Pre-existing Patterns Research Articles

Predictability of Stratospheric Sudden Warmings in the Beijing Climate Center Forecast System with Statistical Error Corrections

AbstractPrevious studies have reported that the predictive limit of stratospheric sudden warming (SSW) events in the Beijing Climate Center forecast system (BCC_CSM) is shorter than 2 weeks. This study continues to analyze the general characteristics of this model in forecasting SSWs and carries out a trial of error corrections. The ratio of the ensemble members that forecast the zonal wind reversal with a 5‐day delay allowed (hit ratio) is higher for SSW events with a small decrease in the zonal mean zonal winds (moderate SSWs) than for events with a large decrease in the zonal mean zonal winds (radical SSWs) in hindcasts initialized around 1 (D‐7) and 2 (D‐14) weeks in advance. The underestimated cumulative eddy heat flux associated with weak wave activities accounts for the weaker‐than‐observed deceleration of westerlies. The preexisting extratropical wave patterns are satisfactorily forecast in D‐14 for most (9/12) cases, and the wave phase bias is reasonably small for those cases. After the climatology bias is deducted from the hindcasts, an increase in the hit ratio can be identified for moderate SSW events as the evolutions of zonal winds are improved. Following the error correction by remapping the zonal wind probability distribution function in the forecast system to the reanalysis, the SSW hit ratios increase in the D‐7 (43% to 57%) and/or D‐14 (11% to 21%) initializations. Based on the composite result, this error correction method robustly improves the hit ratio not only for both radical SSWs and moderate SSWs but also for both polar vortex split SSWs and polar vortex displacement SSWs. The best error correction method might propel the prediction limit of SSW events to around 2 weeks.

The Changing Position of the Center of Mass of the Thorax During Growth in Relation to Pre-existent Vertebral Rotation.

Cross-sectional. The aim of this study was to analyze the thoracic center of mass (COM) position of children at different ages and evaluate its relation with the previously reported pre-existent rotational pattern of the normal spine. The normal, nonscoliotic thoracic spine is known to have a rotational pattern that changes direction during growth, a transition from left-sided toward right-sided rotation with increasing age. This matches the changing curve convexity seen when idiopathic scoliosis develops at different ages. Furthermore, the direction of pre-existent rotation was shown to be related to organ orientation; in situs inversus the rotation is opposite to situs solitus. Computed tomography (CT) scans of the thorax of infantile (0-4 years, n = 40), juvenile (4-10 years, n = 53), and adolescent (10-18 years, n = 62) children without spinal pathology were included from an existing database. The location of the COM inside the thorax was calculated based on Hounsfield-units, representing tissue mass. The COM offset was defined as the shortest distance to the midsagittal plane. At the infantile age, the COM was 2.5 ± 2.1 mm on the right side, at juvenile age not significantly deviated, and at adolescent age 3.1 ± 2.3 mm on the left side of the midsagittal plane. The mean COM offset correlated linearly with age (r = 0.77, P < 0.001). The COM shifts from slightly on the right side of the thorax at the infantile age, to neutral at juvenile age, to the left at adolescent age. This corresponds to the earlier demonstrated change in direction of pre-existent rotation in the normal spine with age, as well as with the well-known changing direction, from left to right, of thoracic curve convexity in scoliosis at different ages. N/ A.

The false vital sign: When pain levels are not predictive of discharge opioid prescriptions

