Burden Of Premature Mortality Research Articles

Carga das Doenças Crônicas Não Transmissíveis nos Países de Língua Portuguesa

Abstract The present study analyzed trends in premature mortality from Noncommunicable diseases (NCDs) between 1990 and 2019, the projections up to 2030, and the risk factors (RFs) attributable to these diseases in the Community of Portuguese Language Countries (CPLP). Estimates from the Global Burden of Disease (GBD) study and the analysis of the burden of premature mortality due to NCDs were used for nine CPLP countries, applying age-standardized rates, using RStudio. Portugal, Brazil, Equatorial Guinea, Angola, and Guinea Bissau showed declining premature mortality rates caused by NCDs, while East Timor, Cape Verde, São Tomé and Príncipe, and Mozambique showed an increase in rates. Projections indicate that none of the countries is expected to achieve the goals of reducing premature mortality due to NCDs by one third by 2030. The attributable burden of disease showed that the most important RFs in 2019 were: high systolic blood pressure (SBP), tobacco, dietary risks, high body mass index (BMI), and air pollution. It can therefore be concluded that there are profound differences in the burden of NCDs among the countries, with better results in Portugal and Brazil, and that no CPLP country is likely to reach the NCD reduction target by 2030.

Recommendations to Enhance Physical Health for Individuals with Severe Mental Illness in Canadian Healthcare Organizations.

As Canadians with severe mental illness remain underserved and experience a high burden of physical health challenges and premature mortality, there is an unprecedented need to provide better physical healthcare to this population. Ways of addressing this gap include the delivery of physical healthcare in mental health settings ("reverse integration"). However, there is limited guidance on how to enact this integration. In this article, we outline the development of an integrated care strategy in Canada's largest mental health hospital and discuss system- and policy-level recommendations that healthcare organizations could consider in their initiatives.

Gender differences in premature mortality for cardiovascular disease in India, 2017–18

BackgroundThe present study tries to provide a comprehensive estimate of gender differences in the years of life lost due to CVD across the major states of India during 2017–18.MethodsThe information on the CVD related data were collected from medical certification of causes of death (MCCD reports, 2018). Apart from this, information from census of India (2001, 2011), SRS (2018) were also used to estimate YLL. To understand the variation in YLL due to CVD at the state level, nine sets of covariates were chosen: share of elderly population, percentage of urban population, literacy rate, health expenditure, social sector expenditure, labour force participation, HDI Score and co-existence of other NCDs such as diabetes, & obesity. The absolute number of YLL and YLL rates were calculated. Further, Pearson’s correlation had been calculated and to understand the effect of explanatory variables on YLL due to CVD, multiple linear regression analysis had been applied.ResultsMen have a higher burden of premature mortality in terms of Years of life lost (YLL) due to CVD than women in India, with pronounced differences at adult ages of 50–54 years and over. The age pattern of YLL rate suggests that the age group 85 + makes the highest contribution to the overall YLL rate due to CVD. YLL rate showed a J-shaped relationship with age, starting high at ages below 1 years, dropping to their lowest among children aged 1–4 years, and rising again to highest levels at 85 + years among both men and women. In all the states except Bihar men had higher estimated YLL due to CVD for all ages than women. Among men the YLL due to CVD was higher in Tamil Nadu followed by Madhya Pradesh and Chhattisgarh. On the other hand, the YLL due to CVD among men was lowest in Jharkhand followed by Assam. Similarly, among women the YLL due to CVD was highest in Tamil Nadu followed by Madhya Pradesh and Chhattisgarh. While, the YLL due to CVD among women was lowest in Jharkhand. Irrespective of gender, all factors except state health expenditure were positively linked with YLL due to CVD, i.e., as state health expenditure increases, the years of life lost (YLL) due to CVDs falls. Among all the covariates, the proportion of a state's elderly population emerges as the most significant predictor variable for YLL for CVDs (r = 0.42 for men and r = 0.50 for women).ConclusionYLL due to cardiovascular disease varies among men and women across the states of India. The state-specific findings of gender differences in years of life lost due to CVD may be used to improve policies and programmes in India.

