Preparation Of Core-shell Nanoparticles Research Articles

The Impact of Magnesium-Aluminum-Layered Double Hydroxide-Based Polyvinyl Alcohol Coated on Magnetite on the Preparation of Core-Shell Nanoparticles as a Drug Delivery Agent.

One of the current developments in drug research is the controlled release formulation of drugs, which can be released in a controlled manner at a specific target in the body. Due to the diverse physical and chemical properties of various drugs, a smart drug delivery system is highly sought after. The present study aimed to develop a novel drug delivery system using magnetite nanoparticles as the core and coated with polyvinyl alcohol (PVA), a drug 5-fluorouracil (5FU) and Mg–Al-layered double hydroxide (MLDH) for the formation of FPVA-FU-MLDH nanoparticles. The existence of the coated nanoparticles was supported by various physico-chemical analyses. In addition, the drug content, kinetics, and mechanism of drug release also were studied. 5-fluorouracil (5FU) was found to be released in a controlled manner from the nanoparticles at pH = 4.8 (representing the cancerous cellular environment) and pH = 7.4 (representing the blood environment), governed by pseudo-second-order kinetics. The cytotoxicity study revealed that the anticancer delivery system of FPVA-FU-MLDH nanoparticles showed much better anticancer activity than the free drug, 5FU, against liver cancer and HepG2 cells, and at the same time, it was found to be less toxic to the normal fibroblast 3T3 cells.

Nanoscale noble metals with a hollow interior formed through inside-out diffusion of silver in solid-state core-shell nanoparticles

Noble metal nanoparticles with hollow interiors and customizable shell compositions have immense potential for a wide variety of applications. Herein, we present a facile, general, and cost-effective strategy for the synthesis of noble metal nanoparticles with hollow structures, which is based on the inside-out diffusion of Ag in solid-state core-shell nanoparticles. This approach starts with the preparation of core-shell nanoparticles with Ag residing in the core region, which are then loaded on a solid substrate and aged in air to allow the inside-out diffusion of Ag from the core region, leading to the formation of monometallic or alloy noble metal nanoparticles with a hollow interior. The synthesis was carried out at room temperature and could be achieved on different solid substrates. In particular, the inside-out diffusion of Ag calls for specific concern with respect to the evaluation of the catalytic performance of the Ag-based core-shell nanoparticles since it may potentially interfere with the physical and chemical properties of the core-shell particles.

キャリアとＤＤＳ ナノ粒子

This review presents the outstanding contributions and preparative techniques in mainly polymeric nanoparticles used as drug delivery systems. Nanoparticles discussed here vary in the diameter from 10 to 1000 nm. The formation of nanoparticles composed of one polymer chain and many polymer chains is reviewed in terms of the intrapolymer and interpolymer self-association and methods of preparation and drug loading are briefly described. Several methods to prepare nanoparticles by dispersing the preformed polymers are also demonstrated, e. g., solvent evaporation method and solvent diffusion method. Particles can be produced via a polymerization process from monomers. The preparative techniques for nanoparticles include emulsion polymerization, miniemulsion polymerization, and microemulsion polymerization. For drug incorporation, preparation of core-shell nanoparticles is also described. As a novel approach to fabricate nanopartides, supra-molecular structured materials such as dendrimers are introduced. Finally, our attempts to utilize nanoparticles for cell-death induction are stated and the concept of ‘cell-death programmed cell’ is proposed in this literature.