Preliminary Verification Research Articles

Research and development of Lycium barbarum compound beverage and preliminary verification of its efficacy

AbstractLycium barbarum contains a variety of phytochemicals, primarily polysaccharides, and other potent compounds. L. barbarum is a plant that has several uses in contemporary society, including food processing and everyday eating. However, through traditional processing methods the medicinal or edible value of L. barbarum cannot be fully exploited, to further improve the utilisation rate of L. barbarum and enrich the variety of L. barbarum market. The L. barbarum compound beverage, which uses L. barbarum as its primary ingredient, was created through a series of trials, including the creation of tea beverage recipes and research on the most suitable content of stabilisers, flavouring agent formulations and so on. In addition, several validation tests, including those involving hypoglycaemic and lipid-lowering were conducted. The results indicated that 0.1 g mL−1 stabiliser CMC-Na, 0.2 g mL−1 erythritol, 3 g mL−1 citric acid, 8% L. barbarum juice, and 6% chrysanthemum tea cold brew extract were the best combinations for food additive formulations. Additionally, compound beverages have hypoglycemic and lipid-lowering effects. In conclusion, the research and development of L. barbarum compound beverages can not only increase the rate at which L. barbarum is utilised but also offer fresh ideas for the research and development of L. barbarum as they transition from cash crop agricultural products to market-oriented standardised processed products.

Embedded model control of networked control systems: An experimental robotic application

In Networked Control System (NCS), the absence of physical communication links in the loop leads to relevant issues, such as measurement delays and asynchronous execution of the control commands. In general, these issues may significantly compromise the performance of the NCS, possibly causing unstable behaviours. This paper presents an original approach to the design of a complete digital control unit for a system characterized by a varying sampling time and asynchronous command execution. The approach is based on the Embedded Model Control (EMC) methodology, whose key feature is the estimation of the disturbances, errors and nonlinearities affecting the plant to control and their online cancellation. In this way, measurement delays and execution asynchronicity are treated as errors and rejected up to a given frequency by the EMC unit. The effectiveness of the proposed approach is demonstrated in a real-world case-study, where the NCS consists of a differential-drive mobile robot (the plant) and a control unit, and the two subsystems communicate through the web without physical connection links. After a preliminary verification using a high-fidelity numerical simulator, the designed controller is validated in several experimental tests, carried out on a real-time embedded system incorporated in the robotic platform.

Pharmacodynamics and mechanism of Erigeron breviscapus granules in the treatment of ischemic stroke in mice by regulating sphingolipid metabolism based on metabolomics

AimErigeron breviscapus (Vant.) Hand.-Mazz. (EB) granules is the extract preparation of EB, with clear curative effect and unclear mechanism. This study intends to systematically explore the specific mechanism of EB granules in the treatment of IS from the metabolic perspective. MethodsThe model of transient middle cerebral artery occlusion (tMCAO) in mice was established by the suture-occluded method. The therapeutic effect of EB granules on tMCAO mice was evaluated by behavioral evaluation, brain water content determination, 2,3,5-triphenyltetrazolium chloride (TTC) staining, hematoxylin-eosin (HE) staining, and levels of lactate dehydrogenase (LDH) and neuron specific enolase (NSE) in serum. In order to screen differential metabolites, non-targeted metabolomics technology was used to detect the metabolites in serum before and after administration. Univariate statistics, multivariate statistics and bioinformatics were used to analyze the changes of metabolites in serum of tMCAO mice. The possible related mechanism of EB granules in treating IS was screened by pathway enrichment analysis, and the preliminary verification was carried out at animal level by enzyme linked immunosorbent assay (ELISA) and western blot (WB). ResultsEB granules could significantly improve behavior of tMCAO mice, reduce brain water content and cerebral infarction volume, improve morphology of brain tissue, reduce the levels of LDH and NSE in serum. A total of 232 differential metabolites were screened, which were mainly enriched in many biological processes such as sphingolipid metabolism. The differential metabolite S1P and its receptors S1PR1 and S1PR2 in sphingolipid metabolism were verified. The results showed that the level of S1P in brain tissue increased and the protein expression of S1PR1 decreased significantly after modeling, and reversed after administration, but there was no significant difference in the protein expression of S1PR2. ConclusionThe therapeutic effects of EB granules may be related to affecting sphingolipid metabolism through regulating S1P/S1PR1.

