Prenatal Psychological Stress Research Articles

Effect of prenatal exposure to maternal cortisol and psychological distress on infant development in Bengaluru, southern India: a prospective cohort study

BackgroundThe mental health status of a pregnant woman and its consequent impact on foetal well being is not given much importance compared to the risk imposed by obstetric complications and medical conditions. Maternal psychological distress is a major public health problem and needs timely detection and intervention to prevent any adverse pregnancy outcome. There is ample evidence from literature that justifies the association of prenatal maternal mental stress and elevated cortisol with delayed infant motor and cognitive development; evidence from India being rather limited. The study aim is to prospectively assess the association of maternal psychological distress and cortisol level with motor and cognitive development of the infant.MethodsA sample of 2612 eligible pregnant women who have been registered for antenatal care at selected public sector hospitals in Bengaluru will be recruited after obtaining written informed consent. They will be assessed for the presence of maternal psychological distress in the form of depression and anxiety using appropriate scales and saliva samples will be collected for cortisol estimation during early, mid and late pregnancy. Follow up visits after delivery will be done on day 10, 3 months, 8 months and 12 months. The Bayley Scales of Infant and Toddler Development [BSID] (Third edition) will be used to measure both motor and mental milestones in terms of Psychomotor Development Index (PDI) and Mental Development Index (MDI). Logistic regression model will be used to determine the association between the exposure variables and outcomes which will be reported as Odd’s Ratio (OR) and 95% confidence intervals (CI).DiscussionOur study findings could add to the growing evidence that maternal psychological distress during pregnancy adversely influences growth and development in the offspring and subsequent development of the child. While maternal anxiety and depression can be measured by using self reporting instruments, estimation of maternal endogenous cortisol levels could serve as a biomarker of prenatal psychological stress. Findings from this study could be used to focus upon the burden of mental health problems during pregnancy and to consider steps to scale up prenatal mental health services in health care settings.

The impact of psychological distress during pregnancy on the developing fetus: biological mechanisms and the potential benefits of mindfulness interventions

The in utero environment plays an essential role in shaping future growth and development. Psychological distress during pregnancy has been shown to perturb the delicate physiological milieu of pregnancy, and has been associated with negative repercussions in the offspring, including adverse birth outcomes, long-term defects in cognitive development, behavioral problems during childhood and high baseline levels of stress-related hormones. Fetal epigenetic programming, involving epigenetic processes, may help explain the link between maternal prenatal stress and its negative effects on the child. Given the potential long-term effects of early-life stress on a child's health, it is crucial to minimize maternal distress during pregnancy. A number of recent studies have examined the usefulness of mindfulness-based programs to reduce prenatal psychological stress and improve maternal psychological health, and these are reviewed here. Overall, the findings are promising, but more research is needed with large studies using randomized controlled study designs. It remains unclear whether or not such interventions could also improve child health outcomes, and whether these changes are modulated at the epigenetic level during fetal development. Further studies in this area are needed.

Prenatal Psychological Stress Modulates Offspring's Long-Term Cardiovascular Activity and Reactivity to Stress

Prenatal Psychological Stress Modulates Offspring's Long-Term Cardiovascular Activity and Reactivity to Stress

Maternal bereavement and childhood asthma-analyses in two large samples of Swedish children.

BackgroundPrenatal factors such as prenatal psychological stress might influence the development of childhood asthma.Methodology and Principal FindingsWe assessed the association between maternal bereavement shortly before and during pregnancy, as a proxy for prenatal stress, and the risk of childhood asthma in the offspring, based on two samples of children 1–4 (n = 426 334) and 7–12 (n = 493 813) years assembled from the Swedish Medical Birth Register. Exposure was maternal bereavement of a close relative from one year before pregnancy to child birth. Asthma event was defined by a hospital contact for asthma or at least two dispenses of inhaled corticosteroids or montelukast. In the younger sample we calculated hazards ratios (HRs) of a first-ever asthma event using Cox models and in the older sample odds ratio (ORs) of an asthma attack during 12 months using logistic regression. Compared to unexposed boys, exposed boys seemed to have a weakly higher risk of first-ever asthma event at 1–4 years (HR: 1.09; 95% confidence interval [CI]: 0.98, 1.22) as well as an asthma attack during 12 months at 7–12 years (OR: 1.10; 95% CI: 0.96, 1.24). No association was suggested for girls. Boys exposed during the second trimester had a significantly higher risk of asthma event at 1–4 years (HR: 1.55; 95% CI: 1.19, 2.02) and asthma attack at 7–12 years if the bereavement was an older child (OR: 1.58; 95% CI: 1.11, 2.25). The associations tended to be stronger if the bereavement was due to a traumatic death compared to natural death, but the difference was not statistically significant.Conclusions/SignificanceOur results showed some evidence for a positive association between prenatal stress and childhood asthma among boys but not girls.

