Premature Signs Research Articles

FAKTOR-FAKTOR INTERNAL YANG MEMPENGARUHI PENGHENTIAN PREMATUR ATAS PROSEDUR AUDIT

This study aims to analyze the internal factors that affect the premature sign-off. These internal factors are the locus of control, self-esteem in relation to ambition, turnover intentions and the auditor's experience of premature sign-off of audit procedure.This research was conducted by distributing questionnaires to 23 Non-Big-Four Public Accountant Firm in Jakarta and getting 108 auditors as respondents. The results of this study indicate that the locus of control has a significant value of 0.000. The significant value of the self-esteem in relation to ambition of0.099. While the significant result of turnover intention is 0.110. And the auditor's experience is 0.001. It was concluded that the proven locus of control had a positive effect on premature sign-off of the audit procedure, while there was insufficient evidence that self-esteem associated with ambition and stopping desire had a positive effect on the premature sign-off of audit procedures. Nor is it sufficient evidence that the auditor's experience negatively affects premature sign-off of audit procedures.Keywords : Premature sign off, Locus of control, Self esteem, Turnover intentions

Senescent Mesenchymal Stem Cells Present at the Early Post Allogeneic Hematopoietic Stem Cell Transplantation Period Are Associated with an Increased Incidence of Acute Graft-Versus Host Disease and Increased Plasma Levels of Fas Ligand

IntroductionMesenchymal stem cells (MSC) are a key component of the hematopoietic niche. In the allogeneic hematopoietic stem cell transplantation (allo-HSCT) setting, the bone marrow stroma, and thus, their MSC remain of host origin. In a preliminary study we observed that, some patients at the early post allo-HSCT period, presented senescent bone marrow (BM) MSC, a finding that has not been previously described nor studied.The aims of our current study were: a) To multiparametrically characterize BM MSC at the early post allo-HSCT period (day +21). b) To confirm senescence of MSC and correlate with clinical and biological parameters (including biomarkers). c) To compare these cells with those from healthy donors.MethodsWe obtained BM samples on the day +21 post allo-HSCT from 136 patients. MSC were isolated, ex-vivo expanded and characterized, according to the criteria of the International Society for Cellular Therapy. We also obtained samples from peripheral blood at same day +21, for the study of biomarkers, which were analyzed by Luminex technique. The data were correlated with information from complete blood counts (CBC), and the morphological study of the bone marrow the same day. MSC from healthy donors were used as control.ResultsPatient baseline and transplant related characteristics are detailed in table 1. MSC were expanded ex-vivo showing normal growth, which were cryopreserved in passage 3 in the 33% (n=45/136) of the patients (Group-MSC-N). On the other hand, the remaining 67% (n=91/136), MSC showed premature signs of senescence, thus, not reaching to passage 1 (Group-MSC-S). Full BM chimerism on day+21 was seen in both groups (p=0.03). Concerning acute graft versus-host disease (aGVHD), in the Group-MSC-S, the incidence was 73% compared to 44% in the Group-MSC-N (p=0.001). The median time of the onset of aGVHD was 43 and 37 days respectively (p=0.04). The majority of cases presented with grades I-II in both groups. Plasma levels of biomarkers showed increased levels of Fas Ligand in the Group-MSC-S (p=0.009). There were no statistically significant differences regarding mortality nor relapse rates.ConclusionsBone marrow Mesenchymal stem cells may be severely damaged in some allo-HSCT recipients early after transplantation (day+21). This fact strongly correlates with the risk of development of acute GVHD. [Display omitted] DisclosuresDíez-Campelo:Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Celgene: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau.

FAKTOR-FAKTOR YANG MEMPENGARUHI PENGHENTIAN PREMATUR ATAS PROSEDUR AUDIT

The purpose of this study is: 1) knowing the sequence of audit procedure which most often signed off by auditor 2) testing effect of external and internal factors on premature signed off of audit procedure. The sample of this study are auditors of the Audit Board of the Republic of Indonesia (BPK RI) in the head office and the representative office. Sampling technique used is convenience sampling. Survey method for this study by distributing questionare. Data analysis uses Friedman test and regression logistic analysis with significance level (α) 5%.Friedman test result indicates that there are sequence of priority of audit procedure tend to be signed off. The most audit procedure which often to be signed off is internal auditor judgment and audit procedure which seldom to be signed off is substantive test. Logistic regression test shows that audit risk, materiality, professional commitment, and locus of control affect premature sign off of audit procedure, meanwhile time budget pressure, time deadline pressure, and role overload do not affect premature sign off of audit procedure.

