Nixtamalization, from the Náhuatl nixtamalli, is a process in which maize is soaked in a vessel containing an alkali solution. The alkali processing of maize is essential in preparing corn for human consumption because it releases lysine and tryptophan and, most importantly, niacin. Without these, when the primary dietary staple is unprocessed maize, the result is malnutrition and disease, pellagra. Nixtamalization originated in pre-Columbian Mesoamerica but there was a paucity of corn processing in pre-Hispanic South America, even though corn was ubiquitous in both regions at a very early date. However, coca was similarly soaked in an alkali solution, with saliva, in the chewer’s mouth in ancient South America. Therefore, the coca chewer also processed plant material, coca, in order to release trace amounts of cocaine along with the vitamins B1, riboflavin and vitamin C. In this paper, I will briefly discuss corn processing in pre-Columbian Mesoamerica and compare it with the ancient tradition of coca chewing in South America, emphasizing the ingenious adaptation of these counter intuitive techniques as survival strategies.