BackgroundPain gained recognition as a vital sign in the early 2000s, underscoring the importance of accurate documentation, characterization, and treatment of pain. No prior studies have demonstrated the utility of the 0–10 pain scale with respect to discharge opioid prescriptions, nor characterized the most influential factors in discharge prescriptions. MethodsInpatient and emergency department(ED) encounters from July 1, 2012 to April 1, 2018 resulting in a discharge prescription for tablet opioid medications were identified. The primary outcome was to determine if pain levels in 24 h prior to discharge correlated with opioids (in milligrams of morphine equivalents (MME)) prescribed. Secondary outcomes included the impact of patient and prescriber demographics, demographics. A generalized linear model was created to investigate factors affecting the quantity of prescribed opioids. Resultsn = 78,691 patient encounters. Overall mean adjusted MME for non-ED visits was 378 versus 197 for ED visits. Whites received the highest quantities; those identifying as non-white and non-black received the lowest. Women received significantly fewer discharge MMEs in both the ED and inpatient cohorts. Provider prescribing patterns exhibited the most profound effect on discharge MMEs. The most prolific (≥300 prescriptions over the study period) writing the largest amount. In the ED, there was a significant negative correlation between documented pain levels and discharge MMEs(ρ = 0.074,p < 0.001). ConclusionsPain scale was significantly negatively correlated with discharge MMEs in the ED and positively correlated in the inpatient population. Individual prescriber characteristics were the more influential variable, with prolific high prescribers writing for the largest MME amounts. The inverse association of pain and MMEs at discharge in the ED, and the large effect pre-existing prescriber patterns exhibited, both improved methodology for assessing and appropriately treating pain, and effective prescriber-targeted interventions, must be a priority.

Gifts of the Immigrants, Woes of the Natives: Lessons from the Age of Mass Migration

AbstractIn this article, I jointly investigate the political and the economic effects of immigration, and study the causes of anti-immigrant sentiments. I exploit exogenous variation in European immigration to U.S. cities between 1910 and 1930 induced by World War I and the Immigration Acts of the 1920s, and instrument immigrants’ location decision relying on pre-existing settlement patterns. I find that immigration triggered hostile political reactions, such as the election of more conservative legislators, higher support for anti-immigration legislation, and lower redistribution. Exploring the causes of natives’ backlash, I document that immigration increased natives’ employment, spurred industrial production, and did not generate losses even among natives working in highly exposed sectors. These findings suggest that opposition to immigration was unlikely to have economic roots. Instead, I provide evidence that natives’ political discontent was increasing in the cultural differences between immigrants and natives. Results in this article indicate that, even when diversity is economically beneficial, it may nonetheless be socially hard to manage.

Does Preexisting Practice Modify How Video Games Recalibrate Physician Heuristics in Trauma Triage?

BackgroundA majority of severely injured patients fail to receive care at trauma centers (undertriage), in part, because of physician judgment. We previously developed two educational video games that reduced physicians' undertriage compared with control in two clinical trials. In this secondary analysis, we investigated heterogeneity of treatment effect of the interventions by assessing physicians' preexisting practice patterns in claims data. We hypothesized that physicians with high preexisting undertriage would benefit most from game-based training. MethodsUsing Medicare claims records from 2010 to 2015, we measured physicians' preexisting triage practices before their participation in one of two trials conducted in 2016 and 2017. We categorized physicians as having received game-based training versus control and noted their postintervention simulation triage performance in the trials. We used multivariable linear regression models to assess the heterogeneity of game-based training effect among physicians with high and low preexisting undertriage. ResultsOf the 394 eligible physicians from our trials, we identified 275 (70%) with claims for Medicare fee-for-service beneficiaries suffering severe injury between 2010 and 2015. On average, the physicians were 44 y old (SD 8.4) with 12 y (SD 8.2) of experience. We found significant interaction between preexisting practice and intervention efficacy (P = 0.04). Physicians with high undertriage before enrollment improved significantly with game-based training compared with the control (46% versus 63%, P < 0.001). Those with low preexisting undertriage did not (58% versus 56%, P = 0.76). ConclusionsUsing claims-based data, we found heterogeneity of treatment effect of interventions designed to recalibrate physician heuristics. Physicians with high preexisting undertriage benefited most from game-based training.