Psychological prenatal stress reduced the number of BrdU immunopositive cells in the dorsal hippocampus without affecting the open field behavior of male and female rats at one month of age

We examined whether prenatal psychological stress with little physical stress causes changes in the behavior and neurogenesis of the offspring of Sprague–Dawley rats at one month. Dams in the last trimester of gestation were psychologically stressed by placing them in a social communication box and shocking a rat on the other side of a transparent wall. They suffered little physical stress. Male and female offspring from the dams showed little change in an open field test at postnatal day (PND) 30. To evaluate neurogenesis in the brain, BrdU was intraperitoneally injected at PND 35 into offspring not used in the open field test. Immunohistochemical examinations of BrdU in their dorsal hippocampus at PNDs 42 and 112 revealed that the number of BrdU immunopositive cells in the offspring of prenatally stressed rats was significantly smaller than in the offspring of unstressed ones. These results together with our previous finding that prenatal psychological stress can alter specific behaviors suggest that prenatal psychological stress can suppress neurogenesis in the dorsal hippocampus of rats of both sexes at PND 35 even though impairment in the behavioral task has not yet appeared.

Stress and Birth Weight: Evidence from Terrorist Attacks

While terrorist attacks are relatively infrequent, Gary Becker and Yona Rubinstein (2008) provide evidence that they generate a disproportionate amount of stress and fear, suggesting that the indirect effects may be far more reaching than the direct effects. The international organization Medecins Sans Frontieres (2006) claims that the physiological effect of civil conflict is Colombian’s worst public health problem. This paper is the first attempt to measure the effect of prenatal psychological stress due to terrorism on child birth outcomes. The medical literature indicates that prenatal stress increases levels of CorticotrophinReleasing Hormone (CRH), which regulates the duration of pregnancy and fetal maturation and thus increases the risk of adverse birth outcomes (Pathik D. Wadhwa et al. 1993, among others). There is also evidence that birth outcomes are most sensitive to maternal stress in early stages of pregnancy (Laura M. Glynn et al. 2001). This study finds that the intensity of random landmine explosions during a woman’s first trimester of pregnancy has a significant negative impact on child birth weight. This finding persists when mother fixed effects are included, suggesting that neither observable nor unobservable characteristics of the mothers are driving the results. I use a large dataset, comprising approximately 4 million births in Colombia from 1998 to 2003, which enables me to observe multiple births by the same mother and gives strong statistical power to discern patterns. The data also allow me to link the date of a landmine explosion with the trimester of the pregnancy, and thereby to identify the stage of pregnancy Stress and Birth Weight: Evidence from Terrorist Attacks

Prenatal psychological stress causes higher emotionality, depression-like behavior, and elevated activity in the hypothalamo-pituitary-adrenal axis

In humans, stressful events during pregnancy may raise the risk of psychiatric disorders in offspring, and studies with rodents have found that physical prenatal stress can cause changes in the physiology, neurobiology, and behavior of offspring. In the present study, we examined whether psychological prenatal stress with little physical stress could cause changes in the neurobiology and behavior of offspring in Sprague–Dawley rats, as physical prenatal stress did. Dams received psychological stress by observing a rat being electrically shocked behind a transparent wall in the social communication box during the last trimester of gestation but were not exposed to any physical stress. Male offspring from the dams exposed to psychological stress showed enhanced emotionality in an open field test, depression-like behavior in a forced swim test, and enhanced activity in the hypothalamo-pituitary-adrenal axis, compared with rats from untreated dams. However, the prenatally stressed rats showed intact ability to acquire context conditioning. This is the first report that psychological prenatal stress in the communication box can cause changes in the neurobiology and behavior of offspring in rodents.

Are prenatal psychological or physical stressors associated with suboptimal outcomes in neonates born to adolescent mothers?

Examined whether prenatal psychological stress and/or physical stress were associated with suboptimal neonatal outcomes in a pilot study of adolescent mothers ( n = 20). The results provide preliminary support for associations between prenatal psychological stress and little evidence for the association between prenatal physical stress and suboptimal neonatal outcomes.

Possible interactions of genetic and immuno-neuro-endocrine regulatory mechanisms in pathogenesis of congenital anomalies

The process of organogenesis depends on genetic and environmental factors. Besides genetic background, congenital anomalies can also be influenced by micro environmental changes, which are related to maternal-foetal interactions followed by the production of cytokines, hormones, neurotransmitters, growth factors and biochemical mediators, and stress proteins. Pre-natal maternal stress, including infections, psychological stress and other teratogens, can influence a disregulation of maternal immune, endocrine and nervous systems, during pregnancy. This is a crucial condition for the abnormal growth and development of the foetus. Activated maternal immune system can alter the cytokine network and make it inadequate for normal embryogenesis and organogenesis. Heat-shock proteins play an important role in stress physiology repairing DNA errors or activating pro-inflammatory response. Regarded from this aspect, the altered cytokine network suggests aetiopathogenetic basis of congenital anomalies in neonates. It is our wish to point out our potentially harmful conditions in the development of congenital anomalies, as well as their control by using pre-natal and pre-conceptional diagnostics and treatment.

