High-risk Pregnant Women Research Articles

Screening for and treatment of bacterial vaginosis reduced preterm delivery in high-risk pregnant women: a systematic review and meta-analysis.

Introduction Bacterial vaginosis (BV) is a risk factor for preterm delivery. Yet, previous studies have found BV treatment ineffective in preventing preterm delivery in unselected population. This study aims to evaluate the effectiveness of BV screening and treatment in reducing the rate of preterm deliveries before 37 weeks in high-risk women. Material and methods Embase, PubMed, Ovid-Medline, and Web of Science were searched. Randomized controlled trials that evaluated antibiotic treatment for BV versus no treatment/placebo were included. The primary outcome was the rate of preterm delivery and/or late miscarriages in pregnant women with a history of preterm delivery. The pooled relative risks (with 95% CI) were estimated. The Cochrane's Q test of heterogeneity and I² were used to assess heterogeneity. In total, 4701 papers were retrieved of which seven met inclusion criteria and were analyzed. Results Among the participating women, 738 were at high risk for preterm delivery and included in the analysis. Among them, 397 and 341 women received active or placebo treatment, respectively. The included studies had a low risk of bias. In six out of seven studies, the risk factor for preterm delivery was a previous preterm delivery. One study (N=16) was excluded from the analysis since no group had preterm deliveries. Treatment for BV in high-risk women reduced the rate of preterm deliveries (pooled RR with 95% CI 0.65 [0.44-0.98[. The protective effect of BV treatment was statistically significant in women treated with clindamycin, and when treatment was started after 20 gestational weeks. Conclusion Screening for and treatment of BV may be effective in preventing preterm delivery in high risk pregnant women. Randomized clinical trials are needed to confirm the findings of this study. Trial registration: This study was registered on PROSPERO (CRD42020162621).

Home care program for high-risk pregnancies: a qualitative study of care providers perspectives from Iran

BackgroundHigh-risk pregnancies are accompanied by significant complications for the mother, fetus, and baby if not controlled and received timely care. During home antenatal care, high-risk pregnant women can receive non-medical interventions by a home visitor.ObjectiveThis study’s main aim was to explore care providers’ perspectives regarding the home care program for high-risk pregnancies.Materials and methodsThis qualitative study was conducted in a university hospital and 5 comprehensive health centers in Ahvaz (Iran) from February 2023 to July 2023. The sampling method used was purposive sampling considering the maximum possible diversity, which continued until data saturation. There were 13 in-depth and semi-structured interviews with care providers. Data were simultaneously analysed using Graneheim and Lundman content analysis by MAXQDA version 20 software.ResultsData analysis led to the extraction of 3 main categories, 10 subcategories, and 24 main codes. The main categories and subcategories were “support dimension (family and community support for high-risk pregnant women),” “education dimension (empowerment of high-risk pregnant women and care providers),” and “infrastructures of the program (acculturalization, provision of program budget and care tariff, means and equipment, security and ethical issues, manpower, and the necessary arrangements for the home care).”ConclusionsProviding home care services for high-risk pregnant women plays a vital role in expanding health justice and ensuring maximum access for high-risk pregnant women to perinatal care. Implementing the home care program requires family and community support, educational empowerment of care providers, and the provision of the necessary infrastructure for the program for high-risk pregnant mothers and their families.

High-risk pregnant women's perceptions of their condition: A qualitative study with an emphasis on psychosocial need.

This qualitative study was carried out with 30 high-risk pregnant women from a Brazilian referral service in women's health. The objective was to analyze the perception of participants regarding their condition, emphasizing their psychosocial needs, to deepen the understanding of subjective, relational, and sociocultural aspects associated with high-risk pregnancy. Data were collected through interviews and participant observation and then explored by thematic content analysis. The participants described pregnancy as planned or as unexpected and associated with greater social prestige and the need for changes, especially related to work and financial conditions. On the other hand, participants mentioned that the risk aspect of pregnancy condition was seen by their social group as something that could have been avoided. Because a high-risk pregnancy is a threat to the baby's physical integrity and life, it leads to the fear of death, which is reinforced by experiences of previous pregnancies. The psychosocial aspects elucidated in the study deal with emotional and labor factors, consistent with existing literature. Participants mentioned family members and health professionals as important support during their pregnancy, especially with regard to daily activities and health care, aimed at promoting favorable outcomes. Some participants reported a lack of support, relational difficulties, and social stigma due to mental illness or advanced age, which were related to experiences of guilt and accountability.

