Background and Aims: Contrast induced nephropathy (CIN) is described in patients undergoing interventional cardiac procedures and a grading system for the same has been in use. The predictors of development of CIN in cirrhotics (CP) has not been studied adequately. It is well known that CP have low creatinine (Cr) clearance and renal reserve and maybe at risk, to develop CIN. We devised a novel scoring system (Contrast Induced Nephropathy In Cirrhosis, CINIC score) to predict CIN in CP using a derivative group (DG) which was validated in a separate cohort (VG). Methods: DG of 350 CP [M=281, F = 69; alcohol = 86, HBV=190, others = 74] with or without decompensation undergoing contrast enhanced computed tomography [CECT, Omnipaque 300 (Iohexol, 1ml/kg; 300mg/ml Iodine)], of abdomen were prospectively studied for development of CIN. CIN was defined as an absolute increase of 0.5mg/dL Cr from baseline or increase in Cr >25% within 48 to 72hrs. Independent risk factors were identified on multivariate analysis, a score derived, based on regression coefficient values rounded for each variable, providing a total score. This was validated in independent VG of 150 CP undergoing CECT. Results: 39 (11.1%) patients developed CIN. On univariate analysis severity of ascites (p 6.2mg/dL, Sen 60%), DM & HTN, 2 each, and CTP 4 (>11, Sen 93%), for a total score of 9. Prediction of CIN was made at a total score of ≥4.5, rounded off to 5 [sensitivity 84%, specificity 76%, AUROC 0.889 (95%CI 0.845–0.933), p < 0.001]. Patients in DG and VG were comparable. In VG, CINIC score predicted CIN with AUROC 96.3 (Sen 80%, Spe 90.4%, PPV 48%, NPV 97.6%). Coordinates of the ROC curve