Development and preliminary verification of a 1D–3D coupled flow and heat transfer model of OTSG

Introduction: A simulation model was developed by coupling a one-dimensional (1D) system code and 3D CFD software, to analyze the three-dimensional (3D) flow and heat transfer characteristics of the once-through steam generator (OTSG).Methods: The shell side of the OTSG was simulated by FLUENT, and the tube side was simulated by the system code LOCUST. Through spatial mapping, the 1D and 3D simulations were coupled along the outer wall of the OTSG's helically coiled tubes.Results and Discussion: This coupling method enabled the acquisition of high-resolution flow and heat transfer characteristics of the OTSG, and the error of heat flux calculation result by the coupled model is within 15%. Through coupling simulation analysis of the prototype OTSG, it was found that the inlet and outlet temperature difference reached as high as 150°C. The unevenness of the radial temperature distribution increased along the flow direction, and the wake swing effect caused by the sweeping flow of the tube bundle at the exit position was evident. The results of this study provide reference and a coupled simulation method for the engineering design and thermal-hydraulic characteristics analysis of OTSG.

Use of fine-needle puncture under endosonographic control in the diagnosis of left atrium sarcoma – case report

Background. Over the past 30 years, with the development of endoscopic technologies and the advent endoscopic ultrasound-guided fine-needle aspiration (EuS-FnA) it has become possible to diagnose with preliminary verification of cardiac tumors, which in turn is an undoubted advantage in detecting cardiac pathology. A rare clinical case is presented: the detection of a tumor of the left atrium using high-tech endoscopic techniques, in particular a EuS-FnA. when studying the surgical material using immunohistochemistry and FISH hybridization, the final diagnosis sounded like intimal sarcoma. Diagnosis of intimal sarcoma is a complex clinical task, and difficulties in making a diagnosis delay the duration of treatment. Our experience demonstrates the modern role of endoscopy as a minimally invasive method of diagnosing intracardiac tumors.

Application of Delphi method in the revision of dietary quality index in the elderly

To revise the dietary evaluation method of the elderly, and scientifically evaluate the dietary quality. Delphi method was used to revise a diet quality evaluation method for the elderly according to expert consultation and statistical analysis. The recommended recipes in The Dietary Guidelines for Chinese Residents(2016) were selected for preliminary verification. Two rounds of expert consultation were conducted, 25 experts in the industry were invited. The withdraw rate of two rounds were 100% and 84%, respectively. The authoritative coefficient were 0.82 and 0.80, the degree of familiarity was 0.92, and the basis for determination were 0.73 and 0.70, respectively. The coordination coefficient W value were 0.095 and 0.098 respectively. Delphi method had some advantages in the revision of dietary index for the elderly. Dietary quality index had some practicability, but it still needs further verification and improvement.

Numerical analysis of plasma channel characteristics and dynamic effects on molten pool in electrical discharge machining

The plasma channel provides the fundamental energy source and acting forces for material removal in electrical discharge machining (EDM). At present, the research on the characteristics of plasma channel is still in the exploratory stage. In this study, to clearly understand the characteristics of plasma channel and its dynamic effects on molten material, the transient mathematical model of plasma channel is first attempted and computed based on magneto-hydrodynamics (MHD). The breakdown process of plasma channel, as well as its inherent characteristics (heat flux, electromagnetic force and expansion pressure) are studied, based on which the dynamic effects of thermal input and force actions on anode molten pool are analyzed. Results show that the plasma channel sequentially experiences diabolo-shaped, lantern-shaped and finally stabilized horn-shaped stages, and the diameter expansion is nearly completed within 2μs which is independent of discharge current. The plasma channel presents time-variant characteristics in terms of heat flux distribution and energy distribution ratio into electrodes and gap dielectric. The electromagnetic force and expansion pressure not only determine the geometry evolution of plasma channel but also provide acting forces, which influence the distribution of hydrostatic pressure in molten pool and shear force on the interface. For preliminary verification purpose, the appearance of plasma channel is observed by high-speed photography, and the dimensions between simulation and experimental craters are compared. The feasibility of established plasma channel model is confirmed to a certain extent by showing an approximated channel appearance, as well as the maximal deviations of 10.8 % and 8.9 % in diameter and depth, respectively.