Erratum: The role of continuity of care in high-risk pregnant women in Indonesia

Erratum: The role of continuity of care in high-risk pregnant women in Indonesia

Investigation of the relationship between self-perception and alexithymia levels of high-risk pregnant women

Abstract Alexithymia, known as emotional unresponsiveness, can occur at any time in response to extreme stress during upsetting life events. A risky pregnancy is also a challenging process associated with psychological and emotional difficulties, and pregnant women may experience perception problems. Therefore, a risky pregnancy diagnosis may trigger the development of alexithymia. This study aimed to examine the relationship between self-perception and alexithymia levels in women diagnosed with high-risk pregnancies. This cross-sectional study was conducted with 250 high-risk pregnant women admitted to the hospital between June and November 2022. Data were gathered using the “Socio-demographic Information Form”, A Alexithymia Scale” and the “Pregnant Women’s Self-Perception Scale “. The data was analyzed using the Independent T-test, One-Way Analysis of Variance (ANOVA), Pearson Correlation Test, and Simple Linear Regression Analysis. The statistical significance level was accepted as p < 0.05. The mean age of the pregnant women in the study group was 30.25 ± 5.78 years. It was found that there was a significant negative correlation between the total score of the A Alexithymia Scale and the Total Score of the Motherhood Perception of Pregnancy Sub-dimension (r=-.197; p < 0.05) and the Total Score of the Body Perception of Pregnancy Sub-dimension (=-.395; p < 0.05). A one-unit increase in the pregnant women’s score on the Body Perception Sub-dimension causes a decrease of 1.822 points in the A Alexithymia Scale score. The study’s findings indicate that pregnant women with a high motherhood perception but a negative body perception have lower alexithymia levels. Therefore, alexithymia levels decrease in pregnant women who can make sense of and express their negative emotions during risky pregnancies.

Advanced management tactics for high-risk pregnant women with moderate novel coronavirus infection COVID-19

Advanced management tactics for high-risk pregnant women with moderate novel coronavirus infection COVID-19

Perspectives of high-risk pregnant women on home care program in high-risk pregnancies: A multicenter, qualitative study

Objective: To explore the perspectives of high-risk pregnant women regarding the home care program for high-risk pregnancies. Methods: This qualitative study was conducted in a university hospital and 5 comprehensive health centers in Ahvaz, Iran, from February 2023 to July 2023. The sampling method used was purposive sampling considering the maximum possible diversity, which continued until data saturation. 11 in-depth and semi-structured interviews were conducted with high-risk pregnant women. Data were simultaneously analysed using Graneheim and Lundman content analysis by MAXQDA version 20 software. Results: Data analysis extracted 3 themes, 12 categories, and 26 subcategories. The themes and categories were “high-risk pregnancy and related issues (pursuing treatment and paying attention to the high-risk situation by pregnant women, psychological aspect of high-risk pregnancy on pregnant women and caregivers, emotional and physical aspects of high-risk pregnancy, the consequences of high-risk pregnancy on the people around them and empowerment of high-risk pregnant women)”, “support dimension (family and community support for high-risk pregnant women)”, and “framework of program (acculturalization, means and equipment, security, manpower and the necessary arrangements for the home care)”. Conclusions: High-risk pregnancy affects various aspects of the lives of high-risk pregnant women and their families. Creating the necessary conditions for providing care at home plays a vital role in supporting high-risk pregnant women and removing related obstacles to receiving prenatal care in person. It will be especially beneficial for high-risk pregnant women in low-income areas.

Exploring Women’s Experiences of Amniocentesis: A Qualitative Content Analysis

Background: The decision and experience of high-risk pregnant women to undergo amniocentesis can depend on their setting, context, social structures, and significant others, including cultural values and beliefs. What is less understood is women’s experience with decision-making, which may contribute to their anxiety during and after amniocentesis. This study aimed to explore the decision-making experiences of Thai pregnant women undergoing amniocentesis. Materials and Methods: A qualitative content analysis approach was employed to collect and analyze data. Purposive sampling and in-depth interviews were conducted between July and October 2021 with 15 Thai high-risk pregnant women after undergoing amniocentesis. Data analysis involved multiple readings of transcriptions to discern themes and understanding of the women’s stories. Results: Four themes of decision-making experiences were identified: (1) “Shocked, worried, and questioned why the risk was high”; (2) “Does my baby have Down syndrome? I want to know”; (3) “Worried”; and (4) “Relief from anxiety.” Conclusions: Women’s experiences with amniocentesis involved uncertain positive and negative feelings through the journey of undergoing, waiting, and receiving the test results. The nurses and nurse-midwives played an important role in counseling Thai pregnant women about whether to undergo amniocentesis.