The burden of mortality due to injury in Cabo Verde, 2018.

External causes continue to be one of the main causes of mortality in the world and Cabo Verde is no exception. Economic evaluations can be used to demonstrate the disease burden of public health problems such as injuries and external causes and support prioritization of interventions aimed at improving the health of the population. The objective of this study was to estimate the indirect costs of premature mortality in 2018 due to injuries and other consequences of external causes in Cabo Verde. Years of potential life lost, years of potential productive life lost and human capital approach were used to estimate the burden and indirect costs of premature mortality. In 2018, 244 deaths were registered due to injury and other consequences of external causes. Males were responsible for 85.4% and 87.73% of years of potential life lost and years of potential productive life lost, respectively. The cost of productivity lost due to premature death caused by injury was 4,580,225.91 USD. The social and economic burden due to trauma was substantial. There is a need for more evidence on the burden of disease due to injuries and their consequences, to support the implementation of targeted multi-sectoral strategies and policies for the prevention, management, and reduction of costs due to injuries in Cabo Verde.

Early childhood lower respiratory tract infection and premature adult death from respiratory disease in Great Britain: a national birth cohort study

Lower respiratory tract infections (LRTIs) in early childhood are known to influence lung development and lifelong lung health, but their link to premature adult death from respiratory disease is unclear. We aimed to estimate the association between early childhood LRTI and the risk and burden of premature adult mortality from respiratory disease. This longitudinal observational cohort study used data collected prospectively by the Medical Research Council National Survey of Health and Development in a nationally representative cohort recruited at birth in March, 1946, in England, Scotland, and Wales. We evaluated the association between LRTI during early childhood (age <2 years) and death from respiratory disease from age 26 through 73 years. Early childhood LRTI occurrence was reported by parents or guardians. Cause and date of death were obtained from the National Health Service Central Register. Hazard ratios (HRs) and population attributable risk associated with early childhood LRTI were estimated using competing risks Cox proportional hazards models, adjusted for childhood socioeconomic position, childhood home overcrowding, birthweight, sex, and smoking at age 20-25 years. We compared mortality within the cohort studied with national mortality patterns and estimated corresponding excess deaths occurring nationally during the study period. 5362 participants were enrolled in March, 1946, and 4032 (75%) continued participating in the study at age 20-25 years. 443 participants with incomplete data on early childhood (368 [9%] of 4032), smoking (57 [1%]), or mortality (18 [<1%]) were excluded. 3589 participants aged 26 years (1840 [51%] male and 1749 [49%] female) were included in the survival analyses from 1972 onwards. The maximum follow-up time was 47·9 years. Among 3589 participants, 913 (25%) who had an LRTI during early childhood were at greater risk of dying from respiratory disease by age 73 years than those with no LRTI during early childhood (HR 1·93, 95% CI 1·10-3·37; p=0·021), after adjustment for childhood socioeconomic position, childhood home overcrowding, birthweight, sex, and adult smoking. This finding corresponded to a population attributable risk of 20·4% (95% CI 3·8-29·8) and 179 188 (95% CI 33 806-261 519) excess deaths across England and Wales between 1972 and 2019. In this prospective, life-spanning, nationally representative cohort study, LRTI during early childhood was associated with almost a two times increased risk of premature adult death from respiratory disease, and accounted for one-fifth of these deaths. National Institute for Health and Care Research Imperial Biomedical Research Centre, Royal Brompton and Harefield National Health Service (NHS) Foundation Trust, Royal Brompton and Harefield Hospitals Charity and Imperial College Healthcare NHS Trust, UK Medical Research Council.