Finite Element In-Depth Verification: Base Displacements of a Spherical Dome Loaded by Edge Forces and Moments

Nowadays, engineers possess a wealth of numerical packages in order to design civil engineering structures. The finite element method offers a variety of sophisticated element types, nonlinear materials, and solution algorithms, which enable engineers to confront complicated design problems. However, one of the difficult tasks is the verification of the produced numerical results. The present paper deals with the in-depth verification of a basic problem, referring to the axisymmetric loading by edge forces/moments of a spherical dome, truncated at various roll-down angles, φo. Two formulations of analytical solutions are derived by the bibliography; their results are compared with those produced by the implementation of the finite element method. Modelling details, such as the finite element type, orientation of joints, application of loading, boundary conditions, and results’ interpretation, are presented thoroughly. Four different ratios of the radius of curvature, r and shell’s thickness, and t are examined in order to investigate the compatibility between the implementation of the finite element method to the “first-order” shell theory. The discussion refers to the differences not only between the numerical and analytical results, but also between the two analytical approaches. Furthermore, it emphasizes the necessity of contacting even linear elastic preliminary verification numerical tests as a basis for the construction of more elaborated and sophisticated models.

Structure and Expression Analysis of PtrSUS, PtrINV, PtrHXK, PtrPGM, and PtrUGP Gene Families in Populus trichocarpa Torr. and Gray.

Exogenous nitrogen and carbon can affect plant cell walls, which are composed of structural carbon. Sucrose synthase (SUS), invertase (INV), hexokinase (HXK), phosphoglucomutase (PGM), and UDP-glucose pyrophosphorylase (UGP) are the key enzymes of sucrose metabolism involved in cell wall synthesis. To understand whether these genes are regulated by carbon and nitrogen to participate in structural carbon biosynthesis, we performed genome-wide identification, analyzed their expression patterns under different carbon and nitrogen treatments, and conducted preliminary functional verification. Different concentrations of nitrogen and carbon were applied to poplar (Populus trichocarpa Torr. and Gray), which caused changes in cellulose, lignin, and hemicellulose contents. In poplar, 6 SUSs, 20 INVs, 6 HXKs, 4 PGMs, and 2 UGPs were identified. Moreover, the physicochemical properties, collinearity, and tissue specificity were analyzed. The correlation analysis showed that the expression levels of PtrSUS3/5, PtrNINV1/2/3/5/12, PtrCWINV3, PtrVINV2, PtrHXK5/6, PtrPGM1/2, and PtrUGP1 were positively correlated with the cellulose content. Meanwhile, the knockout of PtrNINV12 significantly reduced the cellulose content. This study could lay the foundation for revealing the functions of SUSs, INVs, HXKs, PGMs, and UGPs, which affected structural carbon synthesis regulated by nitrogen and carbon, proving that PtrNINV12 is involved in cell wall synthesis.

Transcranial Ultrasonic Focusing by a Phased Array Based on Micro-CT Images.

In this paper, we utilize micro-computed tomography (micro-CT) to obtain micro-CT images with a resolution of 60 μm and establish a micro-CT model based on the k-wave toolbox, which can visualize the microstructures in trabecular bone, including pores and bone layers. The transcranial ultrasound phased array focusing field characteristics in the micro-CT model are investigated. The ultrasonic waves are multiply scattered in skull and time delays calculations from the transducer to the focusing point are difficult. For this reason, we adopt the pulse compression method and the linear frequency modulation Barker code to compute the time delay and implement phased array focusing in the micro-CT model. It is shown by the simulation results that ultrasonic loss is mainly caused by scattering from the microstructures of the trabecular bone. The ratio of main and side lobes of the cross-correlation calculation is improved by 5.53 dB using the pulse compression method. The focusing quality and the calculation accuracy of time delay are improved. Meanwhile, the beamwidth at the focal point and the sound pressure amplitude decrease with the increase in the signal frequency. Focusing at different depths indicates that the beamwidth broadens with the increase in the focusing depth, and beam deflection focusing maintains good consistency in the focusing effect at a distance of 9 mm from the focal point. This indicates that the phased-array method has good focusing results and focus tunability in deep cranial brain. In addition, the sound pressure at the focal point can be increased by 8.2% through amplitude regulation, thereby enhancing focusing efficiency. The preliminary experiment verification is conducted with an ex vivo skull. It is shown by the experimental results that the phased array focusing method using pulse compression to calculate the time delay can significantly improve the sound field focusing effect and is a very effective transcranial ultrasound focusing method.