Gifts of the Immigrants, Woes of the Natives: Lessons from the Age of Mass Migration

In this paper, I jointly investigate the political and the economic effects of immigration and study the causes of anti-immigrant sentiments. I exploit exogenous variation in European immigration to U.S. cities between 1910 and 1930 induced by World War I and the Immigration Acts of the 1920s as well as instrument immigrants' location decision relying on pre-existing settlement patterns. I find that immigration triggered hostile political reactions, such as the election of more conservative legislators, higher support for anti-immigration legislation, and lower redistribution. Exploring the causes of natives' backlash, I document that immigration increased natives' employment, spurred industrial production, and did not generate losses even among natives working in highly exposed sectors. These findings suggest that opposition to immigration was unlikely to have economic roots. Instead, I provide evidence that natives' political discontent was increasing in the cultural differences between immigrants and natives. Results in this paper indicate that, even when diversity is economically beneficial, it may nonetheless be socially hard to manage.

Eurasian Cold Air Outbreaks under Different Arctic Stratospheric Polar Vortex Strengths

AbstractThis study analyzes the differences and similarities of Eurasian cold air outbreaks (CAOs) under the weak (CAOW), strong (CAOS), and neutral (CAON) stratospheric polar vortex states and examines the potential links between the polar vortex and Eurasian CAOs. The results indicate that the colder surface air temperature (SAT) over Europe in the earlier stages of CAOW events is likely because the amplitude of the preexisting negative North Atlantic Oscillation pattern is larger in CAOW events than in CAON and CAOS events. Marked by the considerably negative stratospheric Arctic Oscillation signals entering the troposphere, the SAT at midlatitudes over eastern Eurasia in CAOW events is colder than in CAON events. A larger diabatic heating rate related to a positive sensible heat flux anomaly in CAOW events likely offsets, to some degree, the cooling effect caused by the stronger cold advection and makes the differences in area-averaged SAT anomalies over northern Eurasia between the CAOW and CAON events look insignificant in most stages. Massive anomalous waves from the low-latitude western Pacific merge over northeastern Eurasia, then weaken the westerly wind over this region to create favorable conditions for southward advection of cold air masses in the earlier stages of all three types of CAOs. This study further analyzes the interannual relationship between the stratospheric polar vortex strength and the intensity of Eurasian CAOs and finds that climate models participating in phase 5 of the Coupled Model Intercomparison Project (CMIP5) relative to the reanalysis dataset tend to underestimate the correlation between them. The relationship between them is strengthening under representative concentration pathway 4.5 (RCP4.5) and 8.5 (RCP8.5) scenarios over the period 2006–60. In addition, the intensity of Eurasian CAOs exhibits a decreasing trend in the past and in the future.

Neural crest streaming as an emergent property of tissue interactions during morphogenesis.

A fundamental question in embryo morphogenesis is how a complex pattern is established in seemingly uniform tissues. During vertebrate development, neural crest cells differentiate as a continuous mass of tissue along the neural tube and subsequently split into spatially distinct migratory streams to invade the rest of the embryo. How these streams are established is not well understood. Inhibitory signals surrounding the migratory streams led to the idea that position and size of streams are determined by a pre-pattern of such signals. While clear evidence for a pre-pattern in the cranial region is still lacking, all computational models of neural crest migration published so far have assumed a pre-pattern of negative signals that channel the neural crest into streams. Here we test the hypothesis that instead of following a pre-existing pattern, the cranial neural crest creates their own migratory pathway by interacting with the surrounding tissue. By combining theoretical modeling with experimentation, we show that streams emerge from the interaction of the hindbrain neural crest and the neighboring epibranchial placodal tissues, without the need for a pre-existing guidance cue. Our model suggests that the initial collective neural crest invasion is based on short-range repulsion and asymmetric attraction between neighboring tissues. The model provides a coherent explanation for the formation of cranial neural crest streams in concert with previously reported findings and our new in vivo observations. Our results point to a general mechanism of inducing collective invasion patterns.