Detection of Chronic Obstructive Pulmonary Disease among Smokers Aged ≥40 years Attending Primary Health Care Centers in Baghdad-AL-Karkh and AL-Resafa

Background: Chronic obstructive pulmonary disease causes permanent morbidity, premature mortality and great burden to the healthcare system. Smoking is it's most common risk factor and Spirometry is for diagnosing COPD and monitoring its progression. Objectives: Early detection of chronic obstructive pulmonary disease in symptomatic smokers’ ≥ 40years by spirometry. Methods: A cross sectional study on all symptomatic smokers aged ≥ 40 years attending ten PHCCs in Baghdad Alkarkh and Alrisafa. Those whose FEV1/FVC was &lt;70% on spirometry; after giving bronchodilator, were considered COPD +ve. Results: Overall, airway obstruction was seen in 206(46.8%). It is significantly associated with increase age (50-y), more in male and increase with increase duration and amount of smoking Conclusions: COPD was prevalent among men and women. Early diagnosis of COPD is good for both patient and community. Routine spirometry is an easy way for screening and identifying asymptomatic patients. Before adoption of spirometry Cost-effectiveness is needed.

Premature mortality attributable to NO2 exposure in cities and the role of built environment: A global analysis

BackgroundEnvironmental risks accumulate in cities, including polluted air and health disparities, but these risks can be reduced through scientific city planning. The purpose of this study was to investigate the global burden of premature mortality attributable to NO2 exposure in urban areas and the role of the built environment in this regard. MethodsAn approach based on health impact assessment was used to estimate the premature mortality burdens associated with NO2 exposure in 13,169 urban areas around the world using globally gridded NO2 and population estimates, baseline mortality, and epidemiologically derived exposure-response functions. We used the most recent WHO recommended value (i.e.,10 μg/m3) as a counterfactual concentration. Finally, the relationship between the characteristics of the built environment at the city level and the burden of NO2-related mortality was evaluated. ResultsWorldwide, 549,715(95%CI: 276204–815,023) cases of death attributable to NO2 exposure in urban areas could be prevented if compliance with the latest WHO guideline, accounting for 2.7 % (95%CI:1.4 %–4.0 %) of total mortalities in 2019. Across cities around the world, the age-standardized mortality rate (per 100,000 people) attributable to NO2 exposure ranged from 51.3 (95%CI:25.8–76.0) in Central Asia to 3.4(95%CI: 1.7–5.1) in Oceania. Although there was a significant decrease in premature mortality attributable to NO2 exposure globally, considerable regional heterogeneity exists, with cities in Central Asia and Andean Latin America in particular exhibiting an upward trend. Further, we discovered a positive association between population density and street connectivity with mortality attributable to NO2. While the increase in green and blue space were significantly associated with a lower NO2-associated mortality. ConclusionThe findings of this study provided a comprehensive understanding of the premature mortality burden due to NO2 in cities throughout the world and the role that urban planning policies can play in reducing the health burden associated with air pollution.