A clinical study on the screening efficacy of six thrombotic markers TAT, PIC, TM, t-PAI-C, D-D, and FDP for hypercoagulable state in pregnant women.

To investigate the screening efficacy of six thrombotic markers for hypercoagulable state (HCS) in pregnant women, including thrombin-antithrombin III complex (TAT), plasmin-alpha-2 plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue-type plasminogen activator inhibitor complex(t-PAI-C), D-dimer(D-D), and fibrinogen degradation products (FDP). This was a retrospective study. Eighty-five high-risk pregnant women who underwent antenatal examination at Baoding maternal and Child Health Hospital from December 2022 to September 2023 were included as the observation group, while 85 healthy pregnant women without complications or comorbidities who underwent routine antenatal examinations at our hospital were randomly enrolled as the control group. Analyzed the screening value of these six thrombotic markers in pregnant women at risk of HCS. The levels of TAT, PIC, TM, FDP, and D-D in the observation group were significantly higher than in the control group (P < 0.05, respectively). Pearson correlation analysis showed a weak correlation between maternal age and TAT levels (r = -0.179, P< 0.05) as well as between BMI and FDP and D-D (r = 0.214, 0.232, P< 0.05, respectively). Binary logistic regression analysis revealed that abnormal D-D levels were a risk factor for HCS in pregnant women (OR = 0.117, 95% CI: 0.621-0.639, P< 0.05). The area under the joint curve was 0.757, indicating that the model is of certain predictive value for HCS in pregnant women. TAT, PIC, TM, t-PAI-C, D-D, and FDP can used for the screening of HCS in pregnant women and have a certain predictive value for high-risk pregnant women.

Non-linear dose-response relationship between uterine artery pulsatility index and risk of preeclampsia in early pregnancy: A secondary analysis based on a nested cohort study.

Previous studies have shown that higher uterine artery pulsatility index (UtA-PI) values in early pregnancy have predictive value for the risk of preeclampsia (PE). However, the sensitivity and specificity of this marker remain controversial. This study aims to explore further the association between UtA-PI in early pregnancy and the incidence of preeclampsia. A total of 5000 pregnant women who underwent prenatal examination and delivery at the same hospital were included in this nested cohort study. And the PI values of left and right uterine arteries of the subjects were obtained by transabdominal ultrasound using GE color doppler diagnostic device in early pregnancy (11-13 + 6 weeks), and finally the mean value of both was calculated and recorded as UtA-PI. Among them, 60 pregnant women developed preeclampsia and were randomly divided into a screening group (n = 12) and control group (n = 48) and matched with pregnant women who did not develop preeclampsia during the same period to form a subset for subsequent statistical analysis. A weighted multivariate logistic regression model was used to analyze the association between UtA-PI and PE. Additionally, the non-linear relationship between UtA-PI and the incidence of PE was examined using smooth curve fitting and a generalized additive model. After adjusting for other variables, UtA-PI values were positively correlated with the incidence of PE, and the relationship showed a non-linear U-shaped relationship (inflection point 1.83). Our study showed a significantly increased risk of PE when UtA-PI exceeded 1.83. This provides a basis for clinicians to identify high-risk pregnant women early and implement timely intervention, which helps to reduce maternal and fetal complications and improve health outcomes.

Comparison of Efficacy of Vaginal and Intramuscular Progesterone in Preventing Preterm Birth in High-Risk Pregnant Women

Comparison of Efficacy of Vaginal and Intramuscular Progesterone in Preventing Preterm Birth in High-Risk Pregnant Women

Association of Circulating Neprilysin with BMI, Cardiovascular Health, and Kidney Function in High-Risk Pregnancies: A Pilot Study.