Percolation theory for the recognition of patterns in topographic images of the cortical activity

Electroencephalogram (EEG) is one of the mechanisms used to collect complex data. Its use includes evaluating neurological disorders, investigating brain function and correlations between EEG signals and real or imagined movements. The Topographic Image of Cortical Activity (TICA) records obtained by the EEG make it possible to observe, through color discrimination, the cortical areas that represent greater or lesser activity. Percolation Theory (PT) reveals properties on the aspects of fluid spreading from a central point, these properties being related to the aspects of the medium, topological characteristics and ease of penetration of a fluid in materials. The hypothesis presented so far considers that synaptic activities originate in points and spread from them, causing different areas of the brain to interact in a diffusive associative behavior, generating electric and magnetic fields by the currents that spread through the brain tissue and have an effect on the scalp sensors. Brain areas spatially separated create large-scale dynamic networks that are described by functional and effective connectivity. The proposition is that this phenomenon behaves like a fluidic spreading, so we can use the PT, through the topological analysis we detect specific signatures related to neural phenomena that manifest changes in the behavior of synaptic diffusion. This signature must be characterized by the Fractal Dimension (FD) values of the scattering clusters, these values will be used as properties in the k-Nearest Neighbors (kNN) method, an TICA will be categorized according to the degree of similarity to the preexisting patterns. In this context, our hypothesis will consolidate as a more computational resource in the service of medicine and another way that opens with the possibility of analysis and detailed inferences of the brain through TICA that go beyond a simply visual observation, as it happens in the present day.

Gifts of the Immigrants, Woes of the Natives: Lessons from the Age of Mass Migration - Online Appendix A

In this paper, I show that political opposition to immigration can arise even when immigrants bring economic prosperity. I exploit exogenous variation in European immigration to US cities between 1910 and 1930 induced by World War I and the Immigration Acts of the 1920s, and instrument immigrants’ location decision relying on pre-existing settlement patterns. I find that immigration triggered hostile political reactions, such as the election of more conservative legislators, higher support for anti-immigration legislation, and lower public goods provision. Exploring the causes of natives’ backlash, I document that immigration increased natives’ employment and occupational standing, and fostered industrial production and capital utilization. Even in occupations highly exposed to immigrants’ competition, there were no employment or wage losses among natives, suggesting that political discontent was unlikely to have economic roots. Consistent with this interpretation, I provide evidence that natives’ backlash was increasing in the cultural differences between immigrants and natives. These results indicate that diversity might be economically beneficial but politically hard to manage.

Domain Wall Motions in a Near-Morphotropic Pb(Zr,Ti)O3 Under Mechanical Stress Observed by In Situ Piezoresponse Force Microscopy

Many important material properties of ferroelectric ceramics such as piezoelectric coefficient and hysteresis curve are governed by domain structures and their evolution processes. In the present work, domain wall motions in a near-morphotropic Pb(Zr,Ti)O3 under an external compressive stress were observed using in situ piezoresponse force microscopy (PFM). This specific PZT material was chosen due to its complex microstructure, which originates from the coexistence of tetragonal and rhombohedral phases. A micromechanical test rig was installed on the sample stage controller, enabling precise control of the sample position. For the real-time strain monitoring of the PZT sample, a strain gauge was attached to the sample surface on which the PFM scan was conducted. In addition, analysis of the ferroelectric domain structure was assisted by using the electron backscatter diffraction (EBSD) technique to identify the habit planes of non- 180° domain walls and grain boundaries in the PFM images. From a certain grain, a set of large non-180° needle-like domain patterns in the (101) plane were observed before applying a mechanical stress. With increasing compressive stress levels, another set of non-180° needle-like domain patterns grew in the (011) plane, overwriting the domain patterns in the (101) plane. This indicates that polarization switching processes in ferroelectric ceramics take place via a pattern evolution based on the pre-existing domain patterns. (Received October 22, 2018; Accepted November 19, 2018)

Mobile PEAR transcription factors integrate positional cues to prime cambial growth