First year of the pandemic: Years of Life Lost due to COVID-19 in Serbia

Abstract Background The first case of COVID-19 in Serbia was reported on 6th March 2020. Since then, Serbia has registered several epidemic peaks, which have led to a considerable increase in premature mortality. Basic evaluation of COVID-19 premature mortality burden needs to include frequency of COVID-19 deaths among different age-groups. Methods All-cause mortality data disaggregated by age and sex, population estimates and remaining life expectancy for different age-groups were acquired from the Statistical Office of the Republic of Serbia. Years of Life Lost (YLL) due to COVID-19 were calculated for the period from March to December 2020. European Standard Population was used for calculating age-standardized mortality rates. We acknowledge the support from the BoCO-19 - The Burden of Disease due to COVID-19 project coordinated/led by Robert Koch Institute and supported by the WHO Regional Office for Europe. Results In 2020, there were 127,572 YLLs due to COVID-19, with 81,147 of YLLs (63.6%) attributable to men and 46,425 (36.4%) to women. Contribution of COVID-19 to the total all-cause YLL was also higher in men comparing to women: 11.39% and 7.80%, respectively. Three epidemic peaks were observed in 2020, together composing two thirds (65.6%) of total YLLs due to COVID-19. December was the month with the greatest burden, accounting for 45.8% of all YLLs due to COVID-19. Crude YLL rate for COVID-19 was 1849.1 per 100,000, or 1733.5 per 100,000 after standardization. Conclusions Registered COVID-19 deaths accounted for one tenth of total YLLs in Serbia in 2020, with men contributing almost twice as much to that number compared to women. On average, 12.32 YLLs originated from each registered COVID-19 death. Further studies need to assess the impact of the COVID-19 epidemic on avoidable mortality trends in Serbia. Key messages • COVID-19 deaths comprised one tenth of all-cause YLLs, with two-thirds of COVID-19 YLLs attributable to men. • To reduce premature mortality burden, epidemic peaks need to be prevented.

Early Intervention for Personality Disorder.

Both the DSM-5 Section III Alternative Model for Personality Disorders and the ICD-11 have introduced a genuinely developmental approach to personality disorder. Among young people with personality disorder, compelling evidence demonstrates a high burden of disease, substantial morbidity, and premature mortality, as well as response to treatment. Yet, early diagnosis and treatment for the disorder have struggled to emerge from its identity as a controversial diagnosis to a mainstream focus for mental health services. Key reasons for this include stigma and discrimination, lack of knowledge about and failure to identify personality disorder among young people, along with the belief that personality disorder must always be addressed through lengthy and specialized individual psychotherapy programs. In fact, evidence suggests that early intervention for personality disorder should be a focus for all mental health clinicians who see young people and is feasible by using widely available clinical skills.

The burden of premature mortality from coal-fired power plants in India is high and inequitable

Prior mortality estimates of air pollution from coal-fired power plants in India use PM2.5 exposure-response functions from settings that may not be representative, and do not include other potentially harmful effects of these plants, such as fly ash pollution and heavy freshwater consumption. We use a national, district level dataset to assess the impact of coal-fired power plants on all-cause mortality (15–69 years) in 2014. We compare districts with coal-fired power plants (total capacity >1000 MW) to districts without a coal-fired power plant, estimating the effect of these power plants on all-cause mortality within districts that have these plants. Out of 597 districts in India in 2014, 60 districts had a coal-fired power plant. When compared to districts without a coal-fired power plant, districts with a coal-fired power plant (>1000 MW) had higher rates of age-standardized mortality in both women (0.38, 95% CI: −0.14–0.90) and men (0.55, −0.17–1.27). Similarly, these districts had higher rates of conditional probability of premature death in both women (2.22, −0.13–4.56) and men (2.12, −0.54–4.77). The point estimates for total excess deaths were 19 320 for women and 27 727 for men. In affected districts, the proportion of premature adult deaths attributable to coal-fired power plants was 5.8% (−0.3%–11.9%) in women and 4.3% (−1.1%–9.6%) in men. We estimate that ∼47 000 premature adult deaths can be attributed to large coal-fired power plants in India in 2014. These deaths are concentrated in the ∼10% of districts that have the nation’s power plants, where they are associated with 1 out of 20 premature adult deaths. Effective regulation of emissions from these plants, coupled with a phaseout of coal-fired power plants, can help decrease this burden of inequitable and premature adult mortality.