Inadequate cardiovascular adaptation during pregnancy impairs endothelial function and vascular resistance, contributing to complications such as pre-eclampsia (PE) and gestational hypertension (GH). Neprilysin (NEP), a protease involved in vascular regulation, has been linked to PE, but its role in endothelial function and vascular adaptation remains unclear. This pilot study investigates the associations between soluble neprilysin (sNEP) and markers of vascular and renal function in high-risk pregnancies without PE. Observed parameters were analyzed in 29 high-risk pregnant women across early, mid-, and late pregnancy. sNEP levels were analyzed alongside body mass index (BMI), endothelial dysfunction (ADMA), arterial stiffness (pulse wave velocity, PWV), retinal microvasculature (central retinal arteriolar and venular equivalents, CRAE and CRVE), and kidney function markers. The impact of gestational hypertension (GH) and prior smoking on sNEP levels was also evaluated. In early and mid-pregnancy, sNEP was inversely associated with BMI. During mid-pregnancy, sNEP showed a positive correlation with CRAE and an inverse correlation with PWV, suggesting reduced arterial stiffness. By late pregnancy, sNEP was positively associated with glomerular filtration rate and inversely correlated with creatinine and protein levels, reflecting improved kidney function. Women with GH exhibited elevated sNEP, while former smokers had lower sNEP levels in early pregnancy. These findings suggest that sNEP plays a role in vascular and renal adaption during pregnancy, offering new perspectives on vascular tone regulation in high-risk pregnancies. Further research is needed to clarify these mechanisms and their clinical relevance.

Design and analysis of a telemonitoring system for high-risk pregnant women in need of special care or attention

BackgroundHigh-risk pregnancies, characterized by underlying health issues or unusual circumstances, pose increased risks to both maternal and neonatal health during pregnancy and childbirth. Global guidelines emphasize the importance of early identification, monitoring, and intervention to mitigate these risks.MethodWe decided to design and implement a telemonitoring system for remotely monitoring and managing pregnancies in women with conditions such as hypertension, diabetes, or high-risk pregnancy. When a high-risk pregnant mom is discharged from the hospital, the Healthcare Center or Integrated Healthcare Services Center in her area is immediately notified via SMS to ensure her condition is monitored remotely. In addition to sending notifications, the patient’s medical record, post-discharge care recommendations, drug prescription, re-visit time, and contact details are also sent to them via the application. The high-risk pregnant mom is followed up and all her information is recorded in the application for further use. To evaluate the usability of the proposed telemonitoring system, we conducted a laboratory study involving 92 participants, including pregnant mothers’ care experts at hospitals, healthcare center experts, midwives at integrated healthcare services centers, and midwifery department experts with varying levels of digital skills. Participants performed activities related to the application’s services, while their satisfaction was measured using the QUIS 7.0 questionnaires covering multiple aspects of usability, including user interface, system capabilities, and online help, with ratings on a Likert scale.ResultThe usability evaluation revealed that the average satisfaction score across all usability dimensions was above 8, demonstrating a satisfactory level of system usage from all user perspectives. Additionally, the close alignment of mean and median scores, along with standard deviations below 1 for several dimensions, indicated consistent positive feedback among users.ConclusionOur telemonitoring system demonstrates promise for enhancing the management of high-risk pregnancies, facilitating better health outcomes for mothers and infants through effective remote monitoring and support. The usability test results underscore the platform’s effectiveness and user satisfaction, contributing valuable insights for future improvements in high-risk pregnancy care.

Evaluation of the Effect of Supragingival Scaling on Periodontal Parameters in Pregnant Women with Metabolic Syndrome

ABSTRACT Background: Although there are quite a number of studies on the impacts of periodontal therapeutic management on pregnant females, literature on the impact of supragingival scaling on pregnant females with metabolic syndrome (MS) is wanting. The present investigation was meticulously formulated to ascertain the clinical ramifications of supragingival scaling in pregnant individuals diagnosed with MS. Material and Methods: An intervention study was conducted on 47 pregnant females. The gingival index (GI), plaque index, bleeding on probing, probing depth, and clinical attachment level were among the periodontal parameters evaluated. By the end of 20–21 weeks of pregnancy, all participants had received scaling and polishing at the baseline appointment, along with advice on dental hygiene. Periodontal parameters were gathered again during a follow-up appointment 8 weeks post treatment. A 5% threshold for statistical significance was set, and paired t-test and chi-square test were applied for comparison. Results: Lower levels of PI, GI, and BOP 8 weeks post supragingival scaling were noted than at the baseline. The results obtained were statistically significant (P &lt; 0.001) All patients with severe periodontitis (n = 14) before supragingival scaling shifted to milder forms of the disease. Similarly, moderate periodontitis was seen in 20 patients before the start of the study, and after the intervention, it was reduced to 16 patients. Conclusion: In summary, supragingival scaling lowers the incidence of periodontal disease in pregnant MS females. High-risk pregnant women who receive scaling treatment and instruction on oral hygiene on a regular basis have better oral health, which in turn improves the health of their unborn child.