Apical growth in plants initiates upon seed germination, whereas radial growth is primed only during early ontogenesis in procambium cells and activated later by the vascular cambium1. Although it is not known how radial growth is organized and regulated in plants, this system resembles the developmental competence observed in some animal systems, in which pre-existing patterns of developmental potential are established early on2,3. Here we show that in Arabidopsis the initiation of radial growth occurs around early protophloem-sieve-element cell files of the root procambial tissue. In this domain, cytokinin signalling promotes the expression of a pair of mobile transcription factors-PHLOEM EARLY DOF 1 (PEAR1) and PHLOEM EARLY DOF 2 (PEAR2)-and their four homologues (DOF6, TMO6, OBP2 and HCA2), which we collectively name PEAR proteins. The PEAR proteins form a short-range concentration gradient that peaks at protophloem sieve elements, and activates gene expression that promotes radial growth. The expression and function of PEAR proteins are antagonized by the HD-ZIP III proteins, well-known polarity transcription factors4-the expression of which is concentrated in the more-internal domain of radially non-dividing procambial cells by the function of auxin, and mobile miR165 and miR166 microRNAs. The PEAR proteins locally promote transcription of their inhibitory HD-ZIP III genes, and thereby establish a negative-feedback loop that forms a robust boundary that demarks the zone of cell division. Taken together, our data establish that during root procambial development there exists a network in which a module that links PEAR and HD-ZIP III transcription factors integrates spatial information of the hormonal domains and miRNA gradients to provide adjacent zones of dividing and more-quiescent cells, which forms a foundation for further radial growth.

A Moral Bureaucracy: Enforcement of EU Fundamental Values in Central and Eastern Europe

There is growing sentiment that the rise of illiberal democracy in Central and Eastern Europe poses a serious threat to fundamental European values. Within the framework of the European Union (EU) legal system, how do post-socialist member states actually comply with fundamental European values? While there are multiple contradictory theories about the success or failure of assimilation in the region, there is surprisingly little datadriven literature which directly compares post-socialist member state compliance to the rest of the European member states. This paper fills the gap by comparing post-socialist compliance patterns with the rest of the EU, using data on infringement cases opened by the Commission. It finds that post-socialist member states are generally assimilating into pre-existing patterns of European compliance. However, they are demonstrably worse in fundamental European values compliance—and though a legal basis for enforcing these values exists, the EU currently lacks the practical ability to do so.

Roman Transport Network Connectivity and Economic Integration

We show that the creation of the first integrated pan-European transport network during Roman times influences economic integration over two millennia. Drawing on spatially highly disaggregated data on excavated Roman ceramics, we document that interregional trade was strongly influenced by connectivity within the network. Today, these connectivity differentials continue to influence cross-regional firm investment behaviour. Continuity is largely explained by selective infrastructure routing and cultural integration due to bilateral convergence in preferences and values. Both plausibly arise from network-induced history of repeated socio-economic interaction. We show that our results are Roman-connectivity specific and do not reflect pre-existing patterns of exchange.

Nationwide incidence and risk factors for posttraumatic seizures in children with traumatic brain injury.

