA, K. SUKATASearch for more papers by this author First published: November 10, 1981 https://doi.org/10.1002/chin.198145152AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume12, Issue45November 10, 1981 RelatedInformation

ChemInform Abstract: CONVENIENT AND IMPROVED SYNTHESIS OF UNSTABLE CARBODIIMIDES

Chemischer InformationsdienstVolume 12, Issue 39 Preparative Organic Chemistry ChemInform Abstract: CONVENIENT AND IMPROVED SYNTHESIS OF UNSTABLE CARBODIIMIDES C. PALOMO, C. PALOMOSearch for more papers by this authorR. MESTRES, R. MESTRESSearch for more papers by this author C. PALOMO, C. PALOMOSearch for more papers by this authorR. MESTRES, R. MESTRESSearch for more papers by this author First published: September 29, 1981 https://doi.org/10.1002/chin.198139154AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume12, Issue39September 29, 1981 RelatedInformation

ChemInform Abstract: OLEFIN SYNTHESIS BY REACTION OF ALKYL PHENYL TELLURIDES WITH CHLORAMINE‐T

Chemischer InformationsdienstVolume 12, Issue 38 Preparative Organic Chemistry ChemInform Abstract: OLEFIN SYNTHESIS BY REACTION OF ALKYL PHENYL TELLURIDES WITH CHLORAMINE-T T. OTSUBO, T. OTSUBOSearch for more papers by this authorF. OGURA, F. OGURASearch for more papers by this authorH. YAMAGUCHI, H. YAMAGUCHISearch for more papers by this authorH. HIGUCHI, H. HIGUCHISearch for more papers by this authorY. SAKATA, Y. SAKATASearch for more papers by this authorS. MISUMI, S. MISUMISearch for more papers by this author T. OTSUBO, T. OTSUBOSearch for more papers by this authorF. OGURA, F. OGURASearch for more papers by this authorH. YAMAGUCHI, H. YAMAGUCHISearch for more papers by this authorH. HIGUCHI, H. HIGUCHISearch for more papers by this authorY. SAKATA, Y. SAKATASearch for more papers by this authorS. MISUMI, S. MISUMISearch for more papers by this author First published: September 22, 1981 https://doi.org/10.1002/chin.198138141Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume12, Issue38September 22, 1981 RelatedInformation

ChemInform Abstract: REGIOSPECIFIC SYNTHESIS OF 3‐ALKYLFURANS AND 3‐ALKYLTHIOPHENES VIA ORGANOBORANES

Chemischer InformationsdienstVolume 12, Issue 36 Preparative Organic Chemistry ChemInform Abstract: REGIOSPECIFIC SYNTHESIS OF 3-ALKYLFURANS AND 3-ALKYLTHIOPHENES VIA ORGANOBORANES I. AKIMOTO, I. AKIMOTOSearch for more papers by this authorM. SANO, M. SANOSearch for more papers by this authorA. SUZUKI, A. SUZUKISearch for more papers by this author I. AKIMOTO, I. AKIMOTOSearch for more papers by this authorM. SANO, M. SANOSearch for more papers by this authorA. SUZUKI, A. SUZUKISearch for more papers by this author First published: September 8, 1981 https://doi.org/10.1002/chin.198136145Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume12, Issue36September 8, 1981 RelatedInformation

ChemInform Abstract: FISCHER‐TROPSCH SYNTHESIS ON A PRECIPITATED IRON CATALYST

Chemischer InformationsdienstVolume 12, Issue 36 Preparative Organic Chemistry ChemInform Abstract: FISCHER-TROPSCH SYNTHESIS ON A PRECIPITATED IRON CATALYST R. J. MADON, R. J. MADONSearch for more papers by this authorW. F. TAYLOR, W. F. TAYLORSearch for more papers by this author R. J. MADON, R. J. MADONSearch for more papers by this authorW. F. TAYLOR, W. F. TAYLORSearch for more papers by this author First published: September 8, 1981 https://doi.org/10.1002/chin.198136092AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume12, Issue36September 8, 1981 RelatedInformation

Enzymes in preparative organic synthesis: Coincidence of the pH optimum for catalyst effectiveness with the pH optimum for the catalyzed reaction equilibrium

AbstractThe study concerned the pH profile of the apparent equilibrium constant for synthesis of N‐benzoyl‐L‐phenylalanine ethyl ester from the respective acid and ethanol in the biphasic system chloroform + 5% (v/v) water. The substitution of water (as a reaction medium) for the biphasic aqueous–organic system shifted the pH profile toward neutral pH values. As a result the pH range thermodynamically conducive to synthesis of the final product in the biphasic system coincided with the pH optimum of the catalytic activity of the enzyme used (α‐chymotrypsin). This approach should, in principle, be considered as general: first, per se it is independent of a catalyst (enzyme) nature; second, the biphasic method helps the shift ionic equilibria involving not only organic acids, but also bases. A physical mechanism of the ionic equilibrium shift is the same is both cases, namely, a preferable extraction from water into an organic phase of one generally nonionic (more hydrophobic) form of the reagent.