The environmental justice implications of the Paris low emission zone: a health and economic impact assessment

BackgroundReducing the mortality burden associated with urban air pollution constitutes a public health priority, and evidence of unequal exposure and susceptibility across population subgroups is growing. Many European countries have implemented low emission zones (LEZs) in densely populated city centers. Although LEZs decrease air pollution exposure and health impacts, evidence is lacking on their impact across neighborhoods and socio-economic groups.ObjectivesThe aim of this study was to evaluate the most equitable approach to implementing the second phase of the LEZ in Paris, France. We also present a literature review of the studies evaluating the benefits associated with LEZs in Europe.MethodsA health impact assessment (HIA) was conducted to quantify changes in air pollution exposure and expected health benefits by socioeconomic group and neighborhood related to four hypothetical scenarios for the second phase of the LEZ based on French Deprivation Index scores. The study focused on NO2 and PM2.5 as air pollutants and evaluated the impact of the LEZ on the inequitable burden of childhood asthma and all-cause premature adult mortality. We also conducted an economic evaluation associated with the LEZ benefits on prevented deaths and asthma cases.ResultsThe scenario with the largest LEZ perimeter and the most stringent vehicle standards prevented the highest number of cases and produced the most equitable distribution of health benefits, especially childhood asthma. It is expected that 810 deaths and 3200 cases of asthma could be prevented from the LEZ extension in this scenario. These results were distributed heterogeneously across three socioeconomic (SES) groups, most noticeably with asthma cases as 230, 180, and 210 cases were avoided per 100,000 inhabitants in high, medium, and low SES groups, respectively. We found substantial economic benefits associated with LEZ, with estimates ranging from €0.76 billion to €2.36 billion for prevented deaths. The benefits associated with asthma reduction ranged from €2.3 million to €8.3 million.DiscussionConducting HIAs with a focus on equity will further inform policy makers of the impact of LEZ models on air pollution, health, and environmental justice. Developing these systematic methods and applying them to future LEZs and other air pollution policies will increase their effectiveness to reduce the burden of ambient air pollution on society and the environment.

Research Trends, Hotspots and Frontiers of Ozone Pollution from 1996 to 2021: A Review Based on a Bibliometric Visualization Analysis

A total of 2932 publications in the field of ozone pollution were obtained from the Web of Science and briefly reviewed using a bibliometric analysis and WOS-based citation reports. CiteSpace 5.7.R3 (64 bit) was used to perform a visualization of knowledge mapping by keywords co-words, burst analysis, co-cited reference analysis, and cooperation network analysis. Research topics in this field have mainly focused on three aspects: risk assessment of ozone pollution for both humans and plants under short-term and long-term exposure; ozone pollution characterization and modeling of ozone transport on different scales; and elucidating the mechanism of ozone formation and source apportionment. By clustering the co-cited references using the data from 2016 to 2021, the frontiers are found to be: (1) VOCs’ precursors and ozone transformation mechanism; (2) modeling of source apportionment and source-oriented chemical transport considering meteorological influence to predict ozone concentration at different spatial and temporal scales; and (3) premature mortality and health burden with relation to ozone exposure. It should be mentioned that an emerging research hotspot is the utilization of artificial intelligence (AI) tools (e.g., machine learning, deep learning, etc.) to facilitate the modeling of big data at different scales.

Counting the cost of premature mortality with progressively worse aortic stenosis in Australia: a clinical cohort study

