Introduction: To determine whether percutaneous tibial nerve stimulation (PTNS) applied twice a week is effective in female patients with refractory urinary frequency. Patients and Methods: Twenty-two patients with increased daytime urinary frequency and bladder sensation were enrolled in the prospective study undergoing a total of 10 times of PTNS. The response was assessed using a voiding diary, the 36-item short-form health survey (SF-36) quality-of-life questionnaire and the patient’s self-evaluation table. Results: A statistically significant improvement was found in daytime and nighttime voiding frequency, daytime voiding volume and nighttime lowest voiding volume variables. The self-reported health status transition in SF-36 was statistically lower after the treatment. Ten patients, who evaluated the trial as having had some effect, had more significant improvement statistically in nocturia than did the other 12 patients, who evaluated the trial as having had no effect. Conclusions: Intermittent PTNS twice a week might be an alternative treatment for patients with refractory urinary frequency. However, these preliminary impressions should be further confirmed.
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