OBJECTIVEPosttraumatic seizures (PTSs) are the most common complication following a traumatic brain injury (TBI) and may lead to posttraumatic epilepsy. PTS is well described in the adult literature but has not been studied extensively in children. Here, the authors utilized the largest nationwide registry of pediatric hospitalizations to report the national incidence, risk factors, and outcomes associated with PTS in pediatric TBI.METHODSThe authors queried the Kids' Inpatient Database (KID) using ICD-9-CM codes to identify all patients (age < 21 years) who had a primary diagnosis of TBI (850.xx-854.xx) and a secondary diagnosis of PTS (780.33, 780.39). Parameters of interest included patient demographics, preexisting comorbidities, hospital characteristics, nature of injury (open/closed), injury type (concussion, laceration/contusion, subarachnoid hemorrhage, subdural hematoma, or epidural hematoma), loss of consciousness (LOC), surgical management (Clinical Classification Software code 1 or 2), discharge disposition, in-hospital complications, and in-hospital mortality. The authors utilized the IBM SPSS statistical package (version 24) for univariate comparisons, as well as the identification of independent risk factors for PTS in multivariable analysis (alpha set at < 0.05).RESULTSThe rate of PTS was 6.9% among 124,444 unique patients hospitalized for TBI. The utilization rate of continuous electroencephalography (cEEG) was 0.3% and increased between 2003 (0.1%) and 2012 (0.7%). The most common etiologies of TBI were motor vehicle accident (n = 50,615), accidental fall (n = 30,847), and blunt trauma (n = 13,831). However, the groups with the highest rate of PTS were shaken infant syndrome (41.4%), accidental falls (8.1%), and cycling accidents (7.4%). In multivariable analysis, risk factors for PTS included age 0-5 years (compared with 6-10, 11-15, and 16-20 years), African American race (OR 1.4), ≥ 3 preexisting comorbidities (OR 4.0), shaken infant syndrome (OR 4.4), subdural hematoma (OR 1.6), closed-type injury (OR 2.3), brief LOC (OR 1.4), moderate LOC (OR 1.5), and prolonged LOC with baseline return (OR 1.8). Surgically managed patients were more likely to experience PTS (OR 1.5) unless they were treated within 24 hours of admission (OR 0.8). PTS was associated with an increased likelihood of in-hospital complications (OR 1.7) and adverse (nonroutine) discharge disposition (OR 1.2), but not in-hospital mortality (OR 0.5). The overall utilization rate of cEEG was 1.3% in PTS patients compared with 0.2% in patients without PTS. Continuous EEG monitoring was associated with higher rates of diagnosed PTS (35.4% vs 6.8%; OR 4.9, p < 0.001).CONCLUSIONSPTS is common in children with TBI and is associated with adverse outcomes. Independent risk factors for PTS include younger age (< 5 years), African American race, increased preexisting comorbidity, prolonged LOC, and injury pattern involving cortical exposure to blood products. However, patients who undergo urgent surgical evacuation are less likely to develop PTS.

Hydraulic fracturing for improved nutrient delivery in microbially-enhanced coalbed-methane (MECBM) production

Microbially enhanced coalbed methane (MECBM) recovery is a novel method to increase gas production by injecting nutrients, either with/without microorganisms, in depleted CBM wells. However, to be effective, methanogens require that the nutrient must be delivered efficiently by aqueous solution to a maximally large reservoir volume for microbial colonization. This study seeks to improve understanding of solute transport and microbial gas generation in naturally fractured reservoirs that are both pristine and hydraulically fractured. We complete a field-scale numerical simulation using an equivalent multi-continuum method to define the effectiveness of nutrient delivery. The complex pre-existing fracture pattern in the coalbed is represented by an overprinted discrete fracture network (DFN) to capture the natural heterogeneity and anisotropy of fracture permeability. A simplified PKN model is adopted to simulate hydraulic fracture propagation based on linear elastic fracture mechanics (LEFM). The hydraulically stimulated case is compared to the untreated control case, both without and with a network of natural fractures. Saturated cleat area, cumulative injection volume and prediction of methane yields are systematically modeled and analyzed for all three cases. We show that hydraulically stimulated fracture pathways, especially when connecting with a natural fracture network, optimally deliver nutrient remotely from the injection well, thereby increasing nutrient delivery and improving methane production and potential recovery. However, large magnitudes of proppant embedment and related permeability loss in the hydraulic fractures may reduce MECBM recovery. In the optimal production scenario, the methane production rate may reach 31 ft3/ton, an approximately 5-fold increase over that from the pristine unstimulated case.

Vicariance and dispersal in southern hemisphere freshwater fish clades: a palaeontological perspective.

