Human health and efficiency are largely determined by the microclimate conditions and the air quality in residential, public and industrial buildings in which people spend a significant amount of time. The existing methods of measuring microclimate indicators largely do not correspond to the changed regulatory framework, do not fully reflect all the stages of measurements, have contradictions and inaccuracies, which leads to errors in the measurement and evaluation of the results obtained. The purpose of this study was to develop guidelines for measuring microclimate indicators in residential and public buildings, leveling the existing contradictions in the current documents and meeting modern requirements. The analysis of the current methodological documents regulating the requirements for measuring microclimate indicators was carried out, the main problems encountered by specialists during measurements and evaluation of laboratory and instrumental studies of the microclimate were identified and systematized. To date, the only methodological document in the field of microclimate for residential and public buildings is GOST 30494-2011 "Residential and public buildings. Indoor microclimate parameters". This standard sets the requirements for the organization of control and allows to measure and evaluate the microclimate in almost any residential and public building. However, the standard presents requirements for measurement conditions that are practically unrealizable for many regions of Russia, unreasonably high requirements for measuring instruments (MI), which do not allow to take measurements by MI included in the State Register and having the appropriate scope of application, insufficient requirements for the criteria for the selection of premises and their preparation for an objective assessment of the microclimate parameters, inaccuracies in the presented formulas for calculating the resulting room temperature and inconsistencies in individual paragraphs of the document. There are also no requirements for processing and presenting measurement results. In this situation, the development of a methodology for measuring microclimate indicators in residential and public buildings is extremely relevant. This paper presents the main provisions of the developed draft methodology for measuring microclimate indicators in residential and public buildings at different stages of operation of research objects. The developed procedural guidelines determine the order, conditions for carrying out and minimum scope of instrumental control required for microclimate parameters in residential and public buildings that meet the requirements of sanitary legislation. In the process of procedural guidelines development inconsistencies and discrepancies of current procedural documents were considered as much as possible.