Neonatal puppy survival after planned caesarean section in the bitch using aglepristone as a primer: A retrospective study on 74 cases.

Since most of dystocia end up in caesarean sections (C-sections), the history of any problem during whelping is a good reason to plan in advance a further C-section. Our aim was to confirm that on a large sample and over an extended period of time, mortality in puppies <2weeks of age was low, born after a planned C-section using aglepristone as a primer. Seventy-four C-sections on 59 different bitches were included. Bitches were monitored during oestrus to estimate the day of ovulation by progesterone assays; 60, 61 or 62days after ovulation, foetal viability was checked by ultrasonography and progesterone plasma level was measured. None of the bitches was at term (progesterone plasma level >2ng/ml). An injection of aglepristone was performed in late afternoon to block the effect of progesterone, mimicking its drop at the end of pregnancy. The C-section was conducted the following morning. Twenty-one breeds were represented most of which were bulldogs (26%, 21/74) and Great Danes (16%, 13/74). Four hundred and thirty-five puppies were born. A total of 43/435 puppies died within the first 2weeks (9.89%). None of the puppies showed any external signs of prematurity. The average number of deaths per litter relative to the date after ovulation was similar (0.5 pups per litter at day 60, 0.7 at day 61, 0.4 at day 62). This study shows that planned C-section after an accurate determination of ovulation and using aglepristone as a primer is a safe procedure for bitches and their offspring. It may be offered to owners if a pregnant bitch is "at risk" of dystocia.

Service life modeling of a bridge in a tropical marine environment for durable design

Concrete structures have shown premature signs of deterioration by corrosion due to the penetration of chloride ions. This paper performs service life modeling and validates the results with actual data of the total chloride concentration in a reinforced concrete structure. Chloride profiles are obtained from samples collected from a bridge in southeastern Brazil after 36 years of service. The life span of the concrete structure is assessed. The model offers a suitable option for predicting the life span of concrete structures as an engineering tool for the evaluation of risk areas and the construction of durable projects.

