This study aimed to optimize space closure efficiency by comparing the forces and moments exerted by different designs of clear aligners (CAs) during the movement of maxillary canines into the premolar extraction space. The forces and moments were measured using a multi-axis force/moment transducer on the maxillary right canine. The CAs were fabricated from thermoformed polyethylene terephthalate glycol. The following four edentulous space designs were tested: the edentulous space was left intact (Group 1); the edentulous space was replaced with a premolar pontic (Group 2); the edentulous space was replaced with a half-sized premolar pontic (Group 3); and the edentulous space was replaced with a rectangular column beam (Group 4). The maxillary right canine was moved 0.25 mm distally. All groups experienced buccodistal and intrusive forces; compared with the other groups, Group 1 showed significantly greater intrusive and smaller distal forces, and Group 4 showed significantly greater distal forces. All groups experienced distal tilting, lingual inclination, and mesial rotational moments. These findings suggest that modifying the thickness and extent of the adjacent teeth in the edentulous area of the CA can improve local stiffness, thereby reducing the tipping of the teeth into the edentulous space. This study emphasizes the importance of the CA design in controlling forces and moments for effective orthodontic treatment.