Abstract The objective of this thesis is to assess the prevalence of low quality of life scores in adult cancer survivors. This thesis also intends to examine the predictors for low quality of life, separately for physical quality of life and mental quality of life. Possible predictors explored include diet quality, age at cancer diagnosis, race and ethnicity, body mass index, alcohol intake, physical activity, and more. The data source for this thesis is the National Health and Examination Survey 2005-2012. The sample population included 1244 cancer survivors 20 years or older that answered yes to the question “have you ever been told by a doctor or other health professional that had cancer or malignancy of any kind”? Both, mental and physical health, were determined based on the number of days physical and mental health was not good and dichotomized according to mean value. The four groups identified were low mental health and low physical health (n=148, 11.9%), low mental health and high physical health (n=239, 19.2%), high mental health and low physical health (n=143, 11.5%), and high mental health and high physical health (n=714, 57.4%). The diet quality was calculated using the Healthy Eating Index 2015 since it measures adherence to the Dietary Guidelines for Americans. The SAS Survey Analysis Procedures was used to account for the random multi-stage sampling of NHANES. On the other hand, ANOVA and chi-square were used to determine the possible predictors of low quality of life while multivariable logistic regression analysis was performed to examine the independent predictors of low physical and mental health with statistical significance was set at a two-sided p-value of <0.05. The results showed that age, economic status, and physical activity are predictors of low quality of life for adult cancer survivors. This indicates that future interventions for improving quality of life should be focused on increasing physical activity, especially in middle aged, obese, and economically disadvantaged cancer survivors. Citation Format: Odette Chirinos, Eunkyung Lee. The clinical, behavioral, and demographic factors associated with the quality of life of cancer survivors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5904.