К РЕНТГЕНОЛОГИЧЕСКОЙ ОЦЕНКЕ СТЕПЕНИ ТЯЖЕСТИ СИНДРОМА ДЫХАТЕЛЬНЫХ РАССТРОЙСТВ У НОВОРОЖДЕННЫХ

В останні роки респіраторні розлади новонароджених стали приваблювати велику увагу дослідників, так як нерідко їх результатом є хронічна дихальна недостатність, бронхообструктивний синдром, бронхолегенева дисплазія у дітей більш старшого віку. Своєчасність оцінки стану органів дихання у новонароджених і особливо недоношених, а також наявність ознак морфологічної незрілості при синдромі дихальних розладів (СДР) вимагає широкого використання загальновідомих методів обстеження, зокрема це стосується своєчасного рентгенологічного обстеження.Мета дослідження – визначити рентгенологічні критерії ступеня тяжкості синдрому дихальних розладів (СДР) при пневмонії новонароджених.Матеріали і методи. Проведено клініко-рентгенологічне обстеження 100 новонароджених, з них 50 доношених новонароджених і 50 недоношених новонароджених із недоношеністю I і II ступенів.Результати досліджень та їх обговорення. Новонароджені діти, народжені з СДР, вимагають особливої уваги з перших днів хвороби і професійно грамотної лікарської тактики. При рентгенологічному обстеженні недоношених новонароджених із пневмонією спостерігали превалювання прояву ознак, властиві СДР. Ґрунтуючись на власних спостереженнях і аналізуючи наявну інформацію в літературі, а також узагальнюючи вивчені нами класифікації про рентгенологічні прояви стадій СДР, виділили наступний варіант рентгенологічної верифікації змін за ступенями залежно від тяжкості рентгенологічних проявів та вираження ознак, що бувають при запальному процесі на тлі незрілості легеневої тканини. I ступінь тяжкості: помірне зниження пневматизації, міліарна плямистість, обмежені слабоінтенсивні тіні, нодозно-ретикулярна сітка (розпливчаста), “повітряна бронхограма” помітна. II ступінь тяжкості: зниження пневматизації, грубі, безладно розкидані ділянки ущільнень легеневої тканини, нодозно-ретикулярна сітка, “повітряні бронхограми”. III ступінь тяжкості: виражене зниження пневматизації (“матове скло”), згладження легенево-діафрагмальної і легенево-серцевої межі (симптом “силуету”), “повітряні бронхограми”. IV ступінь тяжкості: “білі легені”. Уточнення лікарем-рентгенологом ступеня тяжкості СДР новонародженого при пневмонії дозволяє найбільш точно й об’єктивно оцінити стан тяжкості хворої дитини.Висновки. Результати рентгенологічних досліджень при пневмонії у новонароджених дітей дозволяють зробити висновок про необхідність проведення їх в неонатальному періоді. Рентгенологічний метод оцінки ступеня тяжкості СДР при пневмонії новонароджених дітей, особливо недоношених, і з синдромом затримки внутрішньоутробного розвитку зручний своєю неінвазивністю, мінімальним променевим навантаженням на обстежуваного, широким спектром показників і багатою інформацією морфологічних даних, що сприяє своєчасній корекції комплексного лікування, особливо при ризику СДР, економії використання лікарських препаратів, зменшенні розвитку постгіпоксичних ускладнень адаптаційного періоду.

Pengaruh Tekanan Waktu, Tindakan Supervisi dan Locus of Control Terhadap Penghentian Prematur Atas Prosedur Audit

Premature sign off of audit procedure is one of those behaviors that can reduce audit quality. The present study was intended to examine whether time pressure, supervision, and locus of control affect the premature sign off of the audit procedure. The population used in this study is all auditors working at Public Accounting Firms in Surabaya. The data used is the primary data in the form of questionnaires distributed to the respondents. The sampling technique used is purposive sampling. The sample of research is 50 auditors from 17 Public Accounting Firms in Surabaya. Data analysis techniques used is multiple regressions. The results of this research showed that time pressure, supervision and locus of control affected the premature sign off of the audit procedures. The implication of this research result for the auditor is the higher the premature discontinuation of the audit procedure performed by the auditor will result in decreased audit quality and increased audit risk.

PENGARUH TEKANAN WAKTU, RISIKO AUDIT, MATERIALITAS, LOCUS OF CONTROL DANTINDAKAN SUPERVISI TERHADAP PENGHENTIAN PREMATUR ATASPROSEDUR AUDIT

The purpose of this researchare to analyze time pressure, audit risk,materiality, Locus of control and supervision that can affect the premature sign off audit procedures. The population in this research is the auditors who work in the public accountant office in DKI Jakarta and as much as 113 respondents are selected as samples in this research. The collection of primary data is carried out by performing survey method which gives written questions in the form of questionnaires and directly distribute it to the respondents in each the public accountant office. The test of data is done the validity and reliability, as well as the normality test. The hypothesis was analyzed using the Multiple Regression Analysis as well as R2-test and T-test assisted with SPSS 20.0 the analyze for the effect of time pressure, audit risk, materiality, locus of control and supervision of the premature sign off audit procedures. The result of the study showed that the time pressure, materiality, Locus of control and supervision have effect positivelyand significant to the premature sign off audit procedures.