On-orbit geometric calibration and preliminary accuracy verification of GaoFen-14 (GF-14) optical two linear-array stereo camera

ABSTRACT The GaoFen-14 (GF-14) satellite is China’s most recent high-resolution earth observation satellite system. It is equipped with a two linear-array stereo camera and is intend for topographic mapping at 1:10,000-scale without ground control points (GCPs). The technical parameters of payloads will change once the satellite enters orbit. As a result, strict on-orbit geometric calibration is necessary. This study performs the on-orbit geometric calibration of the GF-14 stereo camera using ground calibration data. The exterior orientation errors are corrected by a comprehensive bias matrix, internal orientation errors are described by a fifth order polynomial. The results of Yinchuan calibration field show that the planar accuracy is better than 286 m (RMS) before calibration, and improved to 2.11 m (front camera) and 1.51 m (back camera) by external orientation, and further improved to 1.46 m (front camera) and 0.99 m (back camera) after internal calibration. The front intersection accuracy reaches 0.67 m in plane (RMS) and 1.10 m in elevation (RMS), respectively. Checking by multiple global check points (CKPs), the planar and elevation RMS reaches 2.38 m (5.09 m in CE90) and 2.08 m (3.43 m in LE90), respectively.

Theoretical study on the P–N bond dissociation enthalpy in phosphamide and phosphoramidate flame retardants

The phosphamide and phosphoramidate are well known as new types of phosphorus-nitrogen synergistic flame retardant in epoxy resin composites, rigid polyurethane foam and cotton fabric. The P–N bond breakage of the phosphamide and phosphoramidate flame retardants is involved in the flame-retardant process, which is very important for the flame-retardant effect. By comparing the precision of different density functional theory (DFT) on P–N BDEs and it is found that M06-2X provides the most accurate result with a minimum root mean square error (RMSE) of 5.3 kJ/mol. Therefore, the M06-2X method was used to study different types of phosphamide and phosphoramidate flame retardants, including DOPO-based flame retardants, diphenyl-phosphamide, phosphoramidate flame retardants and spirocyclic-bisphosphamide, bisphosphoramidate flame retardants. Through the preliminary verification of the calculation of BDE and the data including indexes of limiting oxygen index (LOI), temperature at 5 wt% loss (T5%) and temperature at maximum mass loss rate (Tmax) in the experimental literature, it is found that P–N BDEs have a certain correlation with the flame-retardant effect. Finally, based on the calculated BDE results and the substituent effect, new flame retardants based on these three parent structures of flame retardants were designed and the flame-retardant effects were predicted. The results show that the parent structures such as diphenyl-phosphoramidate and spirocyclic-bisphosphamide were beneficial to the flame-retardant effect of the flame retardants, and the structural unit on N atom such as aniline and thiazole were more favorable to the flame retardancy of the flame retardants.

Techno-economic analysis of I-CAES systems to increase dispatchability of wind power

The variability of energy production from renewable sources remains the main issue hampering their larger penetration in current energy grids. While batteries have been proven to work well in many applications, their cost and environmental footprint are opening room for alternative systems. In this study, the innovative isothermal compressed air energy storage (I-CAES) system proposed by Sadaat et al. in 2014 is analyzed. In this system layout, a wind turbine is coupled with a CAES system through a hydraulic circuit including a liquid piston. The original work theorized the system and focused only on a preliminary verification under an energy perspective, using data referring to very short time series. In the present study, a long-term techno-economic analysis is performed to provide a more representative insight into the real feasibility of the proposed plant configuration. The analysis is carried out using yearly wind speed data and a 1-minute average approach, so as to correctly track the energy fluxes. A parametric analysis of the system, varying the size of the storage vessel and generator is performed to identify the optimal configuration. Finally, the overall performance is compared with that of a traditional standalone turbine. The effect of fluctuations in the energy price during the day is considered, as well as the impact of possible future scenarios, where traditional systems are penalized due to significant oscillations in power production. Results show that, despite the high compression and expansion efficiencies achieved through the liquid piston, the complexity of the system causes a significant reduction of total energy production affecting the economic performance, although interesting prospects can arise whenever constant-load off-grid users are about to be fed.

Design and evaluation of EMPIX2, a 100 kfps, high dynamic range pixel detector readout ASIC for electron microscopy

EMPIX2 is a novel hybrid pixel detector readout ASIC for electron microscopy with a maximum frame rate of 100 kfps and a very large dynamic range (5 × 105:1). It features 128 × 128 square pixels at a pitch of 150 μm. Adaptive gain switching and charge pump technology are applied to enhance the dynamic range. The pixels can operate in two modes: pulse mode and continuous mode. In pulse mode, ultra-fast gain switching enables a rapid response to pulsed electron sources, making it highly suitable for UEM applications. In continuous mode, the power consumption and dynamic range are optimized for STEM applications. The readout is frame-based, and digital image data is output by 64 pairs of LVDS drivers working in DDR mode at a clock frequency of 400 MHz. A dedicated data acquisition system was developed for the transmission and processing of the image data. Preliminary verification of the readout chip was performed using an on-chip calibration source.