SummaryBackgroundAortic stenosis is the most common cardiac valve disorder requiring clinical management. However, there is little evidence on the societal cost of progressive aortic stenosis. We sought to quantify the societal burden of premature mortality associated with progressively worse aortic stenosis.MethodsIn this observational clinical cohort study, we examined echocardiograms on native aortic valves of 98 565 men and 99 357 women aged 65 years or older across 23 sites in Australia, from Jan 1, 2003, to Dec 31, 2017. Individuals were grouped according to their peak aortic valve velocity in 0·50 m/s increments up to 4·00 m/s or more (severe aortic stenosis), using 1·00–1·99 m/s (no aortic stenosis) as the reference group. Sex-specific premature mortality and years of life lost during a 5-year follow-up were calculated, along with willingness-to-pay to regain quality-adjusted life years (QALYs).FindingsOverall, 20 701 (21·0%) men and 18 576 (18·7%) women had evidence of mild-to-severe aortic stenosis. The actual 5-year mortality in men with normal aortic valves was 32·1% and in women was 26·1%, increasing to 40·9% (mild aortic stenosis) and 52·2% (severe aortic stenosis) in men and to 35·9% (mild aortic stenosis) and 55·3% (severe aortic stenosis) in women. Overall, the estimated societal cost of premature mortality associated with aortic stenosis was AU$629 million in men and $735 million in women. Per 1000 men and women investigated, aortic stenosis was associated with eight more premature deaths in men resulting in 32·5 more QALYs lost (societal cost of $1·40 million) and 12 more premature deaths in women resulting in 57·5 more QALYs lost (societal cost of $2·48 million) when compared with those without aortic stenosis.InterpretationAny degree of aortic stenosis in older individuals is associated with premature mortality and QALYs. In this context, there is a crucial need for cost-effective strategies to promptly detect and optimally manage this common condition within our ageing populations.FundingEdwards LifeSciences, National Health and Medical Research Council of Australia, and the National Heart, Lung, and Blood Institute.

Short-term exposure to ozone and economic burden of premature mortality in Italy: A nationwide observation study

Italy is among the countries with the highest ozone concentration in Europe. However, the mortality burden of ozone and related economic loss has not been fully characterized. This study aimed to estimate the ozone-mortality association in Italy and evaluate attributable mortality burden and related economic loss in 2015–2019. We collected daily all-cause mortality data stratified by age and sex from 2015 to 2019 in 107 provinces of Italy. A two-stage time-series framework was applied to estimate the association between daily maximum eight-hour average ozone and mortality as well as economic loss. An overall increase in the risk of mortality (RR=1.0043, 95% CI: 1.0029, 1.0057) was associated with every 10 µg/m3 increase in ozone. Generally, a total of 70,060 deaths and $65 billion economic loss were attributed to ozone exposure, corresponding to 3.11% of mortality and about 0.5% of the national GDP during the study period, respectively. The highest ozone-related mortality burden (30,910 deaths) and economic loss ($29.24 billion) were observed in the hot season. This nationwide study suggested considerable mortality burden and economic loss were associated with exposure to ozone. More actions and policies should be proposed to reduce ozone levels and help the public protect their health.

The burden of premature mortality among older adults: a population-based study in Malaysia

BackgroundThe populations of many countries—including Malaysia—are rapidly growing older, causing a shift in leading causes of disease and death. In such rapidly ageing populations, it is critical to monitor trends in burden of disease and health of older adults by identifying the leading causes of premature mortality and measuring years of life lost (YLL) to these. The objective of this study, therefore, is to describe the burden (quantified by YLL) associated with major causes of premature mortality among older adults in Malaysia in 2019.MethodsAll deaths that occurred in older adults aged 60 and above in Malaysia in the year 2019 were included in this study. YLL was calculated by summing the number of deaths for the disease category at 5-year age intervals, multiplied by the remaining life expectancy for the specific age and sex group. Both life expectancy and mortality data were obtained from the Department of Statistics Malaysia.ResultsIn 2019, older adults accounted for 67.4% of total deaths in Malaysia (117,102 out of 173,746). The total number of YLL among older adults in Malaysia in 2019 was estimated at 1.36 million YLL, accounting for 39.6% of the total YLL (3.44 million) lost to all premature deaths in that year. The major causes of premature mortality among older adults were ischaemic heart disease (29.5%) followed by cerebrovascular disease (stroke) (20.8%), lower respiratory infections (15.9%), diabetes mellitus (8.1%) and trachea, bronchus and lung cancers (5.0%).ConclusionsNon-communicable diseases (NCD) remained the largest contributor to premature mortality among older adults in Malaysia. Implementation of population-level NCD health promotion programmes, screening programmes among high-risk groups and holistic intervention programmes among populations living with NCD are critical in reducing the overall burden of premature mortality.