Features of the course and effectiveness of treatment of tuberculosis in pregnant women with different HIV status

The study presents the results of comparing the social status and the efficiency of TB treatment in pregnant women with or without HIV treated in Krasnoyarsk Regional TB Clinic № 1 in the years 2010–2014. It is based on a retrospective analysis of health cards of 133 pregnant TB patients divided into groups: Group 1 (TB), n=109; Group 2 (TB and HIV), n=24. More than a half of the women (51,3% and 54,1% accordingly) were new TB patients, the others had been previously treated for TB. A moderate immunodeficiency was more often detected in co-infected pregnant women (mean CD4+ lymphocyte count being 387 cells/ml), although in 4 patients the CD4 count was lower than 200 cells/ml. The registered rates of bacterioexcretion and lung disintegration were practically the same (57,7% and 58,3% versus 53,2% and 54,1% accordingly); MDR TB was diagnosed in 51,1% in Group 1 and in 60,0% in Group 2. Results: Patients of both groups had various social problems. However, the most aggravating medico-social factor among the co-infected women was active drug abuse during pregnancy (proved in 37,5%). The clinical course of TB in patients with HIV was severer, they more often developed acute forms of the disease. Preterm delivery was more frequent in TB/HIV cases (46,1% vs. 12,3%, p<0,01). Children born by the women with HIV co-infection showed signs of prematurity and intrauterine growth retardation more often than those born by HIV-negative patients (50,0% vs. 12,3%, p<0,01). Treatment efficiency for TB was authentically less in co-infected cases (33,4% vs. 58,7%, p<0,01). TB recurrence was more often registered in HIV-positive patients (25,0% vs. 3,1%, p<0,01). As for chemotherapy tolerance, treatment adherence or lethality rate, no authentic differences between the groups have been revealed.

Twin Pregnancy in a Bicornuate Bicervical Uterus Relating to a Case at CHUMEL in Cotonou Benin and Literature Review

We report a case of twin pregnancy in a malformed uterus incidentally discovered during an emergency caesarean section relating to a primigravida at CHU-MEL in Cotonou. The patient is a 25-year-old woman referred from a neighbourhood center, without particular antecedents, admitted there because of an acute fetal distress at 38 weeks of amenorrhea +1 day. The objective examination presents two hemi-vaginas and two hemi-cervixes. The Acute fetal distress diagnosis is confirmed. By means of a caesarean section on 10th June 2016, two male twins have been removed by the cephalic pole from a bicornuate bicervical uterus, J2 being mature and weighing 2700 g and J1 the other presenting signs of prematurity and weighing 1200 g. Referred to the neonatal unit, J2 is allowed to leave after 24 hours of hospitalization and J1 after 5 days of hospitalization. Postoperative care has been simple for the mother and the new-born babies are healthy. Both mother and children are allowed to leave the 5th day after operation.

PENGARUH LOCUS OF CONTROL DAN PERILAKU DISFUNGSIONAL AUDIT TERHADAP KUALITAS AUDIT PADA KANTOR AKUNTAN PUBLIK DI SEMARANG (Studi Empiris Pada Kantor Akuntan Publik di Semarang)

This study aims to look at the effect of variable locus of control, dysfunctional behavior premature sign off and dysfunctional behavior underreporting of time to audit quality in the public accounting firm in Semarang. The study population was the auditors who work in public accounting in Semarang. 2015. The sampling technique in thisstudy using convenience sampling.Jenis data used in this study are derived from primary data from respondents’ answers to the questionnaire that has been distributed on each - each KAP in Semarang. Data quality test results which consist of validity and reliability testing manunjukan that all variables can be said tobe valid and reliable so for the next item - the item on each - each concept is feasible variable is used as a measuring tool. Classical assumption that includemulticollinearity test, heteroscedasticity test, and Uju normality shows that the linear method used to qualify for a statistical test to the regression model. From the results of statistical tests showed that the locus of control with sig.0,147 and behavioral variables sig disfugioal premature sign off with the value sig.0,597, Showing that these two variables did not significantly affect audit quality, and underreporting of time with sig.-.058 , has a negative effecton audit quality.

Luzindole accelerates the aging of estrous function of female rats

In this paper, we investigated the dynamics of aging of the estrous function of female rats kept in the conditions of standard vivarium lighting and receiving luzindol - the blocker of melatonin receptors. Every three months, daily, for two weeks, vaginal smears were taken from the animals and cytological examination of the vaginal contents was conducted. Despite different mechanisms of the development of melatonin system failure (a decreased production of melatonin and a blockade of melatonin receptors), the effects of the influence on the ovulatory function are similar. In case of the blockade of melatonin receptors, the appearance of premature signs of aging of the reproductive function in rats was observed. It was manifested by an increased duration of ovulatory cycle; a decrease in the number of regular cycles; the emergence of irregular cycles; a decrease in the number of short estrous cycles and an increase of long cycles; the early development of persistent estrus.