Novel Method for Assessing the Protection Lifetime of Building Coatings against Fungi

The aim of this study was to develop a novel method for evaluating the service life of building coatings. In Stage 1, we assessed existing methods for determining the degree of fungal overgrowth on building materials (visual assessment, culture method, luminometric ATP (adenosine-5’-triphosphate) measurement, and spectrophotometric assessment of colour changes). Laboratory tests were carried out for 19 types of facade coating (mineral and silicone with/without primer, silicone paint, biocides) and 7 fungal strains (moulds Alternaria alternata, Aspergillus niger, Aureobasidium melanogenum, Cladosporium cladosporioides, Fusarium sp., Penicillium citrinum, and the yeast Rhodotorula mucilaginosa). The number of fungi on the facade coatings after 28 days of incubation was 1.7 × 105–4.6 × 105 CFUs (colony-forming units)/sample. The ATP content was 12 RLUs–30333 RLUs (relative light units). Colour change was ΔE > 5 depending on the coating type and fungal strain. A high or very high correlation was found between the ATP concentration (RLUs), colour change (ΔE), and the results of the culture method (CFUs/sample). In Stage 2, a new methodology for evaluating the protection lifetime of building coatings against fungi was developed, taking into account environmental conditions (impact of ultraviolet radiation, precipitation, presence of organic matter on the surface, quantitative and qualitative composition of bioaerosol). The developed method consists of one research cycle conducted in the laboratory, corresponding to one year under natural conditions. Preliminary verification showed the model to be compatible with long-term observations (3 years) of fungal growth on the facade coatings under real environmental conditions. The novel method could be used to design biodeterioration control and protection strategies for both new and cultural heritage buildings.

The identification of regulatory ceRNA network involved in Drosophila Toll immune responses

Non-coding RNAs play important roles in the innate immunity of Drosophila, with various lncRNAs and miRNAs identified to maintain Drosophila innate immune homeostasis by regulating protein functions. However, it remains unclear whether interactions between lncRNAs and miRNAs give rise to a ceRNA network. In our previous study, we observed the highest differential expression levels of lncRNA-CR11538, lncRNA-CR33942, and lncRNA-CR46018 in wild-type flies after Gram-positive bacterial infection, prompting us to investigate their role in the regulation of Drosophila Toll immune response through RNA-seq analysis. Herein, our comprehensive bioinformatics analysis revealed that lncRNA-CR11538, lncRNA-CR33942, and lncRNA-CR46018 are involved in defense mechanisms and stimulus response. Moreover, lncRNA-CR11538 and lncRNA-CR46018 can also participate in the metabolic recovery processes following Gram-positive bacterial infection. Subsequently, we employed GSEA screening and RT-qPCR to identify seven miRNAs (miR-957, miR-1015, miR-982, miR-993, miR-1007, miR-193, and miR-978) that may be regulated by these three lncRNAs. Furthermore, we predicted the potential target genes in the Toll signaling pathway for these miRNAs and their interaction with the three lncRNAs using TargetScan and miRanda software and preliminary verification. As a result, we established a potential ceRNA regulatory network for Toll immune responses in Drosophila, comprising three lncRNAs and seven miRNAs. This study provides evidence of a ceRNA regulatory network in Drosophila Toll immune responses and offers novel insights into understanding the regulatory networks involved in the innate immunity of other animals.

Three methods for determining respiratory waves from ECG (Part I)

In the diagnosis of many disease entities directly or indirectly related to disorders of respiratory parameters and heart disease, an important support would be to estimate the temporal changes in these parameters (most often respiratory wave (RW) and respiratory rate (RR)) on the basis the results of measurements of other physiological parameters of the patient. Such a possibility exists during ECG examination. The paper presents three methods for estimating RWand RR using ECG signal processing. The three procedures developed are shown: using Savitzky–Golay filtering (S-G), the ECG-Derived Respiration method (EDR) and the Respiratory Sinus Arrhythmia Analysis method (RSA). It must be clearly stated that the proposed methods are not designed to fully diagnose the patient’s respiratory function, but they can be applied to detect some conditions that are difficult to diagnose when performing an ECG, such as sleep-disordered breathing. The obtained results of the analysis were compared with those obtained from a dedicated measurement system developed by the authors. The second part of the paper will show the results of preliminary clinical verification of the developed analysis methods, taking into account the physiological parameters of the patient.

