This study analyzes comments from two major social media, Facebook and Twitter, regarding the controversial cancellation of the 2015 African Cup of Nations (CAN) in Morocco and its transfer to Equatorial Guinea, a move precipitated by the contemporaneous outbreaks of Ebola in West Africa. Using frame analysis methodology (frames being the central ideas structuring a narrative account of an issue, event or controversy), it investigates how the sporting and health worlds are understood and conceptualized on Twitter and Facebook, in the context of a specific event. We also investigated the extent to which these frames are platform-specific. Data were collected by keyword extraction and submitted to a qualitative thematic and frame analysis, from which we identified six frames (Epidemic management, Sporting event, Political, Skepticism, Religion, and Economic). Analysis of these frames identified a number of classic issues from the sociology of not only football and epidemics but also of African political issues. The cancellation of the CAN thus provides an excellent window into the complex links between sport, heath and politics. Indeed, the online comments of social media users expressed a rich range of pre-existing frustrations, beliefs and political positions. Our results show that, in the context of the cancellation of the 2015 CAN, tweets mostly framed the event as an epidemic management issue, while Facebook comments typically framed it as an epidemic management, sporting and political event. Some themes treated in a factual way on Twitter became politicized on Facebook where, in addition, new political themes emerged. We conclude that studying social media conversations relating to a mega-sporting event could provide sociologically valuable insights about topics not typically directly associated with sport or health.