Prediction of low birth weight from fetal ultrasound and clinical characteristics: a comparative study between a low- and middle-income and a high-income country

IntroductionAdverse perinatal outcomes (APO) pose a significant global challenge, particularly in low- and middle-income countries (LMICs). This study aims to analyse two cohorts of high-risk pregnant women for APO to...

Primary and secondary cerclage in high-risk pregnant women: Influence on prolongation of pregnancy and preterm birth

The aim of the study was to evaluate the effectiveness of cerclage in women with previous late miscarriages or premature births. The primary aim was to prolong pregnancy and achieve a term delivery. Secondarily, it was investigated whether an intervention after an early pathological 75-g-oGTT result influences these endpoints. A total of 133 cases were analyzed retrospectively. 80 women underwent primary cerclage between the 14th and 16th week of pregnancy; 53 women underwent secondary cerclage after cervical shortening of less than 25 mm. This group was further subdivided into therapeutic and emergency cerclage groups. Women with early pathologic 75-g-oGTT were treated diabetologically. Primary cerclage prolonged pregnancy by 20.6 weeks and led to a term delivery in 51 women (63.8%). In the group with secondary cerclage, 25 women (47.2%) had a term delivery with a prolongation of 20.1 weeks. For amniotic sac prolapse, the prolongation was 7.9 weeks. Pathological 75-g-oGTT results were found in 63 women. Early intervention had no significant effect on prolongation and term delivery. Primary cerclage was more effective in achieving term delivery. Women with therapeutic cerclage without amniotic sac prolapse also benefited. With cervical shortening without prolapse, the prolongation was the same in both groups. The worst outcome was observed in emergency cerclage with amniotic sac prolapse. An early 75-g-oGTT is important in order to recognize and treat gestational diabetes in time.

Pregnancy outcomes among users and non-users of maternity waiting homes in rural southern Tanzania: a comparative cross-sectional study

Background/Aims Maternity waiting homes are facilities that house high-risk pregnant women before birth, intended to prevent delays accessing care during labour and birth. By ensuring access to timely and appropriate care, maternity waiting homes can reduce maternal and neonatal morbidity. This study aimed to compare pregnancy outcomes between those who had attended maternity waiting homes and those who had not at Nyangao hospital in southern Tanzania. Methods A cross-sectional study was conducted involving women who gave birth at the hospital between 1 January 2017 and 31 September 2019. A total of 3105 files were retrieved and data were extracted using a structured checklist. Chi-squared tests were used to compare demographic characteristics and birth outcomes between the two groups, with P&lt;0.05 deemed statistically significant. Results There were 232 women who had used maternity waiting homes and 462 who had not. Place of residence was significantly linked with increased use of maternity waiting homes, as those who lived ≥50km were more likely to use these facilities (P=0.001). Before birth, the mean length of hospital stay was 14.29 days (±11.32 days) for users and 4.02 days (±4.62 days) for non-users of maternity waiting homes. After birth, the mean length of stay was 2.88 days (±2.97 days) for users and 3.16 days (±3.88 days) for non-users. Using maternity waiting homes reduced the risk of low birth weight (P=0.001) and admission to the neonatal intensive care unit (P=0.012). Conclusions Use of a maternity waiting home is associated with improved maternal and neonatal outcomes. Available maternity waiting homes should be used by women who live a long distance from healthcare facilities and those with high-risk pregnancies. Implications for practice Healthcare professionals providing antenatal services should encourage women who live a significant distance from healthcare facilities and those with high-risk pregnancies to use maternity waiting homes, which have the potential to reduce maternal and neonatal morbidities in the low-resource communities.

Optimalisasi Program Penurunan Stunting Di Desa Nagrak, Kec. Buahdua, Kab. Sumedang

Stunting is a serious nutritional problem and must be faced by Indonesia and other countries. Stunting itself is a disorder of child growth and development where the height of stunted children is shorter than that of children of the same age. This study was conducted to find out whether the stunting reduction program in Nagrak Village is optimal or not. To find out, the researcher used a descriptive qualitative research method. In this study, the researcher collected data by documentation, interview, and observation techniques. In an effort to reduce stunting in Nagrak Village, the focus is on three target groups, namely, adolescents, pregnant women and toddlers 0-59 months. The results of the study show that early detection of nutritional problems in Nagrak Village has been carried out with the existence of a youth posyandu program and also the provision of Blood Supplement Tablets (BST) and anemia checks to schools. In addition, in the target group of pregnant women, assistance has been provided regarding the consumption of nutrition and BST or other supplements and additional nutritional intake has been provided for high-risk pregnant women. Stunting treatment for toddlers 0-59 months is carried out with the posyandu program, where the weight and height of toddlers are measured every month so that their growth and development can be monitored, in addition to the provision of supplementary food (PMT) for toddlers who are indicated to be stunted so that they can meet additional nutritional intake. It was concluded that the stunting reduction program in Nagrak Village has been carried out optimally.

