Premature beats of atrial and ventricular origin disturbing A-V rhythm in man are reported and compared with observations made by others in the experimental animal. All premature beats were followed by noncompensatory pauses. In one instance evidence was obtained that the atrium was activated by the premature ventricular excitation. In a case of upper A-V rhythm the restored beat after a premature ventricular contraction showed merging of the P wave and the QRS complex. An identical phenomenon was observed in the experimental animal and interpreted as due to temporary improvement in the conductivity of His's bundle secondary to retrograde transmission of the premature ventricular impulse to the A-V pacemaker. Upright P waves in Leads II and III were observed in a case in which the sequence of ventricular and atrial contractions indicated the presence of lower A-V rhythm.