ChemInform Abstract: TOTAL SYNTHESIS OF RIFAMYCINS. 1. STEREOCONTROLLED SYNTHESIS OF THE ALIPHATIC C BUILDING BLOCK

Chemischer InformationsdienstVolume 12, Issue 14 Preparative Organic Chemistry ChemInform Abstract: TOTAL SYNTHESIS OF RIFAMYCINS. 1. STEREOCONTROLLED SYNTHESIS OF THE ALIPHATIC C BUILDING BLOCK H. NAGAOKA, H. NAGAOKASearch for more papers by this authorW. RUTSCH, W. RUTSCHSearch for more papers by this authorG. SCHMID, G. SCHMIDSearch for more papers by this authorH. IIO, H. IIOSearch for more papers by this authorM. R. JOHNSON, M. R. JOHNSONSearch for more papers by this authorY. KISHI, Y. KISHISearch for more papers by this author H. NAGAOKA, H. NAGAOKASearch for more papers by this authorW. RUTSCH, W. RUTSCHSearch for more papers by this authorG. SCHMID, G. SCHMIDSearch for more papers by this authorH. IIO, H. IIOSearch for more papers by this authorM. R. JOHNSON, M. R. JOHNSONSearch for more papers by this authorY. KISHI, Y. KISHISearch for more papers by this author First published: April 7, 1981 https://doi.org/10.1002/chin.198114160Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume12, Issue14April 7, 1981 RelatedInformation

ChemInform Abstract: METHANOLYSIS (SOLVOLYSIS) AND SYNTHESIS OF 4′‐SUBSTITUTED 4‐BENZYLOXYBENZYL CHLORIDES AND SOME RELATED COMPOUNDS: COMPARISONS WITH THE CORRESPONDING BENZOYL COMPOUNDS

Chemischer InformationsdienstVolume 12, Issue 13 Preparative Organic Chemistry ChemInform Abstract: METHANOLYSIS (SOLVOLYSIS) AND SYNTHESIS OF 4′-SUBSTITUTED 4-BENZYLOXYBENZYL CHLORIDES AND SOME RELATED COMPOUNDS: COMPARISONS WITH THE CORRESPONDING BENZOYL COMPOUNDS J. A. L. JORGE, J. A. L. JORGESearch for more papers by this authorN. Z. KIYAN, N. Z. KIYANSearch for more papers by this authorY. MIYATA, Y. MIYATASearch for more papers by this authorJ. MILLER, J. MILLERSearch for more papers by this author J. A. L. JORGE, J. A. L. JORGESearch for more papers by this authorN. Z. KIYAN, N. Z. KIYANSearch for more papers by this authorY. MIYATA, Y. MIYATASearch for more papers by this authorJ. MILLER, J. MILLERSearch for more papers by this author First published: March 31, 1981 https://doi.org/10.1002/chin.198113113AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume12, Issue13March 31, 1981 RelatedInformation

Enzymatic synthesis in biphasic aqueous-organic systems. II. Shift of ionic equilibria

Ionic equilibria in ‘water-water-immiscible organic solvent’ systems have been studied. It has been shown that in such systems shift of the apparent p K value of acids and bases takes place (compared to aqueous solutions), the value of the shift being rather high, up to 5 and more pH units (with 2,4-dinitrophenyltryptophan as an acid and neutral red as a base). The p K shift of ionogenic reagents observed in biphasic systems can be used in preparative organic synthesis for increasing the yield of end products in enzyme-catalyzed reactions. In connection with this, the physico-chemical reasons for the equilibrium shift in a chemical reaction that involves one or two ionogenic reagents are theoretically analyzed. The above approach has been tested with two α-chymotrypsin-catalyzed reactions, i.e., synthesis of N- benzoyl- l-phenylalanine ethyl ester (from NBz- lPhe-OH and ethanol) and synthesis of N- acetyl- l-tryptophanyl - l- leucine amide (from NAc- lTrp-OH and lLeu-NH 2). In water the equilibria in these reactions are shifted almost entirely towards the starting reagents with the yield of end product being negligibly low. In biphasic systems consisting of chloroform + 5% (v/v) water or ethyl acetate + 2% (v/v) water, the yield of both the ester and the dipeptide reaches 100%.