Reference Levels of Plasma D-dimer for Normal Pregnant and Their Association with Pregnancy Complications: A Single-center Retrospective Analysis

Background: The objective of this study was to extract maternal plasma D-dimer test results from a large medical records dataset and to establish a reference level for pregnant women in our center. This study aimed to investigate the role and efficacy of D-dimer levels for predicting complications in high-risk pregnant women. Methods: The clinical data of 19,117 women who delivered at Wenzhou People’s Hospital between January 1, 2020, and September 30, 2022, were retrospectively analyzed. A total of 74,401 D-dimer test results were extracted from the laboratory information system. Following data screening and matching, 7692 records of D-dimer test results for healthy pregnant women and 19,005 records for pregnant women with complications were selected. D-dimer reference values were calculated for early pregnancy (1–13 weeks gestation), mid-pregnancy (14–27 weeks gestation), late pregnancy (28–36 weeks gestation), and the end of pregnancy (37–41 weeks gestation). A logistic regression model was used to plot receiver operating characteristic (ROC) and determine cut-off values for predicting pregnancy complications in each phase. Results: The mean D-dimer levels in the healthy pregnancy group were 0.56 mg/L in early pregnancy, 1.08 mg/L in mid-pregnancy, 1.48 mg/L in late pregnancy, and 1.89 mg/L at the end of pregnancy. D-dimer levels were greater in the complication group (which contains 11 common pregnancy disorders, including premature rupture of membranes (PRM), gestational diabetes mellitus (GDM), gestational hypertension (GHP), preeclampsia (PE), placental abnormalities, thyroid dysfunction, hemorrhage, thrombophilia, fetal macrosomia, preterm delivery, and infections) than in the healthy group in all pregnancy phases, with statistically significant differences observed in early, medium, and the end of pregnancy. D-dimer levels showed good diagnostic performance in predicting pregnancy complications in early pregnancy (area under the curve (AUC) = 0.71, cut-off value = 0.87, odds ratio: 7.12, 95% confidence interval (CI): 5.41–9.36, p-value = 0.000). Conclusions: The reference range of D-dimer increases with the progression of gestational phases and demonstrates predictive efficacy for high-risk pregnancy complications during early pregnancy.

The role of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in determining the severity of pre-eclampsia in antenatal women: A case control study

Pre-eclampsia (PE) remains a significant global health concern, affecting 2-8% of pregnancies and contributing to maternal and perinatal morbidity and mortality. Characterized by hypertension and proteinuria after 20 weeks of gestation, PE often involves systemic inflammation and endothelial dysfunction. Its exact etiology is multifactorial, involving immune dysregulation and vascular abnormalities. Early identification of high-risk pregnant women is crucial to mitigate adverse outcomes. In India, PE affects 8-10% of pregnancies.Inflammatory markers such as the Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) have emerged as potential indicators of systemic inflammation. Elevated NLR and PLR levels in PE suggest a role in the disorder's pathophysiology, reflecting immune responses to placental ischemia and pro-inflammatory cytokine release.This study aims to compare NLR and PLR levels between PE patients and normotensive pregnant women, evaluate their association with PE severity, and discuss their potential as predictive biomarkers. A case-control study was conducted with 84 participants, following eligibility criteria via convenient sampling. Demographic characteristics, obstetric history, and CBC-derived biomarkers were assessed.Among 84 pregnant women, 42 had preeclampsia (PE) and 42 were normotensive. The PE group had significantly higher Neutrophil-to-Lymphocyte Ratios (5.11 ± 2.88 vs. 2.74 ± 0.78) and Platelet-to-Lymphocyte Ratios (108 ± 46.7 vs. 85.4 ± 29.4) compared to controls. PE incidence peaked between 34-38 weeks. Higher PLR and NLR values were linked to severe PE. ANC booking was lower in the PE group. Obesity trends were not statistically significant.Significant associations were found between elevated NLR and PLR and PE severity, highlighting their potential clinical utility.Our findings indicate NLR and PLR as valuable biomarkers for predicting and managing PE. Integration of these markers into routine prenatal care could enhance clinical management and improve maternal and fetal outcomes.