In this paper, a statistical analysis of the diurnal, seasonal and solar cycle variation in the TEC longitudinal difference in midlatitudes of East Asia is presented using CODE GIMs data in 2015–2019. Moreover, the empirical neutral wind model HWM-14 and geomagnetic field model IGRF-2020 were employed to analyze the influence of geomagnetic configuration-neutral wind mechanism on the TEC longitudinal difference, and the F2 layer peak electron density (NmF2) data from the Constellation Observing System for Meteorology, Ionosphere and Climate (COSMIC) were also used to study the role of local electron density in the TEC longitudinal difference. For the high solar activity year, the results show that east-west TEC longitudinal difference index Re/w is negative in the noon and positive at evening-night. Moreover, the longitudinal difference of daytime TEC is most evident in summer, less in autumn and least in spring and winter, while the nighttime difference is most obvious in equinox, followed by summer and winter during nighttime. The model simulation shows that the TEC longitude difference around noon is mainly caused by the zonal wind-declination mechanism, and a 4-h time delay seems to be an optimal result for the vertical drift velocity to cause the longitudinal TEC difference during pre-noon hours. At night, the uplifting electron flux, which is a product of local electron density and vertical drift velocity, shows a good correlation with Re/w, indicating that the local electron density is also an important factor affecting the TEC longitudinal difference during the nighttime. Moreover, there was about a 3-h time delay between the TEC longitudinal variations and the uplifting electron flux at night. For the low solar activity years, the western TEC is greater than eastern TEC during most of the year except in the summer nighttime. The TEC diurnal variation in the east and west suggested that the nighttime Re/w should be related to other physical process, such as the midlatitude summer nighttime anomaly (MSNA) in the east and the ionospheric nighttime enhancement (INE). The current study provides evidence for the longitudinal difference of NmF2 in East Asian midlatitudes and geomagnetic configuration-neutral wind mechanism proposed in previous studies and finds some new features which need further studying to improve our current understanding of ionospheric longitudinal difference in the low solar activity years. The results provide new insight into TEC longitudinal variations at midlatitudes, and they can contribute to understanding the ionosphere-thermosphere coupling system.