Faktor Eksternal dan Faktor Internal yang Mempengaruhi Perilaku Auditor dalam Penghentian Prematur Prosedur Audit

This study aims to analyze whether Time Pressure, Risk Audit, Materiality, Procedures Review and Control of Quality, Supervision Measures, External Locus of Control and Self Esteem auditor effect on premature sign off audit procedures. Data collection was conducted by giving questionnaires to auditors working in KAP Yogyakarta. The method of data analysis is validity and reliability testing, hypothesis testing by means of logistic regression analysis and Friedman test. Hypothesis testing is first performed using the Friedman test and the second to the eighth hypothesis using logistic regression. Friedman test showed that there is a priority order audit procedure that are likely to be abandoned. From the results mean rank from Friedman test indicates that the use of information management assertion is a procedure that is often to be abandoned, while the physical examination is the procedure most often to be abandoned. From the logistic regression showed that time pressure, review and quality control procedures, supervision measures, external locus of control and self-esteem have a significant effect on premature sign of audit procedures. But the audit risk and materiality has no affect the premature termination of audit procedures.

Evaluation of CRP as a Preindicative Marker in Women with Preterm Labour and Preterm Prelabour Rupture of Membrane (PPROM)

Evaluation of CRP as a Preindicative Marker in Women with Preterm Labour and Preterm Prelabour Rupture of Membrane (PPROM)

Two superoxide dismutase prion strains transmit amyotrophic lateral sclerosis-like disease.

Amyotrophic lateral sclerosis (ALS) is an adult-onset degeneration of motor neurons that is commonly caused by mutations in the gene encoding superoxide dismutase 1 (SOD1). Both patients and Tg mice expressing mutant human SOD1 (hSOD1) develop aggregates of unknown importance. In Tg mice, 2 different strains of hSOD1 aggregates (denoted A and B) can arise; however, the role of these aggregates in disease pathogenesis has not been fully characterized. Here, minute amounts of strain A and B hSOD1 aggregate seeds that were prepared by centrifugation through a density cushion were inoculated into lumbar spinal cords of 100-day-old mice carrying a human SOD1 Tg. Mice seeded with A or B aggregates developed premature signs of ALS and became terminally ill after approximately 100 days, which is 200 days earlier than for mice that had not been inoculated or were given a control preparation. Concomitantly, exponentially growing strain A and B hSOD1 aggregations propagated rostrally throughout the spinal cord and brainstem. The phenotypes provoked by the A and B strains differed regarding progression rates, distribution, end-stage aggregate levels, and histopathology. Together, our data indicate that the aggregate strains are prions that transmit a templated, spreading aggregation of hSOD1, resulting in a fatal ALS-like disease.

Successful Postnatal Care of a Premature Orphan Foal Delivered by Caesarean Section

A 9-year-old Shagya Arabian pregnant mare showing signs of acute colic, underwent exploratory laparotomy at our clinic. Owing to the discovery of an inoperable leiomyoma in the abdominal cavity, the animal was euthanized. The 305-day-old fetus, which showed signs of prematurity was removed by Caesarean section and resuscitated. Clinicopathologic examination revealed a low neutrophil:lymphocyte ratio. Radiographic evaluation of the carpus and tarsus was performed and showed grade 3 ossification according to the Adams-Poulos Grading System. The immature gastrointestinal tract was unable to digest enteral feeding; this led to the development of enterocolitis and septicemia. Thrombophlebitis developed at the site of the long-acting intravenous catheter and methicillin-resistant Staphylococcus aureus was isolated from the exudate. The guttural pouches were empyematous. Follow-up radiographic examinations indicated improvement in bone maturation. The foal was discharged in a good state of health 35 days postnatum, and apart from an easily managed respiratory tract infection, no further problems were reported.