Widespread fish clades that occur mainly or exclusively in fresh water represent a key target of biogeographical investigation due to limited potential for crossing marine barriers. Timescales for the origin and diversification of these groups are crucial tests of vicariant scenarios in which continental break-ups shaped modern geographic distributions. Evolutionary chronologies are commonly estimated through node-based palaeontological calibration of molecular phylogenies, but this approach ignores most of the temporal information encoded in the known fossil record of a given taxon. Here, we review the fossil record of freshwater fish clades with a distribution encompassing disjunct landmasses in the southern hemisphere. Palaeontologically derived temporal and geographic data were used to infer the plausible biogeographic processes that shaped the distribution of these clades. For seven extant clades with a relatively well-known fossil record, we used the stratigraphic distribution of their fossils to estimate confidence intervals on their times of origin. To do this, we employed a Bayesian framework that considers non-uniform preservation potential of freshwater fish fossils through time, as well as uncertainty in the absolute age of fossil horizons. We provide the following estimates for the origin times of these clades: Lepidosireniformes [125-95million years ago (Ma)]; total-group Osteoglossomorpha (207-167Ma); Characiformes (120-95Ma; a younger estimate of 97-75Ma when controversial Cenomanian fossils are excluded); Galaxiidae (235-21Ma); Cyprinodontiformes (80-67Ma); Channidae (79-43Ma); Percichthyidae (127-69Ma). These dates are mostly congruent with published molecular timetree estimates, despite the use of semi-independent data. Our reassessment of the biogeographic history of southern hemisphere freshwater fishes shows that long-distance dispersals and regional extinctions can confound and erode pre-existing vicariance-driven patterns. It is probable that disjunct distributions in many extant groups result from complex biogeographic processes that took place during the Late Cretaceous and Cenozoic. Although long-distance dispersals likely shaped the distributions of several freshwater fish clades, their exact mechanisms and their impact on broader macroevolutionary and ecological dynamics are still unclear and require further investigation.

Inheritance of OCT4 predetermines fate choice in human embryonic stem cells

It is well known that clonal cells can make different fate decisions, but it is unclear whether these decisions are determined during, or before, a cell's own lifetime. Here, we engineered an endogenous fluorescent reporter for the pluripotency factor OCT4 to study the timing of differentiation decisions in human embryonic stem cells. By tracking single‐cell OCT4 levels over multiple cell cycle generations, we found that the decision to differentiate is largely determined before the differentiation stimulus is presented and can be predicted by a cell's preexisting OCT4 signaling patterns. We further quantified how maternal OCT4 levels were transmitted to, and distributed between, daughter cells. As mother cells underwent division, newly established OCT4 levels in daughter cells rapidly became more predictive of final OCT4 expression status. These results imply that the choice between developmental cell fates can be largely predetermined at the time of cell birth through inheritance of a pluripotency factor.

Neoliberal co-optation and authoritarian renewal: social entrepreneurship networks in Jordan and Morocco

ABSTRACTThis paper analyzes social entrepreneurship networks (SENs) – composed of social entrepreneurs, business and political elites, and international actors – in Jordan and Morocco and how they foster processes of authoritarian renewal through neoliberal forms of co-optation. I argue that these new neoliberal networks and pre-existing patterns of social interaction complement each other, fostering linkages between well-established elites and hand-picked social entrepreneurs as well as societal groups. The two case studies illustrate different trajectories of the development of SENs and their embeddedness in the respective political, social and economic contexts. Importantly, such trajectories indicate a similar direction of travel: social entrepreneurship, rather than acting as a driver of progressive change, has been aligned with the authoritarian regimes and cements neoliberalism as a mode of governance. This mutation of neoliberal tactics towards more inclusionary and consensual patterns seeks to ensure the survival of both neoliberalism and of authoritarian governance. Thus, the article brings to light repertoires of authoritarian neoliberalism that have hitherto been under-studied. Moreover, it offers a critical perspective on social entrepreneurship as an increasingly popular phenomenon that, in academia and beyond, has all too often been approached from an uncritical and apolitical perspective.

Asymmetry In Belief Updating And Carcinogenesis

Accumulating evidence shows that the central nervous system (CNS) regulates the activity of the immune system. Concerning the role of immune system in cancer, psychosocial influences on immune function provide a mechanism of association between psychosocial factors (like interpersonal aggression) and cancer prognosis. Social conflicts between males, involving high aggression stress and threat (psychosocial conflicts) produce both an allostatic state and allostatic load. The costs for aggressors (Hawks) and victims (Doves) tested under semi laboratory conditions are quite different. Testosterone does not cause aggression, only exaggerates the pre-existing pattern and response to environmental triggers of aggression.