BackgroundPregnancy in people Living with HIV/AIDS (PLHIV) involves significant public health risks, including the risk of HIV transmission to uninfected partners and the fetus. Despite the growing importance of fertility issues for HIV-infected people, little is known about their fertility desires in Nepal. This study, therefore, aimed to determine the magnitude of and factors associated with the fertility desire of PLHIV.Patients and MethodsA cross-sectional study was conducted among 280 PLHIV attending the antiretroviral therapy (ART) clinic in Teku Hospital, Nepal. A standard semi-structured questionnaire was administered to participants using systematic random sampling. Data were entered using Epi-data 3.1 and analyzed using SPSS software version 20.ResultsOut of the total participants, 12.1% desired to have a child. Among those having this desire, 44.1% had not decided when to have a child. Reasons for desiring a child were having no children (44.1%), wanting to have a child of different sex than the previous one (29.4%), followed by wanting to have another child (26.5%). Factors such as being male (COR: 3.1, 95% CI: 1.3–7.0), being ≤40 years of age (COR: 3.8, 95% CI: 1.5–9.4), higher age at marriage (COR: 7.7, 95% CI: 1.5–39.6), middle socio-economic status (COR: 3.5, 95% CI: 1.7–7.3), having no children (COR: 22.9, 95% CI: 8.6–60.8) or fewer children (COR: 74.8, 95% CI: 9.7–575.1), greater CD4 count (COR: 2.8, 95% CI: 1.3–5.9) and having moderate knowledge of prevention of mother-to-child transmission (COR: 5.4, 95% CI: 2.3–12.7) had higher odds of having fertility desire.ConclusionAround one in every ten participants had a desire for fertility despite their HIV status. This calls for special attention in promoting integrated services for HIV and reproductive health. It will be important to include counseling and other services for those with fertility desire alongside providing ART.