Early-age cracking in mass concrete: Modeling and case study of an extra-large exhibition pool

Early-age cracking is one of the most common and challenging problems in the construction of mass concrete structures. This paper addresses the effects of factors such as temperature, hydration, creep, and shrinkage on the time-varying properties of concrete during construction by establishing an energy-based constitutive model for early-age concrete within the framework of continuous damage mechanics. The model comprehensively describes the damage of concrete due to the aging effect related to the degree of hydration, where the mechanical damage is driven by the work conjugated to the elastoplastic damage energy release rates. The thermal evolution during hydration is fitted with a large amount of experimental data, enabling the partial decoupling of multi-factor effects and facilitating the establishment of a sequential thermal-mechanical coupling analysis method. After preliminary verification through restrained ring cracking tests, the proposed model and method are applied to simulate the construction of an actual large-scale Orcinus orca exhibition pool. By predicting and analyzing the worst-case scenarios, the cracking risk, potential cracking mode, and cracking location of the large pool are determined, providing an important basis for practical construction control and optimization. Examples of these strategies include segmented schemes, reinforcement optimization, and the addition of tensile fibers, as well as selecting the best wind speed, environmental temperature, and casting temperature during construction. These efforts provided crucial guidance for the actual construction of the exhibition pool, and as a result, no visible cracks were found in the completed structure.

The modified force density method for form-finding of cable net structure

Form-finding is crucial for the design of typical cable net structures. Based on the original basic force density method, a modified force density method utilizing the concept of relation matrix is proposed in this paper. The modified method realizes the establishment of a clear correspondence between members and nodes of cable net structures. On the basis of the relation matrix, the find function is introduced, and the calculation formula of the modified branch-node matrix is derived. Meanwhile, the corresponding analysis steps and calculation process are given. The modified method is verified by the analysis of representative structural forms. The results show that for the saddle-shaped orthogonal cable net structure, the outcomes obtained from the modified force density method highly agree with the theoretical values, providing preliminary verification of the method's effectiveness. For single-layer spoke cable net structures, the relative error between the results calculated by the modified force density method and the numerical solution is approximately 5 %. The results of both methods are relatively consistent, and the relative error varies in relation to the ratio of inner ring cable force density to radial cable force density. For circular single-layer crossed cable net structure without inner ring, the results of the modified force density method are very close to the numerical solution. The maximum relative error between the two is 6.95 %, and the accuracy is higher than that of the nonlinear finite element method. The outcome of this research demonstrates the accuracy of the modified force density method and its effective application in the form-finding of actual cable net structures.

Study on the Mechanism of Dachaihu Decoction in the Treatment of Acute Pancreatitis Based on Artificial Intelligence Combined with in vivo Experiments.

To explore the possible mechanism of Dachaihu Decoction (DCHD) in the treatment of AP, and use in vivo experiments to verify. The targets and active ingredients of DCHD in the treatment of AP were obtained through network pharmacology, and the preliminary verification was carried out by molecular docking. Caerulein was used to develop the AP rat model. H&E staining was performed to observe variations in pancreatic tissue. Western blot and RT-qPCR were conducted to evaluate the associated proteins and mRNA. The network pharmacology and molecular docking results showed that the key targets (EGFR, TNF, SRC, VEGFA and CTNNB1) and key active components (beta-sitosterol, stigmasterol, baicalein, quercetin, and kaempferol) of DCHD in the treatment of AP had good binding. H&E staining revealed that rat pancreatic tissues considerably damaged post caerulein intervention, and it has also been suggested that DCHD ameliorates damage to pancreatic tissue. Simultaneously, EGFR, TNF, SRC, VEGFA protein, and mRNA expression levels were increased in the model group compared to the blank group (P < 0.01), whereas CTNNB1 expression was found to be decreased in the model group (P < 0.01). Compared with the model group, the protein expression levels of EGFR, TNF, SRC, and VEGFA in the treatment group were down-regulated (P < 0.01), and CTNNB1 was up-regulated (P < 0.05). DCHD protects pancreatic tissues and improves symptoms in AP rats by upregulating CTNNB1 protein and mRNA while inhibiting EGFR, TNF, SRC, and VEGFA protein and mRNA expression.