Dysfunctional Audit Behaviors: An Exploratory Study in Pakistan

This study aims to draw attention of auditing researchers and practitioners in Pakistan towards occurrences of dysfunctional audit behaviors among auditors. This is a timely and important accounting text; first, it provides comprehensible explanation of when, how and why auditors resort dysfunctional audit behavior. Second, the organizational behavior and industrial psychology literatures provide the basis for developing and testing a model that may identifies emotional intelligence as moderator in the relationship between professional skepticism, under reporting of time and premature sign off behaviors. Structural Equation Modeling (SEM) will be used to analyze data. Findings will bring practical implications to researchers and audit practitioners wanting to obtain a broader understanding of the underlying determinants of dysfunctional audit behaviors.

Determinant factors of cognitive moral development in audit activities: Ethical decision perspective (Empirical study on public accounting firms)

This study was aimed to investigate the influence of each variable (Machiavellian, Cognitive Moral Development and the Need for Achievement) either directly or indirectly on Premature Sign Off (PSO). For this purpose, a survey method was applied to gather information. The unit of analysis was junior auditors, senior auditors, supervisors and managers in the Public Accounting Firms (PAF) located in the city of Jakarta affiliated with leading foreign Public Accounting Firms (in the category of The Big Four). Relationship between the variables was tested by applying Structural Equation Model (SEM) through AMOS software to prove validity of each proposed hypothesis before. Through hypothesis testing procedures, the research findings showed that Need for Achievement and Cognitive Moral Development negatively and significantly influenced Premature Sign Off. Then, Machiavellian positively and significantly influenced Premature Sign Off. But, Machiavellian negatively and significantly Cognitive Moral Development. In the other side, Need for Achievement positively and significantly influenced Cognitive Moral Development. The conclusion of this research also indicated that the direct influence of Machiavellian on Premature Sign Off was weaker than its indirect influence through Cognitive Moral Development. Conversely, without being mediated by Cognitive Moral Development, Need for Achievement performed the stronger direct influence than its indirect influence.

PENGHENTIAN PREMATUR ATAS PROSEDUR AUDIT DAN FAKTOR –FAKTOR YANG MEMPENGARUHI (Studi Empiris Pada Auditor di Kantor Akuntan Publik Semarang dan Yogyakarta )

The objectives of this research is to test the effect of time pressure, audit risk, materiality, review procedure and quality control, self esteem on premature sign off of audit procedure. This analyze with used the logistic regression is α=5%.  The result of this research indicates that there is a priority sequence of discontinued audit procedure in time pressure conditions. The audit procedure which is often omitted is understanding business's client and the audit procedure which is seldom omitted is physical examination. The logistic regression shows that audit risk, review procedure and quality control have an effect on prematurly signed off of audit procedure. But time pressure, materiality, self esteem have not an effect on prematurly signed off of audit procedure. Keywords : Premature Sign off of Audit Procedure, Time Pressure, Audit Risk, Materialitas, Review Procedure and Quality Control , Self EsteemÂ

UV Protection Mechanism and Property of Functional Ceramic Particles

Sun protection is simply guarding a body from the adverse effects of sunlight. Aside from the hazards of heat, the sun poses the danger of sunburn, which can permanently damage the skin, precancerous changes in the skin, as well as premature wrinkling and signs of aging. UVB (Ultraviolet-B) rays are short wavelengths responsible for sun burns. UVB protection is indicated by SPF (sun protection factor) levels. UVA (Ultraviolet-A) rays penetrate deep into the skin, which can cause premature signs of aging, including sunspots, wrinkles and uneven skin tone. The PA rating system is used to indicate the level of UVA protection. In this report, the mechanism of UV protection by using titanium dioxide and zinc oxide particles are explained. Zinc oxide fine particles have excellent shielding property. We demonstrated the property using zinc oxide particles prepared by a homogeneous precipitation method from aqueous solution of zinc salts. The morphology of the zinc oxide precipitates was significantly changed depending on the precursor composition, the concentration of precipitant, and the reaction temperature. Different UV-vis absorption/reflection characteristics were observed for the particles with different morphologies.