Losses of potential years of life as a result of early death in the largest cities of Ukraine: contribution of infectious diseases

Objective — to estimate demographic losses due to premature death caused by infectious diseases according to the indicators of lost potential years of life (YPLL) in five metropolises of Ukraine in 2005–2019; identify differences in the significance of the two main causes (HIV/AIDS and tuberculosis); and their transformation over time. Materials and methods. Materials — data of the State Statistics Service of Ukraine on the distribution of deaths by sex, age groups and causes of death by year in five largest cities of Ukraine (Dnipro, Kyiv, Lviv, Odessa and Kharkiv) in the dynamics during 2005—2019. Deaths classified as Class I ICD-10 «Certain infectious and parasitic diseases» selected.The method of potential demography and the method of standardization by age (European standard) were used. The absolute number of YPLL from infectious diseases under the age of 65, standardized indicators of lost years of potential life for the largest cities and their average value for all five cities were calculated (with disaggregation by sex). Results and discussion. The average YPLL for all five cities increased in 2005—2019 from 2097.84 to 1666.41 person-years per 100,000 population. For men, the losses are greater, the average for all five cities in 2019 was almost twice as high (1.9 times) than for women.There was a «rotation» of two major diseases of infectious etiology. In all cities, the importance of HIV/AIDS in the formation of losses due to premature mortality increased during the study period. The share of losses from all infectious diseases has increased. In four of the five cities (excluding Kharkiv), it exceeded the proportion of tuberculosis. Conclusions. The use of the method of calculating YPLL as a tool for estimating the burden of premature mortality recommended for the selection of priorities for activities aimed at reducing the loss of human life and achieving Sustainable Development Goals, as well as for monitoring and evaluating its effectiveness.

Trend of nasopharyngeal carcinoma mortality and years of life lost in China and its provinces from 2005 to 2020.

To examine the trends of nasopharyngeal carcinoma (NPC) mortality and years of life lost (YLL) in China and its provinces from 2005 to 2020, our study used data from China National Mortality Surveillance System (NMSS) to estimate the number and rate of mortality and YLL of NPC by age and sex. We calculated average annual percent change (AAPC) to describe the trend of NPC mortality and YLL over time. We also analyzed the proportion of NPC deaths in all cancer deaths and explored the drivers of change in NPC deaths by decomposition analysis. The age-standardized mortality rate (ASMR) of NPC in China had a significant downward trend from 2.0/100 000 in 2005 to 1.4/100 000 in 2020 (AAPC=-2.4, P< .05). Age-standardized YLL rate also showed the similar trends (AAPC=-2.8, P< .05). Southern provinces including Guangdong (163.9/100 000), Guangxi (130.5/100 000), and Hainan (105.6/100 000) had the highest YLL rate in 2020. The mortality and YLL rate increased with age and males were higher than females. From 2005 to 2020, the proportion of NPC deaths in all cancer deaths remained stable at around 1.0% in China. The total number of deaths of NPC increased by 7.3%, of which age-specific mortality, population growth, and population aging accounted for -46.2%, 8.5% and 45.0%, respectively. NPC remains a significant public health issue in China southern provinces and tailored prevention and control strategies should be strengthened to reduce the burden of premature mortality of NPC in high risk areas.

Mortality associated with cysticercosis in a historical cohort from Britain.