Influence of prenatal maternal stress on the immunocompetence of the offspring

To evaluate the effects of prenatal maternal stress on the development of humoral immunocompetence in the offspring and on their hormonal and immunologic responses to postnatal stress, gravid Sprague-Dawley rats were exposed daily on gestational days 15–21 to prenatal environmental stress [(PES) 15 unsignaled, inescapable electric foot-shocks (0.05 mA for 0.5 s)] or prenatal psychological stress [(PPS) pregnant rats were placed in the nonelectrified section of the apparatus and allowed to see, hear, and smell a nonpregnant partner being environmentally stressed]. Pregnant controls (PC) were placed in the apparatus for 30 min. Serum corticosterone (CCS) and immunoglobulin G (IgG) levels were measured in the offspring every 7 days from birth to postnatal day (PND) 28. On PND 29–33, offspring were environmentally stressed; hormonal and immune status were determined on PND 34. Levels of IgG were reduced in PES and PPS offspring on PND 0 and in PES offspring on PND 7 and 28. These changes were unrelated to differences in CCS and did not reflect altered maternal-pup interactions or nutritional factors. Postnatal stress was immunosuppressive in PC pups but did not alter immune parameters in PPS offspring. In PES females, postnatal stress was also immunosuppressive. However, in PES males with alreadu reduced IgG levels postnatal stress enhanced immuno function. These data provide the first experimental evidence that prenatal maternal stress can alter immune parameters in the rat offspring.

Prenatal stress effects on functional development of the offspring

Publisher Summary This chapter reveals prenatal stress effects on functional development of the off spring. The term “psychological stress” is used to denote situations that, although not physically harmful in terms of causing direct tissue damage, evoke behavioral and physiological responses that are characteristic of the “stress” response. Early reports that prenatal psychological stress in human subjects may influence the behavior of the offspring prompted a large number of studies in experimental animals in an attempt to provide more precise information about the nature of the changes induced by such stress and their underlying mechanisms. In the absence of any direct neural connections between the mother and foetus, it has been postulated that hormones (e.g., glucocorticoids, adrenaline) transported from the maternal blood to the placenta are the most likely mediators. The nature of the effect of prenatal stress on early physical development and later behavior appears to depend upon genetic factors, the severity of the stress, and its timing. These in turn determine whether abnormal maternal and foetal hormonal and neuronal activity occurs at a critical period of foetal development.

Prenatal psychological stress effects on offspring behaviour in rats

Prenatal stress experienced by the mother usually results in behavioural changes in the offspring. The first part of this study is concerned with the mothers, who were either psychologically stress...

Prenatal psychological stress effects on taste neophobia

Pregnant mothers were subjects to a novel environment, a treatment which is known to induce an 11-hydroxycorticosterone (stress) response, for 30 min daily for five successive days while control mothers were control handled. The novelty and control treatments were given to the pregnant mothers either during terms 1, 2 or 3 of pregnancy. After parturition, all offspring were fostered to neutral foster mothers. Testing for the neophobic taste response was carried out after the offspring were 90 days old. It was found that prenatally stressed animals responded with increased neophobia to a novel saccharin solution. Female offspring drank significantly more of the test solution than male offspring. The neophobic response appears to be an index of exploration. The neophobic response of prenatally treated rats was found to be in the opposite direction of postnatally treated rats. However, both findings follow similar response patterns of pre- and postnatal stressed rats tested in an open field.

The effects of prenatal psychological stress on the sexual behavior and reactivity of male rats

Male offspring of prenatally stressed rats showed low levels of copulatory behavior during a series of brief tests with estrous females but successfully impregnated female cagemates during long term tests of breeding effectiveness. Sexual performance on the short term tests was inversely related to open field activity with the offspring of prenatally handled mothers exhibiting more sexual behavior and less open field activity. The results support the notion that prenatal stress influences both the sexual behavior and emotional reactivity of male offspring. Deficits observed during short term tests of breeding effectiveness appear to be reversible under optimal conditions.

Prenatal psychological stress and offspring behavior in rats and mice.

AbstractThe experimental literature on the behavioral sequelae of prenatal stress in rodents is reviewed, from which few conclusions can be drawn except that some change in activity‐reactivity may be induced. Were more careful consideration given to certain methodologic dimensions, greater clarity of empirical relations could be achieved. These dimensions are: (1) the sex, species, and strain of animal observed; (2) the specification of the prenatal manipulation; and (3) the precision and completeness of the behavioral description which is the dependent variable studied. Multiple descriptions, as in a test‐battery approach, appear to be inefficient and generally unwarranted.