In this study, the mediating role of psychological resilience in the relationship between negative childhood experiences and academic achievement was examined. The sample of the study consists of 405 participants who graduated from state universities in Turkey in the spring semester of 2022-2023. In the study, the Adverse Childhood Experiences Scale, the Brief Psychological Resilience Scale, and the general weighted grade point average in the university graduation transcripts of the participants were used as data collection tools. The relationships between variables were analyzed using Pearson correlation analysis and regression analysis using Process Macro (Model 4). In the regression analysis, mediation was tested with the Bootstrap technique. According to the results, there were significant negative relationships between adverse childhood experiences and academic achievement and psychological resilience, while there were significant positive relationships between psychological resilience and academic achievement. In addition, adverse childhood experiences are a predictor of academic achievement, and psychological resilience has a partial mediating role in the relationship between adverse childhood experiences and academic achievement. It is thought that the results obtained may contribute to the field within the scope of preventive and intervention guidance services to increase the academic achievement of university students with adverse childhood experiences.