Introductiondental training aims to produce committed dentists who are professional and empathetic in providing patient-centered oral healthcare and improved quality of life. This study aimed to assess the motives of dental students to study dentistry, their specialty preferences, and their empathy scores by motives and specialty preference.Methodsthis cross-sectional study utilized a self-administered questionnaire designed to assess the empathy measured by the Jefferson Scale of Empathy-Health Professions Student version, motives to study dentistry, dental specialty preferences among students of a dental school in Nigeria. Differences in mean empathy across gender, motives to study dentistry, and specialty preferences were analysed with t-test and ANOVA. P-values of <0.05 were considered significant.Resultsa total of 211 students participated fully in the study with a mean age of 21.19 years ± 2.43 and 140 (66.4%) females. Personal interest (27.0%) and failure of admission to other undergraduate programmes (20.9%) were the top two motives for studying dentistry. Oral and maxillofacial surgery (OMFS) was the most preferred specialty (44.1%) and community dentistry and periodontology were the least preferred (2.8%) respectively. The total mean empathy score was 104.06 ± 19.1. The highest empathy score for motivation was for high income from dentistry (112.33 ± 13.34). The participants who preferred paediatric dentistry had the highest empathy score (108.73 ± 13.68).Conclusionknowledge of the empathy levels, the motivation for studying dentistry, and preferences for particular specialties may encourage trainers to ensure the development of a positive attitude among dental students that is professional and empathetic.