The burden of premature mortality associated with human cysticercosis is largely ignored mainly due to poor record-keeping in Taenia solium endemic regions. To document mortality and survival characteristics of an historical cohort with cysticercosis. The years of onset of symptoms and death untill 1957 were extracted from published reports of a British military cohort (n=450) examined in London in the early twentieth century. Data were entered into a Kaplan Meier survival analysis with the presence (or absence) of clinical manifestations as independent variables, which were then fitted into a Cox proportional hazards model to determine their significance. Cysticercosis was responsible for 24 (52.2%) of 46 deaths in the first 15 years of follow-up in comparison to 7 (19.4%) of 36 deaths in the 20-40 years of follow-up period. In the univariate and Cox analyses, intracranial hypertension (hazard ratio [HR]: 8.26; CI: 4.71, 14.49), ocular cysticercosis (HR: 6.60; CI: 3.04, 14.33), and mental disorder (HR: 3.98; CI: 2.22, 7.13) but not epilepsy (HR: 0.66; CI: 0.20, 2.18) were associated with mortality. Over half of all deaths in the first 15 years of follow-up were attributed to cysticercosis. Several deaths occurred early after acquiring cysticercotic infection. Intracranial hypertension, ocular cysticercosis, and mental disorder but not epilepsy were predictors of mortality in this cohort.

Implications of Implementing Promulgated and Prospective Emission Regulations on Air Quality and Health in India during 2030

To improve ambient air quality, India has laid out strict action plans to reduce the increment in emissions over regional to urban scale by the year 2030. This study evaluates policy-induced improvement in air quality and associated health benefits achievable due to reduction in PM2.5 exposure under the adoption of promulgated (S2) and ambitious prospective regulations (S3) with respect to the scenario for Business As Usual (BAU) in 2030. The Weather Research and Forecasting model coupled with online chemistry (WRF-Chem) has been used to simulate ambient PM2.5 exposure to the population under BAU, S2 and S3 emission scenarios. Results show 15% (9 µg m-3) and 49% (32 µg m-3) decreases in all India ambient PM2.5 exposure under S2 and S3 scenarios, respectively, with respect to the BAU scenario. Throughout India, under the S2 and S3 scenarios, 38% and 62% of states would meet the annual National Ambient Air Quality Standard (NAAQS) of 40 µg m-3, respectively. We projected that the S2 emission regulation scenario would prevent 274,000 (8.3%) premature mortalities and improve mean life expectancy by about 0.6 ± 0.2 years in 2030 relative to the BAU scenario. On the other hand, pursuing an ambitious emission scenario, S3 would prevent 775,000 (~23.6%) premature mortality burden and improve mean life expectancy by about 1.9 ± 0.7 years in 2030. Results indicate that ambitious actions beyond the ambitious prospective regulations are vital to gain significant health benefits.

Burden of dust storms on years of life lost in Seoul, South Korea: A distributed lag analysis

Although dust storms have been associated with adverse health outcomes, studies on the burden of dust storms on deaths are limited. As global warming has induced significant climate changes in recent decades, which have accelerated desertification worldwide, it is necessary to evaluate the burden of dust storm-induced premature mortality using a critical measure of disease burden, such as the years of life lost (YLL). The YLL attributable to dust storms have not been examined to date. This study investigated the association between Asian dust storms (ADS) and the YLL in Seoul, South Korea, during 2002–2013. We conducted a time-series study using a generalized additive model assuming a Gaussian distribution and applied a distributed lag model with a maximum lag of 5 days to investigate the delayed and cumulative effects of ADS on the YLL. We also conducted stratified analyses using the cause of death (respiratory and cardiovascular diseases) and sociodemographic status (sex, age, education level, occupation, and marital status). During the study period, 108 ADS events occurred, and the average daily YLL was 1511 years due to non-accidental causes. The cumulative ADS exposure over the 6-day lag period was associated with a significant increase of 104.7 (95% CI, 31.0–178.5 years) and 34.4 years (4.0–64.7 years) in the YLL due to non-accidental causes and cardiovascular mortality, respectively. Sociodemographic analyses revealed associations between ADS exposure and the YLL in males, both <65 and ≥ 65 years old, those with middle-level education, and the unemployed, unmarried, and widowed (26.5–83.8 years). This study provides new evidence suggesting that exposure to dust storms significantly increases the YLL. Our findings suggest that dust storms are a critical environmental risk affecting premature mortality. These results could contribute to the establishment of public health policies aimed at managing dust storm exposure and reducing premature deaths.