Various factors (e.g., hand preference, object properties) constrain reach-to-grasp in hemispace. With object use, end-state comfort (ESC) has been shown to supersede the preferential use of one hand at the midline. To assess how location, size, and orientation of objects (dowel, mallet, cup) influence preferred-hand use and ESC (N = 50; Mage = 20.83), three preferential reaching tasks were implemented. Object location influenced hand selection in all tasks, along with size (cups) and orientation (mallets). Object location and orientation influenced ESC, but only with dowels and mallets. When oriented away from the preferred hand in hemispace, there was a higher occurrence of non-preferred hand use to facilitate ESC. Overall, findings add to understanding of ESC and preferential reaching with varying task demands.